Nitrogen mustard, vincristine, procarbazine, and prednisone as adjuvant chemotherapy in the treatment of medulloblastoma. A Pediatric Oncology Group study.


:In a randomized postoperative trial, adjuvant post-irradiation chemotherapy, consisting of nitrogen mustard, vincristine, procarbazine, and prednisone (MOPP), was tested versus radiation therapy alone for newly diagnosed medulloblastoma in patients between 1 and 21 years of age. Patients treated with irradiation plus MOPP had a statistically significant increase in overall survival rate at 5 years posttreatment compared to patients treated with radiation therapy alone (74% vs. 56%; p = 0.06, adjusted for race and gender). Although the overall study failed to show a statistically significant advantage for irradiation plus MOPP in event-free survival (p = 0.18), statistical significance was attained in children 5 years of age or older (p = 0.05). More severe hematological toxicities occurred in the group with irradiation plus MOPP; however, this hematotoxicity appeared to be tolerable and acceptable. These results suggest that patients may benefit from combined irradiation and chemotherapy following surgery for medulloblastoma.


J Neurosurg


Journal of neurosurgery


Krischer JP,Ragab AH,Kun L,Kim TH,Laurent JP,Boyett JM,Cornell CJ,Link M,Luthy AR,Camitta B




Has Abstract


1991-06-01 00:00:00












  • Factors affecting postoperative cerebrospinal fluid leaks after retrosigmoidal craniotomy for vestibular schwannomas.

    abstract:OBJECT:The aim of this study was to identify patients likely to develop CSF leaks after vestibular schwannoma surgery using a retrospective analysis for the identification of risk factors. METHODS:Between January 2001 and December 2006, 420 patients underwent retrosigmoidal microsurgical tumor removal in a standardize...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审


    authors: Stieglitz LH,Wrede KH,Gharabaghi A,Gerganov VM,Samii A,Samii M,Luedemann WO

    更新日期:2009-10-01 00:00:00

  • Clinical use of supinator motor branch transfer to the posterior interosseous nerve in C7-T1 brachial plexus palsies.

    abstract:OBJECT:In C7-T1 brachial plexus palsies, finger extension and flexion are absent. At the authors' institution, finger flexion has been successfully reconstructed by transferring the brachialis motor branch to the anterior interosseous nerve. However, there is no reliable method for restoring finger extension. In the pr...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Dong Z,Gu YD,Zhang CG,Zhang L

    更新日期:2010-07-01 00:00:00

  • Longitudinal evaluation of corticospinal tract in patients with resected brainstem cavernous malformations using high-definition fiber tractography and diffusion connectometry analysis: preliminary experience.

    abstract:OBJECT:Brainstem cavernous malformations (CMs) are challenging due to a higher symptomatic hemorrhage rate and potential morbidity associated with their resection. The authors aimed to preoperatively define the relationship of CMs to the perilesional corticospinal tracts (CSTs) by obtaining qualitative and quantitative...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Faraji AH,Abhinav K,Jarbo K,Yeh FC,Shin SS,Pathak S,Hirsch BE,Schneider W,Fernandez-Miranda JC,Friedlander RM

    更新日期:2015-11-01 00:00:00

  • The Journal of Neurosurgery in the computer era.

    abstract::The fourth Editor of the Journal of Neurosurgery offers short vignettes on the Editors who preceded and succeeded him. He recounts some of the challenges that were faced and changes that were made during his time as Editor. One of the major changes was production of the Journal via computer. ...

    journal_title:Journal of neurosurgery

    pub_type: 历史文章,杂志文章


    authors: Collins WF

    更新日期:1994-07-01 00:00:00

  • Severe phenytoin-induced bone marrow depression and agranulocytosis treated with human recombinant granulocyte-macrophage colony-stimulating factor. Case report.

    abstract::An unusual instance of severe and potentially lethal depression of the bone marrow is described as a result of the administration of phenytoin for seizure prophylaxis. The patient was treated successfully by prompt cessation of phenytoin and intravenous administration of human recombinant granulocyte-macrophage colony...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Rawanduzy A,Sarkis A,Rovit RL

    更新日期:1993-07-01 00:00:00

  • Limitations of median nerve somatosensory evoked potential monitoring during carotid endarterectomy.

    abstract:OBJECTIVE:Hypoperfusion during carotid artery cross-clamping (CC) for carotid endarterectomy (CEA) may result in the major complication of perioperative stroke. Median nerve somatosensory evoked potential (MNSSEP) monitoring, which is an established method for the prediction of cerebral ischemia, has low sensitivity in...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Okuyama S,Nishimura S,Takahashi Y,Kubota K,Hirano T,Kazama K,Tomii M,Matsuyama J,Mizuno J,Matsushima T,Sato M,Watanabe K

    更新日期:2018-09-07 00:00:00

  • Combined supra/infratentorial-transsinus approach to large pineal region tumors.

    abstract:OBJECT:The authors sought to confirm that the combined supra/infratentorial-transsinus approach offers a safer means of resecting large pineal region tumors than other approaches currently being used. The aforementioned method provides a wider exposure of the pineal region with less brain retraction than the infratento...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Ziyal IM,Sekhar LN,Salas E,Olan WJ

    更新日期:1998-06-01 00:00:00

  • Racial phenotypes in moyamoya disease: a comparative analysis of clinical presentation and natural history in a single multiethnic cohort of 250 hemispheres.

    abstract:OBJECTIVE:The authors aimed to determine whether differences exist in presentation and natural history when comparing Asian patients with moyamoya disease (MMD) to those of other ethnicities in North America. METHODS:A database of 137 patients with MMD presenting to their institution between 1994 and 2015 was reviewed...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Feghali J,Xu R,Yang W,Liew J,Tamargo RJ,Marsh EB,Huang J

    更新日期:2019-10-04 00:00:00

  • Bilateral trigeminal neuralgia.

    abstract::Bilateral trigeminal neuralgia occurred in 32 (11.9%) of 269 consecutive patients who were treated with radiofrequency electrocoagulation (RFE). This is a higher incidence than has been reported before and may be explained by the prospective nature of the present study, the long follow-up period, and the inclusion of ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Brisman R

    更新日期:1987-07-01 00:00:00

  • Selective peripheral denervation for spasmodic torticollis: 13-year experience with 155 patients.

    abstract:OBJECT:Botulinum toxin injections are the best therapeutic option in patients with spasmodic torticollis. Although a small number of patients do not benefit from such therapy, the majority respond well but may develop antibodies to the toxin after repeated applications. In those termed primary nonresponders, no improve...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Braun V,Richter HP

    更新日期:2002-09-01 00:00:00

  • Association between a black band on the inner membrane of a chronic subdural hematoma on T2*-weighted magnetic resonance images and enlargement of the hematoma.

    abstract:OBJECT:The cause and indication for enlargement of chronic subdural hematomas (CSDHs) have remained unresolved. The authors observed a black band on the inner membrane of a CSDH on T2*-weighted magnetic resonance (MR) images obtained in patients with symptoms. After surgical treatment, the band disappeared. The T2*-wei...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Imaizumi T,Horita Y,Honma T,Niwa J

    更新日期:2003-11-01 00:00:00

  • Stilbazulenyl nitrone, a novel azulenyl nitrone antioxidant: improved neurological deficit and reduced contusion size after traumatic brain injury in rats.

    abstract:OBJECT:Stilbazulenyl nitrone (STAZN) is a second-generation azulenyl nitrone that has markedly enhanced antioxidant properties compared with those of conventional alpha-phenyl nitrones. In this study, the authors assessed the potential efficacy of STAZN in a rodent model of fluid-percussion brain injury, which results ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Belayev L,Becker DA,Alonso OF,Liu Y,Busto R,Ley JJ,Ginsberg MD

    更新日期:2002-06-01 00:00:00

  • Giant suprasellar aneurysm associated with optic stalk agenesis and unilateral anophthalmos. Case report.

    abstract::The authors report a patient with unilateral anophthalmos who had a large suprasellar aneurysm associated with aplasia of an optic nerve and the chiasmal commissure. The anatomical findings at craniotomy are described. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Hoff J,Winestock D,Hoyt WF

    更新日期:1975-10-01 00:00:00

  • Vitamin D status and 3-month Glasgow Outcome Scale scores in patients in neurocritical care: prospective analysis of 497 patients.

    abstract::OBJECTIVE Vitamin D deficiency has been associated with a variety of negative outcomes in critically ill patients, but little focused study on the effects of hypovitaminosis D has been performed in the neurocritical care population. In this study, the authors examined the effect of vitamin D deficiency on 3-month outc...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Guan J,Karsy M,Brock AA,Eli IM,Manton GM,Ledyard HK,Hawryluk GWJ,Park MS

    更新日期:2018-06-01 00:00:00

  • Magnetic resonance imaging for the evaluation of patients with occult cervical spine injury.

    abstract::Because it is often difficult to diagnose accurately the structurally intact cervical spine after acute trauma, a series of patients was evaluated with magnetic resonance (MR) imaging to assess its efficacy for the evaluation and clearance of the cervical spine in a trauma victim in the early posttrauma period. Ultral...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Benzel EC,Hart BL,Ball PA,Baldwin NG,Orrison WW,Espinosa MC

    更新日期:1996-11-01 00:00:00

  • Electrospinogram and spinal and cortical evoked potentials in experimental spinal cord trauma.

    abstract::Studies in 28 traumatized cats showed the following acute changes after spinal cord compression in the cord segment below the trauma: 1) increase in size of the spinal cord evoked potential; 2) increase in size of the electrospinogram; and 3) increase in frequency of the electrospinogram. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Morrison G,Lorig RJ,Brodkey J,Nulsen FE

    更新日期:1975-12-01 00:00:00

  • Placental alkaline phosphatase levels in cerebrospinal fluid can have a decisive role in the differential diagnosis of intracranial germ cell tumors.

    abstract:OBJECTIVE:Placental alkaline phosphatase (PLAP) in CSF can provide a very high diagnostic value in cases of intracranial germ cell tumors (GCTs), especially in pure germinomas, to the level of not requiring histological confirmation. Unlike other tumor markers, reliable data analysis with respect to the diagnostic valu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Aihara Y,Watanabe S,Amano K,Komatsu K,Chiba K,Imanaka K,Hori T,Ohba T,Dairoku H,Okada Y,Kubo O,Kawamata T

    更新日期:2018-09-28 00:00:00

  • Chordoid meningioma with polyclonal gammopathy. Case report.

    abstract::The authors present a case of chordoid meningioma in a 55-year-old woman who manifested headache and personality change. Magnetic resonance imaging of the brain and cerebral angiography demonstrated a mass in the right frontal lobe that resembled a typical convexity meningioma. However, the pathological diagnosis was ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审


    authors: Lee DK,Kim DG,Choe G,Chi JG,Jung HW

    更新日期:2001-01-01 00:00:00

  • Patient presentation, angiographic features, and treatment of strangulation-induced bilateral dissection of the cervical internal carotid artery. Report of three cases.

    abstract::Domestic violence leading to strangulation by an abusive spouse can cause carotid artery dissection. This phenomenon is rare and has been described in only three previous instances. The authors present their management strategies in three additional cases. Three young women aged 24 to 43 years were victims of manual s...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Malek AM,Higashida RT,Halbach VV,Dowd CF,Phatouros CC,Lempert TE,Meyers PM,Smith WS,Stoney R

    更新日期:2000-03-01 00:00:00

  • The first formulation of image-based stereotactic principles: the forgotten work of Gaston Contremoulins.

    abstract::Although image-based human stereotaxis began with Spiegel and Wycis in 1947, the major principles of radiographic stereotaxis were formulated 50 years earlier by the French scientific photographer Gaston Contremoulins. In 1897, frustrated by the high morbidity of bullet extraction from the brain, the Parisian surgeon ...

    journal_title:Journal of neurosurgery

    pub_type: 传,历史文章,杂志文章


    authors: Giller CA,Mornet P,Moreau JF

    更新日期:2017-12-01 00:00:00

  • Destructive procedures for control of cancer pain: the case for cordotomy.

    abstract:OBJECT:Historically, destructive procedures for cancer pain were the main line of treatment therapy. However, the use of high-dose opioids has essentially replaced such procedures. Recognition of the limits of medical therapy to treat cancer pain effectively is growing, while conversely, in regions with limited access ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审


    authors: Raslan AM,Cetas JS,McCartney S,Burchiel KJ

    更新日期:2011-01-01 00:00:00

  • Radiosurgery for trigeminal neuralgia: is sensory disturbance required for pain relief?

    abstract:OBJECT:Over the past 15 years stereotactic radiosurgery has become an accepted surgical option for patients with medically unresponsive trigeminal neuralgia (TN). The mechanism whereby radiosurgery causes pain relief remains unclear. METHODS:A review of recent papers on the radiosurgical management of TN reveals a cor...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审


    authors: Pollock BE

    更新日期:2006-12-01 00:00:00

  • Intracerebral toxoplasmosis in patients with acquired immune deficiency syndrome.

    abstract::The acquired immune deficiency syndrome (AIDS) is a recently described T-cell deficiency predisposing patients to a spectrum of opportunistic infections. Kaposi's sarcoma, and other neoplasms. It appears primarily among homosexual males and intravenous drug abusers, but is now being observed in other groups as well. T...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Handler M,Ho V,Whelan M,Budzilovich G

    更新日期:1983-12-01 00:00:00

  • A historical case of beaten-copper cranium.

    abstract::The authors present the oldest historical case of a so-called beaten-copper cranium. The typical pattern was identified on a skull from a child, probably a boy, who died at approximately 6 years of age and was buried in a provisional cemetery used during the siege of Hanau, Germany, in 1635 and 1636. Morphological and...

    journal_title:Journal of neurosurgery

    pub_type: 历史文章,杂志文章


    authors: Rühli FJ,Nicklisch N,Alt KW

    更新日期:2007-01-01 00:00:00

  • Radiosurgery for benign tumors of the spine using the Synergy S with cone-beam computed tomography image guidance.

    abstract:OBJECT:There is a growing body of evidence to support the safe and effective use of spine radiosurgery. However, there is much less experience regarding the use of radiosurgery for the treatment of benign as opposed to malignant spine tumors. This study represents an evaluation of, and reporting on, the technical aspec...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Gerszten PC,Chen S,Quader M,Xu Y,Novotny J Jr,Flickinger JC

    更新日期:2012-12-01 00:00:00

  • Management of large vestibular schwannoma. Part I. Planned subtotal resection followed by Gamma Knife surgery: radiological and clinical aspects.

    abstract:OBJECT:In large vestibular schwannoma (VS), microsurgery is the main treatment option, and complete resection is considered the primary goal. However, previous studies have documented suboptimal facial nerve outcomes in patients who undergo complete resection of large VSs. Subtotal resection is likely to reduce the ris...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: van de Langenberg R,Hanssens PE,van Overbeeke JJ,Verheul JB,Nelemans PJ,de Bondt BJ,Stokroos RJ

    更新日期:2011-11-01 00:00:00

  • Deep brain stimulation versus anterior capsulotomy for obsessive-compulsive disorder: a review of the literature.

    abstract::Obsessive-compulsive disorder (OCD) is a chronic and debilitating psychiatric condition. Traditionally, anterior capsulotomy (AC) was an established procedure for treatment of patients with refractory OCD. Over recent decades, deep brain stimulation (DBS) has gained popularity. In this paper the authors review the pub...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审


    authors: Pepper J,Hariz M,Zrinzo L

    更新日期:2015-05-01 00:00:00

  • Spontaneous hemorrhage associated with a pilomyxoid astrocytoma. Case report.

    abstract::Pilomyxoid astrocytomas have been identified as a more aggressive variant of pilocytic astrocytomas that occur in infants and in young children. These tumors are characterized by a perivascular arrangement of pilocytic cells that has a monomorphous architecture with uniform, elongated bipolar cells loosely ranged with...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审


    authors: Gottfried ON,Fults DW,Townsend JJ,Couldwell WT

    更新日期:2003-08-01 00:00:00

  • The surgical approach to arteriovenous malformations of the lateral and sigmoid dural sinuses.

    abstract::Arteriovenous malformations (AVM's) of lateral and sigmoid sinuses are acquired lesions evolving from a previously thrombosed dural sinus. Their natural history is usually that of gradual progression and hence surgery is frequently necessary. The preferred surgical treatment is complete excision coupled with packing o...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Sundt TM Jr,Piepgras DG

    更新日期:1983-07-01 00:00:00

  • Radiographic absence of the posterior communicating arteries and the prediction of cognitive dysfunction after carotid endarterectomy.

    abstract:OBJECT:Approximately 25% of patients exhibit cognitive dysfunction 24 hours after carotid endarterectomy (CEA). One of the purported mechanisms of early cognitive dysfunction (eCD) is hypoperfusion due to inadequate collateral circulation during cross-clamping of the carotid artery. The authors assessed whether poor co...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Sussman ES,Kellner CP,Mergeche JL,Bruce SS,McDowell MM,Heyer EJ,Connolly ES

    更新日期:2014-09-01 00:00:00