Abstract:
PURPOSE:Ovarian cancer is the most lethal gynaecological malignancy. Despite the introduction of bevacizumab, standard chemotherapy has remained largely unchanged and the vast majority of patients will relapse within the first two years of diagnosis. However, results from recent clinical trials demonstrating clinical benefits of PARP inhibitor treatment are rapidly changing therapeutic options for many patients with ovarian cancer. METHODS:Given the introduction of new therapeutic options in the treatment of ovarian cancer, we critically review key clinical trials, areas of scientific research and its clinical relevance. RESULTS:Most notably, patients with BRCA1/2 mutant ovarian cancer benefit from maintenance treatment with PARP inhibitors after (complete or partial) response to platinum-based chemotherapy. Here, we discuss the mechanism of PARP inhibition, multiple drug resistance mechanisms, including BRCA reverse mutations, altered PARP expression, changes in DNA repair pathways, kinase activation and additional drug targets that may augment PARP inhibition. CONCLUSION:Although the use of PARP inhibitors is a huge step forward, it is apparent that patients, both with and without BRCA-mutant ovarian cancer, will eventually become resistant to PARP inhibitors. Therefore, novel combination therapies may enhance PARP inhibitor efficacy and overcome resistance mechanisms.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Klotz DM,Wimberger Pdoi
10.1007/s00404-020-05677-1subject
Has Abstractpub_date
2020-11-01 00:00:00pages
1087-1102issue
5eissn
0932-0067issn
1432-0711pii
10.1007/s00404-020-05677-1journal_volume
302pub_type
杂志文章,评审abstract::With hypervolemia, hemoconcentration, high vascular resistance and hypertension the SIH offers opposite changes as the physiological pregnancy. The absence of a decrease in hematocrit and MAP is as yet not used as early screening possibility. Doppler flow measurements allow a detection of a fetal brain sparing effect ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/BF02417259
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:We compared the outcomes of bloodless emergency laparotomies for uterine rupture in twenty Jehovah's Witness (JW) women who were in a state of haemorrhagic shock with 45 other women who received blood transfusion. METHODS:The case records of twenty Jehovah's Witness patients, who underwent bloodless emergenc...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-008-0748-7
更新日期:2009-04-01 00:00:00
abstract::We present three cases of chronic kidney disease secondary to large fibroid uterus. The difficulties experienced in their clinical management and a review of literature is outlined. ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-008-0769-2
更新日期:2009-06-01 00:00:00
abstract::We studied drug-induced cardiotoxic effects in 22 pregnant women having tocolysis with intravenous fenoterol and verapamil. Because CK-MB is released from the uterus and placenta, we used the determination of cardiac troponin T (cTnT) as it is one of the most sensitive and specific indicators of myocardial necrosis. C...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s004040050239
更新日期:1999-01-01 00:00:00
abstract:INTRODUCTION:Breast reconstruction with salpingo-oophorectomy can easily be performed in patients with genetic mutations increasing the risk for mammary and ovarian carcinoma. However, many patients are skeptical about having several surgeries, as they may result in additional anesthesiological risks as well as multipl...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-013-3133-0
更新日期:2014-06-01 00:00:00
abstract:INTRODUCTION:A hemangiopericytoma of the breast is uncommon, and a hemangiopericytoma of the breast is even rarer. Only a few cases of hemangiopericytoma of the breast have been reported in literature. CASE REPORT:Here, we report a case of a 66-year-old woman who presented with a mass in her left breast. The patient h...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-007-0470-x
更新日期:2008-04-01 00:00:00
abstract:PURPOSE:This study aimed to develop a valid and reliable tool for evaluation of sexual health assessment in infertile women. METHODS:This was a mixed exploratory study consisting of two phases. At phase one, we reviewed the existing instruments and interviewed 20 infertile women to generate an item pool. Then, the res...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-020-05832-8
更新日期:2020-10-19 00:00:00
abstract:BACKGROUND:Zollinger Ellison syndrome (ZES), an ulcerative disease of the upper gastrointestinal tract that involves the production of high levels of gastrin and gastric acid, is a rare, symptomatic, endocrine neoplastic disease. CASE:We report a rare case of gastrinoma that was first diagnosed during pregnancy in whi...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-007-0319-3
更新日期:2007-08-01 00:00:00
abstract::We report the case of a 66-year-old woman who had a hysterectomy because of uterine tumour. Histological examination showed a leiomyoma with degenerative changes and extensive extramedullary haematopoiesis. There was no evidence of any haematological or systemic disease. Extramedullary haematopoiesis in patients witho...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/BF02389579
更新日期:1990-01-01 00:00:00
abstract:AIM:To report an unusual location of a transmigrated IUD which become embedded in the right ovary causing chronic pelvic pain and dyspareunia. CASE:A 22-year-old woman who had an IUD (Copper T), inserted 7 years ago presented with complaint of lower abdominal pain. Pelvic ultrasonographic examination revealed ovarian ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-008-0882-2
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:There is a debate in the literature whether a pathologic nipple discharge is a distinct sign of breast carcinoma. Our own results obtained by the use of microdochectomy as a minimally invasive operative procedure in 184 patients with pathologic nipple discharge were analysed. The aim of this retrospective 20...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-010-1481-6
更新日期:2011-04-01 00:00:00
abstract::Between 1969 and 1991 there were 166,410 births in Southern Israel with 13 maternal deaths (7.8/100,000). In the Jewish population there were 119,130 deliveries with 7 maternal deaths (5.9/100,000), and the Bedouins had 47,280 deliveries with 6 maternal deaths (12.7/100,000). Prenatal care was an important preventive ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/BF02426359
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:To explore the etiologic factors and treatments of iatrogenic ureteral and bladder injury during obstetric and gynecologic operations. METHODS:Forty-one patients who underwent traditional obstetric and gynecologic operations were found with iatrogenic ureteral and bladder injury, and recruited into our study...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-011-2075-7
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:The objective was to review all obstetric admissions to the intensive care unit (ICU) at the Royal Free Hospital, London, UK, and to identify the risk factors for obstetric admissions to the ICU. METHOD:We carried out a retrospective case-control study. The cases consisted of women admitted to the ICU during...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-004-0695-x
更新日期:2005-09-01 00:00:00
abstract::We report a case of acute disseminated intravascular coagulation (DIC) developed during menstruation in an adenomyosis patient. No known predisposing factor for DIC such as infection or pregnancy was involved in this case. As anticoagulation therapy and supplementation of coagulation factors quickly improve the state,...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s004040100243
更新日期:2002-12-01 00:00:00
abstract:INTRODUCTION:Intentional placental removal for abnormally invasive placenta (AIP) is fundamentally abandoned at planned surgery for it. Whether this holds true even after recent introduction of various hemostatic procedures is unclear. MATERIALS AND METHODS:We discussed on this issue based on our own experiences and a...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-017-4592-5
更新日期:2018-01-01 00:00:00
abstract:AIM:To first compare the accuracy of self-, Physician-HPV testing and VIA as standalone screening tests; and second to compare the accuracy of Self-HPV positive test triaged with VIA with the different standalone screening tests as colposcopy and histologically confirmed CIN for cervical cancer screening in low-resourc...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-014-3321-6
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:The objective of this study was to determine the changes in total plasma thiols (homocysteine, cysteine and cysteinylglycine), lipid peroxidation and nitric oxide concentrations during normal pregnancy. METHODS:These variables were measured in 28 uncomplicated pregnant women at first, second and third trimeste...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-011-2150-0
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:We aimed to evaluate perinatal outcome of seven pregnancies with twin reserve arterial perfusion sequence. MATERIALS AND METHODS:Study group included seven cases of acardiac twins. Out of seven acardiac twins, two cases were followed without interventions. We performed four alcohol ablation and one bipolar c...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-008-0746-9
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:In women presenting with post-menopausal bleeding (PMB), the incidence of endometrial cancer is 1-10 %; Trans-vaginal scan (TVS) is offered as the first line of investigation to triage women further and a thick endometrium (>4 mm) merits endometrial tissue sampling for further evaluation. When it is difficul...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-013-2746-7
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION:Uncontrollable hemorrhage during cytoreductive surgery for advanced carcinoma ovary is a major cause of peri-operative mortality. This case series presents a novel technique of "combined intra pelvic and intra-abdominal packing," a life saving approach for such situations. MATERIALS AND METHODS:This case ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-011-2101-9
更新日期:2012-04-01 00:00:00
abstract::While endometriosis is a common disorder in women of reproductive age, appendiceal endometriosis accounts for less than 1% of all pelvic endometriotic lesions. Involvement at this site may present as acute appendicitis and be diagnosed only upon postoperative histopathologic examination. We report such an occurrence o...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-008-0922-y
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:To establish a reference range for the intracranial translucency (IT). METHODS:In this prospective study, we examined 596 singleton fetuses at 11-14 weeks of gestation using transabdominal ultrasonography. The distribution curves of the anterior-posterior diameter of the IT were established according to the ge...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-014-3410-6
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:The present study aims to explore whether β-EP in serum (sβ-EP) and follicular fluid (ffβ-EP) could predict the in vitro fertilization (IVF) outcomes of patients with polycystic ovary syndrome (PCOS) and diminished ovarian reserve (DOR). METHODS:90 PCOS women, 50 DOR women, and 100 women with normal ovarian fu...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-020-05899-3
更新日期:2020-11-28 00:00:00
abstract:PURPOSE:To investigate the influence of different kinds of endometriotic lesions, especially peritoneal endometriotic implants in pain generation and the pain reduction after surgical excision in a prospective study. METHODS:Fifty-one pre-menopausal patients underwent surgical laparoscopy due to chronic pelvic pain, d...
journal_title:Archives of gynecology and obstetrics
pub_type: 临床试验,杂志文章
doi:10.1007/s00404-008-0921-z
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:Hysterosalpingography (HSG) is an important tool for evaluation of tubal factors in infertility. It does not require anesthesia but can be a painful procedure. Thus, this study was undertaken to establish the role of intracervical block as pain relief modality for HSG. METHODS:This prospective, randomized stud...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00404-012-2515-z
更新日期:2013-01-01 00:00:00
abstract::Sirenomelia sequence is a very rare congenital malformation, with incidence of around 1.5-4.2 per 100,000 births. Prenatal diagnosis of sirenomelia in the first trimester is rare; there are only five cases reported for the present, and the association of sirenomelia with acardiac malformation is even rarer. We present...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-006-0250-z
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:The Nitric Oxide (NO) system plays an important role in the establishment and maintenance of the feto-placental circulation. Research on the pathogenesis of preeclampsia in several studies has established the involvement of the NO-system in preeclampsia and fetal intrauterine growth restriction (IUGR). In th...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-006-0149-8
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:Acrylamide has been associated with carcinogenicity in experimental animals, but potential health risks of dietary acrylamide intake and endometrial cancer in human are inconclusive. Thus, a meta-analysis of prospective cohort studies was conducted to provide a quantitative assessment of the association between...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,meta分析
doi:10.1007/s00404-014-3595-8
更新日期:2015-06-01 00:00:00
abstract::The aim of this study was to evaluate the relationship between the vascular resistance in uterine arteries and the maternal release of adenosine and endothelin-1 in twin gestations with and without preeclampsia. Uterine artery Doppler velocimetry and maternal arterial blood sampling were performed in 14 women with nor...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-001-0283-2
更新日期:2002-12-01 00:00:00