The differential diagnostic value of serum HE4 in ovarian disease with elevated CA125; importance of diagnostic added value in clinical practice.

Abstract:

:For clinical purposes, diagnostic added value of HE4 is important. Diagnostic knowledge is not provided by answering the question, "How accurate is this test?" (test accuracy research). Diagnostic knowledge is the information needed to answer the question, "What is the probability of the presence or absence of a specific disease given these test results?" (diagnostic accuracy research). Therefore, diagnostic added value of HE4 expression (differences of ROC curves for two diagnostic models with and without HE4) is important in clinical practice. Without assessing reliability, we cannot judge about diagnostic value. The diagnostic value is estimated by two parameters: reliability and accuracy.

journal_name

Arch Gynecol Obstet

authors

Sabour S

doi

10.1007/s00404-020-05681-5

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

1041-1042

issue

4

eissn

0932-0067

issn

1432-0711

pii

10.1007/s00404-020-05681-5

journal_volume

302

pub_type

评论,信件
  • Influence of age and human papillomavirus-infection on reliability of cervical cytopathology.

    abstract::The aim of the present study was to evaluate the effect of age and human papillomavirus (HPV) infection associated cellular changes on the predictive value of cervical cytology. In a group of 671 women with Papanicolaou smears suggesting low grade squamous intraepithelial lesion (LSIL), a high grade squamous intraepit...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/BF00634344

    authors: Kainz C,Tempfer C,Gitsch G,Heinzl H,Reinthaller A,Breitenecker G

    更新日期:1995-01-01 00:00:00

  • Anti-Mullerian Hormone: an indicator for the severity of polycystic ovarian syndrome.

    abstract:PURPOSE:Features of polycystic ovarian syndrome (PCOS) including sonographic aspects, androgens, LH and LH/FSH ratio as well as Anti-Mullerian Hormone (AMH) were evaluated according to their diagnostic potency in detecting different degrees of PCOS severity. METHODS:80 women with PCOS diagnosed according to the Rotter...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-014-3317-2

    authors: Köninger A,Koch L,Edimiris P,Enekwe A,Nagarajah J,Kasimir-Bauer S,Kimmig R,Strowitzki T,Schmidt B

    更新日期:2014-11-01 00:00:00

  • [New progestins in oral hormonal contraceptives].

    abstract::Three new progestins with a high gestagenic potency have been developed as derivatives of the levonorgestrel (in brackets: biological active substance in the human): desogestrel (3-keto-desogestrel), norgestimate (norgestimate), gestodene (gestodene). In combination with low dosages of ethinylestradiol (30-35 microgra...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,评审

    doi:10.1007/BF02417654

    authors: Runnebaum B,Rabe T

    更新日期:1989-01-01 00:00:00

  • The challenge of preoperative identification of uterine myomas: Is ultrasound trustworthy? A prospective cohort study.

    abstract:PURPOSE:To correlate preoperative ultrasound examination with intraoperative and anatomo-pathological findings, including estimation of number, localization and size of uterine myomas, uterine diameters and volume. METHODS:A prospective study on 126 women undergoing surgery for uterine myomatosis at Campus Bio-medico ...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-015-3937-1

    authors: Battista C,Capriglione S,Guzzo F,Luvero D,Sadun B,Cafà EV,Sereni MI,Terranova C,Plotti F,Angioli R

    更新日期:2016-06-01 00:00:00

  • Nucleotide variations in mitochondrial DNA and supra-physiological ROS levels in cytogenetically normal cases of premature ovarian insufficiency.

    abstract::Premature ovarian insufficiency (POI) is defined as the cessation of ovarian function under the age of 40 years and is characterized by amenorrhea, hypoestrogenism, and elevated serum gonadotrophin concentration (FSH). It is a heterogeneous disorder with a multicausal pathogenesis; however, majority of cases are idiop...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-010-1623-x

    authors: Kumar M,Pathak D,Kriplani A,Ammini AC,Talwar P,Dada R

    更新日期:2010-12-01 00:00:00

  • Maternal levels of vitamin E in normal and preeclamptic pregnancy.

    abstract::Vitamin E, a potent antioxidant, may play a role in preventing preeclampsia. Maternal blood samples were collected between 28 and 40 weeks' gestation from women with mild preeclampsia (n=17), women with severe preeclampsia (n=16) and the control group (n=15). This control group was consisted of 15 pregnant women witho...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s004040050271

    authors: Akyol D,Mungan T,Görkemli H,Nuhoglu G

    更新日期:2000-04-01 00:00:00

  • Current diagnostic modalities and clinical pitfalls in malignant secondary breast tumours.

    abstract::Breast cancer is the most common malignancy in women with increasing incidence. The occurrence of metastatic disease to the breast in both females and males is relatively rare, constituting 0.5-6% of all breast malignancies. The therapy of secondary breast cancer is usually completely different from that of primary ma...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00404-011-1904-z

    authors: Luedders DW,von Tengg-Kobligk H,Hornemann A,Thill M,Franke FE,Muenstedt K,Bohlmann MK

    更新日期:2011-09-01 00:00:00

  • Type-II endometrial cancer: role of adipokines.

    abstract:BACKGROUND:Type-II endometrial cancer is an estrogen independent and one of the most lethal types of cancer having poor prognosis. Adipokines play a crucial role in the triggering Type-II EMC. In addition, adipokines modulators, therefore, may have beneficial effects in the treatment of Type-II endometrial cancer, whic...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00404-019-05181-1

    authors: Garikapati KK,Ammu VVVRK,Krishnamurthy PT,Chintamaneni PK,Pindiprolu SKSS

    更新日期:2019-08-01 00:00:00

  • Chronic fatigue syndrome: a hormonal origin? A rare case of dysmenorrhea membranacea.

    abstract:BACKGROUND:Membranous dysmenorrhea is a rare entity involving expulsion of fragments of endometrium retaining the shape of the uterus. The condition is often linked to high progesterone levels. An association with a chronic fatigue syndrome was never described. CASE:A 44-year-old woman with a chronic fatigue syndrome ...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00404-008-0795-0

    authors: Veldman J,Van Houdenhove B,Verguts J

    更新日期:2009-05-01 00:00:00

  • Breast cancer patients' satisfaction with individual therapy goals and treatment in a standardized integrative medicine consultancy service.

    abstract:PURPOSE:Complementary medicine services are nowadays usually quite heterogeneous, and little information is available on standards for running an integrative medicine consultancy service. This study aimed to assess patients' satisfaction with a standardized treatment service on integrative medicine. METHODS:Using a cr...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-018-4779-4

    authors: Hack CC,Antoniadis S,Hackl J,Langemann H,Schwitulla J,Fasching PA,Beckmann MW,Theuser AK

    更新日期:2018-07-01 00:00:00

  • Maternal immunization by husband's leukocytes for repeated fetal death associated with mild pre-eclampsia--case report with successful outcome.

    abstract::We report a case of repeated fetal death at 31 gestational weeks associated with mild non-proteinuric pre-eclampsia and intrauterine growth retardation. After double intradermal immunisation with paternal leukocytes, a third pregnancy proceeded uneventfully until it ended at 38 weeks. Maternal anti-paternal blocking a...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/BF02389636

    authors: Steck T,Westphal E,Würfel W

    更新日期:1992-01-01 00:00:00

  • Jejunal obstruction due to rare internal hernia between skeletonized external iliac artery and vein as late complication of laparoscopic hysterectomy with pelvic lymphadenectomy-case report and review of literature.

    abstract:BACKGROUND:Internal herniation of small intestine in the lesser pelvis alongside iliac vasculature is a rare occurrence. Skeletonization of iliac vessels during pelvic lymph node dissection (LND), as part of surgical staging or treatment of patients with uterine, ovarian or urogenital cancer, is a strict prerequisite f...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,评审

    doi:10.1007/s00404-020-05724-x

    authors: Frenzel F,Hollaender S,Fries P,Stroeder R,Stroeder J

    更新日期:2020-11-01 00:00:00

  • Conservative surgical treatment for early-stage vulvar malignant melanoma.

    abstract:PURPOSE:To investigate the efficacy of wide local excision as a surgical treatment for early-stage vulvar melanomas. METHODS:Wide local excision with or without lymph node dissection was performed in three patients with stage I vulvar melanoma (American Joint Committee on Cancer classification, 1992). RESULTS:All thr...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-009-1134-9

    authors: Nasu K,Kai Y,Ohishi M,Kato A,Sato H,Fujiwara S,Takai N,Narahara H

    更新日期:2010-02-01 00:00:00

  • [Assessing the extent of gynecologic tumors by a sonographic tumor score with special reference to ovarian cancer].

    abstract::Ultrasonic findings in 1317 operatively confirmed gynecological tumors were classified according to five degrees of homogeneity: I, clearly outlined solitary cysts; II, clearly outlined homogeneous tumors; III, poorly defined or slightly heterogeneous tumors; IV, marked heterogeneous tumors; V, completely heterogeneou...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/BF02417449

    authors: Schillinger H,Kliem M,Klosa W,Pohl J,Wilhelm C,Madjar H,Zalasa J

    更新日期:1989-01-01 00:00:00

  • Cetuximab monotherapy in advanced cervical cancer: a retrospective study with five patients.

    abstract:OBJECTIVE:Effective cytotoxic treatment options for advanced cervical cancer are exceedingly limited. Therefore, interest has increased in targeted therapeutics for the treatment of cervical cancer. Cetuximab, a monoclonal antibody, binds specifically to the epidermal growth factor receptor (EGFR) and competitively inh...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-010-1389-1

    authors: Hertlein L,Lenhard M,Kirschenhofer A,Kahlert S,Mayr D,Burges A,Friese K

    更新日期:2011-01-01 00:00:00

  • Retrospective study of outcome on vaginal and abdominal delivery in twin pregnancy in which twin 1 is presenting by the breech.

    abstract::We retrospectively reviewed the perinatal outcome of twin pregnancies cohere the first baby was presenting by the breech. 21 were delivered vaginally and 37 abdominally. Differences in perinatal outcome, as measured by Apgar score and mortality, were not apparently different. ...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s004040050201

    authors: Abu-Heija AT,Ziadeh S,Abukteish F,Obeidat A

    更新日期:1998-01-01 00:00:00

  • Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.

    abstract:BACKGROUND:Transversus abdominis plane (TAP) block has been shown to provide pain relief after abdominal procedures. However, TAP block combined with multimodal analgesia technique have not been assessed in a randomized controlled trial. This randomized, controlled, observer-blinded study was designed to evaluate the a...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00404-012-2698-3

    authors: Gasanova I,Grant E,Way M,Rosero EB,Joshi GP

    更新日期:2013-07-01 00:00:00

  • The role of vitamins in the etiology of cervical neoplasia: an epidemiological review.

    abstract::Diet may act as a cofactor in the development of cancer of the cervix. A consistent correlation exists between low tissue concentrations, low serum level, and low intake of vitamin A, beta-carotene, vitamin C, or folic acid and an increased prevalence of cervical neoplasia. A moderate effect is seen in clinical trials...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,评审

    doi:10.1007/BF00933072

    authors: Schneider A,Shah K

    更新日期:1989-01-01 00:00:00

  • OC-125 immunostaining in endometriotic lesion samples.

    abstract:PURPOSE:To determine the presence of OC-125 staining in endometriotic lesions and to verify whether there is an association with endometriosis stage. METHODS:Thirteen patients from the Family Planning programs (group I) and 53 patients from the Chronic Pelvic Pain outpatient clinic (group II) were studied. Endometriot...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-009-1055-7

    authors: Barbosa CP,de Souza AM,Bianco B,Christofolini DM,Mafra FA,de Lima GR

    更新日期:2010-01-01 00:00:00

  • Sexual functioning after total versus subtotal laparoscopic hysterectomy.

    abstract:AIM:To evaluate postoperative sexual functioning and the influence of patients' expectations on the change in sexuality following laparoscopic total (TLH) versus subtotal hysterectomy (LASH). METHODS:A total of 120 women undergoing laparoscopic hysterectomy were preoperatively enrolled in this bicentric prospective st...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-018-4812-7

    authors: Berlit S,Tuschy B,Wuhrer A,Jürgens S,Buchweitz O,Kircher AT,Sütterlin M,Lis S,Hornemann A

    更新日期:2018-08-01 00:00:00

  • Factors affecting the live-birth rate in women with diminished ovarian reserve undergoing IVF-ET.

    abstract:PURPOSE:The occurrence of diminished ovarian reserve (DOR) in women was growing in recent years. Although in vitro fertilization and embryo transfer (IVF-ET) became an effective treatment for DOR, the live-birth (LB) rate remains unsatisfactory. This study aimed to investigate the impact factors of LB rate in women wit...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-018-4884-4

    authors: Huang Y,Li J,Zhang F,Liu Y,Xu G,Guo J,Zhang R,Wu Y,Liu J,Chen K,Zhao W,Wu W,Hu Y,Chen G,Zhang D

    更新日期:2018-11-01 00:00:00

  • Vulvar pilonidal sinuses: treatment of a rare cause of vulvar pain.

    abstract::It is hoped that if cases of vulvar pilonidal sinus (PS) are known to readers of this article, they will be called to the writer's attention and that further studies of the origin and cause of these anterior pathologic developments will result. A delay in diagnosis and treatment of this relatively harmless condition c...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-008-0612-9

    authors: Kafali H,Duvan CI,Bayrak R,Turhan NO

    更新日期:2008-11-01 00:00:00

  • Factors inducing decreased oocyte maturation rate: a retrospective analysis of 20,939 ICSI cycles.

    abstract:PURPOSE:Decreased oocyte maturation rate (OMR) is associated with worse clinical outcomes in IVF/ICSI cycles. The clinical features inducing decreased OMR remain unknown. The study is designed to explore the factors influencing the incidence of decreased OMR and its effects on clinical outcomes. METHODS:This is a retr...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-018-4958-3

    authors: Lin Y,Yang P,Chen Y,Zhu J,Zhang X,Ma C

    更新日期:2019-02-01 00:00:00

  • The Na+/K+ co-transport system in erythrocytes from pregnant patients.

    abstract::In erythrocytes, the extrusion of a cellular sodium level load is accomplished by the Ouabain--sensitive Na+/K+ pump and by the furosemide-sensitive Na+/K(+)--cotransport, which operates against the passive sodium permeability. An abnormal low rate of net sodium extrusion by the Na+/K+ cotransport was observed in pre-...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/BF02766642

    authors: Heilmann L,von Tempelhoff GF,Ulrich S

    更新日期:1993-01-01 00:00:00

  • HCMV seroprevalence in couples under infertility treatment.

    abstract:PURPOSE:Congenital HCMV infection affects about 0.5-0.9 % of newborns in Europe. Primary prevention could effectively be implemented in screening programmes for couples treated for infertility. By supplying epidemiological data, the proportion of women susceptible to primary HCMV infection is estimated. METHODS:Retros...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-015-3640-2

    authors: Kling C,Kabelitz D

    更新日期:2015-08-01 00:00:00

  • Expression and localization of CXCL16 and CXCR6 in ovarian endometriotic tissues.

    abstract:PURPOSE:Inflammatory mediators, including chemokines, may play crucial roles in the development of endometriosis. Therefore, we investigated the expression and localization of CXCL16 and its receptor, CXCR6, in ovarian endometriotic tissues. We also examined whether CXCL16 induces IL-8 production in endometriotic strom...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-011-2002-y

    authors: Manabe S,Iwase A,Goto M,Kobayashi H,Takikawa S,Nagatomo Y,Nakahara T,Bayasula,Nakamura T,Hirokawa W,Kikkawa F

    更新日期:2011-12-01 00:00:00

  • Indication of prophylactic vaccines as a tool for secondary prevention in HPV-linked disease.

    abstract:PURPOSE:To determine whether quadrivalent HPV vaccination is effective in reducing recurrent disease in women with a previous history of HPV disease. METHODS:All women under 45 years of age treated for HPV-linked disease and with negative HPV test, cytology and colposcopy 3 months after treatment were enrolled. Women ...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00404-018-4926-y

    authors: Pieralli A,Bianchi C,Auzzi N,Fallani MG,Bussani C,Fambrini M,Cariti G,Scarselli G,Petraglia F,Ghelardi A

    更新日期:2018-12-01 00:00:00

  • Calcitonin gene- and parathyroid hormone-related peptides in normotensive and preeclamptic pregnancies: a nested case-control study.

    abstract:PURPOSE:To identify whether CGRP and PTHrP serve as screening biomarkers for early detection of preeclampsia or even before the development of preeclampsia in early pregnancy. METHODS:It was a nested case-control study. The subjects were divided into normotensive (controls) and preeclamptic (cases) groups. Serum sampl...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-014-3303-8

    authors: Yadav S,Yadav YS,Goel MM,Singh U,Natu SM,Negi MP

    更新日期:2014-11-01 00:00:00

  • Pseudo-Meig's syndrome with multiple synchronous benign and malignant pelvic tumors.

    abstract:BACKGROUND:Meig's and Pseudo-Meig's syndromes have been reported in association with several malignancies but the concomitant existence of multiple synchronous benign and malignant tumors in association with Pseudo-Meigs' syndrome has not been reported in the published literature. CASE:A 55-year old African American w...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-005-0052-8

    authors: Junaid I,Paz R,Salihu HM,Sharma PP,Aliyu ZY

    更新日期:2006-02-01 00:00:00

  • Advanced age is a risk factor for higher grade perineal lacerations during delivery in nulliparous women.

    abstract:PURPOSE:To identify risk factors for the development of severe perineal lacerations and to give recommendations for their prevention in nulliparous women. METHODS:A retrospective case-control analysis of deliveries at our University Hospital was performed. Multiparae, Caesarean sections, twin pregnancies, fetal breech...

    journal_title:Archives of gynecology and obstetrics

    pub_type: 杂志文章

    doi:10.1007/s00404-009-1063-7

    authors: Hornemann A,Kamischke A,Luedders DW,Beyer DA,Diedrich K,Bohlmann MK

    更新日期:2010-01-01 00:00:00