Endothelial heterogeneity associated with regional athero-susceptibility and adaptation to disturbed blood flow in vivo.

Abstract:

:Endothelial phenotypic heterogeneity plays an important role in the susceptibility of the cardiovascular system to disease. Arteries and heart valves are susceptible to chronic inflammatory disease in regions of blood flow disturbance that implicates hemodynamic forces and transport characteristics as prominent influences on endothelial phenotype. By combining in vivo high-throughput genomics (discovery science) and in vitro mechanistic approaches (reductionist science), we present endothelial patho-susceptibility as an imbalance of multiple interrelated pathways that sensitize the cells to pathological change. The recently identified association of endoplasmic reticulum stress with endothelium in regions of flow disturbance is outlined as an important example of susceptible phenotype linked to proinflammatory and oxidative stress pathways.

journal_name

Semin Thromb Hemost

authors

Davies PF,Civelek M,Fang Y,Guerraty MA,Passerini AG

doi

10.1055/s-0030-1253449

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

265-75

issue

3

eissn

0094-6176

issn

1098-9064

journal_volume

36

pub_type

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