Abstract:
BACKGROUND:Bisphosphonates (BPs) are an important group of drugs used for the treatment of metabolic and oncologic pathologies involving the skeletal system. Osteonecrosis of the jaw (ONJ) is a complication observed in patients using oral or intravenous (IV) BPs. It was suggested that all patients undergoing BP therapy who are expected to receive dental implants should be informed of the possible risks of development of ONJ. The aim of this literature review is to assess the osseointegration of dental implants in patients undergoing BP therapy. METHODS:The MEDLINE-PubMed databases of The National Library of Medicine, National Institutes of Health, Bethesda, Maryland, were searched for articles addressing the focused question: Can dental implants osseointegrate and remain functionally stable in patients undergoing oral and IV BP therapy? Databases were searched from 1995 up to and including February 2010 using the following terms in different combinations: bisphosphonate, dental implant, immediate-loading, implant survival rate, intravenous, oral, osseointegration, and osteonecrosis. RESULTS:The initial search yielded 89 articles. Scrutiny of the titles and abstracts reduced the number of articles to 12 (seven case reports and five retrospective studies). In 10 studies, the patients were using oral BPs, and in two studies, patients were using IV BPs. Six case reports showed that the placement of implants in patients using BPs could yield a successful osseointegration and function. Four retrospective studies demonstrated that BPs did not have a negative influence on implant success. Two studies showed a negative impact of BPs on implant success. CONCLUSION:Dental implants can osseointegrate and remain functionally stable in patients using BPs.
journal_name
J Periodontoljournal_title
Journal of periodontologyauthors
Javed F,Almas Kdoi
10.1902/jop.2009.090587subject
Has Abstractpub_date
2010-04-01 00:00:00pages
479-84issue
4eissn
0022-3492issn
1943-3670journal_volume
81pub_type
杂志文章,评审abstract:BACKGROUND:Chronic periodontitis (CP) is a multifactorial complex periodontal disease involving immune response, inflammation, alveolar bone resorption, and attachment loss. Colony stimulating factor-1 (CSF-1) controls the production, differentiation, and function of macrophages and plays a vital role in the innate imm...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.130688
更新日期:2014-08-01 00:00:00
abstract::Cystatins are physiological inhibitors of cysteine proteinases and widely distributed in human tissues and fluids including saliva. Cystatins S, SA, SN, and D are only found in glandular saliva and tear fluid whereas cystatin C has been detected in all tested biological fluids. Previous studies demonstrated that total...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.3.205
更新日期:1996-03-01 00:00:00
abstract::Chlorhexidine mouthrinse is a widely used adjunct in periodontal therapy due to its bactericidal effects. The effect of this agent on chronic gingivitis and wound healing following surgical therapy in animals and humans has been favorable. The re-establishment of lost connective tissue attachment to the root surface f...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1991.62.7.434
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:The present study was planned to investigate the therapeutic actions of 1-tetradecanol complex (1-TDC), a novel monounsaturated fatty acid mixture, in established periodontitis in rabbits. METHODS:Periodontitis was initiated in 18 New Zealand White rabbits using ligatures around mandibular second premolars,...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2009.090002
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Members of the matrix metalloproteinase (MMP) family are implicated in the chronic remodeling in periodontal diseases. Therefore, we performed a case-control study to investigate a plausible association between susceptibility to chronic periodontitis (CP) and the polymorphisms in the MMP-9 (gelatinase B) gen...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2006.050347
更新日期:2006-11-01 00:00:00
abstract::The modification of a methacrylic gel for use as a periodontal dressing was attempted. The increased adhesion and rigidity of the resultant material appeared consistent with the clinical findings. Satisfactory retention of the dressing was found in 85% of those placed on a group of patients attending for periodontal s...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1975.46.8.465
更新日期:1975-08-01 00:00:00
abstract::Oral melanin pigmentation is not uncommon in some races and ethnic groups. Repigmentation of depigmented oral mucosa has been described after chemical, thermal, surgical, pharmacologic or idiopathic factors. Information on the repigmentation of oral tissues after surgical procedures is extremely limited. The communica...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.1.48
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:The aims of this study are to determine whether the antigen-inexperienced (naive, CD45RB high-density) T-cell (CD4(+)CD45RB(High) T-cell) transfer model is associated with alveolar bone resorption, to elucidate the local osteogenic/adipogenic potential of alveolar bone marrow stromal cells (ABCs) from T-cell...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.140077
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Xenografts to augment the maxillary sinus have been used extensively. The aim of the present study was to evaluate, qualitatively and quantitatively, two different HA derivatives of natural and synthetic sources on newly formed bone in the augmented sinus. METHODS:A bilateral sinus augmentation procedure wi...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2001.72.7.911
更新日期:2001-07-01 00:00:00
abstract::Demineralized freeze-dried bone allograft (DFDBA) has been used extensively in periodontal therapy. The rationale for use of DFDBA includes the fact that proteins capable of inducing new bone; i.e., bone morphogenetic proteins, can be isolated from bone grafts. Commercial bone banks have provided DFDBA to the dental p...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1996.67.9.918
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Prostaglandin E(2) (PGE(2)), which exerts its biologic actions via EP receptors (EP(1), EP(2), EP(3,) and EP(4)), is a bioactive metabolite of arachidonic acid that is produced by cyclooxygenase (COX)-1 and/or COX-2. In the present study, we investigated whether a mouse cementoblast cell line, OCCM-30 cells,...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060257
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Alternative therapeutic approaches have been explored to modulate host response to periodontal disease. Knowledge of new strategies to treat periodontitis is particularly relevant in patients presenting augmented risk to periodontitis, such as smokers. The aim of this study is to investigate the impact of re...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2017.170025
更新日期:2017-08-01 00:00:00
abstract::Chronic inflammatory illnesses such as diabetes, arthritis, and heart disease are now seen as problems that might have impacts on the periodontium, and reciprocal effects of periodontal diseases are being considered as factors potentially affecting the progression of these diseases. Successful management of the inflam...
journal_title:Journal of periodontology
pub_type: 杂志文章,评审
doi:10.1902/jop.2005.76.11-S.2168
更新日期:2005-11-01 00:00:00
abstract::Multiple periodontal lesions were the presenting features leading to a diagnosis of multiple myeloma in a 38-year-old male. Ulceration and bleeding from a rapidly growing retromolar myelomatous mass, multiple foci of alveolar bone destruction and cortical expansion together with multifocal skeletal destruction were th...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1990.61.2.132
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:Periodontal disease results from the pathogenic interactions between the tissue, immune system, and microbiota; however, standard therapy fails to address the cellular mechanism underlying the chronic inflammation. Dendritic cells (DC) are key regulators of T cell fate, and biomaterials that recruit and prog...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1002/JPER.19-0411
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:The objective of this study is to characterize the association between metabolic syndrome (MetS) and periodontitis in women, for which there is limited evidence. METHODS:Cross-sectional associations between MetS and periodontitis were examined in 657 postmenopausal women aged 50 to 79 years enrolled in a pe...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2014.140185
更新日期:2014-11-01 00:00:00
abstract::A theory of periodontal attachment loss which postulates discrete bursts of activity has recently been proposed. This paper identifies several problems in the interpretation of the experimental data that have been used to support the burst model. Major obstacles to valid inferences are associated with the following: s...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1986.57.12.746
更新日期:1986-12-01 00:00:00
abstract::A 4-quadrant, single-blind study was designed to test the efficacy of periodontal disease therapy by local drug delivery. A delivery system made of extruded ethylene vinyl acetate fibers loaded with 25% USP tetracycline hydrochloride was placed and maintained in periodontal pockets for 10 days. The clinical effects of...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1985.56.11s.81
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:The role of keratinized tissue (KT) for maintenance of periodontal health has been debated for many years. This study assesses the long-term "biologic remodeling" of periodontal dimensions of teeth treated with free gingival grafts (FGGs) compared with adjacent/untreated teeth. METHODS:Seventy-four patients...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2017.170010
更新日期:2017-07-01 00:00:00
abstract::Thirty-four areas of gingival recession in ten patients were treated by a coronally repositioned flap procedure. All but four of these areas had received a free gingiva graft previously. The postoperative evaluations of the wound healing were made at 2 weeks and at 1, 2, 4, 6 and 12 months after the final surgery. In ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1980.51.12.686
更新日期:1980-12-01 00:00:00
abstract::von Willebrand's disease (vWD) is one of the most common hereditary hemorrhagic disorders. A mild to moderate deficiency of factor VIII and von Willebrand factor (vWf) often is associated with gingival bleeding. In this case report, the periodontal treatment of a patient with vWD is described. A 45-year-old woman with...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1999.70.5.548
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:The purpose of this multicenter randomly controlled clinical trial was to compare two acellular dermal matrix (ADM) materials produced by different processing techniques, freeze-dried (FDADM) and solvent-dehydrated (SDADM) ADM, in their ability to correct Miller Class I and II recession defects. METHODS:Eig...
journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1902/jop.2014.140198
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Pain generated by needle sticks (Ns) for the delivery of local anesthetic and/or scaling and root planing (SRP) instrumentation is commonly addressed by the use of topical anesthetics, such as a benzocaine-gel preparation (BGP). Pain suppression following such use has been highly variable. Development of med...
journal_title:Journal of periodontology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1902/jop.2001.72.4.479
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Previous studies have focused on antibiotic resistance of Gram-negative bacteria before and after periodontal therapy. The purpose of this analysis is to assess changes in resistance patterns of the commensal Gram-positive microbiota. The viridans group streptococci (VGS) have been suggested to serve as rese...
journal_title:Journal of periodontology
pub_type: 杂志文章,随机对照试验
doi:10.1902/jop.2015.150494
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Several risk indicators for periodontal disease severity have been identified. The association of these factors with tooth loss for periodontal reasons was investigated in this cross-sectional comparative study. METHODS:All extractions performed in 21 general dental practice clinics (25% of such clinics in ...
journal_title:Journal of periodontology
pub_type: 杂志文章,多中心研究
doi:10.1902/jop.2005.76.11.1910
更新日期:2005-11-01 00:00:00
abstract::This study was undertaken to provide histologic observations on the effectiveness of citric acid and tetracycline HCl root surface demineralization when used in conjunction with guided tissue regeneration (GTR) procedures. Eight beagle dogs with naturally-occurring periodontitis were initially treated with scaling and...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1993.64.11.1052
更新日期:1993-11-01 00:00:00
abstract::This report describes a case of rapidly progressive periodontal tissue breakdown and bone loss in an HIV-infected markedly immunosuppressed homosexual male. Within 6 months of initial presentation with a necrotizing ulcerative gingivitis, the lesion extended to a necrotizing ulcerative stomatitis involving the surroun...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1998.69.6.710
更新日期:1998-06-01 00:00:00
abstract::The cross-sectional relationship between severe loss of periodontal attachment (LPA) and worsening immune status due to HIV infection was evaluated in 474 HIV-infected subjects (416 men, 58 women) aged 18 to 49 years who had been classified at stages 1 through 6 of the Walter Reed Army Institute of Research (WR) Stagi...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1995.66.6.421
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Buccal gingival recession is a prevalent problem in populations with a high standard of oral hygiene and is very often associated with a non-carious cervical lesion, complicating treatment. The purpose of this report is to show three cases treated by an integrated periodontal and restorative dentistry approa...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.2007.060402
更新日期:2007-06-01 00:00:00
abstract::In order to provide longitudinal data for endosteal bladevent implants, a continuing study is being conducted from an original group of 49 implants in 32 patients placed 15 years ago. The present work evaluated 26 of these bladevent implants in 18 patients. Three basic patterns were observed 15 years postoperatively: ...
journal_title:Journal of periodontology
pub_type: 杂志文章
doi:10.1902/jop.1987.58.9.589
更新日期:1987-09-01 00:00:00