Biomarkers in amyotrophic lateral sclerosis: a review of new developments.

Abstract:

PURPOSE OF REVIEW:This review draws together the most recent findings in ALS biomarker research from biochemical, imaging and neurophysiology techniques. RECENT FINDINGS:The potential of circulating RNA is highlighted, including new retrieval techniques. With ongoing genetic clinical trials, the need for pharmacodynamic biomarkers is essential. There is a strong case for neurofilament proteins being validated in ALS; their biomarker profile is discussed. Oxidative stress and neuroinflammation studies offer insight into disease mechanisms and offer good biomarker potential. Recent metabolic studies include investigation of lipid profiles, creatinine and ferritin. The potential of chitinase proteins as pharmacodynamic and prognostic biomarkers is highlighted. The role of tau and amyloidβ is debated, as evidenced by the articles presented here. Proteomic approaches provide unbiased discoveries of novel biomarkers, together with confirmation of previous findings. The use of imaging techniques is outlined to demonstrate selective atrophy, volume loss, muscle and tract involvement. In-vivo imaging is discussed with reference to histone deacetylase, oxidative stress, neuroinflammation and metabolic changes. New applications of electrophysiology demonstrate objective muscle biomarkers and brain network perturbations. SUMMARY:The biomarker research field continues to provide insight into the disease. Multicentre collaborations are needed to validate these promising recent findings.

journal_name

Curr Opin Neurol

authors

Verber N,Shaw PJ

doi

10.1097/WCO.0000000000000854

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

662-668

issue

5

eissn

1350-7540

issn

1473-6551

journal_volume

33

pub_type

杂志文章
  • Interictal high-frequency oscillations in focal human epilepsy.

    abstract:PURPOSE OF REVIEW:Localization of focal epileptic brain is critical for successful epilepsy surgery and focal brain stimulation. Despite significant progress, roughly half of all patients undergoing focal surgical resection, and most patients receiving focal electrical stimulation, are not seizure free. There is intens...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000302

    authors: Cimbalnik J,Kucewicz MT,Worrell G

    更新日期:2016-04-01 00:00:00

  • Implementation of the Stroke Action Plan for Europe 2018--2030 during coronavirus disease-2019.

    abstract:PURPOSE OF REVIEW:To describe the background, principles and implementation of the Stroke Action Plan for Europe 2018--2030 (SAP-E) in the perspective of the current COVID-19 pandemic. RECENT FINDINGS:SAP-E sets targets for the implementation of evidence-based preventive actions and stroke services to 2030. A recent m...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000893

    authors: Christensen H,Pezzella FR,Action Plan for Stroke in Europe Implementation Steering Committee.

    更新日期:2021-02-01 00:00:00

  • Spinal dural arteriovenous fistula.

    abstract:PURPOSE OF REVIEW:To summarize clinical key points, diagnostic features, and results of imaging and therapy of spinal dural arteriovenous fistula (SDAVF). RECENT FINDINGS:SDAVF accounts for 70% of spinal arteriovenous malformation with an annual incidence of 5-10 cases per million. At least 80% of patients are male, a...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000200547.22292.11

    authors: Koch C

    更新日期:2006-02-01 00:00:00

  • Psychogenic nonepileptic seizures.

    abstract:PURPOSE OF REVIEW:This review summarizes the recent studies assessing patients with psychogenic nonepileptic seizures and developments in treatment. RECENT FINDINGS:The misdiagnosis of nonepileptic seizure is costly to patients, the healthcare system, and to society. Patients with nonepileptic seizures are prescribed ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e3282f7008f

    authors: LaFrance WC Jr

    更新日期:2008-04-01 00:00:00

  • New treatments and treatment goals for patients with relapsing-remitting multiple sclerosis.

    abstract:PURPOSE OF REVIEW:The aims of this article are to review emerging therapies for multiple sclerosis (MS) and to consider new approaches to assessment and achievement of treatment success in patients with this disease. RECENT FINDINGS:A number of disease-modifying therapies for MS, including oral agents, are in advanced...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000413320.94715.e9

    authors: Fox EJ,Rhoades RW

    更新日期:2012-02-01 00:00:00

  • Treatment of idiopathic inflammatory myopathies.

    abstract:PURPOSE OF REVIEW:This article reviews the results of recent therapeutic trials in dermatomyositis, polymyositis, and inclusion body myositis and suggests an approach to treating patients with inflammatory myopathy. RECENT FINDINGS:We reviewed 10 double-blind, placebo-controlled therapeutic trials in patients with inf...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000093099.34793.40

    authors: Amato AA,Griggs RC

    更新日期:2003-10-01 00:00:00

  • Four birds with one stone? Reparative, neuroplastic, cardiorespiratory, and metabolic benefits of aerobic exercise poststroke.

    abstract:PURPOSE OF REVIEW:Converging evidence from animal models of stroke and clinical trials suggests that aerobic exercise has effects across multiple targets. RECENT FINDINGS:The subacute phase is characterized by a period of heightened neuroplasticity when aerobic exercise has the potential to optimize recovery. In anima...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000383

    authors: Ploughman M,Kelly LP

    更新日期:2016-12-01 00:00:00

  • Genetic dissection of the common epilepsies.

    abstract:PURPOSE OF REVIEW:Only two functionally validated susceptibility genes, CACNA1H and GABRD, have so far been identified in the common epilepsies using a candidate gene approach. The difficulty with the alternative statistical approach, where none of the suggested candidates has been functionally validated, may partly be...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000218232.66054.46

    authors: Tan NC,Mulley JC,Scheffer IE

    更新日期:2006-04-01 00:00:00

  • Community integration following severe childhood traumatic brain injury.

    abstract:PURPOSE OF REVIEW:Severe childhood traumatic brain injury (TBI) is the leading cause of death and acquired disability in children, causing impairments in children's sensory-motor, cognitive and behavioural functioning, with devastating consequences on community integration. Community integration is the ultimate goal of...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e328340296f

    authors: Chevignard MP,Brooks N,Truelle JL

    更新日期:2010-12-01 00:00:00

  • West Nile encephalitis and myelitis.

    abstract:PURPOSE OF REVIEW:This article will review the recent experience with West Nile virus encephalitis and myelitis. RECENT FINDINGS:In the summer of 2003, the majority of cases of West Nile virus infection in the United States were reported from the western states. The transmission of West Nile virus through blood transf...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200406000-00016

    authors: Roos KL

    更新日期:2004-06-01 00:00:00

  • Replacing aspirin and warfarin for secondary stroke prevention: is it worth the costs?

    abstract:PURPOSE OF REVIEW:This review aims to determine whether it is cost-effective to replace aspirin and warfarin with more effective, yet more costly, treatments for secondary stroke prevention. RECENT FINDINGS:For preventing recurrent stroke of arterial origin, clopidogrel and the combination of aspirin and extended-rele...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e328334e67b

    authors: Hankey GJ

    更新日期:2010-02-01 00:00:00

  • Decision-making and the frontal lobes.

    abstract:PURPOSE OF REVIEW:This article reviews the most significant advances concerning the neural correlates of decision-making with emphasis on those imaging studies investigating the neural implementation of evaluative judgment processes. This is done against the background of current concepts from the field of judgment and...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000236621.83872.71

    authors: Volz KG,Schubotz RI,von Cramon DY

    更新日期:2006-08-01 00:00:00

  • Neurosteroids and epilepsy.

    abstract:PURPOSE OF REVIEW:Neurosteroids are a family of compounds synthesized directly in the brain by transforming cholesterol into pregnenolone, which is then converted to compounds such as allopregnanolone and allotetrahydrodeoxycorticosterone. In view of their ability to modulate neurotransmission, neurosteroids may influe...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e32833735cf

    authors: Biagini G,Panuccio G,Avoli M

    更新日期:2010-04-01 00:00:00

  • Sleep and movement disorders.

    abstract:PURPOSE OF REVIEW:The aim is to review sleep disturbances in different movement disorders, mainly Parkinson's disease, and highlight current concepts on merging the boundaries between movement disorders and dissociative states of being. RECENT FINDINGS:Since the observation that rapid eye movement sleep behavior disor...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e3283632cef

    authors: Giannoccaro MP,Antelmi E,Plazzi G

    更新日期:2013-08-01 00:00:00

  • Epilepsy classification: a cycle of evolution and revolution.

    abstract:PURPOSE OF REVIEW:This review presents the new terms and concepts proposed by the International League Against Epilepsy (ILAE) Classification Commission in 2010 to describe seizures and epilepsies. This is the first major revision in 21 years and reflects the rapid evolution in our understanding of the epilepsies. REC...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e32835ee58e

    authors: Korff CM,Scheffer IE

    更新日期:2013-04-01 00:00:00

  • Neuroimaging in developmental disorders.

    abstract:PURPOSE OF REVIEW:This review considers the role of neuroimaging in developmental disorders by highlighting recent studies in two distinct, but overlapping, developmental disorders: autism and fragile X syndrome. RECENT FINDINGS:After a decade of conflicting results in neuroimaging studies of autism, recent studies ha...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000063763.15877.d2

    authors: Greicius MD

    更新日期:2003-04-01 00:00:00

  • Cerebral small vessel diseases: cerebral microangiopathies.

    abstract:PURPOSE OF REVIEW:Small vessel diseases of the brain are still clinically underrecognized whereas their burden is increasing steeply. The most frequent is acquired degenerative small vessel disease. Many hereditary or idiopathic small vessel diseases have also been identified, of which cerebral autosomal-dominant arter...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000162861.26971.03

    authors: Ringelstein EB,Nabavi DG

    更新日期:2005-04-01 00:00:00

  • An update on thrombolytic therapy for acute stroke.

    abstract:PURPOSE OF REVIEW:Stroke is the third leading cause of death after myocardial infarction and cancer, and is the leading cause of permanent disability and disability-adjusted loss of independent life-years in western countries. Thrombolysis is the treatment of choice for acute stroke within 3 h after the onset of sympto...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200402000-00012

    authors: Schellinger PD,Kaste M,Hacke W

    更新日期:2004-02-01 00:00:00

  • Experimental and therapeutic approaches to muscular dystrophies.

    abstract:PURPOSE OF REVIEW:Most patients suffering from muscular dystrophies can now obtain a precise diagnosis of their underlying molecular defect, but no efficient treatment to prevent disability and death. This review summarizes recent progress towards developing efficient treatments for these severe diseases. RECENT FINDI...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200210000-00007

    authors: Skuk D,Vilquin JT,Tremblay JP

    更新日期:2002-10-01 00:00:00

  • Functional brain imaging applications to differential diagnosis in the dementias.

    abstract:PURPOSE OF REVIEW:The diagnosis of dementia rests on an improved knowledge and a better detection of early impairments, to which functional imaging can certainly contribute. RECENT FINDINGS:Progress has been observed at different levels. First, the understanding of different dementias has benefited from explorations o...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200208000-00006

    authors: Salmon E

    更新日期:2002-08-01 00:00:00

  • New drug therapies for multiple sclerosis.

    abstract:PURPOSE OF REVIEW:Multiple sclerosis (MS) is an autoimmune and inflammatory disease of the central nervous system (CNS) that causes neurological disability in young adults and that to date has no cure. Until now, expensive and only partially efficacious therapies have become available. For this reason, researchers, cli...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e32833960f6

    authors: Mangas A,Coveñas R,Geffard M

    更新日期:2010-06-01 00:00:00

  • Impact of brain aging and neurodegeneration on cognition: evidence from MRI.

    abstract:PURPOSE OF REVIEW:We present an overview of recent concepts in mechanisms underlying cognitive decline associated with brain aging and neurodegeneration from the perspective of MRI. RECENT FINDINGS:Recent findings challenge the established link between neuroimaging biomarkers of neurodegeneration and age-related or di...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000029

    authors: Draganski B,Lutti A,Kherif F

    更新日期:2013-12-01 00:00:00

  • The growing clinical spectrum of cerebral amyloid angiopathy.

    abstract:PURPOSE OF REVIEW:Cerebral amyloid angiopathy (CAA) is diagnosed primarily as a cause of lobar intracerebral hemorrhages (ICH) in elderly patients. With improving MRI techniques, however, the role of CAA in causing other symptoms has become clear. Recognizing the full clinical spectrum of CAA is important for diagnosis...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000510

    authors: Wermer MJH,Greenberg SM

    更新日期:2018-02-01 00:00:00

  • Genetic treatments in muscular dystrophies.

    abstract:PURPOSE OF REVIEW:The search for a cure for Duchenne muscular dystrophy and other muscular dystrophies is progressing rapidly despite significant challenges posed by some genes and the complexity of targeting all skeletal muscles. This review focuses on three areas in which experimental clinical studies are in progress...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e3282efc157

    authors: Muntoni F,Wells D

    更新日期:2007-10-01 00:00:00

  • Cognitive impairment in multiple sclerosis.

    abstract:PURPOSE OF REVIEW:For a long time, cognitive impairment in multiple sclerosis patients has been considered less important than, for instance, physical disability. This is no longer true because of the crucial role that cognitive deficits play in the good day-to-day adjustment of patients. This review highlights recent ...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e32810c8e87

    authors: Hoffmann S,Tittgemeyer M,von Cramon DY

    更新日期:2007-06-01 00:00:00

  • Mortality in patients with epilepsy.

    abstract:PURPOSE OF REVIEW:Prospective and retrospective incidence cohort studies have been consistent in identifying an increased mortality in patients with epilepsy, although risk ratios vary considerably. Standardized mortality ratios in these populations range from 1.6 to 5.3, but they tend to be higher in studies in select...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200404000-00010

    authors: Jallon P

    更新日期:2004-04-01 00:00:00

  • Rehabilitation of hemianopia.

    abstract:PURPOSE OF REVIEW:Homonymous hemianopia is the commonest form of acquired homonymous visual field defect; the usual causes are stroke, head injury and intracranial tumours. This impairment can affect a variety of cognitive visual functions, including visual search, safe navigation through changing environments and read...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0b013e32831f1b2c

    authors: Schofield TM,Leff AP

    更新日期:2009-02-01 00:00:00

  • Surgical approaches to vascular anomalies of the child's brain.

    abstract::The population of pediatric patients with cerebrovascular disease presents a unique set of challenges to the neurosurgeon. The wide scope of pathology, including arteriovenous malformations, cavernous malformations and moyamoya disease, coupled with marked advances in diagnosis and treatment of these conditions over t...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/00019052-200204000-00007

    authors: Smith ER,Butler WE,Ogilvy CS

    更新日期:2002-04-01 00:00:00

  • Epidemiology and natural history of multiple sclerosis: new insights.

    abstract:PURPOSE OF REVIEW:The cause of multiple sclerosis remains elusive. We review recent epidemiological studies of genetic and environmental factors that influence susceptibility to the disease and its clinical course. RECENT FINDINGS:Genetic advances strengthen the association of multiple sclerosis with the human leukocy...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/01.wco.0000227033.47458.82

    authors: Kantarci O,Wingerchuk D

    更新日期:2006-06-01 00:00:00

  • Treatment of early Parkinson's disease.

    abstract:PURPOSE OF REVIEW:This review summarizes currently available treatment options and treatment strategies, investigational treatments, and the importance of exercise for early Parkinson's disease. RECENT FINDINGS:The available treatment options for early Parkinson's disease have changed little in the past decade and inc...

    journal_title:Current opinion in neurology

    pub_type: 杂志文章,评审

    doi:10.1097/WCO.0000000000000113

    authors: Pahwa R,Lyons KE

    更新日期:2014-08-01 00:00:00