Treatment strategies for new-onset atrial fibrillation in critically ill patients: Protocol for a systematic review.

Abstract:

BACKGROUND:New-onset atrial fibrillation is frequent in critically ill patients and associated with poorer outcomes in these patients. Numerous interventions are used for the management of new-onset atrial fibrillation, but it is unknown if these interventions improve patient-important outcomes as compared with placebo or no active intervention in adult critically ill patients. METHODS/DESIGN:We will conduct a systematic review with meta-analysis and trial sequential analysis of randomized clinical trials assessing pharmacological and non-pharmacological interventions of new-onset atrial fibrillation as compared with placebo or no active intervention in adult critically ill patients. The primary outcomes are mortality, adverse events and health-related quality of life. We will search the following databases: MEDLINE, EMBASE, Cochrane Library, ClinicalTrials.gov, Science Citation Index and BIOSIS and follow the recommendations by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We will evaluate the overall certainty of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. DISCUSSION:New-onset atrial fibrillation is common in adult critically ill patients. However, the balance between the desirable and undesirable effects of pharmacological and non-pharmacological interventions is unknown. The outlined systematic review aims to provide updated data on this topic. REGISTRATION:Submitted to PROSPERO (CRD42020187178 ). Status: accepted.

authors

Wetterslev M,Granholm A,Haase N,Hassager C,Hylander Møller M,Perner A

doi

10.1111/aas.13672

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

1343-1349

issue

9

eissn

0001-5172

issn

1399-6576

journal_volume

64

pub_type

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