Nitrogen mustard, vincristine, procarbazine, and prednisone as adjuvant chemotherapy in the treatment of medulloblastoma. A Pediatric Oncology Group study.

Abstract:

:In a randomized postoperative trial, adjuvant post-irradiation chemotherapy, consisting of nitrogen mustard, vincristine, procarbazine, and prednisone (MOPP), was tested versus radiation therapy alone for newly diagnosed medulloblastoma in patients between 1 and 21 years of age. Patients treated with irradiation plus MOPP had a statistically significant increase in overall survival rate at 5 years posttreatment compared to patients treated with radiation therapy alone (74% vs. 56%; p = 0.06, adjusted for race and gender). Although the overall study failed to show a statistically significant advantage for irradiation plus MOPP in event-free survival (p = 0.18), statistical significance was attained in children 5 years of age or older (p = 0.05). More severe hematological toxicities occurred in the group with irradiation plus MOPP; however, this hematotoxicity appeared to be tolerable and acceptable. These results suggest that patients may benefit from combined irradiation and chemotherapy following surgery for medulloblastoma.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Krischer JP,Ragab AH,Kun L,Kim TH,Laurent JP,Boyett JM,Cornell CJ,Link M,Luthy AR,Camitta B

doi

10.3171/jns.1991.74.6.0905

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

905-9

issue

6

eissn

0022-3085

issn

1933-0693

journal_volume

74

pub_type

临床试验,杂志文章,随机对照试验
  • Minimally invasive superficial temporal artery to middle cerebral artery bypass through an enlarged bur hole: the use of computed tomography angiography neuronavigation in surgical planning.

    abstract::The authors describe their minimally invasive technique for performing a superficial temporal artery (STA) to middle cerebral artery (MCA) bypass, which relies on an enlarged bur hole (2-2.5 cm) rather than the standard craniotomy. They perform this procedure in a minimally invasive fashion, using CT angiography for i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS/2008/109/9/0553

    authors: Coppens JR,Cantando JD,Abdulrauf SI

    更新日期:2008-09-01 00:00:00

  • Effective suppression of hippocampal seizures in rats by direct hippocampal cooling with a Peltier chip.

    abstract:OBJECT:The use of focal brain cooling to eliminate epileptic discharges (EDs) has attracted increasing attention in the scientific community. In this study, the inhibitory effect of selective hippocampal cooling on experimental hippocampal seizures was investigated using a newly devised cooling system with a thermoelec...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS/2008/108/4/0791

    authors: Tanaka N,Fujii M,Imoto H,Uchiyama J,Nakano K,Nomura S,Fujisawa H,Kunitsugu I,Saito T,Suzuki M

    更新日期:2008-04-01 00:00:00

  • High-resolution 1H-magnetic resonance spectroscopy of pediatric posterior fossa tumors in vitro.

    abstract::High-resolution proton magnetic resonance (MR) spectroscopy was performed on perchlorate extracts of tumors (24 cases) or peritumoral vermis (five cases) obtained at surgery. Fifteen tumors were typical cerebellar astrocytomas and nine were posterior fossa primitive neuroectodermal tumors/medulloblastomas. Spectra obt...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.81.3.0443

    authors: Sutton LN,Wehrli SL,Gennarelli L,Wang Z,Zimmerman R,Bonner K,Rorke LB

    更新日期:1994-09-01 00:00:00

  • Analysis of von hippel-lindau mutations with comparative genomic hybridization in sporadic and hereditary hemangioblastomas: possible genetic heterogeneity.

    abstract:OBJECT:Hemangioblastomas (HBs) occur sporadically or as a manifestation of von Hippel-Lindau (VHL) disease. In the majority of VHL-related HBs, inactivation of the VHL tumor suppressor gene (TSG), which is located on chromosome 3p25-26, is found. The VHL gene is assumed to be involved also in the development of sporadi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2002.97.4.0977

    authors: Gijtenbeek JM,Jacobs B,Sprenger SH,Eleveld MJ,van Kessel AG,Kros JM,Sciot R,van Calenbergh F,Wesseling P,Jeuken JW

    更新日期:2002-10-01 00:00:00

  • Neuroendoscopic findings in patients with intracranial germinomas correlating with diabetes insipidus.

    abstract:OBJECT:Intracranial germinomas commonly occur in the pineal region, the floor of the third ventricle (hypothalamus), or both, and they are often associated with diabetes insipidus (DI). The authors conducted a study to correlate preoperative DI with the endoscopic and magnetic resonance (MR) imaging evidence of tumor o...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2004.100.5.0430

    authors: Wellons JC 3rd,Reddy AT,Tubbs RS,Abdullatif H,Oakes WJ,Blount JP,Grabb PA

    更新日期:2004-05-01 00:00:00

  • Cerebellar stimulation in man. Quantitative changes in spasticity.

    abstract::The effects of chronic anterior lobe cerebellar stimulation on patients with cerebral palsy have been investigated using a new method of quanitfying muscle rigidity and stretch reflexes. The ankle is oscillated sinusoidally, compliance is measured at several frequencies, and electromyographic activity of the extensor ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1978.48.5.0779

    authors: Penn RD,Gottlieb GL,Agarwal GC

    更新日期:1978-05-01 00:00:00

  • Microneurosurgery for aneurysms of the basilar artery.

    abstract::The authors report microsurgical treatment in 32 cases of basilar artery aneurysms, operated on with good results in 28 cases, fair results in one, and poor results in one; there were two deaths. Twenty-nine patients (91%) were able to return to social activities. Characteristics of the surgical techniques include 1) ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1979.51.5.0615

    authors: Sugita K,Kobayashi S,Shintani A,Mutsuga N

    更新日期:1979-11-01 00:00:00

  • Oxidative markers in spontaneous intracerebral hemorrhage: leukocyte 8-hydroxy-2'-deoxyguanosine as an independent predictor of the 30-day outcome.

    abstract:OBJECT:Oxidative stress may play a role in spontaneous intracerebral hemorrhage (ICH), but data on oxidative burden in cerebral hemorrhage are limited, and it is not clear whether oxidative markers add predictive power regarding ICH outcome beyond that of traditional factors. The authors therefore examined redox status...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2011.7.JNS11718

    authors: Chen YC,Chen CM,Liu JL,Chen ST,Cheng ML,Chiu DT

    更新日期:2011-12-01 00:00:00

  • Lymphoplasmacyte-rich meningioma with clinical resemblance to inflammatory pseudotumor. Report of two cases.

    abstract::Two cases of lymphoplasmacyte-rich meningioma manifesting clinical and radiological characteristics unusual for a meningioma are reported. The patient in Case 1 was a 22-year-old man with a 9-year history of bilateral visual disturbances and recent dyspnea. An en plaque skull base mass, which was partially resected, w...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.1997.86.5.0898

    authors: Yamaki T,Ikeda T,Sakamoto Y,Ohtaki M,Hashi K

    更新日期:1997-05-01 00:00:00

  • Revascularization of the extracranial vertebral artery at any level without cross-clamping.

    abstract::Hemodynamic insufficiency resulting from extracranial vertebral artery stenosis or occlusion is believed to be the major cause of vertebrobasilar transient ischemic attacks. The major difficulties in treating this disorder have been exposure of the vertebral artery distal to the stenosis and the risk of vertebral arte...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.62.3.0334

    authors: Senter HJ,Bittar SM,Long ET

    更新日期:1985-03-01 00:00:00

  • Prediction of tolerance to carotid artery occlusion using transcranial Doppler ultrasound.

    abstract::Surgical sacrifice of the carotid artery is a frequently anticipated event during the treatment of certain aneurysms and tumors. The ability to predict tolerance to carotid artery occlusion is therefore of benefit when planning procedures in which the carotid artery is at risk. A trial of carotid artery occlusion usin...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.81.1.0015

    authors: Giller CA,Mathews D,Walker B,Purdy P,Roseland AM

    更新日期:1994-07-01 00:00:00

  • Supratentorial ependymomas. Neuroimaging and clinicopathological correlation.

    abstract::In 10 patients with supratentorial ependymomas, the tumors exhibited hyperdensity on computerized tomography (CT) scanning prior to contrast infusion and, with one exception, all tumors were mixed lesions with the low densities suggesting cystic or necrotic portions. Eighty percent of the tumors contained small calcif...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.64.2.0209

    authors: Centeno RS,Lee AA,Winter J,Barba D

    更新日期:1986-02-01 00:00:00

  • A meningioma and its consequences for American history and the rise of neurosurgery.

    abstract::The case of General Leonard Wood is notable both for its contribution to the field of neurosurgery and its historical significance. As one of Harvey Cushing's first successful brain tumor operations in 1910, Wood's surgery was part of the case series that culminated in Cushing's monograph Meningioma. This case was imp...

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    pub_type: 传,历史文章,杂志文章

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    authors: Ansari SF,Gianaris NG,Cohen-Gadol AA

    更新日期:2011-12-01 00:00:00

  • Phase II clinical study on intraoperative photodynamic therapy with talaporfin sodium and semiconductor laser in patients with malignant brain tumors.

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    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.3171/2013.7.JNS13415

    authors: Muragaki Y,Akimoto J,Maruyama T,Iseki H,Ikuta S,Nitta M,Maebayashi K,Saito T,Okada Y,Kaneko S,Matsumura A,Kuroiwa T,Karasawa K,Nakazato Y,Kayama T

    更新日期:2013-10-01 00:00:00

  • Comparative effectiveness analysis of Pipeline device versus coiling in unruptured aneurysms smaller than 10 mm.

    abstract:OBJECTIVE:Both endovascular coiling and the Pipeline embolization device (PED) have been shown to be safe and clinically effective for treatment of small (< 10 mm) aneurysms. The authors conducted a comparative effectiveness analysis to compare the utility of these treatment methods in terms of health benefits. METHOD...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.8.JNS181080

    authors: Malhotra A,Wu X,Miller T,Matouk CC,Sanelli P,Gandhi D

    更新日期:2019-01-11 00:00:00

  • Placental alkaline phosphatase as a tumor marker for primary intracranial germinoma.

    abstract::A sensitive enzyme-linked immunosorbent assay (ELISA) was used in a retrospective study of placental alkaline phosphatase (PLAP) levels in serum, cerebrospinal fluid (CSF), and intratumoral cyst fluid in primary intracranial germinoma. The ELISA showed no cross-reactivity with intestinal alkaline phosphatase except in...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1988.68.5.0710

    authors: Shinoda J,Yamada H,Sakai N,Ando T,Hirata T,Miwa Y

    更新日期:1988-05-01 00:00:00

  • Ventriculoperitoneal shunt procedure complicated by ureter obstruction. Case report.

    abstract::The authors present the case history of a patient in whom the peritoneal catheter of a ventriculoperitoneal shunt system caused ureter obstruction. This is a rare complication of such a shunt procedure, and the patient's symptoms were relieved by shortening the peritoneal catheter. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1983.59.3.0542

    authors: Clarke CE,Paul KS,Lye RH

    更新日期:1983-09-01 00:00:00

  • Outcome following aneurysm wrapping: a 10-year follow-up review of clipped and wrapped aneurysms.

    abstract::One hundred and eighty-one patients with single aneurysms involving the anterior circulation were treated either by wrapping (60 cases) or clipping (121 cases), and 96.1% of them were followed for 10 years. The rate of early rebleeding (less than 6 months) from wrapped aneurysms was 8.6% (confidence interval 1.4% to 1...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1989.70.6.0841

    authors: Todd NV,Tocher JL,Jones PA,Miller JD

    更新日期:1989-06-01 00:00:00

  • Neoplastic cerebral aneurysm from metastatic gestational choriocarcinoma. Case report.

    abstract::This case of metastatic gestational choriocarcinoma presented as intracerebral hemorrhage from an atypical distal middle cerebral artery aneurysm. Operative evacuation of the intracerebral hematoma was undertaken and histopathological examination revealed choriocarcinoma invading the vessel wall. Neoplastic cerebral a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.63.4.0644

    authors: Pullar M,Blumbergs PC,Phillips GE,Carney PG

    更新日期:1985-10-01 00:00:00

  • Ossification of the pterygoalar and pterygospinous ligaments: a computed tomography analysis of infratemporal fossa anatomical variants relevant to percutaneous trigeminal rhizotomy.

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    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2019.2.JNS182709

    authors: Matys T,Ali T,Zaccagna F,Barone DG,Kirollos RW,Massoud TF

    更新日期:2019-05-10 00:00:00

  • Clinical recording of pressure on the spinal cord and cauda equina. Part 2: position changes in pressure on the cauda equina in central lumbar spinal stenosis.

    abstract::To define the site, degree, and dynamics of mechanical compression of the spinal nerve roots, pressure was measured in 42 patients with clinical symptoms and myelographic findings indicating central lumbar spinal stenosis. Pathological pressure on the cauda equina was found in 67% of the patients. The pressure in the ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1982.57.1.0057

    authors: Magnaes B

    更新日期:1982-07-01 00:00:00

  • Percutaneous flexible bipolar epidural neuroelectrode for spinal cord stimulation. Technical note.

    abstract::This article describes a new flexible bipolar neuroelectrode which is inserted percutaneously into the epidural space for segmental spinal cord stimulation. This electrode was used in experiments with dogs and monkeys for recording cortical somatosensory evoked potentials in order to identify intraoperative spinal cor...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.6.1317

    authors: Kaschner AG,Sandmann W,Larkamp H

    更新日期:1984-06-01 00:00:00

  • Evidence for orbital deformation that may contribute to monocular blindness following minor frontal head trauma.

    abstract::Traction injury to the optic nerve and vasa nervorum is the suggested etiology for monocular blindness following trivial frontal trauma. Holographic interferometry was used on human skulls to demonstrate orbital deformation in response to nondestructive frontal loading. The findings suggest an additional mechanism for...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1981.55.6.0963

    authors: Gross CE,DeKock JR,Panje WR,Hershkowitz N,Newman J

    更新日期:1981-12-01 00:00:00

  • Endovascular treatment of intracranial aneurysms: comparative evaluation in a terminal bifurcation aneurysm model in dogs.

    abstract:OBJECT:The authors investigated whether HydroCoils decreased coil compaction and aneurysm recanalization in a canine model of a large, wide-necked, high-flow bifurcation aneurysm. METHODS:Eleven experimental aneurysms were created. Two aneurysms were untreated (Group 1); three were treated with standard platinum coils...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2004.101.6.0996

    authors: Yoshino Y,Niimi Y,Song JK,Silane M,Berenstein A

    更新日期:2004-12-01 00:00:00

  • A comparison of 3 radiographic scales for the prediction of delayed ischemia and prognosis following subarachnoid hemorrhage.

    abstract:OBJECT:Delayed cerebral ischemia is a major cause of morbidity and death following aneurysmal subarachnoid hemorrhage and requires timely intervention for a successful outcome to be achieved. In this study the investigators compared the commonly used Fisher scale with 2 newer radiographic scales for the prediction of v...

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    pub_type: 杂志文章

    doi:10.3171/JNS/2008/109/8/0199

    authors: Kramer AH,Hehir M,Nathan B,Gress D,Dumont AS,Kassell NF,Bleck TP

    更新日期:2008-08-01 00:00:00

  • Primary visual cortical thickness in correlation with visual field defects in patients with pituitary macroadenomas: a structural 7-Tesla retinotopic analysis.

    abstract:OBJECTIVE:Vision loss remains a debilitating complication of pituitary adenomas, although there is considerable variability in visual impairment before and after decompression surgery. Growing evidence suggests secondary damage to remote visual structures may contribute to vision loss in patients with chiasmatic compre...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2019.7.JNS191712

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    更新日期:2019-10-18 00:00:00

  • Surgical seeding of chordomas.

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    authors: Arnautović KI,Al-Mefty O

    更新日期:2001-11-01 00:00:00

  • Treatment of spontaneous carotid-cavernous fistula in Ehlers-Danlos syndrome by transvenous occlusion with Guglielmi detachable coils. Case report and review of the literature.

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    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.2000.93.4.0689

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    更新日期:2000-10-01 00:00:00

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    pub_type: 杂志文章

    doi:10.3171/jns.1992.77.1.0001

    authors: Steiner L,Lindquist C,Adler JR,Torner JC,Alves W,Steiner M

    更新日期:1992-07-01 00:00:00

  • Expanded polytetrafluoroethylene graft for bypass surgery using the excimer laser-assisted nonocclusive anastomosis technique.

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    pub_type: 杂志文章

    doi:10.3171/jns.2006.105.5.758

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    更新日期:2006-11-01 00:00:00