Abstract:
:Learning disabilities represent the main childhood complication in neurofibromatosis type 1 (NF1). Patients frequently exhibit T2-weighted hyperintensities called unidentified bright objects (UBOs) on brain magnetic resonance imaging (MRI), with unclear relationship to such cognitive disabilities. This study aimed to determine whether thalamo-striatal UBOs correlate with cognitive disturbances. Thirty-seven NF1 children were studied: 24 with UBOs (18 of which were thalamo-striatal UBOs), and 13 without UBOs. NF1 subjects carrying thalamo-striatal UBOs had significantly lower IQs and visuospatial performances than those without UBOs in this location. These results suggest that UBOs may contribute to NF1 cognitive impairments through thalamo-cortical dysfunction.
journal_name
Dev Neuropsycholjournal_title
Developmental neuropsychologyauthors
Chabernaud C,Sirinelli D,Barbier C,Cottier JP,Sembely C,Giraudeau B,Deseille-Turlotte G,Lorette G,Barthez MA,Castelnau Pdoi
10.1080/87565640903265137subject
Has Abstractpub_date
2009-01-01 00:00:00pages
736-48issue
6eissn
8756-5641issn
1532-6942pii
916957816journal_volume
34pub_type
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