Structure and Mode-of-Action of the Two-Peptide (Class-IIb) Bacteriocins.

Abstract:

:This review focuses on the structure and mode-of-action of the two-peptide (class-IIb) bacteriocins that consist of two different peptides whose genes are next to each other in the same operon. Optimal antibacterial activity requires the presence of both peptides in about equal amounts. The two peptides are synthesized as preforms that contain a 15-30 residue double-glycine-type N-terminal leader sequence that is cleaved off at the C-terminal side of two glycine residues by a dedicated ABC-transporter that concomitantly transfers the bacteriocin peptides across cell membranes. Two-peptide bacteriocins render the membrane of sensitive bacteria permeable to a selected group of ions, indicating that the bacteriocins form or induce the formation of pores that display specificity with respect to the transport of molecules. Based on structure-function studies, it has been proposed that the two peptides of two-peptide bacteriocins form a membrane-penetrating helix-helix structure involving helix-helix-interacting GxxxG-motifs that are present in all characterized two-peptide bacteriocins. It has also been suggested that the membrane-penetrating helix-helix structure interacts with an integrated membrane protein, thereby triggering a conformational alteration in the protein, which in turn causes membrane-leakage. This proposed mode-of-action is similar to the mode-of-action of the pediocin-like (class-IIa) bacteriocins and lactococcin A (a class-IId bacteriocin), which bind to a membrane-embedded part of the mannose phosphotransferase permease in a manner that causes membrane-leakage and cell death.

authors

Nissen-Meyer J,Oppegård C,Rogne P,Haugen HS,Kristiansen PE

doi

10.1007/s12602-009-9021-z

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

52-60

issue

1

eissn

1867-1306

issn

1867-1314

journal_volume

2

pub_type

杂志文章
  • In Vitro Evaluation of the Probiotic Potential of Halotolerant Lactobacilli Isolated from a Ripened Tropical Mexican Cheese.

    abstract::Three halotolerant lactobacilli (Lactobacillus plantarum, L. pentosus, and L. acidipiscis) isolated from a ripened Mexican tropical cheese (double cream Chiapas cheese) were evaluated as potential probiotics and compared with two commercial probiotic strains (L. casei Shirota and L. plantarum 299v) from human origin. ...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-013-9144-0

    authors: Melgar-Lalanne G,Rivera-Espinoza Y,Reyes Méndez AI,Hernández-Sánchez H

    更新日期:2013-12-01 00:00:00

  • Probiotic Activity of a Bacterial Strain Isolated from Ancient Permafrost Against Salmonella Infection in Mice.

    abstract::Bacillus cereus strain F, collected from relict permafrost located in Siberia, was analyzed for probiotic activity in the mouse Salmonella enterica model. Viable bacterial cells were found in frozen soils taken at Mammoth Mountain in Yakutia from a depth below the level of seasonal thawing. Geological data indicated t...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-012-9105-z

    authors: Fursova O,Potapov V,Brouchkov A,Pogorelko G,Griva G,Fursova N,Ignatov S

    更新日期:2012-09-01 00:00:00

  • Lactobacillus salivarius NK02: a Potent Probiotic for Clinical Application in Mouthwash.

    abstract::A specific strain of naturally occurring oral lactobacilli was isolated and identified based on morphological, biochemical, and 16S rRNA gene sequencing. The phylogenetic affiliation of the isolate confirmed that the NK02 strain had close association with the Lactobacillus salivarius. An effective mouthwash was develo...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s12602-017-9296-4

    authors: Sajedinejad N,Paknejad M,Houshmand B,Sharafi H,Jelodar R,Shahbani Zahiri H,Noghabi KA

    更新日期:2018-09-01 00:00:00

  • Are Probiotics Effective in Targeting Alcoholic Liver Diseases?

    abstract::Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders including steatosis, steatohepatitis, fibrosis, and cirrhosis. Despite intensive research in the last two decades, there is currently no Food and Drug Administration-approved therapy for treating ALD. Several studies have demonstrated the importan...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-018-9419-6

    authors: Hong M,Han DH,Hong J,Kim DJ,Suk KT

    更新日期:2019-06-01 00:00:00

  • Correction to: Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth.

    abstract::The original version of this article contained mistakes, and the authors would like to correct them. The correct details are given below. ...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 已发布勘误

    doi:10.1007/s12602-018-9412-0

    authors: Leventogiannis K,Gkolfakis P,Spithakis G,Tsatali A,Pistiki A,Sioulas A,Giamarellos-Bourboulis EJ,Triantafyllou K

    更新日期:2019-06-01 00:00:00

  • Comparative Activities of Cattle and Swine Platelet Microbicidal Proteins.

    abstract::The bactericidal activities of cattle and swine platelet microbicidal proteins (PMPs) with their comparison with human PMP were studied. Activities of PMP were tested against Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Staphylococcus epidermidis, Micrococcus lysodeikticus and Escherichia coli. B. subtil...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-009-9016-9

    authors: Ivanov IB,Gritsenko VA

    更新日期:2009-12-01 00:00:00

  • Quorum Sensing Circuits in the Communicating Mechanisms of Bacteria and Its Implication in the Biosynthesis of Bacteriocins by Lactic Acid Bacteria: a Review.

    abstract::It is well established that bacteria communicate between each other by using different mechanisms; among which, quorum sensing (QS) is the best known one. Indeed, intra- and intercellular communications of microorganisms, as well as the regulation of metabolism and reaction to the surrounding environmental conditions,...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章,评审

    doi:10.1007/s12602-019-09555-4

    authors: Kareb O,Aïder M

    更新日期:2020-03-01 00:00:00

  • A New Synthetic Peptide with In vitro Antibacterial Potential Against Escherichia coli O157:H7 and Methicillin-Resistant Staphylococcus aureus (MRSA).

    abstract::In this work, we performed the rational design of a cationic antimicrobial peptide, GIBIMPY4, using the software DEPRAMPs developed at the GIBIM research group. GIBIMPY4 has a length of 17 amino acids, it is amphipathic, its structure is α-helix and it has a net charge of (+5). Solid-phase peptide synthesis was perfor...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-016-9219-9

    authors: Prada YA,Guzmán F,Rondón P,Escobar P,Ortíz C,Sierra DA,Torres R,Mejía-Ospino E

    更新日期:2016-09-01 00:00:00

  • Gene Cloning, Expression, and Antifungal Activities of Permatin from Naked Oat (Avena nuda).

    abstract::Thaumatin-like proteins (TLPs) are the products of a large, highly complex gene family involved in host defense. TLPs also belong to the pathogenesis-related family 5 (PR-5) of plant defense proteins. Most TLPs exhibit potential antifungal activities, and their accumulation in the plant is related to many physiologica...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-018-9422-y

    authors: Liu J,Han D,Shi Y

    更新日期:2019-03-01 00:00:00

  • Characterization of Probiotic Properties of Antifungal Lactobacillus Strains Isolated from Traditional Fermenting Green Olives.

    abstract::The aim of this work is to characterize the potential probiotic properties of 14 antifungal Lactobacillus strains isolated from traditional fermenting Moroccan green olives. The molecular identification of strains indicated that they are composed of five Lactobacillus brevis, two Lactobacillus pentosus, and seven Lact...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-019-09543-8

    authors: Abouloifa H,Rokni Y,Bellaouchi R,Ghabbour N,Karboune S,Brasca M,Ben Salah R,Chihib NE,Saalaoui E,Asehraou A

    更新日期:2020-06-01 00:00:00

  • The Effects of Synbiotic Supplementation on Carotid Intima-Media Thickness, Biomarkers of Inflammation, and Oxidative Stress in People with Overweight, Diabetes, and Coronary Heart Disease: a Randomized, Double-Blind, Placebo-Controlled Trial.

    abstract::Synbiotics are known to exert multiple beneficial effects, including anti-inflammatory and antioxidant actions. The aim of this study was to evaluate the effects of synbiotic supplementation on carotid intima-media thickness (CIMT), biomarkers of inflammation, and oxidative stress in people with overweight, diabetes, ...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s12602-017-9343-1

    authors: Farrokhian A,Raygan F,Soltani A,Tajabadi-Ebrahimi M,Sharifi Esfahani M,Karami AA,Asemi Z

    更新日期:2019-03-01 00:00:00

  • Beneficial Protective Role of Endogenous Lactic Acid Bacteria Against Mycotic Contamination of Honeybee Beebread.

    abstract::The purpose of this article is to reveal the role of the lactic acid bacteria (LAB) in the beebread transformation/preservation, biochemical properties of 25 honeybee endogenous LAB strains, particularly: antifungal, proteolytic, and amylolytic activities putatively expressed in the beebread environment have been stud...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-017-9379-2

    authors: Janashia I,Choiset Y,Jozefiak D,Déniel F,Coton E,Moosavi-Movahedi AA,Chanishvili N,Haertlé T

    更新日期:2018-12-01 00:00:00

  • Evaluation of the Probiotic Potential of Saccharomyces cerevisiae Strain (C41) Isolated from Tibicos by In Vitro Studies.

    abstract::Artisanal fermented beverages have been associated with beneficial effects for a long time. In Mexico, there are a wide variety of artisanal fermented beverages such as Tepache, where the fermentation is initiated by the addition of grains of a polysaccharide-containing biofilm matrix formed by a symbiotic association...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-018-9471-2

    authors: Romero-Luna HE,Hernández-Sánchez H,Ribas-Aparicio RM,Cauich-Sánchez PI,Dávila-Ortiz G

    更新日期:2019-09-01 00:00:00

  • Antibacterial Activity of Subtilosin Alone and Combined with Curcumin, Poly-Lysine and Zinc Lactate Against Listeria monocytogenes Strains.

    abstract::In this paper, the antibacterial effects of the Bacillus amyloliquefaciens-produced bacteriocin subtilosin, both alone and in combination with curcumin, ε-poly-L-lysine (poly-lysine), or zinc lactate, were examined against Listeria monocytogenes. Results indicated that subtilosin inhibits both of the studied bacterial...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-010-9042-7

    authors: Amrouche T,Sutyak Noll K,Wang Y,Huang Q,Chikindas ML

    更新日期:2010-12-01 00:00:00

  • Evaluation of Lactic Acid Bacteria Isolated from Fermented Plant Products for Antagonistic Activity Against Urinary Tract Pathogen Staphylococcus saprophyticus.

    abstract::Urinary tract infections (UTIs) are the most common infectious diseases in infants and the elderly; they are also the most common among nosocomial infections. The treatment of UTIs usually involves a short-term course of antibiotics. The purpose of this study was to identify the strains of lactic acid bacteria (LAB) t...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-017-9302-x

    authors: Tsai CC,Lai TM,Lin PP,Hsieh YM

    更新日期:2018-06-01 00:00:00

  • Neuroprotective Effects of Heat-Killed Lactobacillus plantarum 200655 Isolated from Kimchi Against Oxidative Stress.

    abstract::Oxidative stress plays an important role in exacerbating neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. In a previous study, Lactobacillus plantarum 200655 was shown to possess probiotic and antioxidant potential. The current study aimed to evaluate the neuropro...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-020-09740-w

    authors: Cheon MJ,Lee NK,Paik HD

    更新日期:2021-01-17 00:00:00

  • Effect of Dietary Probiotic Lactobacillus helveticus on Growth Performance, Antioxidant Levels, and Absorption of Essential Trace Elements in Goldfish (Carassius auratus).

    abstract::In this study, we have investigated the effect of probiotic Lactobacillus helveticus CD6 supplemented into simple laboratory fish feed (LFF) and complex, multi-ingredient market fish feed (MFF) on growth performance, antioxidant levels, and essential trace element absorption in goldfish (Carassius auratus). Twenty-fou...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-018-9428-5

    authors: Ahire JJ,Mokashe NU,Chaudhari BL

    更新日期:2019-06-01 00:00:00

  • Lactobacillus rhamnosus BFE 5264 and Lactobacillus plantarum NR74 Promote Cholesterol Excretion Through the Up-Regulation of ABCG5/8 in Caco-2 Cells.

    abstract::The effect of two putative probiotic strains, Lactobacillus rhamnosus BFE5264 and Lactobacillus plantarum NR74, on the control of cholesterol efflux in enterocytes was assessed by focusing on the promotion of ATP-binding cassette sub-family G members 5 and 8 (ABCG5 and ABCG8). Differentiated Caco-2 enterocytes were tr...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-011-9086-3

    authors: Yoon HS,Ju JH,Kim H,Lee J,Park HJ,Ji Y,Shin HK,Do MS,Lee JM,Holzapfel W

    更新日期:2011-12-01 00:00:00

  • The Effect of Various Probiotic Strains or Avilamycin Feed Additive on Immune Defense Markers and Acute-Phase Response to Salmonella Infection in Chickens.

    abstract::Probiotics are a nutritional tool for disease prevention. It has been proposed that stimulation of immune response could affect the growth-promoting properties of antimicrobial growth promoters as well as the control of foodborne pathogens. The current study compares immune response in the blood of 280 non-infected an...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-010-9054-3

    authors: Bielecka M,Smoragiewicz W,Siwicki AK,Wójcik R,Biedrzycka E,Orłowski A,Kask S,Jankowski J,Karska-Wysocki B,Ham D

    更新日期:2010-10-01 00:00:00

  • Assessment of Efficacy of BLIS-Producing Probiotic K12 for the Prevention of Group A Streptococcus Pharyngitis: a Short Communication.

    abstract::The neutral outcome of the recently reported school-based trial of probiotic K12 (The effect of the oral probiotic Streptococcus salivarius K12 on group A streptococcus pharyngitis: a pragmatic trial in schools) can be attributed at least partially to several readily identifiable confounding factors. Mainly, the execu...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-018-9398-7

    authors: Di Pierro F

    更新日期:2019-03-01 00:00:00

  • Effect of Encapsulated Lactobacillus bulgaricus on Innate Immune System and Hematological Parameters in Rainbow Trout (Oncorhynchus mykiss), Post-Administration of Pb.

    abstract::The present study was conducted to investigate the effects of probiotic and encapsulated Lactobacillus bulgaricus on hematological and immunological factors after lead toxicity in rainbow trout (Oncorhynchus mykiss). Two hundred and forty fish weighing about 16 ± 3.8 g were divided randomly in to four groups including...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-019-09544-7

    authors: Mohammadian T,Dezfuly ZT,Motlagh RG,Jangaran-Nejad A,Hosseini SS,Khaj H,Alijani N

    更新日期:2020-06-01 00:00:00

  • Encapsulation of Lactobacillus plantarum 423 and its Bacteriocin in Nanofibers.

    abstract::Plantaricin 423, produced by Lactobacillus plantarum 423, was encapsulated in nanofibers that were produced by the electrospinning of 18% (w/v) polyethylene oxide (200 000 Da). The average diameter of the nanofibers was 288 nm. Plantaricin 423 activity decreased from 51 200 AU/ml to 25 600 AU/ml and from 204 800 AU/ml...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-009-9024-9

    authors: Heunis TD,Botes M,Dicks LM

    更新日期:2010-03-01 00:00:00

  • Effects of Dietary Supplementation of Recombinant Plectasin on Growth Performance, Intestinal Health and Innate Immunity Response in Broilers.

    abstract::The present study was conducted to evaluate the effects of dietary supplementation of recombinant plectasin (Ple) on the growth performance, intestinal health, and serum immune parameters in broilers. A total of 288 1-day-old male broilers (Arbor Acres) were randomly allotted to four dietary treatments including the b...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-019-9515-2

    authors: Ma JL,Zhao LH,Sun DD,Zhang J,Guo YP,Zhang ZQ,Ma QG,Ji C,Zhao LH

    更新日期:2020-03-01 00:00:00

  • In Vitro Antimicrobial Activity and Downregulation of Virulence Gene Expression on Helicobacter pylori by Reuterin.

    abstract::Helicobacter pylori is an infectious agent commonly associated with gastrointestinal diseases. The use of probiotics to treat this infection has been documented, however, their potential antimicrobial metabolites have not yet been investigated. In the present study, the effect of reuterin produced by Lactobacillus reu...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-017-9342-2

    authors: Urrutia-Baca VH,Escamilla-García E,de la Garza-Ramos MA,Tamez-Guerra P,Gomez-Flores R,Urbina-Ríos CS

    更新日期:2018-06-01 00:00:00

  • Hematobiochemical and Immunological Responses of Rats Treated with Multi-strain Probiotics and Infected with Trypanosoma brucei.

    abstract::The effects of treatment with probiotics on the immunological and hematobiochemical changes in Trypanosoma brucei infection were investigated. Probiotic strains used are Bifidobacterium BB-12, Lactobacillus acidophilus LA-5, Lactobacillus delbrueckii LBY-27, Lactobacillus paracasei LC-01, and Streptococcus thermophilu...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-019-09592-z

    authors: Okolo CC,Nweze NE,Eze IJ

    更新日期:2020-09-01 00:00:00

  • Leuconostoc mesenteroides subsp. mesenteroides SD23 Prevents Metabolic Dysfunction Associated with High-Fat Diet-Induced Obesity in Male Mice.

    abstract::High-fat diet (HFD) consumption induces obesity and increases blood glucose, insulin resistance, and metabolic disorders. Recent studies suggest that probiotics might be a novel approach to counteract these effects in the treatment of obesity. Here, we evaluated the effect of Leuconostoc mesenteroides subsp. mesentero...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-019-09556-3

    authors: Castro-Rodríguez DC,Reyes-Castro LA,Vega CC,Rodríguez-González GL,Yáñez-Fernández J,Zambrano E

    更新日期:2020-06-01 00:00:00

  • Characterization and Antioxidant Property of Probiotic and Synbiotic Yogurts.

    abstract::The effect of a prebiotic (fructooligosaccharides) or a synbiotic components (prebiotic and probiotic) on the viability, proteolysis and antioxidant properties of probiotic and synbiotic yogurt during 28 days of storage at 4 °C has been investigated. Yogurt starters in conjunction with either probiotic bacteria Lactob...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-012-9099-6

    authors: Madhu AN,Amrutha N,Prapulla SG

    更新日期:2012-06-01 00:00:00

  • From Farm to Fingers: an Exploration of Probiotics for Oysters, from Production to Human Consumption.

    abstract::Oysters hold a unique place within the field of aquaculture as one of the only organisms that is regularly shipped live to be consumed whole and raw. The microbiota of oysters is capable of adapting to a wide range of environmental conditions within their dynamic estuarine environments; however, human aquaculture prac...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章,评审

    doi:10.1007/s12602-019-09629-3

    authors: Yeh H,Skubel SA,Patel H,Cai Shi D,Bushek D,Chikindas ML

    更新日期:2020-06-01 00:00:00

  • Adhesion Capacity of Weissella cibaria to Bovine Mammary Tissue and the Effect of Bio-Sealant Topical Application on Physicochemical Properties of Milk.

    abstract::The ability of a probiotic strain (Weissella cibaria) to adhere on tissue and the effect of its topical application in nipples of lactating cows on physicochemical characteristics of milk were evaluated. An ex vivo model was used to demonstrate the adhesion capacity of W. cibaria. Tissue samples were randomly distribu...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-018-9481-0

    authors: Serna-Cock L,Pabón-Rodríguez OV,Giraldo-Gómez GI

    更新日期:2019-12-01 00:00:00

  • Lactobacillus plantarum Strains Isolated from Polish Regional Cheeses Exhibit Anti-Staphylococcal Activity and Selected Probiotic Properties.

    abstract::Twenty-nine Lactobacillus plantarum strains isolated from different types of Polish regional cheeses (Oscypek and Korycinski) were assessed for selected probiotic properties and anti-staphylococcal activity. Most of the tested L. plantarum strains were considered safe. Whole bacterial cultures (WBC) and cell-free supe...

    journal_title:Probiotics and antimicrobial proteins

    pub_type: 杂志文章

    doi:10.1007/s12602-019-09587-w

    authors: Ołdak A,Zielińska D,Łepecka A,Długosz E,Kołożyn-Krajewska D

    更新日期:2020-09-01 00:00:00