Abstract:
:Nephrogenic rests are nodular collections of undifferentiated renal blastema cells in the postnatal kidney that are recognized as putative precursor lesions of Wilms tumor. In this study, we report the case of a 3-year-old boy who was diagnosed with a hyperplastic intralobar nephrogenic rest extending through the renal pelvis and ureter. After radical nephrectomy, adjuvant chemotherapy was performed as done in stage II Wilms tumor. We also investigated the mutation of the WT1 gene and identified a related single-nucleotide polymorphism (rs16754). We consider that not only various genetic mutations but also single-nucleotide polymorphisms or other epigenetic factors might be involved in the development of Wilms tumor.
journal_name
Urologyjournal_title
Urologyauthors
Mizuno K,Hayashi Y,Tozawa K,Iwatsuki S,Kojima Y,Kohri Kdoi
10.1016/j.urology.2009.09.012subject
Has Abstractpub_date
2010-07-01 00:00:00pages
149-52issue
1eissn
0090-4295issn
1527-9995pii
S0090-4295(09)02539-4journal_volume
76pub_type
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