Thalamo-striatal T2-weighted hyperintensities (unidentified bright objects) correlate with cognitive impairments in neurofibromatosis type 1 during childhood.

Abstract:

:Learning disabilities represent the main childhood complication in neurofibromatosis type 1 (NF1). Patients frequently exhibit T2-weighted hyperintensities called unidentified bright objects (UBOs) on brain magnetic resonance imaging (MRI), with unclear relationship to such cognitive disabilities. This study aimed to determine whether thalamo-striatal UBOs correlate with cognitive disturbances. Thirty-seven NF1 children were studied: 24 with UBOs (18 of which were thalamo-striatal UBOs), and 13 without UBOs. NF1 subjects carrying thalamo-striatal UBOs had significantly lower IQs and visuospatial performances than those without UBOs in this location. These results suggest that UBOs may contribute to NF1 cognitive impairments through thalamo-cortical dysfunction.

journal_name

Dev Neuropsychol

authors

Chabernaud C,Sirinelli D,Barbier C,Cottier JP,Sembely C,Giraudeau B,Deseille-Turlotte G,Lorette G,Barthez MA,Castelnau P

doi

10.1080/87565640903265137

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

736-48

issue

6

eissn

8756-5641

issn

1532-6942

pii

916957816

journal_volume

34

pub_type

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