Abstract：
BACKGROUND:Although most patients with cutaneous melanoma are non-Hispanic whites (NHWs), minorities consistently suffer worse melanoma-specific survival (MSS). Much of the literature comes from analyses of registries from the 1990s and 2000s. OBJECTIVE:We sought to evaluate whether and to what degree racial disparity in MSS persists since 2010. METHODS:We analyzed 381,035 patients from the Surveillance, Epidemiology, and End Results registry. Race categories included Hispanic, NHW, non-Hispanic black (NHB), non-Hispanic Asian or Pacific Islander (NHAPI), and non-Hispanic American Indian/Alaska Native (NHAIAN). We evaluated the association between MSS and race in 3 time periods: before the year 2000, 2000 to 2009, and 2010 or later. NHW was the reference group for all analyses. RESULTS:Racial disparity worsened from before the year 2000 to 2010 or later for Hispanic (P < .001), NHB (P = .024), and NHAPI (P < .001) patients. Across all minority groups, patients with localized disease suffered increasing disparity (P = .010 for Hispanic, P < .001 for NHB, P = .023 for NHAPI, and P = .042 for NHAIAN patients). Among those with regional and distant disease, Hispanic patients were the only minority to experience worsening disparity (P = .001 and P = .019, respectively). LIMITATIONS:Lack of immunotherapy and targeted treatment information. CONCLUSIONS:Racial disparity in MSS is worsening. Improving postdiagnosis management for minorities with localized disease is imperative to mitigate disparity and improve survival.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Qian Y,Johannet P,Sawyers A,Yu J,Osman I,Zhong Jdoi
10.1016/j.jaad.2020.08.097subject
Has Abstractpub_date
2020-08-27 00:00:00eissn
0190-9622issn
1097-6787pii
S0190-9622(20)32494-4pub_type
杂志文章abstract：BACKGROUND:Clusters of rare cylindroma or spiradenoma tumors are a recurrent clinical presentation, yet conventional genetic testing results in individuals with these tumors are frequently normal. OBJECTIVE:To determine if genetic mosaicism accounts for such cases. METHODS:A study of 6 cases from a series of 55 patie...
journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：2019-06-01 00:00:00
