Amyloid deposition in a renal transplant in familial Mediterranean fever.

Abstract:

:A patient with familial Mediterranean fever and amyloidosis who received a cadaver renal transplant 6 1/2 years ago was studied to determine the relation of the serum precursor of secondary amyloid (SAA) to the clinical course and to the deposition of amyloid in the transplant. Amyloid fibrils extracted from the patient's kidneys contained protein AA as a major constituent, which identified the amyloid as secondary. Protein AA antiserum was used in an indirect immunofluorescent technique to stain amyloid deposits in sections of the original kidney. A renal biopsy at 2 years showed no amyloid, but a renal biopsy at 4 years showed amyloid. Serum levels of SAA from 3 years before transplant to 6 years after transplant were elevated throughout most of the course.

journal_name

Ann Intern Med

authors

Benson MD,Skinner M,Cohen AS

doi

10.7326/0003-4819-87-1-31

subject

Has Abstract

pub_date

1977-07-01 00:00:00

pages

31-4

issue

1

eissn

0003-4819

issn

1539-3704

journal_volume

87

pub_type

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