Abstract：
:Chagas disease is one of the most prevalent tropical neglected diseases and causes high mortality and morbidity in endemic countries. Current treatments for this disease, nifurtimox and benznidazole, are ineffective in the chronic phase of the disease and produce severe adverse effects. Therefore, novel therapies are urgently required. The trace element selenium has an important role in human health, due to its antioxidant, antiinflammatory and pro-immune properties. Actually, its deficiency has been related to several diseases and supplementation with this element has been proven to be beneficial for multiple pathologies. Furthermore, the usefulness of organic-selenium compounds has been studied in many disorders, showing promising results. The aim of this review is to analyse the available literature regarding the role of selenium in Chagas disease in order to determine whether its use could be beneficial for the management of this pathology.
journal_name
Eur J Med Chemjournal_title
European journal of medicinal chemistryauthors
Alcolea V,Pérez-Silanes Sdoi
10.1016/j.ejmech.2020.112673subject
Has Abstractpub_date
2020-11-15 00:00:00pages
112673eissn
0223-5234issn
1768-3254pii
S0223-5234(20)30645-0journal_volume
206pub_type
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journal_title：European journal of medicinal chemistry
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