Abstract:
BACKGROUND:There is limited data about the performance of QuantiFERON-TB Gold (QFT-G) test in detecting latent tuberculosis infection (LTBI) in our region. We intended to determine the performance of QFT-G compared to conventional tuberculin skin test (TST) in detecting LTBI in HIV-positive individuals in Iran. METHODS:This study was conducted in a HIV clinic in Tehran, Iran in April 2007. A total of 50 consecutive HIV-positive patients, not currently affected with active tuberculosis (TB), were recruited; 43 (86%) were male. The mean age was 38 ± 7.2 years (21-53). All had history of Bacillus Calmette Guerin (BCG) vaccination. A TST with purified protein derivative (PPD) and whole-blood interferon-gamma release assay (IGRA) in reaction to ESAT-6 and CFP-10 antigens was performed and measured by enzyme-linked immuno-sorbent assay (ELISA). The agreement between TST and QFT-G results were analyzed using Kappa test. RESULTS:A total of 36 (72%) patients had negative and 14 (28%) revealed positive TST. For QFT-G, 20 (40%) tested positive, 19 (38%) tested negative, and the results in 11 cases (22%) were indeterminate. A total of 14 (28%) patients had a CD4 count of <200. Of the 14, TST + group, 12 had QFT-G +, only one case TST+/QFT-G-, and QFT-G was indeterminate in one TST positive case. Of the 36 patients with negative TST tests, 8 (22%) had positive GFT-G and 10 (28%) yielded indeterminate results. There was no association between a positive TST and receiving highly active anti-retroviral therapy (HAART) or absolute CD4 counts. Similarly, the association between QFT-G results and receiving HAART or CD4 counts was not significant (P = 0.06). Although TST results were not significantly different in patients with CD4 < 200 vs. CD4 >200 (P = 0.295), association between QFT-G results and CD4 cutoff of 200 reached statistical significance (P = 0.027). Agreement Kappa coefficient between TST and QFT-G was 0.54 (Kappa = 0.54, 95% CI = 38.4-69.6,P < 0.001). CONCLUSION:Detecting LTBI in HIV-positive individuals showed moderate agreement between QFT-G and LTBI in our study. Interestingly, our findings revealed that nontuberculous mycobacteria and prior BCG vaccination have minimal influence on TST results in HIV patients in Iran.
journal_name
Ann Thorac Medjournal_title
Annals of thoracic medicineauthors
Mardani M,Tabarsi P,Mohammadtaheri Z,Chitsaz E,Farokhzad B,Hadavand F,Gachkar L,Nemati K,Masjedi MRdoi
10.4103/1817-1737.58959subject
Has Abstractpub_date
2010-01-01 00:00:00pages
43-6issue
1eissn
1817-1737issn
1998-3557journal_volume
5pub_type
杂志文章abstract:INTRODUCTION:Ventilator-associated pneumonia (VAP) is one of the most serious hospital-acquired infections to occur among mechanically ventilated patients. Many risk factors for VAP have been identified in the literature; however, there is a lack of studies examining the association between endotracheal tube (ETT) repo...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/atm.ATM_26_19
更新日期:2019-10-01 00:00:00
abstract:INTRODUCTION:Fiber-optic bronchoscopy (FOB) with bronchoalveolar lavage (BAL) is a common procedure performed in immunocompromised patients with undiagnosed pulmonary pathology. Identifying patients with the highest potential diagnostic yield may help to avoid morbidity in patients unlikely to benefit from the procedur...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/1817-1737.114302
更新日期:2013-07-01 00:00:00
abstract::Hereditary hemoglobin disorders affecting the globin chain synthesis namely thalassemia syndromes and sickle cell disease (SCD) are the most common genetic disorders in human. Around 7% of the world population carries genes for these disorders, mainly the Mediterranean Basin, Middle and Far East, and Sub-Saharan Afric...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/1817-1737.134039
更新日期:2014-07-01 00:00:00
abstract::Advances in our understanding of human immunodeficiency virus (HIV) infection have led to improved care and incremental increases in survival. However, the pulmonary manifestations of HIV/acquired immunodeficiency syndrome (AIDS) remain a major cause of morbidity and mortality. Respiratory complaints are not infrequen...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/1817-1737.69106
更新日期:2010-10-01 00:00:00
abstract::[This corrects the article on p. 100 in vol. 10, PMID: 25829960.]. ...
journal_title:Annals of thoracic medicine
pub_type: 已发布勘误
doi:10.4103/1817-1737.160849
更新日期:2015-07-01 00:00:00
abstract::Bronchiolitis obliterans organizing pneumonia (BOOP) was first described in the early 1980s as a clinicopathologic syndrome characterized symptomatically by subacute or chronic respiratory illness and histopathologically by the presence of granulation tissue in the bronchiolar lumen, alveolar ducts and some alveoli, a...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/1817-1737.39641
更新日期:2008-04-01 00:00:00
abstract:STUDY OBJECTIVES:Obstructive sleep apnea (OSA) is common in adult populations. Accumulating data indicate that it is independently associated with a variety of cardiovascular diseases and has prognostic importance in affected cases. In this study, we aimed to evaluate coronary flow reserve (CFR) in patients with OSA an...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/atm.ATM_195_16
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Pulmonary arterial hypertension (PAH) is a major cause of morbidity and mortality in patients with systemic sclerosis (SSc). The objective of this study is to describe the clinical characteristics, mortality, and predictors of SSc-PAH in Saudi patients. METHODS:Retrospective chart review study of SSc patien...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/atm.ATM_33_18
更新日期:2019-01-01 00:00:00
abstract::An 18-year-old male presented with 4 weeks' history of productive cough and fever that had started 1 day after alleged ingestion of a plastic whistle. Multiple courses of antibiotics had proved ineffective. Crepitation and a localized wheeze on right chest were observed on clinical examination. Chest radiograph showed...
journal_title:Annals of thoracic medicine
pub_type:
doi:10.4103/1817-1737.33702
更新日期:2007-07-01 00:00:00
abstract::NASAM (National Approach to Standardize and Improve Mechanical Ventilation) is a national collaborative quality improvement project in Saudi Arabia. It aims to improve the care of mechanically ventilated patients by implementing evidence-based practices with the goal of reducing the rate of ventilator-associated event...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/atm.ATM_63_19
更新日期:2019-04-01 00:00:00
abstract::A 21-year-old primigravida, at 32 weeks of gestation, presented with acute onset of respiratory failure and circulatory shock. Chest imaging showed findings suggestive of ruptured hydatid cyst, which was confirmed by histology post-thoracotomy. Tissue cultures from the removed cyst grew Mycobacterium tuberculosis also...
journal_title:Annals of thoracic medicine
pub_type:
doi:10.4103/1817-1737.32234
更新日期:2007-04-01 00:00:00
abstract:AIM:The aim of this study was to investigate the alterations of pulmonary function tests (PFTs) and their relationship with disease activity in inflammatory bowel diseases (IBDs). METHODS:Sixty-four IBD patients (31 Crohn's disease [CD] and 33 ulcerative colitis [UC]) and thirty healthy individuals (controls) were stu...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/1817-1737.191877
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Physicians may experience periods of acute sleep deprivation while on-call, in addition to baseline chronic sleep deprivation which may affect physicians' performance and patients' safety. The purpose of this study was to determine the effect of acute sleep deprivation due to working long on-ca...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/1817-1737.105715
更新日期:2013-01-01 00:00:00
abstract:AIMS:Flexible bronchoscopy is a common procedure performed in pulmonary medicine, critical care, and thoracic surgery. In this study, we aimed to assess the prevalence and predictors of anxiety in patients undergoing diagnostic bronchoscopy. METHODS:This is a prospective study conducted at King Abdulaziz University Ho...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/atm.ATM_38_19
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:While lung cancer is the leading cancer cause of death, it is largely preventable. Furthermore, early diagnosis enhances the chance of cure. Therefore, we developed guidelines for lung cancer prevention and early detection. METHODS:A multidisciplinary team of experts in lung cancer representing different he...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/atm.ATM_147_18
更新日期:2018-10-01 00:00:00
abstract::Patient-ventilator asynchrony (PVA) is common in patients receiving noninvasive ventilation (NIV). This occurs primarily when the triggering and cycling-off of ventilatory assistance are not synchronized with the patient's inspiratory efforts and could result in increased work of breathing and niv failure. In general,...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章,评审
doi:10.4103/atm.ATM_24_19
更新日期:2020-01-01 00:00:00
abstract:AIMS:The aim of the study was to evaluate the clinical utility and safety of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in patients with mediastinal and hilar lymphadenopathy and to explicitly describe the utility of this procedure in patient's outcome. METHODS:A retrospective review ...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/atm.ATM_317_17
更新日期:2018-04-01 00:00:00
abstract::We report a case of pulmonary strongyloidiasis in a patient with large granular lymphocytosis. He was on short-term high dose immunosuppressant therapy. A 77-year-old white male presented to the emergency room with fever and shortness of breath for 10 days. The patient had been diagnosed about 3 months prior to this p...
journal_title:Annals of thoracic medicine
pub_type:
doi:10.4103/1817-1737.78432
更新日期:2011-04-01 00:00:00
abstract:CONTEXT:Bronchoscopic intervention can provide immediate relief from suffocation and an opportunity for additional treatment in patients with malignant airway obstruction. However, few studies have specifically identified prognostic factors affecting the survival of advanced lung or esophageal cancer patients receiving...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/1817-1737.109818
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Allergic Broncho Pulmonary Aspergillosis (ABPA) is a rare disease characterized by an allergic inflammatory response to the colonization by aspergillus or other fungi in the airways. The aim was to study the clinical, radiological, and serological characteristics of patients of ABPA. MATERIALS AND METHODS:A...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/1817-1737.140130
更新日期:2014-10-01 00:00:00
abstract::This paper summarizes the roundtable discussion from the Second International Patient Safety Conference held in April 9-11, 2013, Riyadh, Saudi Arabia. The objectives of the roundtable discussion were to: (1) review the conceptual framework for building capacity in quality and safety in critical care. (2) examine exam...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/1817-1737.118480
更新日期:2013-10-01 00:00:00
abstract::Pulmonary hypertension (PH) in the Intensive Care Unit (ICU) may be due to preexisting pulmonary vascular lung disease, liver disease, or cardiac diseases. PH also may be caused by critical illnesses, such as acute respiratory distress syndrome (ARDS), acute left ventricular dysfunction and pulmonary embolism, or may ...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/1817-1737.134056
更新日期:2014-07-01 00:00:00
abstract::The professional content of sleep medicine has grown significantly over the past few decades, warranting the recognition of sleep medicine as an independent specialty. Because the practice of sleep medicine has expanded in Saudi Arabia over the past few years, a national regulation system to license and ascertain the ...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/1817-1737.105710
更新日期:2013-01-01 00:00:00
abstract::Swyer-James-MacLeod (SJM) syndrome is a chronic, progressive lung disease as a result of infection and bronchial obstruction that ultimately leads to emphysema. It is associated with chronic cough, sputum production and recurrent chest infections and is occasionally seen in women of reproductive age. The radiological ...
journal_title:Annals of thoracic medicine
pub_type:
doi:10.4103/1817-1737.37976
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The goal of the study was to assess asthma control using asthma control test (ACT) and to explore the factors that effects asthma control among participants with bronchial asthma in the outpatient clinic setting. METHODS:This cross-sectional descriptive study was conducted in the outpatient prima...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/1817-1737.152450
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Adequate sleep has been considered important for the adolescent's health and well being. On the other hand, self-imposed sleep curtailment is now recognized as a potentially important and novel risk factor for obesity. The present study aimed to assess the prevalence of short sleep duration and its associati...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/1817-1737.98845
更新日期:2012-07-01 00:00:00
abstract::With increased exposure of patients to routine imaging, incidental benign intrathoracic masses are frequently recognized. Most have classical imaging features, which are pathognomonic for their benignity. The aim of this pictorial review is to educate the reader of radiological features of several types of intrathorac...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章,评审
doi:10.4103/1817-1737.160365
更新日期:2015-10-01 00:00:00
abstract::Novel coronavirus disease 2019 (COVID-19) is known to cause severe pneumonia and acute respiratory distress syndrome which may lead to death. Several treatments have been tested in the race to find a treatment regimen for this deadly viral infection. Tocilizumab, a recombinant humanized anti-interleukin-6 receptor mon...
journal_title:Annals of thoracic medicine
pub_type:
doi:10.4103/atm.ATM_286_20
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:The effects of first-line chemotherapy on overall survival (OS) might be confounded by subsequent therapies in patients with small cell lung cancer (SCLC). We examined whether progression-free survival (PFS), post-progression survival (PPS), and tumor response could be valid surrogate endpoints for OS after ...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/1817-1737.146885
更新日期:2015-01-01 00:00:00
abstract::This paper summarizes the roundtable discussion in September 25, 2013, Riyadh, Saudi Arabia as part of the World Sepsis Day held in King Abdulaziz Medical City, Riyadh. The objectives of the roundtable discussion were to (1) review the chasm between the current management of sepsis and best practice, (2) discuss syste...
journal_title:Annals of thoracic medicine
pub_type: 杂志文章
doi:10.4103/1817-1737.134066
更新日期:2014-07-01 00:00:00