Abstract：
:Salmonella enterica serovar Enteritidis remains the most prevalent serotype causing human salmonellosis through the consumption of contaminated foods, especially poultry products. The development of a subunit vaccine against S. Enteritidis can not only protect chickens against Salmonella infection in the poultry industry but also cut the transmission sources. In this study, both the expressed recombinant outer membrane protein F (rOmpF) and extracted outer membrane vesicles (OMVs) were developed as subunit vaccines against S. Enteritidis challenge in chickens. Immunization with the subunit vaccine could induce not only antibody production but also strong cell-mediated immune response. Both rOmpF plus QuilA adjuvant and OMVs alone had highly protective efficacy against S. Enteritidis challenge and rapidly decreased the colonization of bacteria in chicken. These findings revealed the potential application of rOmpF and OMVs as subunit vaccines in the poultry industry.
journal_name
Vaccinejournal_title
Vaccineauthors
Li Q,Ren J,Xian H,Yin C,Yuan Y,Li Y,Ji R,Chu C,Qiao Z,Jiao Xdoi
10.1016/j.vaccine.2020.08.074subject
Has Abstractpub_date
2020-10-21 00:00:00pages
7094-7099issue
45eissn
0264-410Xissn
1873-2518pii
S0264-410X(20)31126-9journal_volume
38pub_type
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