Abstract:
BACKGROUND:Recent studies show that contrast-enhanced ultrasonography (CEUS) using SonoVue has the potential to improve the performance of sentinel lymph node biopsy (SLNB) in patients with early breast cancer. However, the evidence of SLNB using CEUS in patients converting from cN1 to cN0 after neoadjuvant chemotherapy (NAC) is lacking. The aim of this prospective study is to evaluate the feasibility of CEUS using SonoVue for the identification of sentinel lymph node (SLN) and the value of the combination of CEUS and blue dye (BD) for SLNB in patients converting from cN1 to cN0 following NAC. METHODS:Patients with cytology-proven node positive breast cancer at the initial diagnosis (stage T1-T3N1M0) from January 2018 to January 2019, underwent NAC. Patients converting from cN1 to cN0 following NAC were enrolled and randomized into two groups for SLNB: the combination method group using CEUS and BD together, and the single BD method group. Then all patients underwent complete axillary lymph node dissection (ALND) and primary breast surgery. Compared with the final pathological results, the identification rate, sensitivity, specificity, accuracy, false negative rate, negative predictive value, positive predictive value were recorded and compared between two methods. RESULTS:A total of 400 patients with stage T1-T3N1M0 disease underwent NAC between January 2018 to January 2019, among which 134 (33.5%) patients had clinically negative node confirmed by imaging after NAC and randomized into two groups. Each group included 67 cases. In the combination method group, contrast-enhanced lymphatic vessels in 66 cases of 67 were clearly visualized by US soon after the periareolar injection of SonoVue and the SLNs were accurately localized. The identification rate of the combination method was 98.5%%, which was significantly higher than 83.6% (56/67) using the single BD method. The mean numbers of SLNs identified by the combination method was higher than that by the single BD method. Compared with pathological diagnosis, sensitivity, specificity, accuracy, the positive predictive value, the negative predictive value, and the FNR of the combingation method were 84.4%, 100%, 89.4%, 100%, 75%, and 15.6%, respectively. In contrast, sensitivity, specificity, accuracy, the positive predictive value, the negative predictive value, and the FNR using single blue dye were 73.9%, 100%, 89.3%, 100%, 84.6%, and 26.1%, respectively. The FNR using the combination method was significantly lower than that using single BD. CONCLUSION:Identification of SLNs in patients converting from cN1 to cN0 following NAC by CEUS is a technically feasible. The combination of CEUS and BD is more effective than BD alone for SLNB in patients converting from cN1 to cN0 following NAC.
journal_name
Arch Gynecol Obstetjournal_title
Archives of gynecology and obstetricsauthors
Wu X,Tang L,Huang W,Huang S,Peng W,Hu Ddoi
10.1007/s00404-020-05646-8subject
Has Abstractpub_date
2020-09-01 00:00:00pages
685-692issue
3eissn
0932-0067issn
1432-0711pii
10.1007/s00404-020-05646-8journal_volume
302pub_type
杂志文章abstract::The aim of this study was to evaluate the relationship between the vascular resistance in uterine arteries and the maternal release of adenosine and endothelin-1 in twin gestations with and without preeclampsia. Uterine artery Doppler velocimetry and maternal arterial blood sampling were performed in 14 women with nor...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-001-0283-2
更新日期:2002-12-01 00:00:00
abstract:PURPOSE:To evaluate the clinical efficacy of letrozole on ovulation induction and hormone replacement therapy (HRT) during endometrial preparation for frozen-thawed embryo transfer (FET). METHODS:We analyzed totally 1,230 cycles of patients that underwent FET from October 2010 to September 2012. Seven hundred and thir...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00404-013-3044-0
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:To evaluate the clinical outcomes after fresh transfer of blastocysts cultured from vitrified-thawed cleavage embryos (VTCE) compared with conventional frozen-thawed blastocysts transfer (FBT), or with the usual fresh blastocysts transfer (FRBT). METHODS:A total of 155 cycles undergoing fresh transfer of VTCE ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-019-05236-3
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:Postpartum depression (PPD) stands out as an important health issue that affects not only the mother but her partner and the entire family. A few studies from Turkey have found the high prevalence for PPD. In the current study we aimed: (1) to report the prevalence of postpartum depression among Turkish women i...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-010-1402-8
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:Our objective was to review the hysterectomies performed in our clinic for the last 17 years to reveal the facts in relation to the operation. MATERIALS AND METHODS:The records of the patients who had undergone hysterectomy in Istanbul University Cerrahpasa School of Medicine Department of Obstetrics and Gyn...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-003-0546-1
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:The management of ovarian cancer during pregnancy represents a major challenge and requires close multidisciplinary team approach. CASE:A 35-year-old pregnant woman with a yolk sac tumor underwent left salpingo-oophorectomy at 25 weeks of gestation. Chemotherapy was deferred to the end of the pregnancy owin...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-009-0977-4
更新日期:2009-11-01 00:00:00
abstract:INTRODUCTION:Polycystic ovary syndrome (PCOS) is a disorder associated with insulin resistance and obesity. Aim of our study is to clarify the prevalence of underweight in PCOS patients and whether metabolic and androgen profiles of PCOS differ depending on normal or low body weight. METHODS:Out of 1269 consecutive pa...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-017-4422-9
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to estimate the percentage of patients with metastatic ovarian, fallopian tube, and primary peritoneal cancer requiring ultra-radical surgery to achieve cytoreduction to less than 1 cm (optimal) or no macroscopic residual disease (complete). METHODS:Perioperative data were collected ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-016-4265-9
更新日期:2017-03-01 00:00:00
abstract::Gastrointestinal stromal tumors (GISTs) of the rectum are rare, and their clinical manifestations are variable. We report the case of a 23-year-old woman who was referred complaining of dyspareunia during coitus. We performed digital vaginal and rectal investigations, ultrasound, colonoscopy, and computed tomography. ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-009-1102-4
更新日期:2010-01-01 00:00:00
abstract::In the original version of this article contained an error in figure 1. It was provided in German. ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00404-018-4785-6
更新日期:2018-07-01 00:00:00
abstract:INTRODUCTION:Conization of the uterine cervix is a common gynecological procedure that sometimes causes cervical stenosis which creates difficulties for future gynecological procedures. MATERIAL:We present a very unusual case where strenuous effort was needed to obtain safe access to the endocervical canal and endomet...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-010-1832-3
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy and safety of intravenous ferric carboxymaltose administration to pregnant women with varying severities of iron deficiency anemia and iron deficiency without anemia. METHODS:In this prospective observational study of local obstetric practice, we analyzed data from 863 pregnant women w...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-018-4782-9
更新日期:2018-07-01 00:00:00
abstract::Posthysterectomy ectopic pregnancy is an unusual condition that may present soon after hysterectomy or several years later. Similarly, although tubal ligation is a widespread method of contraception, tubal pregnancy after tubal ligation is not common either. If any of these conditions are rare, having an ectopic pregn...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-008-0645-0
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:Normal labor curves have not been assessed for women undergoing a trial of labor after cesarean delivery (TOLAC). This study examined labor patterns during TOLAC in relation to epidural analgesia use. METHODS:Retrospective cohort study of deliveries of women undergoing TOLAC at a single, academic, tertiary med...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-018-4956-5
更新日期:2019-01-01 00:00:00
abstract::Ectopic pregnancy is the gynaecological emergency par excellence and remains the leading cause of pregnancy-related first trimester deaths in the UK. Its prevalence continues to rise because of increases in the incidence of the risk factors predisposing to ectopic pregnancy. Classically, the diagnosis is based on a hi...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-008-0731-3
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the effectiveness of Metformin on ovulation and eventual clinical pregnancy in different phenotypes of polycystic ovary syndrome (PCOS). MATERIALS AND METHODS:A total of 359 subjects who had proven PCOS according to Rotterdam criteria were prospectively selected. Patien...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00404-013-2800-5
更新日期:2013-11-01 00:00:00
abstract::Long-term treatment of the estrogen sensitive human breast cancer cell line EFM-19 with the antiestrogenic compound Tamoxifen resulted in a variant line EFM-19 T, which was stimulated by Tamoxifen. Estrogen receptor analysis by radioligand assay (charcoal method), revealed a 2.5 fold higher receptor concentration in E...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/BF02767330
更新日期:1993-01-01 00:00:00
abstract:AIMS:Postoperative seroma is the most frequent sequelae after mastectomy and axillary surgery with no optimal regimens for seroma resolution recommended in routine clinical. Indwelling cannulas with needle and catheter have been widely used in long-term medication therapies, but evidence of indwelling cannulas in serom...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00404-019-05396-2
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:Fetal akinesia deformation sequence (FADS) is a clinically and genetically heterogenous disorder. In this study, the different sonographic abnormalities are described in a larger number of affected fetuses. METHODS:This retrospective study included 79 cases of suspected FADS observed in our tertiary referral c...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-016-4017-x
更新日期:2016-10-01 00:00:00
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journal_title:Archives of gynecology and obstetrics
pub_type: 临床试验,杂志文章
doi:10.1007/s00404-008-0921-z
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:Research of psychological factors associated with imminent preterm labor (PTL) is sparse, compared with considerable research of preterm birth. We explored state and trait psychological variables associated with PTL, both pre- and postpartum. METHODS:During 2012-2014, 56 women hospitalized due to PTL, and 33 p...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-015-3898-4
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:Zygote intrafallopian transfer (ZIFT) is an effective option for patients who have experienced repeated implantation failures (RIF) in assisted reproductive technology (ART) treatment. However, advance planning for the day of the operation can be problematic. Using a hormone replacement cycle (HRC) makes it pos...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-014-3324-3
更新日期:2014-11-01 00:00:00
abstract::The prevalence of cerebral palsy (CP) has increased over the last 15 years in most countries. This is explained by an improved survival of very low birth weight prematures. In term infants birth asphyxia is of minor significance as a cause for CP. In only 10% of all CP cases following delivery at term, birth asphyxia ...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract::Samples of 40 endometrial carcinomas were examined by immunohistochemical methods for CA19-9, CA125 and CEA. CA19-9 was detected in 93%, CA125 in 65% and CEA in 58%. CA19-9 was detected in more than 50% of tumor cells in 14 cases and the same was true for CA125 in six cases. In no tumor was CEA found in more than half...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/BF00931402
更新日期:1988-01-01 00:00:00
abstract::Breast cancer is the most common malignancy in women with increasing incidence. The occurrence of metastatic disease to the breast in both females and males is relatively rare, constituting 0.5-6% of all breast malignancies. The therapy of secondary breast cancer is usually completely different from that of primary ma...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,评审
doi:10.1007/s00404-011-1904-z
更新日期:2011-09-01 00:00:00
abstract:PURPOSE:To analyze whether pelvic floor muscle training (PFMT) associated with weight loss (WL) is better than isolated PFMT to provide additional beneficial effects to urinary symptoms in women with MUI. METHODS:A randomized, simple-blind parallel controlled trial was performed and included women with MUI aged betwee...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00404-019-05319-1
更新日期:2019-11-01 00:00:00
abstract:PURPOSE:Wolf-Hirschhorn syndrome (WHS) is a contiguous gene syndrome due to terminal chromosome 4p deletions. We explored prenatal diagnosis of WHS by ultrasound as well as karyotype and single nucleotide polymorphism array (SNP array) to characterize the structural variants of WHS prenatally. METHODS:Ten prenatal cas...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-018-4798-1
更新日期:2018-08-01 00:00:00
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journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/s00404-013-2930-9
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVES:To compare the effects of letrozole and clomiphene citrate (CC) on endometrial response in PCOS using subendometrial spiral artery Doppler. METHODS:Fifty consecutive patients of anovulatory PCOS were recruited. Twenty-five patients (58 cycles) received 2.5-5 mg of letrozole; 25 patients (56 cycles) received...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00404-008-0714-4
更新日期:2009-03-01 00:00:00
abstract::We examined cytological vaginal smears of 17 women before and after three months of dermal estrogen (1 g of 0.01% estradiol ointment or 0.3% estriol ointment once daily), applied to the face for dermatological indications. The mean age was 57.1 +/- 7.6 years (range from 46 to 66). Seven women had estrogenic smears (mo...
journal_title:Archives of gynecology and obstetrics
pub_type: 杂志文章
doi:10.1007/BF02768732
更新日期:1993-01-01 00:00:00