Circular RNAs: Potential Star Molecules Involved in Diabetic Retinopathy.


:Purpose: To summarize the research status on the function and mechanism of circRNAs in regulating the occurrence of diabetic retinopathy (DR). Methods: We systematically searched PubMed,, and ARVO Abstracts website and reviewed relevant studies. Results: Thousands of circRNAs were found to be aberrantly expressed in DR patients, animal models, or cell models. A few circRNAs, such as cPWWP2A, circDNMT3B, circHIPK3, circ_0005015, et al were demonstrated to play an important role in DR by regulating the angiogenesis, proliferation, apoptosis, and inflammatory response of various cells in the retina. Conclusion: CircRNAs are involved in the development of DR. CircRNAs can not only serve as DR biomarkers, but also become therapeutic targets for DR. The role of plenty of circRNAs in DR is yet to be discovered.


Curr Eye Res


Current eye research


He M,Zhou R,Liu S,Cheng W,Wang W




Has Abstract


2020-08-30 00:00:00








  • Effects of glaucoma on Chrna6 expression in the retina.

    abstract:PURPOSE:Recent advances in technology now provide tools capable of tracking genome-wide expression changes occurring in progressive pathological processes. The present experiments were carried out to determine if acetylcholine receptor α 6 subunit (Chrna6) is a reliable retinal ganglion cell (RGC) marker in adult mouse...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Munguba GC,Geisert EE,Williams RW,Tapia ML,Lam DK,Bhattacharya SK,Lee RK

    更新日期:2013-01-01 00:00:00

  • Activation of a caspase-3-independent mode of cell death associated with lysosomal destabilization in cultured human retinal pigment epithelial cells (ARPE-19) exposed to 7beta-hydroxycholesterol.

    abstract:PURPOSE:To characterize the possible cytotoxic effects of oxysterols (7beta-hydroxycholesterol (7beta-OH), 25-hydroxycholesterol (25-OH)) in human retinal pigment epithelial cells (ARPE-19) and to detail the relationships between some of these effects. METHODS:ARPE-19 cells were treated with 7beta-OH and 25-OH. Cell v...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Malvitte L,Montange T,Vejux A,Joffre C,Bron A,Creuzot-Garcher C,Lizard G

    更新日期:2008-09-01 00:00:00

  • Vitamin A is stored as fatty acyl esters of retinol in the lacrimal gland.

    abstract::Many tissues which require vitamin A store the vitamin as long-chain fatty acyl esters of retinol. As part of a study designed to characterize vitamin A metabolism in the lacrimal gland, which transports retinol from blood to lacrimal gland fluid, extracts from lacrimal glands of rabbits and rats were analyzed by non-...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Ubels JL,Osgood TB,Foley KM

    更新日期:1988-10-01 00:00:00

  • Nephropathic cystinosis: immunohistochemical and histopathologic studies of cornea, conjunctiva and iris.

    abstract::Specimens of a cornea, conjunctiva and iris were removed at the time of penetrating keratoplasty in a case of nephropathic cystinosis. Immunohistochemical studies revealed the presence of class II antigens on the stromal keratocytes of the cornea and the vascular endothelial cells, pericytes and fibroblasts of the con...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Kaiser-Kupfer MI,Chan CC,Rodrigues M,Datiles MB,Gahl WA

    更新日期:1987-04-01 00:00:00

  • Real-time confocal microscopic observations on human corneal nerves and wound healing after excimer laser photorefractive keratectomy.

    abstract:PURPOSE:Corneal wound healing after excimer laser photorefractive keratectomy (PRK) passes through a series of characteristic stages which have earlier been defined by means of histological, histochemical, and biochemical approaches. We investigated the potential of confocal microscopy to verify morphological changes i...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Linna T,Tervo T

    更新日期:1997-07-01 00:00:00

  • Cytotoxic properties of sunitinib and sorafenib on human corneal epithelial cells.

    abstract:PURPOSE:To generate toxicology profiles of individual drugs on human corneal epithelial cells (HCEC) and compare their in vitro cytotoxicity. METHODS:Monolayer cultures of HCEC were harvested from two human donor eyes. Sunitinib (0.3-10 µg/mL) and Sorafenib (0.3-100 µg/mL), diluted in culture medium (CnT-BM.1, CELLnTE...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Bayyoud T,Hofmann J,Spitzer M,Bartz-Schmidt KU,Yoeruek E

    更新日期:2014-02-01 00:00:00

  • Aberrant Epigenetic Alterations of Glutathione-S-Transferase P1 in Age-Related Nuclear Cataract.

    abstract:PURPOSE:Oxidative damage of lens tissue contributes to the formation of age-related cataract. Pi-class glutathione-S-transferase (GSTP1) plays a role in the removal of oxidative adducts by transferring them to glutathione. To assess epigenetic regulation of GSTP1 and its potential role in age-related nuclear cataract (...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Chen J,Zhou J,Wu J,Zhang G,Kang L,Ben J,Wang Y,Qin B,Guan H

    更新日期:2017-03-01 00:00:00

  • Cystathionine β-synthase Deficiency Impairs Vision in the Fruit Fly, Drosophila melanogaster.

    abstract:PURPOSE:Deficiency in Cystathionine β-synthase (CBS) leads to an abnormal accumulation of homocysteine and results in classical homocystinuria, a multi-systemic disorder that affects connective tissue, muscles, the central nervous system, and the eyes. However, the genetic players and mechanisms underlying vision alter...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Flores-Flores M,Moreno-García L,Castro-Martínez F,Nahmad M

    更新日期:2020-09-07 00:00:00

  • Comparison of Aqueous Humor Nitric Oxide Levels After Different Corneal Collagen Cross-Linking Methods.

    abstract:PURPOSE:Nitric oxide production can cause either apoptotic or necrotic cell death through oxidative stress. We aimed to investigate the nitrite oxide metabolites (NOx) and nitrite levels in the aqueous humor of rabbit eyes after different methods of corneal collagen cross-linking (CXL). MATERIALS AND METHODS:Twenty-fo...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Yuksel N,Ozel-Turkcu U,Yalinbas D,Novruzlu S,Bilgihan A,Bilgihan K

    更新日期:2016-12-01 00:00:00

  • MMP9 is involved in glycation end-products induced increase of retinal vascular permeability in rats and the therapeutic effect of minocycline.

    abstract:PURPOSE:To determine the role of matrix metalloproteinase 9 (MMP9) in advanced glycation end-products (AGEs) induced damage to blood-retinal barrier (BRB) and the therapeutic effects of minocycline, an MMP inhibitor, against the BRB damages. METHODS:Forty-eight Sprague Dawley rats were randomly assigned to 3 groups (1...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Chen YD,Xu X,Xia X,Wu H,Liu K,Zheng Z,Zhu D

    更新日期:2008-11-01 00:00:00

  • In Vivo Retinal Vein Bypass Surgery in a Porcine Model.

    abstract:PURPOSE:To evaluate the feasibility of retinal vein bypass surgery for induced branch retinal-vein occlusion (BRVO) in the living porcine eye. METHODS:Fifteen minipigs were used in the study. Seven days before vascular surgery, hyaluronidase and plasmin were intravitreally injected for induction of posterior vitreous ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Shen LJ,Chen YQ,Cheng D,Zhang C,Jiang L,Hong M,Kang QY

    更新日期:2016-01-01 00:00:00

  • Synthetic peptides derived from IRBP induce EAU and EAP in Lewis rats.

    abstract::In an earlier study we isolated three cyanogen bromide cleavage fragments of bovine IRBP that exhibited high levels of immunopathogenicity, producing inflammatory changes in the eyes (EAU) and pineal gland (EAP) of Lewis rats. These fragments have been localized within the IRBP sequence. In order to identify these put...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Sanui H,Redmond TM,Hu LH,Kuwabara T,Margalit H,Cornette JL,Wiggert B,Chader GJ,Gery I

    更新日期:1988-07-01 00:00:00

  • Effect of subconjunctival and intraocular bevacizumab injections on corneal neovascularization in a mouse model.

    abstract:PURPOSE:This study sought to evaluate the efficacy of bevacizumab (Avastin), an anti-VEGF agent, in the reduction of corneal neovascularization in a rodent model, and compare between the effect of intraocular and subconjunctival injection. METHODS:Corneal neovascularization was induced by application of a mixture of 7...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Avisar I,Weinberger D,Kremer I

    更新日期:2010-02-01 00:00:00

  • A comparison of three methods for trephining donor corneal buttons: endothelial cell loss and microscopic ultrastructural evaluation.

    abstract:PURPOSE:To evaluate the ultrastructure of the cut edge and associated endothelial cell loss following donor cornea trephination with a standard punch, vacuum punch, and vacuum trephine and artificial anterior chamber system. MATERIALS AND METHODS:This laboratory investigation compared trephinations (8.0 mm) performed ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Moshirfar M,Meyer JJ,Kang PC

    更新日期:2009-11-01 00:00:00

  • Corneal thickness and volume measurements by swept source anterior segment optical coherence tomography in normal subjects.

    abstract:PURPOSE:To evaluate central corneal thickness (CCT) and corneal volume (CV) in healthy eyes using swept source anterior segment optical coherence tomography (SS-AS-OCT) and other devices. METHODS:Thirty-three healthy right eyes of 33 subjects were investigated. CCT was measured with SS-AS-OCT, rotating Scheimpflug cam...

    journal_title:Current eye research

    pub_type: 临床试验,杂志文章


    authors: Fukuda R,Usui T,Miyai T,Mori Y,Miyata K,Amano S

    更新日期:2013-05-01 00:00:00

  • Retinoic acid receptors and retinoid X receptors in the mature retina: subtype determination and cellular distribution.

    abstract:PURPOSE:In the mature retina retinoic acid (RA) biosynthesis was reported to be regulated by light. RA is of vital importance for proper function of the retina. RA activity is mediated by interaction with nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs). The purpose of this study was to determine ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Janssen JJ,Kuhlmann ED,van Vugt AH,Winkens HJ,Janssen BP,Deutman AF,Driessen CA

    更新日期:1999-10-01 00:00:00

  • Agreement of retinal nerve fiber layer defect location between red-free fundus photography and cirrus HD-OCT maps.

    abstract:PURPOSE:To investigate the agreement of angular locations of retinal nerve fiber layer (RNFL) defect margins in glaucomatous eyes by using red-free fundus photographs and Cirrus high-definition optical coherence tomography (OCT) RNFL deviation and thickness maps. METHODS:We examined 380 RNFL defects that showed clear ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Hwang YH,Kim YY,Kim HK,Sohn YH

    更新日期:2014-11-01 00:00:00

  • Dispersion of DMPC liposomes in contact lenses for ophthalmic drug delivery.

    abstract::Approximately 90% of all ophthalmic drug formulations are now applied as eyedrops. Although eyedrops are convenient and well accepted by patients, about 95% of the drug contained in the drops is lost due to absorption through the conjunctiva or through the tear drainage. A major fraction of the drug eventually enters ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Gulsen D,Li CC,Chauhan A

    更新日期:2005-12-01 00:00:00

  • The effect of topical retinoic acid (Etretinate) on mouse conjunctival Langerhans cells.

    abstract::Four groups of BALB/c mice were treated locally with different concentrations (0.1-1.0%) of retinoic acid (Etretinate) ointment for a period of one to four weeks. A fifth group was treated with the ointment base only. Ia-positive dendritic cells were identified by an indirect immunofluorescence technique which was con...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Kremer I,Gabai U,Arbizo M,Arbizo V,Laibson PR

    更新日期:1995-03-01 00:00:00

  • High proportion of nontypeable Streptococcus pneumoniae isolates among sporadic, nonoutbreak cases of bacterial conjunctivitis.

    abstract:PURPOSE:Outbreaks of bacterial conjunctivitis have been linked to nontypeable strains of Streptococcus pneumoniae that lack a capsule, a key virulence factor for invasive infections. In contrast, isolates from sporadic, nonoutbreak cases of conjunctivitis were thought to be similar to invasive or nasopharyngeal isolate...

    journal_title:Current eye research

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Haas W,Hesje CK,Sanfilippo CM,Morris TW

    更新日期:2011-12-01 00:00:00

  • Contractile effect of aqueous Pleurotus tuberregium extract on the isolated bovine iris.

    abstract:BACKGROUND:Aqueous extract of Pleurotus tuberregium (PT) has been shown to reduce intraocular pressure (IOP) but the underlying mechanism has not been explained. PURPOSE:To investigate the effect of PT on the bovine iris in vitro in comparison with acetylcholine (ACh). METHOD:Strips of the iris were mounted in 10 ml ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Akinlabi GA,Asowata OE,Ozolua RI,Akpaja OO,Iyawe V

    更新日期:2013-03-01 00:00:00

  • Serum-free culture of porcine and rabbit corneal epithelial cells.

    abstract::To better define the growth requirements for corneal epithelial cells, methods for serum-free culture were established. Sheets of corneal epithelium from eyes of swine and rabbits were obtained by dispase treatment of corneal buttons, and single cells and small clumps were obtained by further dissociation with trypsin...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Hackworth LA,Faraji-Shadan F,Schuschereba ST,Bowman PD

    更新日期:1990-09-01 00:00:00

  • Normal expression levels of cathepsins, protease inhibitors, and Sp1 in conjunctival tissues from patients with keratoconus.

    abstract:PURPOSE:In keratoconus corneas, it has been shown that levels of degradative enzymes and transcription factor Sp1 are elevated and those of inhibitors are reduced, especially in the epithelial layer. This study is to determine whether the biochemical abnormalities identified in corneas also exist in conjunctival tissue...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Maruyama I,Zhou L,Sugar J,Yue BY

    更新日期:2000-11-01 00:00:00

  • Highly selective inhibitor of inducible nitric oxide synthase enhances S-antigen-induced uveitis.

    abstract:PURPOSE:Investigated the effect of N-3-aminomethylbenzylacetamidine (1400 W), a highly selective inhibitor of inducible nitric oxide synthase (iNOS), on the effector phase of EAU. METHODS:Sixteen Lewis rats were sensitized with bovine retinal S-antigen; ten of them injected subcutaneously with 1400 W (20 mg/kg) three ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Charlotte F,Ito S,Wu G,Kimoto T,Rao N

    更新日期:2003-01-01 00:00:00

  • Aqueous humor levels of topically applied levofloxacin in human eyes.

    abstract:PURPOSE:To evaluate transcorneal penetration of topically applied 0.5% levofloxacin into the aqueous humor in human eyes. METHODS:Twenty cataract patients (14 females, 6 males) received 3 drops of 0.5% levofloxacin at 15 min intervals from 90 minutes before the surgery. At the beginning of the cataract surgery, 50 mic...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Yamada M,Mochizuki H,Yamada K,Kawai M,Mashima Y

    更新日期:2002-05-01 00:00:00

  • Modification of amniotic membrane as a depot carrier for bevacizumab - an in-vitro model for a slow release mechanism.

    abstract:PURPOSE:Corneal ulceration may be treated with human amniotic membrane (HAM) while neovascularization remains a common complication of corneal ulceration. As several factors contained within HAM may contribute to reduced corneal scarring, we investigated if HAM may be additionally loaded with bevacizumab and potentiall...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Mayer WJ,Grüterich M,Kook D,Sigg W,Kernt M,Messmer EM,Haritoglou C,Kampik A,Wolf A

    更新日期:2013-04-01 00:00:00

  • Early development of retinal subtypes in long-term cultures of human embryonic retina.

    abstract:PURPOSE:To study early signs of neuronal and glial differentiation in the human embryonic retina. MATERIALS AND METHODS:6.5-to 8-week-old human embryos were obtained from elective abortions. The neuroretinas were kept in culture as full-thickness sheets for 7-42 days. RESULTS:The control retinas consisted of a neurob...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Engelsberg K,Ehinger B,Ghosh F

    更新日期:2008-02-01 00:00:00

  • Prostaglandins increase proMMP-1 and proMMP-3 secretion by human ciliary smooth muscle cells.

    abstract:PURPOSE:The mechanism by which prostaglandin(PG)F2 alpha increases uveoscleral outflow and lowers intraocular pressure in primates is not known. In cultured human ciliary muscle cells, PGF2 alpha induces the expression of the protooncogene c-fos which is known to induce the transcription of genes such as matrix metallo...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Lindsey JD,Kashiwagi K,Boyle D,Kashiwagi F,Firestein GS,Weinreb RN

    更新日期:1996-08-01 00:00:00

  • Quantitative analysis of collagen from normal developing corneas and corneal scars.

    abstract::We measured the relative solubility of collagen in acetic acid after pepsin digestion and tentatively identified the types of collagen present in corneas of rabbits of various ages and in corneal scar tissue, using hydroxyproline assays and polyacrylamide gel electrophoretic analyses. More than 80% of the collagen in ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Cintron C,Hong BS,Kublin CL

    更新日期:1981-01-01 00:00:00

  • Quantitative Analysis of Optical Coherence Tomography Angiography Features in Patients with Nonocular Behcet's Disease.

    abstract:PURPOSE:To quantitatively measure the flow, nonflow, density, and foveal avascular zone (FAZ) assessment tool parameters of optical coherence tomography angiography (OCTA) in patients with nonocular Behcet's Disease (BD), and to compare the results with those obtained in healthy controls. METHODS:FAZ parameters, flow ...

    journal_title:Current eye research

    pub_type: 杂志文章


    authors: Goker YS,Yılmaz S,Kızıltoprak H,Tekin K,Demir G

    更新日期:2019-02-01 00:00:00