High precision and fast functional mapping of cortical circuitry through a novel combination of voltage sensitive dye imaging and laser scanning photostimulation.

abstract：:Responses of low characteristic-frequency (CF) neurons in the inferior colliculus were obtained to amplitude-modulated (AM) high-frequency tones in which the modulation rate was equal to the neuron's CF. Despite all spectral components lying outside the pure tone-evoked response areas, discharge rates were modulated b...

journal_title：Journal of neurophysiology

authors： McAlpine D

更新日期：2004-09-01 00:00:00

abstract：:Fast inhibitory synaptic transmission in the medial vestibular nucleus (MVN) is mediated by GABA(A) receptors (GABA(A)Rs) and glycine receptors (GlyRs). To assess their relative contribution to inhibition in the MVN, we recorded miniature inhibitory postsynaptic currents (mIPSCs) in physiologically characterized type ...

journal_title：Journal of neurophysiology

authors： Camp AJ,Callister RJ,Brichta AM

更新日期：2006-05-01 00:00:00

abstract：:Peripheral denervation has been shown to cause reorganization of the deafferented somatotopic region in primary somatosensory cortex (S1). However, the basic mechanisms that underlie reorganization are not well understood. In the experiments described in this paper, a novel in vivo/in vitro preparation of adult rat S1...

journal_title：Journal of neurophysiology

authors： Hickmott PW,Merzenich MM

更新日期：2002-09-01 00:00:00

abstract：:Impairments in human motor patterns are complex: what is often observed as a single global deficit (e.g., limping when walking) is actually the sum of several distinct abnormalities. Motor adaptation can be useful to teach patients more normal motor patterns, yet conventional training paradigms focus on individual fea...

journal_title：Journal of neurophysiology

authors： Statton MA,Toliver A,Bastian AJ

更新日期：2016-05-01 00:00:00

abstract：:Adaptation of fingertip forces to friction at the grasping surface is necessary to prevent use of inadequate or excessive grip forces. In the current study we investigated the effect of blocking tactile information from the fingertips noninvasively on the adaptation and efficiency of grip forces to surface friction du...

journal_title：Journal of neurophysiology

authors： Bilaloglu S,Lu Y,Geller D,Rizzo JR,Aluru V,Gardner EP,Raghavan P

更新日期：2016-03-01 00:00:00

abstract：:Because the subthalamic nucleus (STN) acts as a driving force of the basal ganglia, it is important to know how the activities of STN neurons are regulated. Previously, we have reported that a subset of STN neurons generates a plateau potential in a voltage-dependent manner. These plateau potentials can be evoked only...

journal_title：Journal of neurophysiology

authors： Otsuka T,Abe T,Tsukagawa T,Song WJ

更新日期：2004-07-01 00:00:00

abstract：:A brain slice preparation from guinea pigs and intracellular recording techniques were used to examine the effects of carbachol application on the three classes (A, B, and C) of neurons (n = 68, 40 of class A, 12 of class B, 16 of class C) within the mediolateral part of the lateral septum (LSml). Bath application of ...

journal_title：Journal of neurophysiology

authors： Carette B

更新日期：1998-09-01 00:00:00

abstract：:The aim of this study was to investigate the contribution of feedback from large-diameter sensory fibers to the adaptation of soleus muscle activity after small ankle trajectory modifications during human walking. Small-amplitude and slow-velocity ankle dorsiflexion enhancements and reductions were applied during the ...

journal_title：Journal of neurophysiology

authors： Mazzaro N,Grey MJ,Sinkjaer T,Andersen JB,Pareyson D,Schieppati M

更新日期：2005-06-01 00:00:00

abstract：:Experimental and clinical evidence indicates that pain can affect cognitive processes, but the cortical networks involved in pain-cognition interactions are unclear. In this study, we determined the effect of pain on the activity of cortical areas involved in cognition acting as a whole (i.e., a network). Subjects und...

journal_title：Journal of neurophysiology

authors： Seminowicz DA,Davis KD

更新日期：2007-05-01 00:00:00

abstract：:While the effects of sensory feedback on bimanual tasks have been studied extensively at two ends of the motor control hierarchy, the cortical and behavioral levels, much less is known about how it affects the intermediate levels, including neural control of homologous muscle groups. We investigated the effects of som...

journal_title：Journal of neurophysiology

authors： Nguyen HB,Lee SW,Harris-Love ML,Lum PS

更新日期：2017-02-01 00:00:00

abstract：:Hyperreflexia and spasticity are chronic complications in spinal cord injury (SCI), with limited options for safe and effective treatment. A central mechanism in spasticity is hyperexcitability of the spinal stretch reflex, which presents symptomatically as a velocity-dependent increase in tonic stretch reflexes and e...

journal_title：Journal of neurophysiology

authors： Bandaru SP,Liu S,Waxman SG,Tan AM

更新日期：2015-03-01 00:00:00

abstract：:Sensorineural hearing loss during early childhood alters auditory cortical evoked potentials in humans and profoundly changes auditory processing in hearing-impaired animals. Multiple mechanisms underlie the early postnatal establishment of cortical circuits, but one important set of developmental mechanisms relies on...

journal_title：Journal of neurophysiology

authors： Rao D,Basura GJ,Roche J,Daniels S,Mancilla JG,Manis PB

更新日期：2010-11-01 00:00:00

abstract：:1. Excitatory postsynaptic currents (EPSCs) in parasympathetic preganglionic neurons (PGNs) were examined by the use of the whole cell patch-clamp recording technique in slice preparations of the neonatal rat lumbosacral spinal cord. Synaptic responses were evoked in PGNs by extracellular stimulation of a neighboring ...

journal_title：Journal of neurophysiology

authors： Araki I,De Groat WC

更新日期：1996-07-01 00:00:00

abstract：:Hypercapnia-induced arousal from sleep is an important protective mechanism pertinent to a number of diseases. Most notably among these are the sudden infant death syndrome, obstructive sleep apnea and sudden unexpected death in epilepsy. Serotonin (5-HT) plays a significant role in hypercapnia-induced arousal. The me...

journal_title：Journal of neurophysiology

authors： Buchanan GF,Smith HR,MacAskill A,Richerson GB

更新日期：2015-07-01 00:00:00

abstract：:Under binaural listening conditions, the detection of target signals within background masking noise is substantially improved when the interaural phase of the target differs from that of the masker. Neural correlates of this binaural masking level difference (BMLD) have been observed in the inferior colliculus and te...

journal_title：Journal of neurophysiology

authors： Hughes LE,Rowe JB,Ghosh BC,Carlyon RP,Plack CJ,Gockel HE

更新日期：2014-12-15 00:00:00

abstract：:Caenorhabditis elegans responds to chemical cues using a small number of chemosensory neurons that detect a large variety of molecules in its environment. During chemotaxis, C. elegans biases its migration in spatial chemical gradients by lengthening (/shortening) periods of forward movement when it happens to be movi...

journal_title：Journal of neurophysiology

authors： Luo L,Gabel CV,Ha HI,Zhang Y,Samuel AD

更新日期：2008-05-01 00:00:00

abstract：:1. Intrasomal recordings were made with microelectrodes from 153 warm (infrared) neurons in the trigeminal ganglia of 36 crotaline snakes, Trimeresurus flavoviridis. Background discharges were observed at room temperature. The 153 warm neurons were classified into two groups: 81 were sensitive to less than or equal to...

journal_title：Journal of neurophysiology

authors： Terashima S,Liang YF

更新日期：1991-08-01 00:00:00

abstract：:1. In a brain stem slice preparation, we recorded glutamatergic excitatory postsynaptic currents (EPSCs) in hypoglossal motoneurons (HMs) evoked by extracellular stimulation in the reticular formation just ipsilateral to the hypoglossal motor nucleus (n. XII). Serotonin (5-HT) inhibited glutamatergic synaptic transmis...

journal_title：Journal of neurophysiology

authors： Singer JH,Bellingham MC,Berger AJ

更新日期：1996-08-01 00:00:00

abstract：:Retinal ganglion cells (RGC) transmit visual signals to thalamocortical relay neurons in the lateral geniculate nucleus via retinogeniculate synapses. Relay neuron spike patterns do not simply reflect those of RGCs, but the mechanisms controlling this transformation are not well understood. We therefore examined synap...

journal_title：Journal of neurophysiology

authors： Blitz DM,Regehr WG

更新日期：2003-10-01 00:00:00

abstract：:Microelectrode arrays (MEAs) are appealing tools to probe large neural ensembles and build neural prostheses. Microelectronics microfabrication technologies now allow building high-density MEAs containing several hundreds of microelectrodes. However, several major problems become limiting factors when the size of the ...

journal_title：Journal of neurophysiology

authors： Heim M,Rousseau L,Reculusa S,Urbanova V,Mazzocco C,Joucla S,Bouffier L,Vytras K,Bartlett P,Kuhn A,Yvert B

更新日期：2012-09-01 00:00:00

abstract：:Variations in cortical oscillations in the alpha (7-14 Hz) and beta (15-29 Hz) range have been correlated with attention, working memory, and stimulus detection. The mu rhythm recorded with magnetoencephalography (MEG) is a prominent oscillation generated by Rolandic cortex containing alpha and beta bands. Despite its...

journal_title：Journal of neurophysiology

authors： Jones SR,Pritchett DL,Sikora MA,Stufflebeam SM,Hämäläinen M,Moore CI

更新日期：2009-12-01 00:00:00

abstract：:1. Using an optical method for measuring membrane potential, we have been able to monitor action-potential activity simultaneously in 14 neurons of the supraesophageal ganglion of the barnacle. 2. Under favorable conditions, 4-mV synaptic potentials could also be detected optically. ...

journal_title：Journal of neurophysiology

authors： Salzberg BM,Grinvald A,Cohen LB,Davila HV,Ross WN

更新日期：1977-11-01 00:00:00

abstract：:The inferior olive is the sole source of the climbing fiber system, one of the two major afferent systems of the cerebellum; however, its exact role remains unknown. A longstanding hypothesis is that the inferior olive with its unique intrinsic rhythmic firing properties mediates motor timing. However, direct evidence...

journal_title：Journal of neurophysiology

authors： Liu T,Xu D,Ashe J,Bushara K

更新日期：2008-09-01 00:00:00

abstract：:We report the first optical recordings of action potentials, in single trials, from one or a few (approximately 1-2 microm) mammalian nerve terminals in an intact in vitro preparation, the mouse neurohypophysis. The measurements used two-photon excitation along the "blue" edge of the two-photon absorption spectrum of ...

journal_title：Journal of neurophysiology

authors： Fisher JA,Barchi JR,Welle CG,Kim GH,Kosterin P,Obaid AL,Yodh AG,Contreras D,Salzberg BM

更新日期：2008-03-01 00:00:00

abstract：:The contributions of the hyperpolarization-activated current, I(h), to generation of rhythmic activities are well described for various central neurons, particularly in thalamocortical circuits. In the present study, we investigated effects of a general anesthetic, propofol, on native I(h) in neurons of thalamus and c...

journal_title：Journal of neurophysiology

authors： Chen X,Shu S,Bayliss DA

更新日期：2005-12-01 00:00:00

abstract：:The discharge patterns of single units in the ventral cochlear nucleus (VCN) of anesthetized guinea pigs were examined in response to iterated rippled noise (IRN) as a function of the IRN delay (which determines the IRN pitch) and the IRN sound level. Delays were varied over five octaves in half-octave steps, and soun...

journal_title：Journal of neurophysiology

authors： Wiegrebe L,Winter IM

更新日期：2001-03-01 00:00:00

abstract：:1. Neuronal responses to cutaneous and noncutaneous stimulation were examined in the hindlimb representation of the precentral motor cortex (MI) and the first somatosensory cortex (SI) of unanesthetized monkeys. 2. MI can be divided into two distinct parts of the basis of its afferent input. The rostral part receives ...

journal_title：Journal of neurophysiology

authors： Tanji J,Wise SP

更新日期：1981-03-01 00:00:00

abstract：:Endocannabinoids released from the postsynaptic neuronal membrane can activate presynaptic CB1 receptors and inhibit neurotransmitter release. In hippocampal slices, depolarization of the CA1 pyramidal neurons elicits an endocannabinoid-mediated inhibition of gamma-aminobutyric acid release known as depolarization-ind...

journal_title：Journal of neurophysiology

authors： Sheinin A,Talani G,Davis MI,Lovinger DM

更新日期：2008-08-01 00:00:00

abstract：:Studies on animals have shown that noise-induced hearing loss is followed by an increase of spontaneous firing at several stages of the central auditory system. This central hyperactivity has been suggested to underpin the perception of tinnitus. It was shown that decreasing cochlear activity can abolish the noise-ind...

journal_title：Journal of neurophysiology

authors： Noreña AJ,Mulders WH,Robertson D

更新日期：2015-01-01 00:00:00

abstract：:In this study, the representation of taste in the orbitofrontal cortex was investigated to determine whether or not a pleasant and an aversive taste have distinct or overlapping representations in this region. The pleasant stimulus used was sweet taste (1 M glucose), and the unpleasant stimulus was salt taste (0.1 M N...

journal_title：Journal of neurophysiology

authors： O'Doherty J,Rolls ET,Francis S,Bowtell R,McGlone F

更新日期：2001-03-01 00:00:00