Risk factors of chemotherapy-induced nausea and vomiting in patients with metastatic colorectal cancer: a prospective cohort study (YCOG1301).

Abstract:

PURPOSE:Although the effectiveness of antiemetic therapy for colorectal cancer chemotherapy has improved with further drug development, some patients still suffer from chemotherapy-induced nausea and vomiting (CINV) even with only 5-hydroxytryptamine-3 receptor antagonist and dexamethasone. The present study investigated the risk factors of CINV in patients who received chemotherapy for colorectal cancer and clarified which patients need additional neurokinin 1 receptor antagonist. METHODS:Patients with colorectal cancer receiving moderate-emetic-risk chemotherapy (MEC) were enrolled in this prospective single-arm study with intravenous palonosetron 0.75 mg and dexamethasone 9.9 mg before chemotherapy and with paroral dexamethasone 8 mg on days 2 and 3. The primary endpoint was the complete response (CR) rate for delayed-phase CINV. RESULTS:A total of 179 patients were eligible for this study. The delayed CR rate was 84.9% (152/179). There were no significant differences in any risk factors, but women with a low body mass index (BMI) (a combination of "female sex" and "BMI < 20") showed a significantly lower rate of CC (complete control) (odds ratio [OR] = 0.45, 95% confidence interval [CI] = 0.17-1.13; p = 0.039), and young patients with a low BMI (combination of "age < 65" and "BMI < 20") showed a significantly lower rate of CR (OR = 0.34, 95% CI = 0.13-0.88; p = 0.022) than the other patients. CONCLUSIONS:This study failed to identify any single risk factors associated with delayed CINV in patients who received chemotherapy for advanced colorectal cancer. However, combinations of "thin and women" or "young and thin patients" might be possible predictive conditions, thus, candidates for NK1 receptor antagonist administration in MEC. Further investigations are required to develop criteria for the supplementation of NK1 receptor antagonist.

journal_name

Int J Colorectal Dis

authors

Takei S,Ishibe A,Watanabe J,Watanabe K,Suwa Y,Suzuki S,Nakagawa K,Suwa H,Ota M,Ichikawa Y,Kunisaki C,Yamanaka T,Endo I

doi

10.1007/s00384-020-03731-7

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

2323-2329

issue

12

eissn

0179-1958

issn

1432-1262

pii

10.1007/s00384-020-03731-7

journal_volume

35

pub_type

杂志文章
  • A systematic review and meta-analysis of adjuvant chemotherapy after neoadjuvant treatment and surgery for rectal cancer.

    abstract:BACKGROUND:Current guidelines support the use of adjuvant chemotherapy (CT) following neoadjuvant chemoradiotherapy (CTRT) and surgery to treat rectal cancer, although clinical trials have provided little evidence that it is effective. We performed a systematic review of published studies to assess whether adjuvant CT ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00384-014-2082-9

    authors: Petrelli F,Coinu A,Lonati V,Barni S

    更新日期:2015-04-01 00:00:00

  • The number of metastatic lymph nodes exhibiting poorly differentiated clusters predicts survival in patients with pStage III colorectal cancer.

    abstract:PURPOSE:Many studies have proposed alternative designations for lymph node (LN) status in colorectal cancer (CRC); however, knowledge of histopathological features in metastatic lymph nodes (MLNs) is limited. This study investigated the clinicopathological significance of poorly differentiated clusters (PDCs) in MLNs. ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-015-2393-5

    authors: Kinoshita O,Kishimoto M,Murayama Y,Kuriu Y,Nakanishi M,Sakakura C,Otsuji E,Yanagisawa A

    更新日期:2016-02-01 00:00:00

  • Mega-megacolon: a case report.

    abstract:PURPOSE:Large bowel obstruction and megacolon formation secondary to complicated diverticulitis is rare. METHODS:We present a case of an 84-year-old woman surviving large bowel obstruction and mega-megacolon formation secondary to complicated diverticulitis, with an impressive presentation of abdominal distention. RE...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03642-7

    authors: Larentzakis A,Kalyva A,Kantas T,Michalopoulos NV,Zografos CG,Zografos GC

    更新日期:2020-08-01 00:00:00

  • Influence of laparoscopy and laparotomy on systemic and peritoneal T lymphocytes in a rat model.

    abstract::Little is known about the local influence of pneumoperitoneum on components of the peritoneal immune defense mechanisms. We investigated CD25, CD4, CD8 expression and CD4/CD8 ratio of systemic and peritoneal T lymphocytes in a rat model. Fifty male Sprague Dawley rats underwent laparotomy, CO2 pneumoperitoneum, helium...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s003840100296

    authors: Gutt CN,Hollander D,Brier CH,Kim ZG,Lorenz M

    更新日期:2001-08-01 00:00:00

  • National trends in intestinal resection for Crohn's disease in the post-biologic era.

    abstract:INTRODUCTION:Prior international datasets have demonstrated equivocal results in the rate of surgical procedures for the treatment of Crohn's disease (CD) following the introduction of biologic medications. The first biologic medication licensed for use in the Republic of Ireland (ROI) was infliximab in 1999. The curre...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-013-1698-5

    authors: Burke JP,Velupillai Y,O'Connell PR,Coffey JC

    更新日期:2013-10-01 00:00:00

  • Mesenteric fibromatosis.

    abstract::Mesenteric fibromatosis is a rare, locally invasive, non-metastasizing type of intra-abdominal fibromatoses with a very high rate of recurrence. Because of rarity, these tumors pose a diagnostic and therapeutic challenge. These tumors may remain asymptomatic, but commonly present as a painless mass. There are no clear...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,评审

    doi:10.1007/s00384-014-1995-7

    authors: Chaudhary P

    更新日期:2014-12-01 00:00:00

  • Timing of surgery in ulcerative colitis in the biologic therapy era-the patient's perspective.

    abstract:BACKGROUND:There is no general consensus regarding the ideal timing of surgery in patients with refractory ulcerative colitis (UC). Decision-making and timing of restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is influenced by treating physicians and patients themselves. The aim of this study was t...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-018-3129-0

    authors: Gröne J,Lorenz EM,Seifarth C,Seeliger H,Kreis ME,Mueller MH

    更新日期:2018-10-01 00:00:00

  • Detection of micrometastases and skip metastases with ex vivo sentinel node mapping in carcinoma of the colon and rectum.

    abstract:BACKGROUND:The debate over sentinel lymph node mapping (SLNM) and focused pathologic examination to detect micrometastases in patients with colorectal cancer (CRC) continues. We present in this paper our experience with SLNM for CRCs to improve staging. In addition, we have detailed the mapping procedure on an anatomic...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-006-0132-7

    authors: Yagci G,Unlu A,Kurt B,Can MF,Kaymakcioglu N,Cetiner S,Tufan T,Sen D

    更新日期:2007-02-01 00:00:00

  • Study protocol for a multicenter prospective controlled and randomized trial of transanal total mesorectal excision versus laparoscopic low anterior resection in rectal cancer.

    abstract:PURPOSE:Compared with the open approach, laparoscopic total mesorectal excision (TME) achieves faster patient recovery, reduces morbidity rates, and shortens hospital stay. However, in laparoscopic low anterior resection (L-LAR), conversion to open surgery is required in almost 20% of cases. Transanal TME (Ta-TME) comb...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s00384-018-2996-8

    authors: Serra-Aracil X,Zárate A,Mora L,Serra-Pla S,Pallisera A,Bonfill J,Bargalló J,Pando A,Delgado S,Balleteros E,Pericay C

    更新日期:2018-05-01 00:00:00

  • Equivalent Helicobacter pylori infection rates in Lynch syndrome mutation carriers with and without a first-degree relative with gastric cancer.

    abstract:BACKGROUND:Patients with Lynch syndrome (LS) are at an increased risk of developing gastric cancer. In 2010, a guideline that recommended to screen all patients for Helicobacter pylori was implemented in the Netherlands. H. pylori is an important risk factor in the development of gastric cancer in the general populatio...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-016-2524-7

    authors: Soer EC,Leicher LW,Langers AM,van de Meeberg PC,van der Wouden EJ,Koornstra JJ,Bigirwamungu-Bargeman M,Vasen HF,de Vos tot Nederveen Cappel WH

    更新日期:2016-03-01 00:00:00

  • External coating of colonic anastomoses: a systematic review.

    abstract:PURPOSE:Colon anastomotic leakage remains both a frequent and serious complication in gastrointestinal surgery. External coating of colonic anastomoses has been proposed as a means to lower the rate of this complication. The aim of this review was to evaluate existing studies on external coating of colonic anastomoses....

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s00384-012-1547-y

    authors: Pommergaard HC,Achiam MP,Rosenberg J

    更新日期:2012-10-01 00:00:00

  • Dynamic magnetic resonance imaging evaluation of pelvic reconstruction with porcine dermal collagen mesh following extra-levator abdominoperineal excision for primary rectal cancer.

    abstract:PURPOSE:Extra-levator abdominoperineal excision for rectal cancer includes resection of the levator ani muscle and therefore makes pelvic reconstruction advisable. The aim of our study was to evaluate morphologic and functional long-term results of pelvic floor augmentation with porcine dermal collagen mesh by dynamic ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-015-2169-y

    authors: Dinnewitzer A,Meissnitzer M,Meissnitzer T,Nawara C,Augschöll C,Buchner S,Mayer F,Öfner D

    更新日期:2015-04-01 00:00:00

  • Deficiency of epithelial basement membrane laminin in ulcerative colitis affected human colonic mucosa.

    abstract::Imbalances in epithelium-matrix interactions have been discussed as a pathomechanism in ulcerative colitis, causing a colonic mucosal barrier dysfunction. Laminin, the major noncollagenous component of the basement membrane, plays a role in epithelial basal lamina formation and promotes differentiation of human entero...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s003840050006

    authors: Schmehl K,Florian S,Jacobasch G,Salomon A,Körber J

    更新日期:2000-02-01 00:00:00

  • Long-term manometric study of anal sphincter function after hemorrhoidectomy.

    abstract:BACKGROUND AND AIM:Data on maximum resting pressure (MRP) and maximum squeeze pressure (MSP) changes after hemorrhoidectomy are not univocal and follow-up of patients undergoing surgery is mostly short-lived. The aim of this study was to prospectively examine during 1-year follow-up the long-term manometric results of ...

    journal_title:International journal of colorectal disease

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00384-006-0174-x

    authors: Patti R,Almasio PL,Arcara M,Sparacello M,Termine S,Bonventre S,Di Vita G

    更新日期:2007-03-01 00:00:00

  • Association between increased tumor necrosis factor alpha levels and acquired activated protein C resistance in patients with metastatic colorectal cancer.

    abstract:PURPOSE:The purpose of this study was to investigate the possible association between tumor necrosis factor-α (TNF-α) levels and defects in the activated protein C (APC) system as a determinant of venous thromboembolism (VTE) in metastatic colorectal cancer patients (mCRC) undergoing chemotherapy. METHODS:TNF-α levels...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-012-1493-8

    authors: Ferroni P,Riondino S,Portarena I,Formica V,La Farina F,Martini F,Massimiani G,Palmirotta R,Guadagni F,Roselli M

    更新日期:2012-12-01 00:00:00

  • Dysplasia detection is similar between chromoendoscopy and high-definition white-light colonoscopy in inflammatory bowel disease patients: a US-matched case-control study.

    abstract:INTRODUCTION:Inflammatory bowel disease (IBD) patients are at greater risk of developing colorectal cancer (CRC). Detection of precursor dysplasia is important for cancer prevention. Recent guidelines recommend dye chromoendoscopy (DCE) as the preferred method for dysplasia detection. Universal adoption of DCE is time-...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03719-3

    authors: Clarke K,Kang M,Gorrepati VS,Stine JG,Tinsley A,Williams E,Moyer M,Coates M

    更新日期:2020-12-01 00:00:00

  • Healing of colonic anastomoses after immediate postoperative intraperitoneal administration of oxaliplatin.

    abstract:AIM:The aim of this experimental study was to investigate the effect of intraperitoneal administration of oxaliplatin on the healing of colonic anastomoses when injected immediately after colon resection. MATERIALS AND METHODS:Thirty male Wistar rats were used. During the operation, the rats were randomized to two gro...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-008-0538-5

    authors: Kanellos D,Pramateftakis MG,Demetriades H,Zacharakis E,Angelopoulos S,Mantzoros I,Kanellos I,Despoudi K,Zaraboukas T,Koliakos G,Galovatsea K,Lazaridis H

    更新日期:2008-12-01 00:00:00

  • The prognostic and clinicopathological value of tumor-associated macrophages in patients with colorectal cancer: a systematic review and meta-analysis.

    abstract:PURPOSE:There is a growing literature on the significance of tumor-associated macrophages (TAMs) in colorectal cancer (CRC). However, the role of TAMs in predicting the prognosis of CRC remains controversial. The current study aims to determine the prognostic and clinicopathological value of different types and distrib...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,评审

    doi:10.1007/s00384-020-03686-9

    authors: Yang Z,Zhang M,Peng R,Liu J,Wang F,Li Y,Zhao Q,Liu J

    更新日期:2020-09-01 00:00:00

  • Association between serum bilirubin and mucosal healing among Japanese patients with ulcerative colitis: a cross-sectional study.

    abstract:PURPOSE:Bilirubin is known to have antioxidant effects. Several pieces of evidence regarding association between serum bilirubin and UC exist. Three studies found that serum bilirubin was inversely associated with severity of ulcerative colitis (UC), but no evidence regarding an association between serum bilirubin and ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03774-w

    authors: Shiraishi K,Furukawa S,Yagi S,Hanayama M,Mori K,Ninomiya T,Suzuki S,Ohashi K,Murakami H,Takeshita E,Ikeda Y,Hiasa Y

    更新日期:2021-02-01 00:00:00

  • Laparoscopic adult colorectal surgeon and adolescents with inflammatory bowel disease: a safe combination?

    abstract:INTRODUCTION:A multidisciplinary tertiary service for adolescents with inflammatory bowel disease (IBD) was commenced in April 2008, aiming to provide specialist treatment for adolescent patients and bridge the gap between existing paediatric and adult surgical services. A single laparoscopic colorectal surgeon who nor...

    journal_title:International journal of colorectal disease

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00384-010-1058-7

    authors: Courtney ED,Brennan M,Noble-Jamieson G,Heuschkel R,Davies RJ

    更新日期:2011-03-01 00:00:00

  • The effect of hysterectomy on ano-rectal physiology.

    abstract::Hysterectomy is associated with severe constipation in a subgroup of patients, and an adverse effect on colonic motility has been described in the literature. The onset of irritable bowel syndrome and urinary bladder dysfunction has also been reported after hysterectomy. In this prospective study, we investigated the ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s003840050147

    authors: Kelly JL,O'Riordain DS,Jones E,Alawi E,O'Riordain MG,Kirwan WO

    更新日期:1998-01-01 00:00:00

  • Pelvic abscess associated with anastomotic leak in patients with ileal pouch-anal anastomosis (IPAA): transanastomotic or CT-guided drainage?

    abstract:AIM:Evidence is lacking whether an abscess associated with anastomotic leak after an ileal pouch-anal anastomosis (IPAA) should be drained by transanal or CT-guided drainage. Therefore, the aim of this study was to compare outcomes after the two techniques for drainage. METHOD:Patients who underwent IPAA (1984-2009) a...

    journal_title:International journal of colorectal disease

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00384-011-1272-y

    authors: Kirat HT,Remzi FH,Shen B,Kiran RP

    更新日期:2011-11-01 00:00:00

  • Colorectal cancer surveillance in Portuguese families with lynch syndrome: a cohort study.

    abstract:PURPOSE:Lynch syndrome (LS) is associated with a high risk of colorectal cancer (CRC). The aim of this study was to assess the cumulative risk for the development of colorectal adenomas or carcinomas in a LS CRC surveillance program and to audit the quality of the endoscopic procedures. METHODS:We evaluated 147 asympt...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-018-3002-1

    authors: Vale Rodrigues R,Claro I,Lage P,Rosa I,Ferreira S,Pereira da Silva J,Dias Pereira A

    更新日期:2018-06-01 00:00:00

  • Persistent fecal incontinence into adulthood after repair of anorectal malformations.

    abstract:PURPOSE:Persistent fecal incontinence beyond childhood is common in ARM patients. The aim of this study was to analyze a consecutive series of adult patients with persistent incontinence, establish the causes, and evaluate whether further treatment could be offered. METHODS:Forty-four adult ARM patients with reported ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-018-3220-6

    authors: Danielson J,Karlbom U,Graf W,Wester T

    更新日期:2019-03-01 00:00:00

  • Observations on the characteristics of stimulated defaecation in severe idiopathic constipation.

    abstract::A combined manometric and radioisotope study is described which was designed to investigate the motility characteristics of induced defaecation in the colon, rectum and anal canal, in patients with severe constipation. Five women with severe idiopathic constipation, aged 30-45 years, were studied. A multiple channel w...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/BF00341220

    authors: Kamm MA,van der Sijp JR,Lennard-Jones JE

    更新日期:1992-12-01 00:00:00

  • Impaired rectal sensation in idiopathic faecal incontinence.

    abstract::In 15 patients suffering from idiopathic faecal incontinence and in 15 matched controls, manometric studies of anorectal pressure and studies of the rectoanal reflex and rectal sensitivity were carried out. Patients with idiopathic faecal incontinence had normal resting pressure but reduced squeeze and stress pressure...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/BF01647996

    authors: Hancke E,Schürholz M

    更新日期:1987-08-01 00:00:00

  • Bilateral type diverticular disease of the colon.

    abstract::7,543 double-contrast barium enema studied for the presence of diverticula which were classified into right-sided, left-sided and bilateral types, and the relationship of the frequency (detection rate) and numbers of diverticula to age were examined for the earlier (1982-87) and later (1988-92) periods. Diverticular d...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/BF00342463

    authors: Miura S,Kodaira S,Aoki H,Hosoda Y

    更新日期:1996-01-01 00:00:00

  • Anorectal manometric parameters are influenced by gender and age in subjects with normal bowel function.

    abstract:PURPOSE:Anorectal manometry provides objective information about anorectal function, but its results depend on the examiner's skill, the type of equipment, and subject characteristics like age or gender. This single institution, prospective study was performed to investigate the effect of gender and age on the results ...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-014-1961-4

    authors: Lee HR,Lim SB,Park JY

    更新日期:2014-11-01 00:00:00

  • Indocyanine green fluorescent imaging on anastomotic leakage in colectomies: a network meta-analysis and systematic review.

    abstract:PURPOSE:The usage of indocyanine green (ICG) dye is commonly associated with decreased anastomotic leakage rates in colectomies. This study aims to perform a network meta-analysis to assess the usage of ICG fluorescence imaging in right-sided colectomies. METHODS:Medline, Embase, Cochrane Trials, CNKI, and WanFang ele...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章

    doi:10.1007/s00384-020-03723-7

    authors: Mok HT,Ong ZH,Yaow CYL,Ng CH,Buan BJL,Wong NW,Chong CS

    更新日期:2020-12-01 00:00:00

  • Rectocele: pathogenesis and surgical management.

    abstract:BACKGROUND:Rectocele is a common finding in patients with intractable evacuatory disorders. Although much rectocele surgery is conducted by gynecologists en passant with other forms of vaginal surgery, many reports lack appreciation of the importance of coincident anorectal symptoms, and do not report functional and cl...

    journal_title:International journal of colorectal disease

    pub_type: 杂志文章,评审

    doi:10.1007/s00384-003-0478-z

    authors: Zbar AP,Lienemann A,Fritsch H,Beer-Gabel M,Pescatori M

    更新日期:2003-09-01 00:00:00