The historical basis of a misconception leading to undertreating atopic dermatitis (eczema): facts and controversies.

Abstract:

:The quest for clarifying the pathophysiology of atopic dermatitis (eczema) has lasted for 25 centuries. Yearning to discern the primum movens of atopic dermatitis, physicians aimed to identify the curative therapy. Recent scientific efforts has brought to the light an ever-growing amount of interplaying pathophysiologic factors, including the epidermal barrier, the digestive flora, food, early infections and antigenic stimulations, and innate and adaptive immune response; however, overfocusing on some of these factors, along with misconceptions about the benefit/risk balance of topical therapies, has sometimes led topical therapies being disregarded. Reviewing the history of pathophysiologic concepts, we aim to return topical therapies to the center of the clinical management of atopic dermatitis.

journal_name

Clin Dermatol

journal_title

Clinics in dermatology

authors

Farhi D,Taïeb A,Tilles G,Wallach D

doi

10.1016/j.clindermatol.2009.03.009

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

45-51

issue

1

eissn

0738-081X

issn

1879-1131

pii

S0738-081X(09)00055-8

journal_volume

28

pub_type

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