Efficacy of light therapy for a college student sample with non-seasonal subthreshold depression: An RCT study.


BACKGROUND:Light therapy has been successfully used to treat seasonal and non-seasonal depression, but there is limited evidence for its efficacy in subthreshold depression. This study examines the efficacy of light therapy for symptoms of depression and anxiety in non-seasonal subthreshold depression. METHODS:College students with non-seasonal subthreshold depression were recruited. The participants were randomly allocated to one of the three conditions: high- (LT-5000 lux) and low-intensity (LT-500 lux) light therapy conditions and a waiting-list control condition (WLC). The primary outcome was Hamilton Depression Rating Scale (HAMD), and secondary outcomes were Beck Depression Inventory-II (BDI-II) and state anxiety inventory (SAI), which were assessed at baseline (Week 0), during the trial (Week 4), and after completion of the light therapy (Week 8). RESULTS:A total of 142 participants completed the trial. The LT-5000 (effect size [d] = 1.56, 95% CI: 1.15 to 1.98) and LT-500 conditions (d = 0.84, 95% CI: 0.43 to 1.26) were significantly superior to the WLC condition. For the LT-5000, LT-500, and WLC conditions by the end of the 8-week trial, a response on the HAMD was achieved by 70.0%, 42.0% and 19.0% of the participants, and remission was achieved by 76.0%, 54.0%, and 19.0%, respectively. LIMITATIONS:The subjects were not followed up regularly after completion of the trial. CONCLUSION:Light therapy, both at high- and low-intensity, was efficacious in the treatment of college students with non-seasonal subthreshold depression. High-intensity light therapy was superior to low-intensity light therapy by the end of an 8-week trial.


J Affect Disord


Jiang L,Zhang S,Wang Y,So KF,Ren C,Tao Q




Has Abstract


2020-12-01 00:00:00












  • Age predicts low-frequency transcranial magnetic stimulation efficacy in major depression.

    abstract:BACKGROUND:Transcranial magnetic stimulation (TMS) effectiveness in major depression has so far been studied mainly with high-frequency (>1 Hz) administration (HF-TMS). However, some available studies with low-frequency TMS (LF-TMS) have provided similar response rates to HF-TMS with better tolerance, but the evidence ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验


    authors: Aguirre I,Carretero B,Ibarra O,Kuhalainen J,Martínez J,Ferrer A,Salva J,Roca M,Gili M,Montoya P,Garcia-Toro M

    更新日期:2011-05-01 00:00:00

  • Qzone use and depression among Chinese adolescents: A moderated mediation model.

    abstract:BACKGROUND:Social networking sites (SNSs), which provide abundant social comparison opportunities, are ubiquitous around the world, especially among adolescents. In China, Qzone stands out as the most popular SNS. Due to the opportunity it provides for meticulous self-presentation, SNS may give the impression that othe...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Niu GF,Luo YJ,Sun XJ,Zhou ZK,Yu F,Yang SL,Zhao L

    更新日期:2018-04-15 00:00:00

  • Augmenting psychoeducation with a mobile intervention for bipolar disorder: a randomized controlled trial.

    abstract:BACKGROUND:Psychosocial interventions for bipolar disorder are frequently unavailable and resource intensive. Mobile technology may improve access to evidence-based interventions and may increase their efficacy. We evaluated the feasibility, acceptability and efficacy of an augmentative mobile ecological momentary inte...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验


    authors: Depp CA,Ceglowski J,Wang VC,Yaghouti F,Mausbach BT,Thompson WK,Granholm EL

    更新日期:2015-03-15 00:00:00

  • Association between serum BDNF levels and maternal perinatal depression: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD.

    abstract:INTRODUCTION:A large amount of studies demonstrated reduced serum Brain-Derived Neurotrophic Factor (BDNF) levels in stress-related and depressive disorders. However, it is still unclear if a similar deficit in BDNF concentrations might also characterize maternal perinatal depression. METHODS:We performed a bibliograp...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Mandolini GM,Lazzaretti M,Delvecchio G,Bressi C,Soares JC,Brambilla P

    更新日期:2020-01-15 00:00:00

  • Plasma nortriptyline and clinical response in depression.

    abstract::Plasma levels of nortriptyline below 50 ng/ml or above 150 ng/ml have been reported to yield results inferior to intermediate levels. In the present study, patients with uncomplicated primary, nonbipolar depression were randomly assigned to 12 weeks of treatment with NT alone or with cognitive therapy. Nine of 35 pati...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Murphy GE,Simons AD,Wetzel RD

    更新日期:1985-03-01 00:00:00

  • Disappearance of memory deficits in outpatient depressives responding to imipramine.

    abstract::We evaluated learning and memory in 50 depressed patients prior to and following 4 week treatment with imipramine compared to 21 normal controls tested at corresponding times. At baseline, the depressives did worse than normals on most memory tasks with the difficult memory tasks, regardless of store, modality or type...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Peselow ED,Corwin J,Fieve RR,Rotrosen J,Cooper TB

    更新日期:1991-03-01 00:00:00

  • Overlap and distinctiveness of psychological risk factors in patients with ischemic heart disease and chronic heart failure: are we there yet?

    abstract:OBJECTIVE:Growing evidence supports the importance of psychological factors in the etiology and progression of cardiovascular disease (CVD). However, this research has been criticized due to overlap between psychological constructs. We examined whether psychological questionnaires frequently used in cardiovascular rese...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Pelle AJ,Denollet J,Zwisler AD,Pedersen SS

    更新日期:2009-02-01 00:00:00

  • Chronic medical conditions and metabolic syndrome as risk factors for incidence of major depressive disorder: A longitudinal study based on 4.7 million adults in South Korea.

    abstract:BACKGROUND:The assessment of comorbid physical illness and metabolic or cardiovascular risk factors as potential risk factors for onset of major depressive disorder (MDD) is crucial. We aimed to investigate potential risk factors for the development of MDD among individuals with chronic medical conditions and metabolic...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Han KM,Kim MS,Kim A,Paik JW,Lee J,Ham BJ

    更新日期:2019-10-01 00:00:00

  • Introducing the concept of modern depression in Japan; an international case vignette survey.

    abstract:AIM:Japanese psychiatrists have increasingly reported patients with depression that does not seem to fit the criteria of the ICD-10 and the DSM-IV, and which has recently been called modern type depression (MTD). We explored whether MTD is frequently seen in Japan and also in other countries, and if so, how patients wi...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Kato TA,Shinfuku N,Fujisawa D,Tateno M,Ishida T,Akiyama T,Sartorius N,Teo AR,Choi TY,Wand AP,Balhara YP,Chang JP,Chang RY,Shadloo B,Ahmed HU,Lerthattasilp T,Umene-Nakano W,Horikawa H,Matsumoto R,Kuga H,Tanaka M,

    更新日期:2011-12-01 00:00:00

  • Lithium treatment at 52.

    abstract::The paper reviews briefly and comments in detail on selected events in the history of lithium treatment. The events include Cade's discovery of lithium's antimanic action, the discovery and establishment of its prophylactic action, the ensuing debate, amelioration and prevention of side effects and risks, use during p...

    journal_title:Journal of affective disorders

    pub_type: 历史文章,杂志文章,评审


    authors: Schou M

    更新日期:2001-12-01 00:00:00

  • Gender differences in the prevalence of depression: a survey in primary care.

    abstract::Epidemiological surveys demonstrate that unipolar depression is more common in females than in males. Gender-specific cultural and social factors may contribute to the female preponderance. This study explores this possibility in a cross-cultural sample of general-practice patients systematically recruited in the WHO ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Maier W,Gänsicke M,Gater R,Rezaki M,Tiemens B,Urzúa RF

    更新日期:1999-06-01 00:00:00

  • Free T4 index and clinical outcome in patients with depression.

    abstract:INTRODUCTION:Many studies of patients with major depression have reported that a significant decrease in serum free T(4) index is associated with specific treatments; what has been unanswered is whether these observations are generalizable. This study evaluated baseline thyroid function and its relationship to rapidity...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Abulseoud O,Sane N,Cozzolino A,Kiriakos L,Mehra V,Gitlin M,Masseling S,Whybrow P,Altshuler LL,Mintz J,Frye MA

    更新日期:2007-06-01 00:00:00

  • Efficacy of exercise as an adjunct treatment for clinically depressed inpatients during the initial stages of antidepressant pharmacotherapy: An open randomized controlled trial.

    abstract:BACKGROUND:Physical exercise as adjunctive treatment for hospitalized patients with major depressive disorder (MDD) has been of increasing interest in the past few years. While preliminary findings are promising, these prior studies have been plagued by inclusion of participants at different stages of medication use at...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验


    authors: Legrand FD,Neff EM

    更新日期:2016-02-01 00:00:00

  • Cortical mechanisms of the symptomatology in major depressive disorder: a resting EEG study.

    abstract:BACKGROUND:Diagnosis and treatment rely on symptom criteria in modern psychiatry. However, the cortical mechanisms of symptomatology in major depressive disorder (MDD) are still not clear. This study examined neural correlates of symptom clusters of MDD by electroencephalography (EEG). METHODS:Resting state eye-closed...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Lee TW,Yu YW,Chen MC,Chen TJ

    更新日期:2011-06-01 00:00:00

  • Clinical effects of electroconvulsive therapy in severe depression and concomitant changes in cerebral glucose metabolism--an exploratory study.

    abstract:OBJECTIVE:Electroconvulsive therapy (ECT) is an effective mode of treatment--especially for severe depression and for depression refractory to pharmacotherapy, nevertheless the mode of action of ECT is far from being fully understood. This study assessed the effects of a series of ECT in depressive subjects on cerebral...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Reininghaus EZ,Reininghaus B,Ille R,Fitz W,Lassnig RM,Ebner C,Annamaria P,Hofmann P,Kapfhammer HP,Reingard A,Fazekas F,Ropele S,Enzinger C

    更新日期:2013-04-05 00:00:00

  • Mental health diagnoses and early removal of long-acting reversible contraception.

    abstract:BACKGROUND:Having a mental health diagnosis is associated with contraceptive non-adherence and user-related contraceptive failures of short-acting methods. There is a lack of research on the relationship between mental health diagnoses and early discontinuation of highly effective long-acting reversible (LARC) methods ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Bello JK,Salas J,Meyer D,Heiden-Rootes K,Davis DM,Keegan Garrett E,White MM,Schmeidler P

    更新日期:2020-02-01 00:00:00

  • Temporal trends in antidepressant prescribing to children in UK primary care, 2000-2015.

    abstract:BACKGROUND:The prevalence of antidepressant prescribing in children and adolescents increased steadily in the United States and parts of Europe between 2005 and 2012 despite regulatory safety warnings. Little is known about the characteristics of those being prescribed antidepressants for the first time. METHODS:A lon...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Sarginson J,Webb RT,Stocks SJ,Esmail A,Garg S,Ashcroft DM

    更新日期:2017-03-01 00:00:00

  • Adverse childhood experiences and the risk of depressive disorders in adulthood.

    abstract:BACKGROUND:Research examining the association between childhood abuse and depressive disorders has frequently assessed abuse categorically, thus not permitting discernment of the cumulative impact of multiple types of abuse. As previous research has documented that adverse childhood experiences (ACEs) are highly interr...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Chapman DP,Whitfield CL,Felitti VJ,Dube SR,Edwards VJ,Anda RF

    更新日期:2004-10-15 00:00:00

  • Gender differences in a cohort study of 604 bipolar patients: the role of predominant polarity.

    abstract:BACKGROUND:Some clinical differences between gender regarding the course and outcome of bipolar disorders have already been described and some others remain still controversial. AIMS:To explore gender differences regarding clinical and socio-demographic characteristics amongst bipolar patients with particular attentio...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Nivoli AM,Pacchiarotti I,Rosa AR,Popovic D,Murru A,Valenti M,Bonnin CM,Grande I,Sanchez-Moreno J,Vieta E,Colom F

    更新日期:2011-10-01 00:00:00

  • Deliberate self harm patients with depressive disorders: treatment and outcome.

    abstract:BACKGROUND:Depression is the most common psychiatric disorder in deliberate self-harm (DSH) patients and in those who commit suicide. The aim of this study was to examine the treatment received by DSH patients with depression and their progress following DSH. METHODS:A representative sample of 106 patients with an ICD...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Haw C,Houston K,Townsend E,Hawton K

    更新日期:2002-06-01 00:00:00

  • Depression-related cognitive impairment: possibilities for its pharmacological treatment.

    abstract::Depression-related cognitive impairment (DRCI) is a condition which despite its initial treatment response, shows a progressive deterioration. No consistent therapeutic strategies have been proposed to combat this condition. This may be due to a reluctance to treat the cognitively impaired, a failure to recognise the ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Mitchell AJ,Dening TR

    更新日期:1996-01-22 00:00:00

  • Default mode network subsystem alterations in bipolar disorder during major depressive episode.

    abstract:BACKGROUND:Default mode network (DMN) has been widely reported to be altered in bipolar disorder during major depressive episode (BDD). Recent studies supported the idea that DMN is not an unitary system, but composed of smaller and distinct functional subsystems. The current study aimed to investigate the abnormal fun...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Yang Y,Cui Q,Lu F,Pang Y,Chen Y,Tang Q,Li D,Lei T,He Z,Hu S,Deng J,Chen H

    更新日期:2021-02-15 00:00:00

  • Residual symptoms in depressed patients who successfully respond to short-term psychotherapy.

    abstract:BACKGROUND:Most investigations of residual symptoms have focused on partial responders to antidepressant medications. Comparatively few have examined residual symptoms among patients who achieved a more successful response to treatment. In addition, few studies have assessed residual symptoms among patients treated wit...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ogrodniczuk JS,Piper WE,Joyce AS

    更新日期:2004-11-01 00:00:00

  • Do the dissociative side effects of ketamine mediate its antidepressant effects?

    abstract:BACKGROUND:The N-methyl-d-aspartate receptor antagonist ketamine has rapid antidepressant effects in major depression. Psychotomimetic symptoms, dissociation and hemodynamic changes are known side effects of ketamine, but it is unclear if these side effects relate to its antidepressant efficacy. METHODS:Data from 108 ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Luckenbaugh DA,Niciu MJ,Ionescu DF,Nolan NM,Richards EM,Brutsche NE,Guevara S,Zarate CA

    更新日期:2014-04-01 00:00:00

  • Fluoxetine: no association with suicidality in obsessive-compulsive disorder.

    abstract::Since (a) obsessive-compulsive disorder (OCD) may involve serotonergic neural transmission abnormalities also though to be related to regulation of suicide and aggression, (b) comorbidity between OCD and depression is substantial, and (c) depression is a major risk factor for suicide, a comprehensive analysis of clini...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Beasley CM Jr,Potvin JH,Masica DN,Wheadon DE,Dornseif BE,Genduso LA

    更新日期:1992-01-01 00:00:00

  • Older maternal age and major depressive episodes in the first two years after birth: findings from the Parental Age and Transition to Parenthood Australia (PATPA) study.

    abstract:BACKGROUND:This study examines whether (1) older maternal age is associated with increased risk of depressive episodes between four months and two years after first birth and (2) the role of subsequent reproductive, social and child factors in vulnerability to later onset depression. METHOD:592 women were recruited in...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: McMahon CA,Boivin J,Gibson FL,Hammarberg K,Wynter K,Fisher JR

    更新日期:2015-04-01 00:00:00

  • Perinatal depression and omega-3 fatty acids: a Mendelian randomisation study.

    abstract:BACKGROUND:There have been numerous studies investigating the association between omega-3 fatty acids (FAs) and depression, with mixed findings. We propose an approach which is largely free from issues such as confounding or reverse causality, to investigate this relationship using observational data from a pregnancy c...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Sallis H,Steer C,Paternoster L,Davey Smith G,Evans J

    更新日期:2014-09-01 00:00:00

  • Response style, interpersonal difficulties and social functioning in major depressive disorder.

    abstract:BACKGROUND:It is postulated that depressed patients who engaged in self-focused rumination on their depressive symptoms may experience more hopelessness, more interpersonal distress and poorer social functioning while patients who distract themselves may experience less severe hopelessness and better social functioning...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Lam D,Schuck N,Smith N,Farmer A,Checkley S

    更新日期:2003-08-01 00:00:00

  • The high prevalence of bipolar II and associated cyclothymic and hyperthymic temperaments in HIV-patients.

    abstract:BACKGROUND:Although recent studies have shown high rates of current and lifetime depression in HIV-infected patients, there is little systematic data on the occurrence of bipolarity in these patients. METHOD:We compared 46 HIV patients with index major depressive episode (MDE) to an equal number of age- and sex-matche...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Perretta P,Akiskal HS,Nisita C,Lorenzetti C,Zaccagnini E,Della Santa M,Cassano GB

    更新日期:1998-09-01 00:00:00

  • Family history of suicidal behavior and early traumatic experiences: additive effect on suicidality and course of bipolar illness?

    abstract:BACKGROUND:Bipolar disorder (BD) is associated with a high prevalence of suicide attempt and completion. Family history of suicidal behavior and personal history of childhood abuse are reported risk factors for suicide among BD subjects. METHODS:BD individuals with family history of suicidal behavior and personal hist...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Carballo JJ,Harkavy-Friedman J,Burke AK,Sher L,Baca-Garcia E,Sullivan GM,Grunebaum MF,Parsey RV,Mann JJ,Oquendo MA

    更新日期:2008-07-01 00:00:00