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The effect of compliance with a perioperative goal-directed therapy protocol on outcomes after high-risk surgery: a before-after study.

Abstract：

:Perioperative goal-directed therapy is considered to improve patient outcomes after high-risk surgery. The association of compliance with perioperative goal-directed therapy protocols and postoperative outcomes is unclear. The purpose of this study is to determine the effect of protocol compliance on postoperative outcomes following high-risk surgery, after implementation of a perioperative goal-directed therapy protocol. Through a before-after study design, patients undergoing elective high-risk surgery before (before-group) and after implementation of a perioperative goal-directed therapy protocol (after-group) were included. Perioperative goal-directed therapy in the after-group consisted of optimized stroke volume variation or stroke volume index and optimized cardiac index. Additionally, the association of protocol compliance with postoperative complications when using perioperative goal-directed therapy was assessed. High protocol compliance was defined as ≥ 85% of the procedure time spent within the individual targets. The difference in complications during the first 30 postoperative days before and after implementation of the protocol was assessed. In the before-group, 214 patients were included and 193 patients in the after-group. The number of complications was higher in the before-group compared to the after-group (n = 414 vs. 282; p = 0.031). In the after-group, patients with high protocol compliance for stroke volume variation or stroke volume index had less complications compared to patients with low protocol compliance for stroke volume variation or stroke volume index (n = 187 vs. 90; p = 0.01). Protocol compliance by the attending clinicians is essential and should be monitored to facilitate an improvement in postoperative outcomes desired by the implementation of perioperative goal-directed therapy protocols.

journal_name

J Clin Monit Comput

journal_title

Journal of clinical monitoring and computing

authors

Boekel MF,Venema CS,Kaufmann T,van der Horst ICC,Vos JJ,Scheeren TWL

doi

10.1007/s10877-020-00585-w

subject

Has Abstract

pub_date

2020-09-12 00:00:00

eissn

1387-1307

issn

1573-2614

pii

10.1007/s10877-020-00585-w

pub_type

杂志文章

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The effect of compliance with a perioperative goal-directed therapy protocol on outcomes after high-risk surgery: a before-after study.