Cardiovascular Determinants of Aerobic Exercise Capacity in Adults With Type 2 Diabetes.

Abstract:

OBJECTIVE:To assess the relationship between subclinical cardiac dysfunction and aerobic exercise capacity (peak VO2) in adults with type 2 diabetes (T2D), a group at high risk of developing heart failure. RESEARCH DESIGN AND METHODS:Cross-sectional study. We prospectively enrolled a multiethnic cohort of asymptomatic adults with T2D and no history, signs, or symptoms of cardiovascular disease. Age-, sex-, and ethnicity-matched control subjects were recruited for comparison. Participants underwent bioanthropometric profiling, cardiopulmonary exercise testing, and cardiovascular magnetic resonance with adenosine stress perfusion imaging. Multivariable linear regression analysis was undertaken to identify independent associations between measures of cardiovascular structure and function and peak VO2. RESULTS:A total of 247 adults with T2D (aged 51.8 ± 11.9 years, 55% males, 37% black or south Asian ethnicity, HbA1c 7.4 ± 1.1% [57 ± 12 mmol/mol], and duration of diabetes 61 [32-120] months) and 78 control subjects were included. Subjects with T2D had increased concentric left ventricular remodeling, reduced myocardial perfusion reserve (MPR), and markedly lower aerobic exercise capacity (peak VO2 18.0 ± 6.6 vs. 27.8 ± 9.0 mL/kg/min; P < 0.001) compared with control subjects. In a multivariable linear regression model containing age, sex, ethnicity, smoking status, and systolic blood pressure, only MPR (β = 0.822; P = 0.006) and left ventricular diastolic filling pressure (E/e') (β = -0.388; P = 0.001) were independently associated with peak VO2 in subjects with T2D. CONCLUSIONS:In a multiethnic cohort of asymptomatic people with T2D, MPR and diastolic function are key determinants of aerobic exercise capacity, independent of age, sex, ethnicity, smoking status, or blood pressure.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Gulsin GS,Henson J,Brady EM,Sargeant JA,Wilmot EG,Athithan L,Htike ZZ,Marsh AM,Biglands JD,Kellman P,Khunti K,Webb D,Davies MJ,Yates T,McCann GP

doi

10.2337/dc20-0706

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

2248-2256

issue

9

eissn

0149-5992

issn

1935-5548

pii

dc20-0706

journal_volume

43

pub_type

杂志文章
  • Short stature and the risk of adiposity, insulin resistance, and type 2 diabetes in middle age: the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994.

    abstract:OBJECTIVE:To investigate the association between stature-related measurements (height, leg length, and leg length-to-height ratio) and adiposity, insulin resistance, and glucose intolerance. RESEARCH DESIGN AND METHODS:We conducted a cross-sectional analysis of a nationally representative sample of 7,424 adults aged 4...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc05-1997

    authors: Asao K,Kao WH,Baptiste-Roberts K,Bandeen-Roche K,Erlinger TP,Brancati FL

    更新日期:2006-07-01 00:00:00

  • Biphasic insulin aspart 30/70: pharmacokinetics and pharmacodynamics compared with once-daily biphasic human insulin and Basal-bolus therapy.

    abstract::OBJECTIVE Pharmacological profiles of biphasic insulin aspart 30/70 (BIAsp 30) once daily (OD), twice daily (b.i.d.), and three times daily (t.i.d.) were compared with other insulin regimens in two crossover glucose clamp studies of insulin-treated type 2 diabetic patients. RESEARCH DESIGNS AND METHODS Study 1 consist...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-0097

    authors: Heise T,Heinemann L,Hövelmann U,Brauns B,Nosek L,Haahr HL,Olsen KJ

    更新日期:2009-08-01 00:00:00

  • Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2).

    abstract:OBJECTIVE:We investigated the natural history of glucokinase (GCK)-related maturity-onset diabetes of the young type 2 (MODY2), notably the factors associated with deterioration of hyperglycemia over time. RESEARCH DESIGN AND METHODS:We report an 11-year follow-up of glucose tolerance and indexes of insulin secretion ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-2017

    authors: Martin D,Bellanné-Chantelot C,Deschamps I,Froguel P,Robert JJ,Velho G

    更新日期:2008-07-01 00:00:00

  • Reduction in cardiovascular risk factors with intensive diabetes treatment in insulin-dependent diabetes mellitus.

    abstract::We measured plasma lipid and lipoprotein levels at baseline and at 6-mo intervals in 47 normolipidemic patients with classic insulin-dependent diabetes mellitus treated either with a conventional (n = 21) or intensive (n = 26) diabetes-treatment program. Patients were followed for a mean of 3 yr (range 1-4 yr). Intens...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.10.6.729

    authors: Rosenstock J,Strowig S,Cercone S,Raskin P

    更新日期:1987-11-01 00:00:00

  • Long-term Effects of Disasters on Seniors With Diabetes: Evidence From Hurricanes Katrina and Rita.

    abstract:OBJECTIVE:To estimate the long-run mortality effects of Hurricanes Katrina and Rita on seniors with diabetes. RESEARCH DESIGN AND METHODS:We performed a retrospective cohort analysis of Medicare enrollment and claims data covering four states and ∼10 years. Affected individuals were identified by whether they lived in...

    journal_title:Diabetes care

    pub_type: 历史文章,杂志文章

    doi:10.2337/dc19-0567

    authors: Quast T,Andel R,Sadhu AR

    更新日期:2019-11-01 00:00:00

  • Long-term predictors of insulin resistance: role of lifestyle and metabolic factors in middle-aged men.

    abstract:OBJECTIVE:Predictors of insulin resistance have hitherto only been examined in cross-sectional studies without information on lifestyle factors. Few researchers have measured insulin sensitivity directly and compared different metabolic and lifestyle predictors in a large population. RESEARCH DESIGN AND METHODS:Our ai...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc07-0360

    authors: Risérus U,Arnlöv J,Berglund L

    更新日期:2007-11-01 00:00:00

  • Early-morning hyperglycemia in diabetic individuals treated with continuous subcutaneous insulin infusion.

    abstract::Significantly early-morning hyperglycemia was observed in insulin-dependent diabetic individuals who were otherwise well controlled while receiving a continuous subcutaneous insulin infusion (CSII) at standard doses. We measured the levels of the five key counterregulatory hormones (CRH) throughout the night for a tot...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.6.2.135

    authors: Geffner ME,Frank HJ,Kaplan SA,Lippe BM,Levin SR

    更新日期:1983-03-01 00:00:00

  • Insulin-dependent diabetes mellitus and child abuse: is there a relationship?

    abstract::Many of the family psychosocial variables significantly related to child abuse are also significantly related to insulin-dependent diabetes mellitus (IDDM) control. These variables are reviewed, and an increased child abuse risk factor for children with IDDM is discussed. Behavioral indicators of families experiencing...

    journal_title:Diabetes care

    pub_type: 杂志文章,评审

    doi:10.2337/diacare.9.3.302

    authors: Horan PF,Gwynn C,Renzi D

    更新日期:1986-05-01 00:00:00

  • Incidence of type 2 diabetes using proposed HbA1c diagnostic criteria in the european prospective investigation of cancer-norfolk cohort: implications for preventive strategies.

    abstract:OBJECTIVE:To evaluate the incidence and relative risk of type 2 diabetes defined by the newly proposed HbA(1c) diagnostic criteria in groups categorized by different baseline HbA(1c) levels. RESEARCH DESIGN AND METHODS:Using data from the European Prospective Investigation of Cancer (EPIC)-Norfolk cohort with repeat H...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc09-2326

    authors: Chamnan P,Simmons RK,Forouhi NG,Luben RN,Khaw KT,Wareham NJ,Griffin SJ

    更新日期:2011-04-01 00:00:00

  • Diabetes, glycemic control, and new-onset heart failure in patients with stable coronary artery disease: data from the heart and soul study.

    abstract:OBJECTIVE:Diabetes is a predictor of both coronary artery disease (CAD) and heart failure. It is unknown to what extent the association between diabetes and heart failure is influenced by other risk factors for heart failure. RESEARCH DESIGN AND METHODS:We evaluated the association of diabetes and A1C with incident he...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc10-0286

    authors: van Melle JP,Bot M,de Jonge P,de Boer RA,van Veldhuisen DJ,Whooley MA

    更新日期:2010-09-01 00:00:00

  • Frequency of severe hypoglycemia in patients with type I diabetes with impaired awareness of hypoglycemia.

    abstract:OBJECTIVE:To determine the frequency of hypoglycemia in patients with type I diabetes and impaired awareness of hypoglycemia by prospective assessment. RESEARCH DESIGN AND METHODS:A prospective study was undertaken for 12 months in 60 patients with type I diabetes: 29 had impaired awareness of hypoglycemia and 31 reta...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.17.7.697

    authors: Gold AE,MacLeod KM,Frier BM

    更新日期:1994-07-01 00:00:00

  • Physiological differences between interstitial glucose and blood glucose measured in human subjects.

    abstract:OBJECTIVE:This study investigated whether glucose readings from a sensor sampling in interstitial fluid differ substantially from blood glucose (BG) values measured at the same time. RESEARCH DESIGN AND METHODS:We have evaluated the relationship between BG and glucose extracted from interstitial fluid using the GlucoW...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章

    doi:10.2337/diacare.26.8.2405

    authors: Kulcu E,Tamada JA,Reach G,Potts RO,Lesho MJ

    更新日期:2003-08-01 00:00:00

  • Effects of dapagliflozin, an SGLT2 inhibitor, on HbA(1c), body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy.

    abstract:OBJECTIVE:To examine the safety and efficacy of dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, added on to pioglitazone in type 2 diabetes inadequately controlled on pioglitazone. RESEARCH DESIGN AND METHODS:Treatment-naive patients or those receiving metformin, sulfonylurea, or thiazolidinedione entered a...

    journal_title:Diabetes care

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2337/dc11-1693

    authors: Rosenstock J,Vico M,Wei L,Salsali A,List JF

    更新日期:2012-07-01 00:00:00

  • Diabetes Epidemiology in the COVID-19 Pandemic.

    abstract::Diabetes has been identified as an important risk factor for mortality and rates of progression to acute respiratory distress syndrome (ARDS) in hospitalized patients with coronavirus disease 2019 (COVID-19). However, many recent reports on this topic reflect hurried approaches and have lacked careful epidemiologic de...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-1295

    authors: Selvin E,Juraschek SP

    更新日期:2020-08-01 00:00:00

  • Sustained Intensive Treatment and Long-term Effects on HbA1c Reduction (SILVER Study) by CGM in People With Type 1 Diabetes Treated With MDI.

    abstract:OBJECTIVE:Continuous glucose monitoring (CGM) reduces HbA1c and time spent in hypoglycemia in people with type 1 diabetes (T1D) treated with multiple daily insulin injections (MDI) when evaluated over shorter time periods. It is unclear to what extent CGM improves and helps to maintain glucose control, treatment satisf...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc20-1468

    authors: Lind M,Ólafsdóttir AF,Hirsch IB,Bolinder J,Dahlqvist S,Pivodic A,Hellman J,Wijkman M,Schwarcz E,Albrektsson H,Heise T,Polonsky W

    更新日期:2021-01-01 00:00:00

  • Markedly Decreasing Incidence of Blindness in People With and Without Diabetes in Southern Germany.

    abstract:OBJECTIVE:Studies comparing the incidence of blindness in persons with and without diabetes are scarce worldwide. In Germany, a decline in the incidence of blindness was found during the 1990s. The aim of this study was to analyze the recent time trend. RESEARCH DESIGN AND METHODS:Data were based on administrative fil...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc17-2031

    authors: Claessen H,Kvitkina T,Narres M,Trautner C,Zöllner I,Bertram B,Icks A

    更新日期:2018-03-01 00:00:00

  • Cardiovascular Autonomic Neuropathy and Cardiovascular Outcomes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study.

    abstract:OBJECTIVE:To examine whether cardiovascular autonomic neuropathy (CAN) is an independent risk factor of cardiovascular disease (CVD) events during DCCT/EDIC. RESEARCH DESIGN AND METHODS:Standardized cardiovascular autonomic reflex tests (R-R response to paced breathing, Valsalva maneuver, postural changes in blood pre...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc16-1397

    authors: Pop-Busui R,Braffett BH,Zinman B,Martin C,White NH,Herman WH,Genuth S,Gubitosi-Klug R,DCCT\/EDIC Research Group.

    更新日期:2017-01-01 00:00:00

  • Glucosuria in children with diabetes: advantages of the 2-drop Clinitest method.

    abstract::In order to assess the actual and theoretical limitations of using the traditional urinary glucose determinations as an indicator of plasma glucose concentration, we have measured plasma and urine glucose concentrations in 37 children with diabetes mellitus. A constant blood withdrawal system enabled an accurate estim...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.2.4.349

    authors: Winter RJ,Traisman HS,Green OC

    更新日期:1979-07-01 00:00:00

  • Excess BMI Accelerates Islet Autoimmunity in Older Children and Adolescents.

    abstract:OBJECTIVE:Sustained excess BMI increases the risk of type 1 diabetes (T1D) in autoantibody-positive relatives without diabetes of patients. We tested whether elevated BMI also accelerates the progression of islet autoimmunity before T1D diagnosis. RESEARCH DESIGN AND METHODS:We studied 706 single autoantibody-positive...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc19-1167

    authors: Ferrara-Cook C,Geyer SM,Evans-Molina C,Libman IM,Becker DJ,Gitelman SE,Redondo MJ,Type 1 Diabetes TrialNet Study Group.

    更新日期:2020-03-01 00:00:00

  • Prospective evaluation of HDL cholesterol changes after diet and physical conditioning programs for patients with type II diabetes mellitus.

    abstract::High-density lipoprotein (HDL) cholesterol is known to be low in patients with diabetes mellitus. Low HDL levels are correlated with premature cardiovascular mortality in several major epidemiologic studies and many investigators believe increases in HDL cholesterol may reduce the risk of coronary heart disease. We ev...

    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2337/diacare.8.4.343

    authors: Kaplan RM,Wilson DK,Hartwell SL,Merino KL,Wallace JP

    更新日期:1985-07-01 00:00:00

  • HLA-DQ beta typing and non-Asp57 alleles in IDDM and nondiabetic subjects in New Zealand.

    abstract:OBJECTIVE:To determine the frequency of IDDM risk-associated HLA-DQ beta alleles in New Zealanders with IDDM and nondiabetic control subjects, and to examine these as susceptibility markers in relation to IDDM incidence. RESEARCH DESIGN AND METHODS:HLA-DQ beta typing was conducted in 55 juvenile-onset IDDM subjects di...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.16.8.1179

    authors: Forbes LV,Brown LJ,Scott RS

    更新日期:1993-08-01 00:00:00

  • Urinary C-peptide as a measure of beta-cell function after a mixed meal in healthy subjects: comparison of four-hour urine C-peptide with serum insulin and plasma C-peptide.

    abstract::Urinary C-peptide (UCP) is a noninvasive measure of integrated insulin production, and the usefulness of 24-h collections has been previously reported. Only small numbers of subjects have been studied using shorter urine collections. To see how well 4-h urine collections for C-peptide (UCP) correlate with serum immuno...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.6.5.488

    authors: Hoogwerf BJ,Barbosa JJ,Bantle JP,Laine D,Goetz FC

    更新日期:1983-09-01 00:00:00

  • Family functioning and metabolic control of school-aged children with IDDM.

    abstract::The relationship of two aspects of family life to metabolic control were examined as part of a longitudinal study of school-aged children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Glycosylated hemoglobin level was the primary index of metabolic control; weight-adjusted insulin dosage served as a...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.12.6.409

    authors: Kovacs M,Kass RE,Schnell TM,Goldston D,Marsh J

    更新日期:1989-06-01 00:00:00

  • Apolipoprotein E polymorphism as a risk factor for vascular disease in diabetic patients.

    abstract:OBJECTIVE:To examine the prevalence of cardiovascular disease in diabetic patients as a function of apolipoprotein (apo) E polymorphism. RESEARCH DESIGN AND METHODS:The apo E phenotypes and plasma lipid, lipoprotein, and apo levels were determined for 517 Italian diabetic patients. The prevalence of cardiovascular dis...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.18.4.504

    authors: Boemi M,Sirolla C,Amadio L,Fumelli P,Pometta D,James RW

    更新日期:1995-04-01 00:00:00

  • Impaired glucose tolerance and diabetes mellitus in elderly subjects.

    abstract::In a 10-yr prospective population study 406 subjects who were 70 yr old received an oral glucose tolerance test. Of these subjects 169 were retested at 80. Three sets of diagnostic criteria were evaluated, of which the WHO criteria are recommended for screening studies in this age group. The prevalences of diabetes me...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.5.6.600

    authors: Agner E,Thorsteinsson B,Eriksen M

    更新日期:1982-11-01 00:00:00

  • Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: the sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor 1alpha genes.

    abstract:OBJECTIVE:We have demonstrated high heritability of insulin secretion measured as acute insulin response to glucose times insulin sensitivity (disposition index). Furthermore, we showed that obese normoglycemic family members of a type 2 diabetic proband failed to compensate for the insulin resistance of obesity by inc...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.24.3.472

    authors: Elbein SC,Sun J,Scroggin E,Teng K,Hasstedt SJ

    更新日期:2001-03-01 00:00:00

  • Efficacy and cost of postpartum screening strategies for diabetes among women with histories of gestational diabetes mellitus.

    abstract:OBJECTIVE:To compare the cost and time to diagnosis associated with several screening strategies for diabetes in women with histories of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:We simulated screening for diabetes with fasting plasma glucose (FPG), a 2-h oral glucose tolerance test (OGTT), and ...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-2237

    authors: Kim C,Herman WH,Vijan S

    更新日期:2007-05-01 00:00:00

  • Lipid, glycemic, and insulin responses to meals rich in saturated, cis-monounsaturated, and polyunsaturated (n-3 and n-6) fatty acids in subjects with type 2 diabetes.

    abstract:OBJECTIVE:The recommendations for dietary fats in patients with type 2 diabetes are based largely on the impact of fatty acids on fasting serum lipid and glucose concentrations. How fatty acids affect postprandial insulin, glucose, and triglyceride concentrations, however, remains unclear. The objective of this study w...

    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc07-1026

    authors: Shah M,Adams-Huet B,Brinkley L,Grundy SM,Garg A

    更新日期:2007-12-01 00:00:00

  • Effects of gastric bypass surgery in patients with type 2 diabetes and only mild obesity.

    abstract:OBJECTIVE:Roux-en-Y gastric bypass (RYGB) ameliorates type 2 diabetes in severely obese patients through mechanisms beyond just weight loss, and it may benefit less obese diabetic patients. We determined the long-term impact of RYGB on patients with diabetes and only class I obesity. RESEARCH DESIGN AND METHODS:Sixty-...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-2289

    authors: Cohen RV,Pinheiro JC,Schiavon CA,Salles JE,Wajchenberg BL,Cummings DE

    更新日期:2012-07-01 00:00:00

  • Intraoral tactile sensitivity in adults with diabetes.

    abstract:OBJECTIVE:The intraoral tactile sensitivity (ITS) of diabetic and nondiabetic subjects was compared. The effects of age, ethnicity, sex, and intraoral site were considered. RESEARCH DESIGN AND METHODS:The sample comprised 589 participants of the Oral Health: San Antonio Longitudinal Study of Aging. A total of 107 subj...

    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/diacare.27.4.869

    authors: Shinkai RS,Hatch JP,Cornell JE,Yeh CK

    更新日期:2004-04-01 00:00:00