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The Effect of Mechanical Properties of Synthetic Prostheses Made by Electrospinning on the Results of Experimental Implantation in the Infrarenal Abdominal Aorta.

Abstract：

BACKGROUND:The research aims to study the effect of circumferential compliance of synthetic vascular prostheses on their healing during implantation in the infrarenal abdominal aorta of pigs. METHODS:In an experiment, 12 pigs were implanted with blood vessel prostheses in the infrarenal abdominal aorta. The prostheses possessed elastic characteristics obtained by a tensile testing machine, and differed in circumferential compliance: rigid (polycaprolactone [PCL]); less compliant than the native aorta (polyurethane [PU]); comparable in compliance to the native aorta (copolymer of vinylidene fluoride with hexafluoropropylene) before (FKM) and after radiation treatment (FKM-γ). The implanted prostheses compliance was measured by aortography during the first 3 days and 1 month after implantation, the condition of the prosthesis capsule was evaluated by macroscopic preparations and histologic examination. RESULTS:Pulsation on PCL prostheses was nonexistent immediately after implantation. On PU prostheses, slight pulsation was noted during the first 3 days and disappeared after 1 month. On FKM prostheses, although pulsation persisted after 1 month, a significant expansion of prostheses was also recorded as a result of fatigue plastic deformation. On FKM-γ prostheses, pulsation comparable in magnitude with aortic pulsation was present 1 month after implantation with no change in the size of the prosthesis. Macroscopic preparations reveal significant differences in the formed connective tissue capsule. The PCL prosthesis capsule is thick, narrowing the lumen of the vessel from the outside. The outer surface of PU prostheses is covered with a thinner uniform fibrous capsule. The inner surface of the FKM and FKM-γ prostheses is covered with a thin layer of smooth whitish tissue. The FKM prosthesis, unlike the FKM-γ prosthesis, is sharply expanded. In all cases, moderate aortic expansion was observed distal to the prosthesis. According to the histologic data, the outer and inner capsules of PCL prostheses are covered with a thick layer of fibrous tissue with signs of productive inflammation and foci of calcification. PU prostheses are surrounded by a thick connective tissue capsule partially endothelialized from the inside; the outer capsule is randomly populated with fibroblastic cells. FKM prostheses have a thin outer capsule where smooth muscle cells are visible, mainly oriented along and across the prosthesis axis; the inner capsule is thin and completely covered with a layer of endothelial cells from the side of the lumen. A layered structure is visible in the prosthesis capsule of FKM-γ, and the fibroblast cells in each layer of the capsule are oriented along or across the prosthesis axis, similar to the structure of a natural arterial vessel. The inner surface of the prosthesis is completely endothelialized. CONCLUSIONS:The healing and degree of inflammation in a capsule of blood vessel prostheses implanted in the infrarenal abdominal aorta of pigs depend on the degree of their circumferential compliance. Although maintaining pulsations, the cellular structure of the capsule is characterized by a greater degree of differentiation and approaches the structure of the native arterial wall.

journal_name

Ann Vasc Surg

journal_title

Annals of vascular surgery

authors

Tsygankov YM,Zhorzholiani ST,Khugaev GA,Tevosov DR,Shepelev AD,Krasheninnikov SV,Gorodkov AY,Bockeria LA

doi

10.1016/j.avsg.2020.08.117

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

506-516

eissn

0890-5096

issn

1615-5947

pii

S0890-5096(20)30798-6

journal_volume

pub_type

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The Effect of Mechanical Properties of Synthetic Prostheses Made by Electrospinning on the Results of Experimental Implantation in the Infrarenal Abdominal Aorta.