Extracellular-regulated kinase-mitogen-activated protein kinase cascade: unsolved issues.

abstract：:Adenosine triphosphate (ATP), which plays a crucial role in both developing and mature cochleae, is released from greater epithelial ridge (GER) supporting cells of the rat cochlea, but the organelles in which ATP is stored have not yet been identified. Thus, we studied the organelles involved in ATP storage and sugge...

journal_title：Journal of cellular biochemistry

authors： Chen J,Hou S,Yang J

更新日期：2019-12-01 00:00:00

abstract：:Methylmercury (MeHg) is an extremely important environmental toxicant posing serious health risks to human health and a big source of environmental pollutant. Numerous evidence available showing a link between nervous system toxicity and MeHg exposure. Other forms of mercury are reason of metabolic toxic effects and a...

journal_title：Journal of cellular biochemistry

authors： Maqbool F,Bahadar H,Hassani S,Niaz K,Baeeri M,Rahimifard M,Ghasemi-Niri SF,Abdollahi M

更新日期：2019-09-01 00:00:00

abstract：:Cancer of the ovary is the leading cause of death from gynecologic malignancy. To understand better these aggressive tumors, the development of in vitro models to study human ovarian cancer is critical. However, the establishment of long-term cell lines has been difficult, due to the generalized poor survival of patie...

journal_title：Journal of cellular biochemistry

authors： Becker JL,Prewett TL,Spaulding GF,Goodwin TJ

更新日期：1993-03-01 00:00:00

abstract：:The sequences from several independent cDNA clones encoding the chicken vitamin D receptor as well as primer extension assay have clearly delineated the 5' terminus and the transcriptional start site. Screening a chicken genomic library produced genomic clones containing vitamin D receptor (VDR) gene fragments. Restri...

journal_title：Journal of cellular biochemistry

authors： Lu Z,Jehan F,Zierold C,DeLuca HF

更新日期：2000-02-01 00:00:00

abstract：:Previously, we have reported that inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels by glibenclamide induced intracellular Ca2+ release from IP(3)-sensitive stores and apoptosis in HepG2 human hepatoblastoma cells (Kim JA, Kang YS, Lee SH, Lee EH, Yoo BH, Lee YS. 1999. Biochem Bioph...

journal_title：Journal of cellular biochemistry

authors： Kim JA,Kang YS,Lee SH,Lee EH,Lee YS

更新日期：2001-01-01 00:00:00

abstract：:Cervical cancer is one of the leading killers for female worldwide. Nevertheless, the less knowledge of molecular mechanism for cervical cancer limited the improvement of treatment effects. High-mobility group box 2 (HMGB2) belongs to the HMGB family, which could play diverse roles in cell proliferation. This work mai...

journal_title：Journal of cellular biochemistry

authors： Zhang P,Lu Y,Gao S

更新日期：2019-10-01 00:00:00

abstract：:We investigated the effects of vitamin D3 on the signaling pathways by prostaglandin E2 (PGE2) in osteoblast-like MC3T3-E1 cells. The pretreatment with 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), an active form of vitamin D3, significantly inhibited cAMP accumulation induced by 10 microM PGE2 in a dose-dependent manner i...

journal_title：Journal of cellular biochemistry

authors： Tokuda H,Kotoyori J,Suzuki A,Oiso Y,Kozawa O

更新日期：1993-06-01 00:00:00

abstract：:Herbal plants are enriched with compounds with a wide range of biological activities. Furanodiene is a sesquiterpene isolated from Rhizoma Curcumae. Growing evidence shows furanodiene exhibits diversified activities of hepatoprotection, anti-inflammation, anti-angiogenesis, and anti-tumor. However, its biological acti...

journal_title：Journal of cellular biochemistry

authors： Zhong ZF,Li YB,Wang SP,Tan W,Chen XP,Chen MW,Wang YT

更新日期：2012-08-01 00:00:00

abstract：:Currently, traditional predictors of prognosis (tumor size, nodal status, progesterone receptor [PR], estrogen receptor [ER], or human epidermal growth factor receptor-2 [HER2]) are insufficient for precise survival prediction for triple-negative breast cancer (TNBC). Long noncoding RNAs (lncRNAs) have been observed t...

journal_title：Journal of cellular biochemistry

authors： Fan CN,Ma L,Liu N

更新日期：2019-03-01 00:00:00

abstract：:Integrins may play important roles in many cellular events, such as cell proliferation, differentiation, and apoptosis. We showed previously that overexpression of integrin beta1 inhibits cell proliferation in SMMC-7721 cells. Here we reported that one of the cyclin-dependent kinase (CDK) inhibitors, p27(Kip1) was inv...

journal_title：Journal of cellular biochemistry

authors： Fu Y,Fang Z,Liang Y,Zhu X,Prins P,Li Z,Wang L,Sun L,Jin J,Yang Y,Zha X

更新日期：2007-10-15 00:00:00

abstract：PURPOSE:Endometrial carcinoma (EC), a common gynecological malignancy with high incidence, affects the mental and physical health of women. Mounting evidence shows that long noncoding RNAs (lncRNAs), messenger RNAs (mRNAs), and microRNAs (miRNAs) have instrumental roles in various biological processes associated with t...

journal_title：Journal of cellular biochemistry

authors： Zhao D,Ren C,Yao Y,Wang Q,Li F,Li Y,Jiang A,Wang G

更新日期：2020-03-01 00:00:00

abstract：:Curcumin, the active component of the spice turmeric, induce global DNA hypomethylation as it has been shown to inhibit DNA methyltransferases. It promotes cell death in cancer cells by arresting in the G1 phase. It was explained to cause increased expression of cell cycle regulator, p21 (WAF1/Cip1); however, the mech...

journal_title：Journal of cellular biochemistry

authors： Chatterjee B,Ghosh K,Kanade SR

更新日期：2019-01-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) serve as competitive endogenous RNAs (ceRNAs) that play significant regulatory roles in the pathogenesis of tumors. However, the role of lncRNAs, especially the lncRNA-related ceRNA regulatory network, in glioblastoma (GBM) has not been fully elucidated. The goal of the current study was ...

journal_title：Journal of cellular biochemistry

authors： Liu Z,Wang X,Yang G,Zhong C,Zhang R,Ye J,Zhong Y,Hu J,Ozal B,Zhao S

更新日期：2020-07-01 00:00:00

abstract：:Prolongation of cell survival through prevention of apoptosis is considered to be a significant factor leading to anabolic responses in bone. The current studies were carried out to determine the role of the small GTPase, RhoA, in osteoblast apoptosis, since RhoA has been found to be critical for cell survival in othe...

journal_title：Journal of cellular biochemistry

authors： Yoshida T,Clark MF,Stern PH

更新日期：2009-04-01 00:00:00

abstract：:Survivin is recognized as an attractive target in cancer therapy because of its selective overexpression in the majority of tumors. Upregulated expression of this protein correlates with increased tumor grade, recurrence risk and decreased cancer patients survival. In this study, we assessed the efficacy of two surviv...

journal_title：Journal of cellular biochemistry

authors： Croci DO,Cogno IS,Vittar NB,Salvatierra E,Trajtenberg F,Podhajcer OL,Osinaga E,Rabinovich GA,Rivarola VA

更新日期：2008-10-01 00:00:00

abstract：:A quantitative PCR method was used to map a functional origin of DNA replication in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene in normal human fibroblasts. This PCR method measures the abundance of specific sequences in short fragments of newly replicated DNA from logarithmically growing cells. Qua...

journal_title：Journal of cellular biochemistry

authors： Cohen SM,Brylawski BP,Cordeiro-Stone M,Kaufman DG

更新日期：2002-01-01 00:00:00

abstract：:Hepassocin (HPS) is a specific mitogenic active factor for hepatocytes, and inhibits growth by overexpression in hepatocellular carcinoma (HCC) cells. However, the mechanism of HPS regulation on growth of liver-derived cells still remains largely unknown. In this study, we found that HPS was expressed and secreted int...

journal_title：Journal of cellular biochemistry

authors： Cao MM,Xu WX,Li CY,Cao CZ,Wang ZD,Yao JW,Yu M,Zhan YQ,Wang XH,Tang LJ,Chen H,Li W,Ge CH,Yang XM

更新日期：2011-10-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) play an important role in regulating angiogenesis and immune balance. The abnormal MSCs in proliferation and function were reported at maternal fetal interface in patients with pre-eclampsia (PE). Long non-coding RNA MALAT1 was known to regulate the function of trophoblast cells. However,...

journal_title：Journal of cellular biochemistry

authors： Li X,Song Y,Liu F,Liu D,Miao H,Ren J,Xu J,Ding L,Hu Y,Wang Z,Hou Y,Zhao G

更新日期：2017-09-01 00:00:00

abstract：:Chylomicrons play a role in atherosclerosis, however, because the mechanisms involved in the cell uptake of these particles are not fully understood, investigations were carried out using a radioactively labeled protein-free triacylglycerol-rich emulsion incubated with peritoneal macrophages obtained from normal and a...

journal_title：Journal of cellular biochemistry

authors： Carvalho MD,Harada LM,Gidlund M,Ketelhuth DF,Boschcov P,Quintão EC

更新日期：2002-01-01 00:00:00

abstract：:Genistein, a natural isoflavone phytoestrogen present in soybeans, caused a dose-dependent growth inhibition of the two hormone-sensitive cell lines T47D and ZR75.1 and of the two hormone-independent cell lines MDAMB-231 and BT20. Flow cytometric analysis of cells treated for 4 days with 15 and 30 microM genistein sho...

journal_title：Journal of cellular biochemistry

authors： Cappelletti V,Fioravanti L,Miodini P,Di Fronzo G

更新日期：2000-09-14 00:00:00

abstract：:Overweight and obesity are established factors underpin several metabolic impairments, including the cardiovascular. Although the diversity of factors involved in overweight/obesity-induced cardiovascular diseases, mitochondria has been highlighted due to its role in cardiac metabolism. As obesity can be originated in...

journal_title：Journal of cellular biochemistry

authors： de Moura Freitas C,Nascimento LCPD,Braz GRF,Andrade-Silva SC,Lima-Junior NC,de Araujo Silva T,Fernandes MP,Ferreira DJS,Lagranha CJ

更新日期：2018-10-28 00:00:00

abstract：:As a de-ubiquitin enzyme, ubiquitin C-terminal hydrolase (UCH)-L1 has been shown to be overexpressed in several human cancers. However, the function of UCH-L1 in invasion of breast cancers is still unclear. Here we report that the expression of UCH-L1 is significantly higher in cancer cells with higher invasive abilit...

journal_title：Journal of cellular biochemistry

authors： Luo Y,He J,Yang C,Orange M,Ren X,Blair N,Tan T,Yang JM,Zhu H

更新日期：2018-01-01 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) exhibits an inverse correlation with estrogen receptor (ER) expression in the majority of breast cancers, predicting a poor response to endocrine therapy and poor survival rate. Inappropriate overexpression of EGFR in breast cancer is associated with a more aggressive phenot...

journal_title：Journal of cellular biochemistry

authors： Wilson MA,Chrysogelos SA

更新日期：2002-01-01 00:00:00

abstract：:Intrauterine growth restriction leads to the development of adult onset obesity/metabolic syndrome, diabetes mellitus, cardiovascular disease, hypertension, stroke, dyslipidemia, and non-alcoholic fatty liver disease/steatohepatitis. Continued postnatal growth restriction has been shown to ameliorate many of these seq...

journal_title：Journal of cellular biochemistry

authors： Freije WA,Thamotharan S,Lee R,Shin BC,Devaskar SU

更新日期：2015-04-01 00:00:00

abstract：:Osteosarcoma is the most common malignant bone tumor in children and adolescents with high rate of incidence, high frequency of recurrence, and high degree of metastasis. This study aimed to investigate the effects of long noncoding RNA antisense ncRNA in the abundant in neuroepithelium area (ANA)/B-cell translocation...

journal_title：Journal of cellular biochemistry

authors： Zhao J,Zhang C,Gao Z,Wu H,Gu R,Jiang R

更新日期：2018-08-01 00:00:00

abstract：:Previous studies from this and other laboratories have shown that variants of tumor cell lines can be selected for resistance to the lytic action of natural killer (NK) cells. One of these (K562-Clone I), when made resistant to the toxic effects of Concanavalin A (Con A-R1), regained its sensitivity to NK. Comparing t...

journal_title：Journal of cellular biochemistry

authors： Bernier LG,Sullivan AK

更新日期：1988-06-01 00:00:00

abstract：:Rapid detection and classification of cancer cells with label-free and non-destructive methods are helpful for rapid screening of cancer patients in clinical settings. Here, surface-enhanced Raman scattering (SERS) was used for rapid, unlabeled, and non-destructive detection of seven different cell types, including hu...

journal_title：Journal of cellular biochemistry

authors： Fang Y,Lin T,Zheng D,Zhu Y,Wang L,Fu Y,Wang H,Wu X,Zhang P

更新日期：2021-02-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) increases steady-state mRNA levels of several extracellular matrix proteins in mineralized connective tissues. Bone sialoprotein (BSP) is a major constituent of the bone matrix, thought to initiate and regulate the formation of mineral crystals. To determine the molecular pat...

journal_title：Journal of cellular biochemistry

authors： Ogata Y,Niisato N,Furuyama S,Cheifetz S,Kim RH,Sugiya H,Sodek J

更新日期：1997-06-15 00:00:00

abstract：:Atherosclerosis and related cardiovascular diseases (CVD) represent one of the greatest threats to human health worldwide. The protection of vascular smooth muscle cells (VSMCs) from apoptosis in the plaque has become an important therapeutic target for atherosclerotic plaque stabilization. A significant association o...

journal_title：Journal of cellular biochemistry

authors： Ye Y,Fu F,Li X,Yang J,Liu H

更新日期：2016-01-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) SM protein is a member of a highly conserved family of proteins present in most mammalian herpes viruses. There is a significant amount of functional and sequence divergence among the homologs encoded by the human herpes viruses, including differences in mechanism of action and varying eff...

journal_title：Journal of cellular biochemistry

authors： Swaminathan S

更新日期：2005-07-01 00:00:00