Plasma nitrite response in older women to a physical function test.

Abstract:

BACKGROUND AND AIMS:Nitric oxide (NO) may play a critical role in facilitating the delivery of blood to active skeletal muscle, ultimately impacting functional health in older adults. Plasma nitrite is a useful marker of vascular NO bioavailability. The aim of the current investigation was to examine the effect of a widely used physical function test on plasma nitrite concentrations in older adults. METHODS:Venous blood was drawn before, immediately following, and 10 minutes following the completion of a 400-m walk test. Blood samples were added to heparin and frozen for subsequent analysis of nitrite levels using chemiluminescence. RESULTS:Twenty six (79±4 yrs) women participated in this study. Plasma nitrite levels decreased approximately 22% from baseline following a 400-m walk. Percent change in plasma nitrite was related to walking speed (r=-0.550, p=0.004). CONCLUSIONS:These data suggest an alteration in plasma nitrite concentration following a functional test which may impact functional health.

journal_name

Aging Clin Exp Res

authors

Dobrosielski DA,Presley T,Perlegas A,Marsh AP,Kim-Shapiro D,Rejeski WJ

doi

10.3275/6734

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

383-6

issue

5-6

eissn

1594-0667

issn

1720-8319

pii

6734

journal_volume

22

pub_type

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