Abstract:
:The ruffled border is the most specific marker of the active osteoclast (OC) as it forms only when the cell is resorbing bone. We provide evidence that this complex cytoskeletal structure reflects insertion of the lysosomal vesicles into the bone-apposed plasma membrane under the aegis of the Ca-sensing, exocytic protein, synaptotagmin VII (SytVII). In the manner, SytVII permits transport of matrix-degrading molecules into the resorptive microenvironment. SytVII also regulates secretion of bone matrix molecules by osteoblasts. Thus, SytVII-deficient mice experience suppressed bone resorption and formation with the latter deficiency predominant thereby yielding osteoporosis characterized by attenuated remodeling.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Zhao H,Ito Y,Chappel J,Andrews N,Ross FP,Teitelbaum SLdoi
10.1007/978-1-4419-1050-9_11subject
Has Abstractpub_date
2010-01-01 00:00:00pages
105-9eissn
0065-2598issn
2214-8019journal_volume
658pub_type
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