Abstract：
:Introduction of 15-30 U of interleukin-2 (IL-2) into the 3rd ventricle of Wistar rats was followed by a marked and significant decrease in neuron discharge frequency in the ventromedial nucleus of hypothalamus and a marked increase in the supraoptic and paraventricular nuclei. The monoclonal antibody ART62 partly blocked these effects. The conventional anti-IL-2 receptor monoclonal antibody ART18 had only a non-significant influence on the effects of IL-2. Since the supraoptic and paraventricular nuclei secrete the antidiuretic hormone, their excitation may offer a partial explanation of the considerable water retention observed during IL-2 therapy against neoplasia.
journal_name
Brain Resjournal_title
Brain researchauthors
Bindoni M,Perciavalle V,Berretta S,Belluardo N,Diamantstein Tdoi
10.1016/0006-8993(88)90578-1subject
Has Abstractpub_date
1988-10-11 00:00:00pages
10-4issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(88)90578-1journal_volume
462pub_type
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