Abstract：
OBJECTIVE:To summarize the existing evidence on the efficacy of artemether and arteether, two artemisinin derivatives, versus quinine for treating cerebral malaria in children. METHODS:We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and the http://clinicaltrials.gov web site. We also checked the reference lists of existing systematic reviews and of all trials identified by the above methods. We searched exclusively for randomized controlled trials (RCTs) comparing artemether/arteether with quinine for treating cerebral malaria in children. Two independent reviewers assessed study eligibility and trial quality and extracted the data. FINDINGS:Nine RCTs were included in the analysis, and all were from Africa. Five had adequate allocation concealment. Seven trials compared artemether with quinine (1220 children), and two compared arteether with quinine (194 children). No statistically significant difference was found between artemisinin derivatives and quinine in preventing mortality (relative risk, RR: 0.91; 95% confidence interval, CI: 0.73-1.14; I(2): 0%). The quality of the evidence, as assessed by the Grade evidence profile, was moderate. The only serious adverse event was seen in a patient in the quinine group who developed fatal black water fever. CONCLUSION:Artemisinin derivatives are not inferior to quinine in preventing death in children with cerebral malaria.
journal_name
Bull World Health Organjournal_title
Bulletin of the World Health Organizationauthors
Kyu HH,Fernández Edoi
10.2471/BLT.08.060327subject
Has Abstractpub_date
2009-12-01 00:00:00pages
896-904issue
12eissn
0042-9686issn
1564-0604journal_volume
87pub_type
杂志文章,评审abstract：:The mechanisms of dissemination of arthropod-borne human and animal pathogens are of considerable interest to the epidemiologist, veterinarian and biologist. Birds which are hosts to such pathogens and their arthropod vectors could transport them over long distances during their spring and autumn migratory flights.In ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1964-01-01 00:00:00
abstract：:Achieving universal health coverage (UHC) involves distributing resources, especially human resources for health (HRH), to match population needs. This paper explores the policy lessons on HRH from four countries that have achieved sustained improvements in UHC: Brazil, Ghana, Mexico and Thailand. Its purpose is to in...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.13.118729
更新日期：2013-11-01 00:00:00
abstract：PROBLEM:In many countries, the tuberculosis (TB) annual case detection rate is below the target of 70%. In the Lao People's Democratic Republic in 2005, it did not exceed 55% APPROACH:The DOTS strategy promotes passive case detection of TB. In order to increase the detection rate, we validated a questionnaire targetin...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/blt.06.038539
更新日期：2007-09-01 00:00:00
abstract：:A form of endemic syphilis exists in the Bakwena Reserve of the Bechuanaland Protectorate known by the local name of "dichuchwa". It is similar to bejel, njovera and the endemic syphilis reported elsewhere in the world. The Government of the Protectorate, with the assistance of WHO and UNICEF, began in November 1953 a...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1956-01-01 00:00:00
abstract：:As a basis for considering the forms and patterns of national committees on vital and health statistics in the future, the author first discusses the six main objectives of national systems of those statistics. Turning then to the aims of the national committees themselves, he observes that such is the variety of stat...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1954-01-01 00:00:00
abstract：:The basic problem in the study of tick-borne virus diseases is to establish where the virus is maintained in nature. In general, this focus will be found where there are large and relatively stable populations of ticks, small rodents and insectivores. In the Tribec region the principal vector of tick-borne encephaliti...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1967-01-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence and intensity of Schistosoma japonicum infection and associated morbidity, and to estimate the infected human and buffalo populations in the Dongting Lake region, Hunan province, China. METHODS:We used data from the third national schistosomiasis periodic epidemiological survey (P...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/blt.06.034033
更新日期：2007-07-01 00:00:00
abstract：:A large number of organisms such as viruses, protozoa, helminths, fungi and bacteria, especially mycobacteria, need cell-mediated immunological processes for their elimination. As well as being involved in protection, cell-mediated immunological processes are also involved in a number of allergic reactions to products...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.5935/0305-7518.19700030
更新日期：1969-01-01 00:00:00
abstract：OBJECTIVE:We aimed to determine the burden of bacillary dysentery in China, its cross-regional variations, trends in morbidity and mortality, the causative bacterial species and antimicrobial resistance patterns. METHODS:We extracted and integrated governmental statistics and relevant medical literature published from...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/blt.05.023853
更新日期：2006-07-01 00:00:00
abstract：:An extensive outbreak of Hong Kong influenza occurred in the USA during the autumn and early winter of 1968-69. Introduction and seeding of the virus occurred in September and early October as individuals returned from the Far East. Civilian outbreaks did not develop until late October and November. By 28 December, al...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1969-01-01 00:00:00
abstract：OBJECTIVES:To determine the extent to which families follow referral and follow-up recommendations given in accordance with the Integrated Management of Childhood Illnesses (IMCI) strategy and the factors that influence families' responses to such recommendations. METHODS:Children aged 2 months-5 years who presented t...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVE:To develop a tool for evaluating the risk that an outbreak of meningitis will occur in a particular district of the Niger after outbreaks have been reported in other, specified districts of the country. METHODS:A Bayesian network was represented by a graph composed of 38 nodes (one for each district in the N...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.11.086009
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:To quantify long-term health service use (HSU) following non-fatal injury in adults. METHODS:A retrospective, population-based, matched cohort study identified an inception cohort (1988-91) of injured people who had been hospitalized (ICD-9-CM 800-995) aged 18-64 years (n = 21 032) and a matched non-injured ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/blt.06.030833
更新日期：2006-10-01 00:00:00
abstract：:The availability of affordable medicines is a major barrier to providing high-quality health care in many countries. Fatima Suleman talks to Fiona Fleck. ...
journal_title：Bulletin of the World Health Organization
pub_type： 传,历史文章,新闻
doi：10.2471/BLT.17.031217
更新日期：2017-12-01 00:00:00
abstract：:Health care reform in Europe is discussed in the light of the Ljubljana Charter, with particular reference to progress made in Estonia and Lithuania. ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Some of the acute diarrhoeas of man are specific infectious diseases. Another and major proportion have no demonstrated infectious agent. No characteristic clinical pattern regularly distinguishes one specific disease entity from another, nor specific from non-specific infections, nor epidemic from endemic disease. Si...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1964-01-01 00:00:00
abstract：:Each of 87 strains of brucellae examined for its utilization of amino acid and carbohydrate substrates displayed a metabolic pattern that characterized it as to its species identity, irrespective of its serological and biochemical characters. Strains that displayed the metabolic pattern of Br. abortus were lysed by Br...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1962-01-01 00:00:00
abstract：:This literature review indicates that menstrual regulation during the fifth to seventh week of pregnancy is not always as free from risk as has sometimes been claimed. In particular, it has a higher failure rate, in terms of continued pregnancy, than has abortion by suction in later stages of pregnancy.Vacuum aspirati...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:The knowledge that domestic cats were susceptible to infection with freshly isolated A/Hong Kong/68 influenzavirus led to studies on the susceptibility of some other animal species to this virus, as well as to studies on the ability of egg-passaged Hong Kong virus and an Asian virus to infect cats. The ability of a re...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：:Based on studies carried out by the author and his associates in areas of Japan and South Asia where malayan and bancroftian filariasis is endemic, this paper recommends methods for use in microfilaria surveys and in the analysis of data obtained in such surveys. The author recommends the use of measured blood samples...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1967-01-01 00:00:00
abstract：:The effect of Plasmodium falciparum infection on the response to immunization with tetanus toxoid in pregnancy is of importance because malaria is more frequent and severe in pregnant women. This paper presents the results of a study in west Kenya of the antibody response to an adsorbed tetanus toxoid in primigravidae...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:This paper describes the preparation and test procedures for a second batch of lyophilized LBM combination antiserum pools, A through H, used for identifying 42 enteroviruses. Each pool is selectively composed of 10 or 11 of 42 individual enterovirus equine sera so that it contains 500 antibody units of each serum com...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:New initiatives are aiming to reduce the global burden of schistosomiasis, mainly through the large-scale application of chemotherapy. To target chemotherapy effectively, rapid assessment procedures are needed for identifying high-risk communities that are foci for the disease. In this review, we examine the developme...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:Described is a computer software package, EPIZOO, which has been developed specifically for undergraduate and postgraduate education, self-training, problem-solving, and simulation studies in veterinary epidemiology. The program is based on action-oriented animal population health/disease analyses and programming. EPI...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Chloroquine-resistant Plasmodium falciparum has been spreading rapidly after its emergence in 1988 in Yekepa. The in vivo and in vitro susceptibilities to quinine and quinidine, compared to chloroquine, were studied by investigating the number of treatment days required for radical cure and estimating the quinine conc...
journal_title：Bulletin of the World Health Organization
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1991-01-01 00:00:00
abstract：:At the request of the Ministry of Health of the USSR, a controlled field trial of a polyvaccine containing typhoid, paratyphoid and dysentery antigens and a purified tetanus toxoid was undertaken in 1958. The main object of this trial, which was carried out over a 10-month period simultaneously in four localities, was...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1962-01-01 00:00:00
abstract：:The clinical manifestations of acute poisoning by organophosphorus compounds in man are in accord with, initially, the stimulation and, later, the blocking of cholinergic transmission due to acetylcholinesterase inhibition. The manifestations involve mainly the para-sympathetic nerves, the neuromuscular junctions, and...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,评审
doi：
更新日期：1971-01-01 00:00:00
abstract：:Venereal diseases are known to occur most frequently in the age-groups of greatest sexual activity and more frequently among people in certain occupations (e.g., migrant labourers, military personnel and seafarers) than among the general population. The Brussels Agreement of 1924 and the great improvements in conditio...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1963-01-01 00:00:00
abstract：:The association between oral leukoplakia and possible etiological factors in patients at a Bombay hospital was analysed by a new multivariate computer analysis based on information theory. It was found that the most important etiological factors were bidi smoking and age. The well known sex-leukoplakia relationship wa...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1972-01-01 00:00:00
abstract：:The paper presents clinical observations on 1 233 persons with smallpox who were admitted to the Infectious Diseases Hospital, Calcutta, in 1973. The disease was of the modified type in 53 patients (4.3%), the ordinary type in 717 (58.2%), the flat type in 249 (20.2%), and the haemorrhagic type in 214 (17.3%). The fat...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
