The ongoing racial disparities in melanoma: An analysis of the Surveillance, Epidemiology, and End Results database (1975-2016).


BACKGROUND:Although most patients with cutaneous melanoma are non-Hispanic whites (NHWs), minorities consistently suffer worse melanoma-specific survival (MSS). Much of the literature comes from analyses of registries from the 1990s and 2000s. OBJECTIVE:We sought to evaluate whether and to what degree racial disparity in MSS persists since 2010. METHODS:We analyzed 381,035 patients from the Surveillance, Epidemiology, and End Results registry. Race categories included Hispanic, NHW, non-Hispanic black (NHB), non-Hispanic Asian or Pacific Islander (NHAPI), and non-Hispanic American Indian/Alaska Native (NHAIAN). We evaluated the association between MSS and race in 3 time periods: before the year 2000, 2000 to 2009, and 2010 or later. NHW was the reference group for all analyses. RESULTS:Racial disparity worsened from before the year 2000 to 2010 or later for Hispanic (P < .001), NHB (P = .024), and NHAPI (P < .001) patients. Across all minority groups, patients with localized disease suffered increasing disparity (P = .010 for Hispanic, P < .001 for NHB, P = .023 for NHAPI, and P = .042 for NHAIAN patients). Among those with regional and distant disease, Hispanic patients were the only minority to experience worsening disparity (P = .001 and P = .019, respectively). LIMITATIONS:Lack of immunotherapy and targeted treatment information. CONCLUSIONS:Racial disparity in MSS is worsening. Improving postdiagnosis management for minorities with localized disease is imperative to mitigate disparity and improve survival.


J Am Acad Dermatol


Qian Y,Johannet P,Sawyers A,Yu J,Osman I,Zhong J




Has Abstract


2020-08-27 00:00:00








  • Diverse presentations of cutaneous mosaicism occur in CYLD cutaneous syndrome and may result in parent-to-child transmission.

    abstract:BACKGROUND:Clusters of rare cylindroma or spiradenoma tumors are a recurrent clinical presentation, yet conventional genetic testing results in individuals with these tumors are frequently normal. OBJECTIVE:To determine if genetic mosaicism accounts for such cases. METHODS:A study of 6 cases from a series of 55 patie...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Arefi M,Wilson V,Muthiah S,Zwolinski S,Bajwa D,Brennan P,Blasdale K,Bourn D,Burn J,Santibanez-Koref M,Rajan N

    更新日期:2019-12-01 00:00:00

  • An unusual case of non-Langerhans cell histiocytosis.

    abstract::A 28-month-old boy had firm, red nodules for 4 months that were mostly localized to the face. The eruption was preceded by conjunctivitis, eyelid edema, and swelling of the root of the nose. He also had dyspnea, anisocoria with areflexia, swelling of the parotid glands, and hepatosplenomegaly. A bone marrow aspirate s...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Caputo R,Grimalt R,Ermacora E,Cavicchini S,Portaleone D

    更新日期:1994-02-01 00:00:00

  • Effect of sequential applications of topical tacrolimus and topical corticosteroids in the treatment of pediatric atopic dermatitis: an open-label pilot study.

    abstract:BACKGROUND:The efficacy of combination therapy with topical corticosteroids and tacrolimus in the treatment of atopic dermatitis remains to be established. OBJECTIVE:Our aim was to determine whether a regimen of sequential application of topical corticosteroids and topical tacrolimus is effective in the treatment of p...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章


    authors: Kubota Y,Yoneda K,Nakai K,Katsuura J,Moriue T,Matsuoka Y,Miyamoto I,Ohya Y

    更新日期:2009-02-01 00:00:00

  • Mental health impairment among children with atopic dermatitis: A United States population-based cross-sectional study of the 2013-2017 National Health Interview Survey.

    abstract:BACKGROUND:Atopic dermatitis (AD) is associated with mental health disorders, but its impact on global mental health symptoms is less clear. OBJECTIVE:To determine the association between pediatric AD and mental health impairment. METHODS:In a cross-sectional study using 2013-2017 United States National Health Interv...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Wan J,Takeshita J,Shin DB,Gelfand JM

    更新日期:2020-06-01 00:00:00

  • Chronic pruritic eruption in patients with acquired immunodeficiency syndrome associated with increased antibody titers to mosquito salivary gland antigens.

    abstract::Five of seven patients with acquired immunodeficiency syndrome (AIDS) who had pruritus and a chronic, nonspecific-appearing skin eruption had increased antibody titers to antigens in the salivary glands of Aedes taeniorhynchus, a salt marsh mosquito common to South Florida. We hypothesize that the pruritus and skin le...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Penneys NS,Nayar JK,Bernstein H,Knight JW

    更新日期:1989-08-01 00:00:00

  • Assessment of intraoperative pain during Mohs micrographic surgery (MMS): An opportunity for improved patient care.

    abstract:BACKGROUND:Intraoperative pain during Mohs micrographic surgery (MMS) has not been characterized. However, many patients report postoperative pain on the day of MMS. OBJECTIVE:We sought to determine if patients experience pain during their MMS visit. METHODS:In phase I of this study, patients were asked to report int...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Connolly KL,Nehal KS,Dusza SW,Rossi AM,Lee EH

    更新日期:2016-09-01 00:00:00

  • Inflammatory melanoma.

    abstract::Cutaneous inflammatory metastatic carcinoma is a well-documented entity most frequently associated with carcinoma of the breast. We present two patients with extensive inflammatory involvement of the skin overlying dermal lymphatic invasion by metastatic melanoma. The dermal lymphatic invasion and gross characteristic...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Haupt HM,Hood AF,Cohen MH

    更新日期:1984-01-01 00:00:00

  • Epidemiology and treatment of angiolymphoid hyperplasia with eosinophilia (ALHE): A systematic review.

    abstract:BACKGROUND:Current knowledge of angiolymphoid hyperplasia with eosinophilia (ALHE) derives from retrospective reports and case series, leading to a nonevidence-based treatment approach. OBJECTIVE:We sought to systematically review the literature relating to cutaneous ALHE to estimate its epidemiology and treatment out...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审


    authors: Adler BL,Krausz AE,Minuti A,Silverberg JI,Lev-Tov H

    更新日期:2016-03-01 00:00:00

  • Linear IgM dermatosis of pregnancy.

    abstract::An intensely pruritic dermatosis that occurred in a woman during the third trimester of pregnancy is described. The clinical manifestations included red follicular papules symmetrically distributed on the skin of the forearms, abdomen, thighs, and legs. The histopathologic findings were not specific. However, immunopa...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Alcalay J,Ingber A,Hazaz B,David M,Sandbank M

    更新日期:1988-02-01 00:00:00

  • The impact of dupilumab on patch testing and the prevalence of comorbid allergic contact dermatitis in recalcitrant atopic dermatitis: A retrospective chart review.

    abstract:BACKGROUND:It is unclear whether the type 2 T helper cell-specific immunosuppressive action of dupilumab interferes with patch testing. OBJECTIVES:We sought to evaluate the reliability of patch testing on dupilumab and the contribution of allergic contact dermatitis (ACD) to complex dermatitis in patients with residua...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Raffi J,Suresh R,Botto N,Murase JE

    更新日期:2020-01-01 00:00:00

  • Dermatology and the Americans With Disabilities Act: a review of the case law.

    abstract::The Americans With Disabilities Act (ADA) defines disability as a physical or mental impairment that substantially limits one or more major life activities. Although dermatology has received relatively little attention in the context of disability law, dermatologic diseases are properly covered by the ADA and are subj...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审


    authors: Curry ML,Curry JA,Cockerell CJ

    更新日期:2002-12-01 00:00:00

  • Angioedema: manifestations and management.

    abstract::Angioedema is characterized by localized swelling of sudden onset affecting the skin and/or mucous membranes. It can be classified into hereditary and acquired forms. Hereditary angioedema is a rare disease inherited as an autosomal dominant trait and caused by a deficiency of C1-esterase inhibitor. Acute attacks are ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审


    authors: Greaves M,Lawlor F

    更新日期:1991-07-01 00:00:00

  • Eosinophilic spongiosis: a clinicopathologic review of seventy-one cases.

    abstract::Eosinophilic spongiosis has a distinctive but not diagnostic histologic pattern of the epidermis. This pattern may be seen in a wide variety of clinical disorders. We have observed it most commonly in bullous pemphigoid, particularly the urticarial stage. In most biopsy specimens that show eosinophilic spongiosis, add...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Crotty C,Pittelkow M,Muller SA

    更新日期:1983-03-01 00:00:00

  • Treatment of Behçet's disease with granulocyte and monocyte adsorption apheresis.

    abstract::The painful orogenital ulcerations of Behçet's disease are among the major symptoms of patients and are often intractable. We assessed the efficacy of granulocyte and monocyte adsorption apheresis therapy in two patients, a 21-year-old man with orogenital ulcerations and a 50-year-old woman with genital ulceration and...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Kanekura T,Gushi A,Iwata M,Fukumaru S,Sakamoto R,Kawahara K,Maruyama I,Kanzaki T

    更新日期:2004-08-01 00:00:00

  • Conventional radiotherapy in the treatment of lentigo maligna and lentigo maligna melanoma.

    abstract::Forty cases of lentigo maligna (LM) and lentigo maligna melanoma (LMM) treated by conventional fractionated radiotherapy are reviewed. Fourteen of seventeen LM patients are alive and well 4 months to 5 years following irradiation, one patient died of intercurrent disease without recurrence, and two had residual or rec...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Harwood AR

    更新日期:1982-03-01 00:00:00

  • Subcutaneous fat in normal and diseased states 3. Adipogenesis: from stem cell to fat cell.

    abstract::The quest for effective strategies to treat obesity has propelled fat research into an exploration of the molecular processes that drive adipocyte formation, and hence body fat mass. The development of obesity is dependent on the coordinated interplay of adipocyte hypertrophy (increased fat cell size), adipocyte hyper...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审


    authors: Avram MM,Avram AS,James WD

    更新日期:2007-03-01 00:00:00

  • The Demodex mite population in rosacea.

    abstract:BACKGROUND:The cause of rosacea is unknown; among other factors a causative role has been postulated for the hair follicle mites Demodex folliculorum and Demodex brevis. OBJECTIVE:Our purpose was to compare the population density of Demodex mites in facial skin of defined categories of patients with rosacea with contr...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Bonnar E,Eustace P,Powell FC

    更新日期:1993-03-01 00:00:00

  • HLA-DR1 is not a sign of poor prognosis for the development of multiple basal cell carcinomas.

    abstract:BACKGROUND:HLA-DR1 is associated with the development of multiple basal cell carcinomas (BCC). However, the association is weak. OBJECTIVE:The purpose of our study was to determine whether HLA-DR1 is a marker for susceptibility to the development of many BCCs during a lifetime. METHODS:Persons with multiple BCCs were...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Czarnecki D,Lewis A,Nicholson I,Tait B,Nash C

    更新日期:1992-05-01 00:00:00

  • Extended efalizumab therapy improves chronic plaque psoriasis: results from a randomized phase III trial.

    abstract:BACKGROUND:Efalizumab inhibits multiple T-cell-mediated processes. OBJECTIVE:To evaluate 12- and 24-week efalizumab therapy for psoriasis. METHODS:In this phase III, randomized, double-blind trial, 498 patients received subcutaneous 1 or 2 mg/kg/wk efalizumab or placebo for 12 weeks. Efalizumab-treated patients who a...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Leonardi CL,Papp KA,Gordon KB,Menter A,Feldman SR,Caro I,Walicke PA,Compton PG,Gottlieb AB,Efalizumab Study Group.

    更新日期:2005-03-01 00:00:00

  • Treatment of cicatricial (benign mucous membrane) pemphigoid with dapsone.

    abstract::Treatment of cicatricial pemphigoid is a problem because patients afflicted are elderly, the disease is chronic, systemic agents required for control are potentially toxic (particularly to older patients), and the disease is often in an advanced stage when the diagnosis is established and requires aggressive therapy f...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Rogers RS 3rd,Seehafer JR,Perry HO

    更新日期:1982-02-01 00:00:00

  • Clinically occult cutaneous metastases.

    abstract::Cutaneous metastases present themselves in a variety of clinical patterns and tend to be manifested as indurated papules/nodules/tumors. Some of those clinical expressions are unique for certain types of metastases. This report describes an entirely different phenomenon of clinically incognito cutaneous metastases tha...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Resnik KS,DiLeonardo M,Gibbons G

    更新日期:2006-12-01 00:00:00

  • Antinuclear antibody-negative systemic lupus erythematosus. I. Anti-Ro(SSA) and anti-La(SSB) antibodies.

    abstract::Anti-Ro(SSA) and anti-La(SSB) antibodies are found in approximately 25% of systemic lupus erythematosus patients. These antibodies are also detected in lupus patients who fail to demonstrate a significant antinuclear antibody (ANA) titer when mouse liver is employed as the substrate. Approximately 5% to 10% of systemi...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Provost TT,Reichlin M

    更新日期:1981-01-01 00:00:00

  • Prediction of histologic melanocytic dysplasia from clinical observation.

    abstract:BACKGROUND:The dysplastic melanocytic nevus (DMN) is a putative precursor for malignant melanoma in persons with a family history of melanoma and multiple large atypical moles. Furthermore, the concept that DMN confers increased risk for melanoma has been extended to those without a family history of melanoma. Some inv...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Roush GC,Dubin N,Barnhill RL

    更新日期:1993-10-01 00:00:00

  • Essential progressive telangiectasia in an autoimmune setting: successful treatment with acyclovir.

    abstract::A unique, progressive syndrome of muscle weakness, ascending telangiectasia, and venous ectasia of the legs developed in a 55-year-old woman with autoimmune thyroiditis. Myopathy was documented by electromyography and electron microscopy. Her constellation of findings is considered to be of autoimmune origin. Treatmen...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章


    authors: Shelley WB,Shelley ED

    更新日期:1989-11-01 00:00:00

  • Human papillomavirus-related genital disease in the immunocompromised host: Part I.

    abstract::Human papillomavirus (HPV) is responsible for common condyloma acuminata and a number of premalignant and malignant anogenital lesions. These conditions are of particular concern in immunocompromised individuals who have higher risk of malignant transformation and are more difficult to treat. This is part I of a two-p...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审


    authors: Gormley RH,Kovarik CL

    更新日期:2012-06-01 00:00:00

  • Action of isotretinoin in acne rosacea and gram-negative folliculitis.

    abstract::Good to excellent clinical results have been obtained in the treatment of severe inflammatory acne (acne conglobata, acne fulminans, and acne conglobata with hidradenitis and dissecting cellulitis of the scalp) with orally administered isotretinoin (13-cis-retinoic acid). Similar promising results have been obtained i...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章


    authors: Plewig G,Nikolowski J,Wolff HH

    更新日期:1982-04-01 00:00:00

  • Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the continuous treatment of patients with moderate to severe psoriasis: Results from the phase III, double-blinded, placebo- and active comparator-

    abstract:BACKGROUND:Guselkumab, an interleukin-23 blocker, was superior to adalimumab in treating moderate to severe psoriasis in a phase II trial. OBJECTIVES:We sought to compare efficacy and safety of guselkumab with adalimumab and placebo in patients with psoriasis treated for 1 year. METHODS:Patients were randomized to gu...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,随机对照试验


    authors: Blauvelt A,Papp KA,Griffiths CE,Randazzo B,Wasfi Y,Shen YK,Li S,Kimball AB

    更新日期:2017-03-01 00:00:00

  • Dermal implants: safety of products injected for soft tissue augmentation.

    abstract::Soft tissue augmentation is a frequently performed outpatient operation. Products available for soft tissue augmentation vary in chemistry, clinical indications, and toxicity. This review examines safety and efficacy data for collagen implants (Zyderm and Zyplast), gelatin matrix implants (Fibrel), and injectable sili...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审


    authors: Clark DP,Hanke CW,Swanson NA

    更新日期:1989-11-01 00:00:00

  • Hidradenitis suppurativa: Current and emerging treatments.

    abstract::The treatment of hidradenitis suppurativa (HS) has remained challenging because of the many knowledge gaps regarding etiology. However, recent studies into the pathogenesis of HS have enabled the investigation of newer therapies. The second article in this continuing medical education series reviews the evidence for e...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审


    authors: Goldburg SR,Strober BE,Payette MJ

    更新日期:2020-05-01 00:00:00

  • Mohs micrographic surgery for eyelid sebaceous carcinoma: A multicenter cohort of 360 patients.

    abstract:BACKGROUND:The decision to perform Mohs micrographic surgery (MMS) or wide local excision (WLE) for eyelid sebaceous carcinoma (SC) is controversial. OBJECTIVE:To compare local recurrence, metastasis, and tumor-related mortality of patients with eyelid SC who were initially treated with MMS versus with WLE. METHODS:A...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,多中心研究


    authors: Zhou C,Wu F,Chai P,Shi Y,Ye J,Shi X,Tan J,Ding Y,Luo Y,Esmaeli B,Jia R,Fan X

    更新日期:2019-06-01 00:00:00