ER stress-related molecules induced by Hantaan virus infection in differentiated THP-1 cells.


:Endoplasmic reticulum stress (ER stress) can be induced by virus infection. In this part, we explored whether Hantaan virus (HTNV) infection could induce ER stress in differentiated THP-1 (dTHP-1) cells. It showed that the mRNA and protein levels of ER stress-related 78 kDa glucose-regulated protein (GRP78, HSPA5) and mRNA levels of X box-binding protein 1 (XBP-1), activating transcription factor 6(ATF6) and PKR-like ER kinase (PERK) after HTNV infection, were significantly higher than that in uninfected control group. However, the mRNA levels of C/EBP homologous protein (CHOP), glucose-regulated protein 94 (GRP94, HSPC4), and inositol-requiring enzyme1 (IRE1) were not significantly different between the infected group and the untreated group in 2 h after virus infection. It is unusual in activating GRP78 but not GRP94. Meanwhile, dTHP-1 cells infected with HTNV at 12 h did not show obvious apoptosis. These results indicated that the HTNV infection could induce the unfolded protein response (UPR) in dTHP-1 cells, without directly leading to cell apoptosis during 12 h after virus infection.


Cell Stress Chaperones


Cell stress & chaperones


Li Z,Shen Y,Song Y,Zhang Y,Zhang C,Ma Y,Zhang F,Chen L




Has Abstract


2021-01-01 00:00:00














  • In vitro augmentation of mesenchymal stem cells viability in stressful microenvironments : In vitro augmentation of mesenchymal stem cells viability.

    abstract::Mesenchymal stem cells (MSCs) are under intensive investigation for use in cell-based therapies because their differentiation abilities, immunomodulatory effects, and homing properties offer potential for significantly augmenting regenerative capacity of many tissues. Nevertheless, major impediments to their therapeut...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章,评审


    authors: Amiri F,Jahanian-Najafabadi A,Roudkenar MH

    更新日期:2015-03-01 00:00:00

  • Induction of Hsp22 (HspB8) by estrogen and the metalloestrogen cadmium in estrogen receptor-positive breast cancer cells.

    abstract::Estrogen (E2) plays a critical role in the etiology and progression of human breast cancer. The estrogenic response is complex and not completely understood, including in terms of the involved responsive genes. Here we show that Hsp22 (synonyms: HspB8, E2lG1, H11), a member of the small heat shock protein (sHSP) super...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Sun X,Fontaine JM,Bartl I,Behnam B,Welsh MJ,Benndorf R

    更新日期:2007-01-01 00:00:00

  • Release of heat shock protein 70 and the effects of extracellular heat shock protein 70 on the production of IL-10 in fibroblast-like synoviocytes.

    abstract::It has recently been suggested that heat shock protein (Hsp) 70, an intracellular protein, can be released into the extracellular compartment and exert important immunomodulatory functions. Although elevated Hsp70 has been found in synovial fluid from patients with rheumatoid arthritis (RA), its sources and extracellu...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Luo X,Zuo X,Zhang B,Song L,Wei X,Zhou Y,Xiao X

    更新日期:2008-09-01 00:00:00

  • Bacterial stimulation upregulates the surface expression of the stress protein gp96 on B cells in the frog Xenopus.

    abstract::The presence of the soluble intracellular heat shock protein gp96 (an endoplasmic reticulum resident protein) at the surface of certain cell types is an intriguing phenomenon whose physiological significance has been unclear. We have shown that the active surface expression of gp96 by some immune cells is found throug...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Morales H,Muharemagic A,Gantress J,Cohen N,Robert J

    更新日期:2003-10-01 00:00:00

  • Caffeic acid phenethyl ester (CAPE) possesses pro-hypoxia and anti-stress activities: bioinformatics and experimental evidences.

    abstract::Honeybee propolis and its bioactive component, caffeic acid phenethyl ester (CAPE), are known for a variety of therapeutic potentials. By recruiting a cell-based reporter assay for screening of hypoxia-modulating natural drugs, we identified CAPE as a pro-hypoxia factor. In silico studies were used to probe the capaci...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Bhargava P,Kumari A,Putri JF,Ishida Y,Terao K,Kaul SC,Sundar D,Wadhwa R

    更新日期:2018-09-01 00:00:00

  • Heat shock proteins in the therapy of autoimmune diseases: too simple to be true?

    abstract::Autoimmune diseases are characterized by the loss of immune tolerance to self-antigens which leads to an excessive immune responses and chronic inflammation. Although much progress has been made in revealing key players in pathophysiology of various autoimmune diseases, their therapy remains challenging and consists o...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章,评审


    authors: Tukaj S,Kaminski M

    更新日期:2019-05-01 00:00:00

  • Identification of two small heat shock proteins with different response profile to cadmium and pathogen stresses in Venerupis philippinarum.

    abstract::Small heat shock proteins (sHSPs) encompass a widespread and diverse class of proteins with molecular chaperone activity. In the present study, two sHSP isoforms (VpsHSP-1 and VpsHSP-2) were cloned from Venerupis philippinarum haemocytes by Rapid Amplification of cDNA Ends (RACE) approaches. The expression profiles of...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Li C,Wang L,Ning X,Chen A,Zhang L,Qin S,Wu H,Zhao J

    更新日期:2010-11-01 00:00:00

  • Heat stress induces epithelial plasticity and cell migration independent of heat shock factor 1.

    abstract::Current cancer therapies including cytotoxic chemotherapy, radiation and hyperthermic therapy induce acute proteotoxic stress in tumour cells. A major challenge to cancer therapeutic efficacy is the recurrence of therapy-resistant tumours and how to overcome their emergence. The current study examines the concept that...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Lang BJ,Nguyen L,Nguyen HC,Vieusseux JL,Chai RC,Christophi C,Fifis T,Kouspou MM,Price JT

    更新日期:2012-11-01 00:00:00

  • Alteration of Cpn60 expression in pancreatic tissue of rats with acute pancreatitis.

    abstract::The expression of heat-shock protein 60 (also known as chaperonin 60, Cpn60) in experimental acute pancreatitis (AP) is considered to play an active role in the prevention of abnormal enzyme accumulation and activation in pancreatic acinar cells. However, there are controversial results in the literature regarding the...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Li XL,Li K,Li YY,Feng Y,Gong Q,Li YN,Li XJ,Chen CJ

    更新日期:2009-03-01 00:00:00

  • Expression of heat shock protein 70 in the thermally stressed antarctic clam Laternula elliptica.

    abstract::Heat shock protein 70 (designated Laternula elliptica Hsp70 (LEHsp70)) expression was investigated in an Antarctic mud clam to see whether or not the inducible heat shock response has been conserved throughout over 25 million years of adaptation to constant low environmental temperatures. LEHsp70 cDNA was cloned and s...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Park H,Ahn IY,Lee HE

    更新日期:2007-10-01 00:00:00

  • The effect of hyperthermia on the induction of cell death in brain, testis, and thymus of the adult and developing rat.

    abstract::Stressful stimuli can elicit 2 distinct reactive cellular responses, the heat shock (stress) response and the activation of cell death pathways. Most studies on the effects of hyperthermia on the mammalian nervous system have focused on the heat shock response, characterized by the transient induction of Hsps, which p...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Khan VR,Brown IR

    更新日期:2002-01-01 00:00:00

  • Upregulation of heat-shock proteins in larvae, but not adults, of the flesh fly during hot summer days.

    abstract::Heat-shock proteins (HSPs) are highly expressed when organisms are exposed to thermal stresses. The HSPs are considered to play significant roles in thermal adaptation because they function as molecular chaperones facilitating proper protein synthesis. The expression of HSPs under field conditions, however, has not be...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Harada E,Goto SG

    更新日期:2017-11-01 00:00:00

  • Stress levels over time in the introduced ascidian Styela plicata: the effects of temperature and salinity variations on hsp70 gene expression.

    abstract::Species distribution, abundance, and long-term survival are determined by biotic and abiotic regimes. However, little is known about the importance of these factors in species range expansion. Styela plicata is a solitary ascidian introduced all over the world by ship fouling, including salt marsh habitats, where intr...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Pineda MC,Turon X,López-Legentil S

    更新日期:2012-07-01 00:00:00

  • Conformational changes resulting from pseudophosphorylation of mammalian small heat shock proteins--a two-hybrid study.

    abstract::The human genome codes for 10 so-called mammalian small heat shock or stress proteins (sHsp) with the various tissues expressing characteristic sets of sHsps. Most sHsps interact with each other and form homo- and heterooligomeric complexes. Some of the sHsps are phosphoproteins in vivo, and phosphorylation has been i...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Sun X,Welsh MJ,Benndorf R

    更新日期:2006-04-01 00:00:00

  • Mutation of the Ser18 phosphorylation site on the sole Saccharomyces cerevisiae UCS protein, She4, can compromise high-temperature survival.

    abstract::Folding of the myosin head often requires the joint actions of Hsp90 and a dedicated UNC45, Cro1, She4 (UCS) domain-containing cochaperone protein. Relatively weak sequence conservation exists between the single UCS protein of simple eukaryotes (She4 in budding yeast) and the two UCS proteins of higher organisms (the ...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Gomez-Escalante S,Piper PW,Millson SH

    更新日期:2017-01-01 00:00:00

  • The messenger and the message: gp96 (GRP94)-peptide interactions in cellular immunity.

    abstract::Vaccination of mice with tumor-derived stress proteins, such as Hsp70 and gp96 (GRP94), can elicit antitumor immune responses, yielding a marked suppression of tumor growth and metastasis. The molecular basis for this response is proposed to reflect a peptide-binding function for these proteins. In this view, stress p...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章,评审


    authors: Nicchitta CV,Carrick DM,Baker-Lepain JC

    更新日期:2004-01-01 00:00:00

  • An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space.

    abstract::The HSP60/HSP10 chaperonin assists folding of proteins in the mitochondrial matrix space by enclosing them in its central cavity. The chaperonin forms part of the mitochondrial protein quality control system. It is essential for cellular survival and mutations in its subunits are associated with rare neurological diso...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Bie AS,Cömert C,Körner R,Corydon TJ,Palmfeldt J,Hipp MS,Hartl FU,Bross P

    更新日期:2020-05-01 00:00:00

  • Quantification of cellular protein expression and molecular features of group 3 LEA proteins from embryos of Artemia franciscana.

    abstract::Late embryogenesis abundant (LEA) proteins are highly hydrophilic, low complexity proteins whose expression has been correlated with desiccation tolerance in anhydrobiotic organisms. Here, we report the identification of three new mitochondrial LEA proteins in anhydrobiotic embryos of Artemia franciscana, AfrLEA3m_47,...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Boswell LC,Moore DS,Hand SC

    更新日期:2014-05-01 00:00:00

  • Diversity of physiological cell reactivity to heat shock protein 60 in different mouse strains.

    abstract::Heat shock proteins (Hsp) are families of highly conserved molecules and immunodominant antigens in some infections and in autoimmune diseases. Some reports suggest that different regions of the Hsp60 molecule induce distinct immune responses. However, there are no reports comparing physiological T-cell reactivity to ...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Luna E,Postol E,Caldas C,Mundel LR,Porto G,Iwai LK,Ho PL,Kalil J,Coelho V

    更新日期:2007-07-01 00:00:00

  • Toxoplasma gondii-derived heat shock protein HSP70 functions as a B cell mitogen.

    abstract::We have investigated the role of Toxoplasma gondii-derived heat shock protein 70 (TgHSP70) as a B cell mitogen by measuring proliferative responses in vitro. TgHSP70 induced prominent proliferative responses in murine B cells derived not only from T gondii-infected but also from uninfected mice. Nude mice responded to...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Aosai F,Chen M,Kang HK,Mun HS,Norose K,Piao LX,Kobayashi M,Takeuchi O,Akira S,Yano A

    更新日期:2002-10-01 00:00:00

  • Upregulation of heat shock proteins and the promotion of damage-associated molecular pattern signals in a colorectal cancer model by modulated electrohyperthermia.

    abstract::In modulated electrohyperthermia (mEHT) the enrichment of electric field and the concomitant heat can selectively induce cell death in malignant tumors as a result of elevated glycolysis, lactate production (Warburg effect), and reduced electric impedance in cancer compared to normal tissues. Earlier, we showed in HT2...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Andocs G,Meggyeshazi N,Balogh L,Spisak S,Maros ME,Balla P,Kiszner G,Teleki I,Kovago C,Krenacs T

    更新日期:2015-01-01 00:00:00

  • Cloning and expression of a transcription factor activator protein-1 member identified from the swimming crab Portunus trituberculatus.

    abstract::Transcription activator proteins are regulatory proteins that bind to the promoter regions of target genes. Transcription activator protein-1 (AP-1) regulates numerous genes related to the immune system, apoptosis, and proliferation. In this study, the full-length cDNA of AP-1 from Portunus trituberculatus (PtAP-1) wa...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Wang H,Shi C,Kong M,Mu C,Wei H,Wang C

    更新日期:2018-11-01 00:00:00

  • An intron-containing, heat-inducible stress-70 gene in the millipede Tachypodoiulus niger (Julidae, Diplopoda).

    abstract::The highly conserved part of the nucleotide-binding domain of the hsp70 gene family was amplified from the soil diplopod Tachypodoiulus niger (Julidae, Diplopoda). Genomic DNA yielded 701, 549 and 540 bp sequences, whereas cDNA from heat shocked animals produced only one distinct fragment of 543 bp. The sequences coul...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Knigge T,Bachmann L,Köhler HR

    更新日期:2014-09-01 00:00:00

  • An animal model to evaluate the function and regulation of the adaptively evolving stress protein SEP53 in oesophageal bile damage responses.

    abstract::Squamous epithelium in mammals has evolved an atypical stress response involving down-regulation of the classic HSP70 protein and induction of sets of proteins including one named SEP53. This atypical stress response might be due to the unusual environmental pressures placed on squamous tissue. In fact, SEP53 plays a ...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Nelson L,Anderson S,Archibald AL,Rhind S,Lu ZH,Condie A,McIntyre N,Thompson J,Nenutil R,Vojtesek B,Whitelaw CB,Little TJ,Hupp T

    更新日期:2008-09-01 00:00:00

  • Preferential activation of HSF-binding activity and hsp70 gene expression in Xenopus heart after mild hyperthermia.

    abstract::We have examined the effect of mild hyperthermia on the pattern of heat shock transcription factor (HSF) binding activity, heat shock protein 70 (hsp70) and hsp30 gene expression and protein denaturation in selected tissues of adult Xenopus namely, heart, hind limb muscle, eye, liver and spleen. In these studies it wa...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Ali A,Fernando P,Smith WL,Ovsenek N,Lepock JR,Heikkila JJ

    更新日期:1997-12-01 00:00:00

  • Neutrophil gelatinase-associated lipocalin induces the expression of heme oxygenase-1 and superoxide dismutase 1, 2.

    abstract::Lipocalin-2 (Lcn2, NGAL) is a member of the lipocalin super family with diverse function such as the induction of apoptosis, the suppression of bacterial growth, and modulation of inflammatory response. Much interest has recently been focused on the physiological/pathological role of the lipocalin-2 that is considered...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Bahmani P,Halabian R,Rouhbakhsh M,Roushandeh AM,Masroori N,Ebrahimi M,Samadikuchaksaraei A,Shokrgozar MA,Roudkenar MH

    更新日期:2010-07-01 00:00:00

  • Eukaryotic response to hypothermia in relation to integrated stress responses.

    abstract::Eukaryotic cells respond to hypothermic stress through a series of regulatory mechanisms that preserve energy resources and prolong cell survival. These mechanisms include alterations in gene expression, attenuated global protein synthesis and changes in the lipid composition of the phospholipid bilayer. Cellular resp...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章,评审


    authors: Adjirackor NA,Harvey KE,Harvey SC

    更新日期:2020-11-01 00:00:00

  • Butyric acid retention in gingival tissue induces oxidative stress in jugular blood mitochondria.

    abstract::Butyric acid (BA) is a major extracellular metabolite produced by anaerobic periodontopathic bacteria and is commonly deposited in the gingival tissue. BA induces mitochondrial oxidative stress in vitro; however, its effects in vivo were never elucidated. Here, we determined the effects of butyric acid retention in th...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Cueno ME,Imai K,Matsukawa N,Tsukahara T,Kurita-Ochiai T,Ochiai K

    更新日期:2013-09-01 00:00:00

  • Development of stable HSPA1A promoter-driven luciferase reporter HepG2 cells for assessing the toxicity of organic pollutants present in air.

    abstract::HSPA1A (HSP70-1) is a highly inducible heat shock gene up-regulated in response to environmental stresses and pollutants. The aim of our study was to evaluate the sensitivity of the stable metabolically competent HepG2 cells containing a human HSPA1A promoter-driven luciferase reporter (HepG2-luciferase cells) for ass...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Xin L,Li X,Deng H,Kuang D,Dai X,Huang S,Wang F,He M,Currie RW,Wu T

    更新日期:2012-09-01 00:00:00

  • Hyperbaric oxygen therapy (HBOT) suppresses biomarkers of cell stress and kidney injury in diabetic mice.

    abstract::The disease burden from diabetic kidney disease is large and growing. Effective therapies are lacking, despite an urgent need. Hyperbaric oxygen therapy (HBOT) activates Nrf2 and cellular antioxidant defenses; therefore, it may be generally useful for treating conditions that feature chronic oxidative tissue damage. H...

    journal_title:Cell stress & chaperones

    pub_type: 杂志文章


    authors: Verma R,Chopra A,Giardina C,Sabbisetti V,Smyth JA,Hightower LE,Perdrizet GA

    更新日期:2015-05-01 00:00:00