ER stress-related molecules induced by Hantaan virus infection in differentiated THP-1 cells.

abstract：:Mesenchymal stem cells (MSCs) are under intensive investigation for use in cell-based therapies because their differentiation abilities, immunomodulatory effects, and homing properties offer potential for significantly augmenting regenerative capacity of many tissues. Nevertheless, major impediments to their therapeut...

journal_title：Cell stress & chaperones

authors： Amiri F,Jahanian-Najafabadi A,Roudkenar MH

更新日期：2015-03-01 00:00:00

abstract：:Estrogen (E2) plays a critical role in the etiology and progression of human breast cancer. The estrogenic response is complex and not completely understood, including in terms of the involved responsive genes. Here we show that Hsp22 (synonyms: HspB8, E2lG1, H11), a member of the small heat shock protein (sHSP) super...

journal_title：Cell stress & chaperones

authors： Sun X,Fontaine JM,Bartl I,Behnam B,Welsh MJ,Benndorf R

更新日期：2007-01-01 00:00:00

abstract：:It has recently been suggested that heat shock protein (Hsp) 70, an intracellular protein, can be released into the extracellular compartment and exert important immunomodulatory functions. Although elevated Hsp70 has been found in synovial fluid from patients with rheumatoid arthritis (RA), its sources and extracellu...

journal_title：Cell stress & chaperones

authors： Luo X,Zuo X,Zhang B,Song L,Wei X,Zhou Y,Xiao X

更新日期：2008-09-01 00:00:00

abstract：:The presence of the soluble intracellular heat shock protein gp96 (an endoplasmic reticulum resident protein) at the surface of certain cell types is an intriguing phenomenon whose physiological significance has been unclear. We have shown that the active surface expression of gp96 by some immune cells is found throug...

journal_title：Cell stress & chaperones

authors： Morales H,Muharemagic A,Gantress J,Cohen N,Robert J

更新日期：2003-10-01 00:00:00

abstract：:Honeybee propolis and its bioactive component, caffeic acid phenethyl ester (CAPE), are known for a variety of therapeutic potentials. By recruiting a cell-based reporter assay for screening of hypoxia-modulating natural drugs, we identified CAPE as a pro-hypoxia factor. In silico studies were used to probe the capaci...

journal_title：Cell stress & chaperones

authors： Bhargava P,Kumari A,Putri JF,Ishida Y,Terao K,Kaul SC,Sundar D,Wadhwa R

更新日期：2018-09-01 00:00:00

abstract：:Autoimmune diseases are characterized by the loss of immune tolerance to self-antigens which leads to an excessive immune responses and chronic inflammation. Although much progress has been made in revealing key players in pathophysiology of various autoimmune diseases, their therapy remains challenging and consists o...

journal_title：Cell stress & chaperones

authors： Tukaj S,Kaminski M

更新日期：2019-05-01 00:00:00

abstract：:Small heat shock proteins (sHSPs) encompass a widespread and diverse class of proteins with molecular chaperone activity. In the present study, two sHSP isoforms (VpsHSP-1 and VpsHSP-2) were cloned from Venerupis philippinarum haemocytes by Rapid Amplification of cDNA Ends (RACE) approaches. The expression profiles of...

journal_title：Cell stress & chaperones

authors： Li C,Wang L,Ning X,Chen A,Zhang L,Qin S,Wu H,Zhao J

更新日期：2010-11-01 00:00:00

abstract：:Current cancer therapies including cytotoxic chemotherapy, radiation and hyperthermic therapy induce acute proteotoxic stress in tumour cells. A major challenge to cancer therapeutic efficacy is the recurrence of therapy-resistant tumours and how to overcome their emergence. The current study examines the concept that...

journal_title：Cell stress & chaperones

authors： Lang BJ,Nguyen L,Nguyen HC,Vieusseux JL,Chai RC,Christophi C,Fifis T,Kouspou MM,Price JT

更新日期：2012-11-01 00:00:00

abstract：:The expression of heat-shock protein 60 (also known as chaperonin 60, Cpn60) in experimental acute pancreatitis (AP) is considered to play an active role in the prevention of abnormal enzyme accumulation and activation in pancreatic acinar cells. However, there are controversial results in the literature regarding the...

journal_title：Cell stress & chaperones

authors： Li XL,Li K,Li YY,Feng Y,Gong Q,Li YN,Li XJ,Chen CJ

更新日期：2009-03-01 00:00:00

abstract：:Heat shock protein 70 (designated Laternula elliptica Hsp70 (LEHsp70)) expression was investigated in an Antarctic mud clam to see whether or not the inducible heat shock response has been conserved throughout over 25 million years of adaptation to constant low environmental temperatures. LEHsp70 cDNA was cloned and s...

journal_title：Cell stress & chaperones

authors： Park H,Ahn IY,Lee HE

更新日期：2007-10-01 00:00:00

abstract：:Stressful stimuli can elicit 2 distinct reactive cellular responses, the heat shock (stress) response and the activation of cell death pathways. Most studies on the effects of hyperthermia on the mammalian nervous system have focused on the heat shock response, characterized by the transient induction of Hsps, which p...

journal_title：Cell stress & chaperones

authors： Khan VR,Brown IR

更新日期：2002-01-01 00:00:00

abstract：:Heat-shock proteins (HSPs) are highly expressed when organisms are exposed to thermal stresses. The HSPs are considered to play significant roles in thermal adaptation because they function as molecular chaperones facilitating proper protein synthesis. The expression of HSPs under field conditions, however, has not be...

journal_title：Cell stress & chaperones

authors： Harada E,Goto SG

更新日期：2017-11-01 00:00:00

abstract：:Species distribution, abundance, and long-term survival are determined by biotic and abiotic regimes. However, little is known about the importance of these factors in species range expansion. Styela plicata is a solitary ascidian introduced all over the world by ship fouling, including salt marsh habitats, where intr...

journal_title：Cell stress & chaperones

authors： Pineda MC,Turon X,López-Legentil S

更新日期：2012-07-01 00:00:00

abstract：:The human genome codes for 10 so-called mammalian small heat shock or stress proteins (sHsp) with the various tissues expressing characteristic sets of sHsps. Most sHsps interact with each other and form homo- and heterooligomeric complexes. Some of the sHsps are phosphoproteins in vivo, and phosphorylation has been i...

journal_title：Cell stress & chaperones

authors： Sun X,Welsh MJ,Benndorf R

更新日期：2006-04-01 00:00:00

abstract：:Folding of the myosin head often requires the joint actions of Hsp90 and a dedicated UNC45, Cro1, She4 (UCS) domain-containing cochaperone protein. Relatively weak sequence conservation exists between the single UCS protein of simple eukaryotes (She4 in budding yeast) and the two UCS proteins of higher organisms (the ...

journal_title：Cell stress & chaperones

authors： Gomez-Escalante S,Piper PW,Millson SH

更新日期：2017-01-01 00:00:00

abstract：:Vaccination of mice with tumor-derived stress proteins, such as Hsp70 and gp96 (GRP94), can elicit antitumor immune responses, yielding a marked suppression of tumor growth and metastasis. The molecular basis for this response is proposed to reflect a peptide-binding function for these proteins. In this view, stress p...

journal_title：Cell stress & chaperones

authors： Nicchitta CV,Carrick DM,Baker-Lepain JC

更新日期：2004-01-01 00:00:00

abstract：:The HSP60/HSP10 chaperonin assists folding of proteins in the mitochondrial matrix space by enclosing them in its central cavity. The chaperonin forms part of the mitochondrial protein quality control system. It is essential for cellular survival and mutations in its subunits are associated with rare neurological diso...

journal_title：Cell stress & chaperones

authors： Bie AS,Cömert C,Körner R,Corydon TJ,Palmfeldt J,Hipp MS,Hartl FU,Bross P

更新日期：2020-05-01 00:00:00

abstract：:Late embryogenesis abundant (LEA) proteins are highly hydrophilic, low complexity proteins whose expression has been correlated with desiccation tolerance in anhydrobiotic organisms. Here, we report the identification of three new mitochondrial LEA proteins in anhydrobiotic embryos of Artemia franciscana, AfrLEA3m_47,...

journal_title：Cell stress & chaperones

authors： Boswell LC,Moore DS,Hand SC

更新日期：2014-05-01 00:00:00

abstract：:Heat shock proteins (Hsp) are families of highly conserved molecules and immunodominant antigens in some infections and in autoimmune diseases. Some reports suggest that different regions of the Hsp60 molecule induce distinct immune responses. However, there are no reports comparing physiological T-cell reactivity to ...

journal_title：Cell stress & chaperones

authors： Luna E,Postol E,Caldas C,Mundel LR,Porto G,Iwai LK,Ho PL,Kalil J,Coelho V

更新日期：2007-07-01 00:00:00

abstract：:We have investigated the role of Toxoplasma gondii-derived heat shock protein 70 (TgHSP70) as a B cell mitogen by measuring proliferative responses in vitro. TgHSP70 induced prominent proliferative responses in murine B cells derived not only from T gondii-infected but also from uninfected mice. Nude mice responded to...

journal_title：Cell stress & chaperones

authors： Aosai F,Chen M,Kang HK,Mun HS,Norose K,Piao LX,Kobayashi M,Takeuchi O,Akira S,Yano A

更新日期：2002-10-01 00:00:00

abstract：:In modulated electrohyperthermia (mEHT) the enrichment of electric field and the concomitant heat can selectively induce cell death in malignant tumors as a result of elevated glycolysis, lactate production (Warburg effect), and reduced electric impedance in cancer compared to normal tissues. Earlier, we showed in HT2...

journal_title：Cell stress & chaperones

authors： Andocs G,Meggyeshazi N,Balogh L,Spisak S,Maros ME,Balla P,Kiszner G,Teleki I,Kovago C,Krenacs T

更新日期：2015-01-01 00:00:00

abstract：:Transcription activator proteins are regulatory proteins that bind to the promoter regions of target genes. Transcription activator protein-1 (AP-1) regulates numerous genes related to the immune system, apoptosis, and proliferation. In this study, the full-length cDNA of AP-1 from Portunus trituberculatus (PtAP-1) wa...

journal_title：Cell stress & chaperones

authors： Wang H,Shi C,Kong M,Mu C,Wei H,Wang C

更新日期：2018-11-01 00:00:00

abstract：:The highly conserved part of the nucleotide-binding domain of the hsp70 gene family was amplified from the soil diplopod Tachypodoiulus niger (Julidae, Diplopoda). Genomic DNA yielded 701, 549 and 540 bp sequences, whereas cDNA from heat shocked animals produced only one distinct fragment of 543 bp. The sequences coul...

journal_title：Cell stress & chaperones

authors： Knigge T,Bachmann L,Köhler HR

更新日期：2014-09-01 00:00:00

abstract：:Squamous epithelium in mammals has evolved an atypical stress response involving down-regulation of the classic HSP70 protein and induction of sets of proteins including one named SEP53. This atypical stress response might be due to the unusual environmental pressures placed on squamous tissue. In fact, SEP53 plays a ...

journal_title：Cell stress & chaperones

authors： Nelson L,Anderson S,Archibald AL,Rhind S,Lu ZH,Condie A,McIntyre N,Thompson J,Nenutil R,Vojtesek B,Whitelaw CB,Little TJ,Hupp T

更新日期：2008-09-01 00:00:00

abstract：:We have examined the effect of mild hyperthermia on the pattern of heat shock transcription factor (HSF) binding activity, heat shock protein 70 (hsp70) and hsp30 gene expression and protein denaturation in selected tissues of adult Xenopus namely, heart, hind limb muscle, eye, liver and spleen. In these studies it wa...

journal_title：Cell stress & chaperones

authors： Ali A,Fernando P,Smith WL,Ovsenek N,Lepock JR,Heikkila JJ

更新日期：1997-12-01 00:00:00

abstract：:Lipocalin-2 (Lcn2, NGAL) is a member of the lipocalin super family with diverse function such as the induction of apoptosis, the suppression of bacterial growth, and modulation of inflammatory response. Much interest has recently been focused on the physiological/pathological role of the lipocalin-2 that is considered...

journal_title：Cell stress & chaperones

authors： Bahmani P,Halabian R,Rouhbakhsh M,Roushandeh AM,Masroori N,Ebrahimi M,Samadikuchaksaraei A,Shokrgozar MA,Roudkenar MH

更新日期：2010-07-01 00:00:00

abstract：:Eukaryotic cells respond to hypothermic stress through a series of regulatory mechanisms that preserve energy resources and prolong cell survival. These mechanisms include alterations in gene expression, attenuated global protein synthesis and changes in the lipid composition of the phospholipid bilayer. Cellular resp...

journal_title：Cell stress & chaperones

authors： Adjirackor NA,Harvey KE,Harvey SC

更新日期：2020-11-01 00:00:00

abstract：:Butyric acid (BA) is a major extracellular metabolite produced by anaerobic periodontopathic bacteria and is commonly deposited in the gingival tissue. BA induces mitochondrial oxidative stress in vitro; however, its effects in vivo were never elucidated. Here, we determined the effects of butyric acid retention in th...

journal_title：Cell stress & chaperones

authors： Cueno ME,Imai K,Matsukawa N,Tsukahara T,Kurita-Ochiai T,Ochiai K

更新日期：2013-09-01 00:00:00

abstract：:HSPA1A (HSP70-1) is a highly inducible heat shock gene up-regulated in response to environmental stresses and pollutants. The aim of our study was to evaluate the sensitivity of the stable metabolically competent HepG2 cells containing a human HSPA1A promoter-driven luciferase reporter (HepG2-luciferase cells) for ass...

journal_title：Cell stress & chaperones

authors： Xin L,Li X,Deng H,Kuang D,Dai X,Huang S,Wang F,He M,Currie RW,Wu T

更新日期：2012-09-01 00:00:00

abstract：:The disease burden from diabetic kidney disease is large and growing. Effective therapies are lacking, despite an urgent need. Hyperbaric oxygen therapy (HBOT) activates Nrf2 and cellular antioxidant defenses; therefore, it may be generally useful for treating conditions that feature chronic oxidative tissue damage. H...

journal_title：Cell stress & chaperones

authors： Verma R,Chopra A,Giardina C,Sabbisetti V,Smyth JA,Hightower LE,Perdrizet GA

更新日期：2015-05-01 00:00:00