Glycerophospholipid profile alterations are associated with murine muscle-wasting phenotype.

Abstract:

INTRODUCTION:Phospholipids are essential components of cellular membranes and are closely associated with cellular functions, but relationships involving skeletal muscle phospholipid profiles and their physiological phenotypes have remained unclear. METHODS:We carried out comprehensive phospholipid analyses using liquid chromatography-tandem mass spectrometry to determine the phospholipid profiles of skeletal muscles derived from muscle-wasting mouse models, including denervated and Duchenne muscular dystrophy mouse models (mdx) as well as rescued mdx mice expressing truncated dystrophin. RESULTS:Consistent phosphatidylcholine and phosphatidylethanolamine alterations in skeletal muscles isolated from denervated and mdx mice were observed. Notably, the levels of these phospholipids binding polyunsaturated fatty acids were reduced in denervated and mdx muscles. Moreover, rescuing the mdx pathology by expressing truncated dystrophin led to the restoration of phospholipid profiles. DISCUSSION:Our findings support the hypothesis that phospholipid profiles of the skeletal muscle may be associated with skeletal muscle function.

journal_name

Muscle Nerve

journal_title

Muscle & nerve

authors

Senoo N,Miyoshi N,Kobayashi E,Morita A,Tanihata J,Takeda S,Miura S

doi

10.1002/mus.26993

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

413-418

issue

3

eissn

0148-639X

issn

1097-4598

journal_volume

62

pub_type

杂志文章
  • Direct spinal stimulation for intraoperative monitoring during scoliosis surgery.

    abstract::Intraoperative electrophysiological monitoring of the spinal cord has traditionally been done by recording somatosensory evoked potentials (SEP). There is a risk that SEPs can be unaltered when significant injury to the anterior spinal cord has occurred. The purpose of this report is to describe a simple technique for...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880180309

    authors: Phillips LH 2nd,Blanco JS,Sussman MD

    更新日期:1995-03-01 00:00:00

  • Quantitative evaluation of hand motor function using a gyrosensor in mild and moderate carpal tunnel syndrome.

    abstract:INTRODUCTION:The objective of this study was to determine whether patients with carpal tunnel syndrome (CTS) manifest changes in early-stage motor function and to investigate the utility of a gyrosensor for quantitative evaluation of motor function. METHODS:Angular velocity signal was measured during finger tapping in...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26424

    authors: Seok HY,Kim JW,Kim YH,Park MH,Kwon DY

    更新日期:2019-04-01 00:00:00

  • Stem cell route to neuromuscular therapies.

    abstract::As applied to skeletal muscle, stem cell therapy is a reincarnation of myoblast transfer therapy that has resulted from recent advances in the cell biology of skeletal muscle. Both strategies envisage the reconstruction of damaged muscle from its precursors, but stem cell therapy employs precursors that are earlier in...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.10243

    authors: Partridge TA

    更新日期:2003-02-01 00:00:00

  • Experimental investigation of muscular neurotization in the rat.

    abstract::Reinnervation of a free muscle graft by nerves from an adjacent intact muscle is called muscular neurotization. This paper investigates the mechanisms and stimuli responsible for muscular neurotization in the rat. Sternohyoid or sternomastoid muscles were transplanted as free muscle grafts to the ventral surface of an...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880100607

    authors: Must R

    更新日期:1987-07-01 00:00:00

  • Quantitative muscle ultrasound in upper extremity mononeuropathies.

    abstract:INTRODUCTION:We assessed the potential use of quantitative ultrasound (QUS) in the evaluation hand muscles affected by upper extremity mononeuropathies. METHODS:The gray scale levels (GSLs) of abductor pollicis brevis (APB), abductor digiti minimi (ADM), and first dorsal interosseous (FDI) of 30 healthy and 30 upper e...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26481

    authors: Wang Y,Gutierrez H,Martucci M,Poussaint A,Qi K,Sanchez B,Rutkove SB

    更新日期:2019-07-01 00:00:00

  • Muscle activation of the quadriceps and hamstrings during incremental running.

    abstract:INTRODUCTION:The aim of this study was to determine the patterns of responses for the electromyographic (EMG) amplitude vs. oxygen uptake ( V̇O2 ) relationships from muscles of the quadriceps femoris and hamstrings during incremental treadmill running. METHODS:Twelve men volunteered to perform an incremental test to e...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24901

    authors: Camic CL,Kovacs AJ,Enquist EA,McLain TA,Hill EC

    更新日期:2015-12-01 00:00:00

  • Repeatability, consistency, and accuracy of hand-held dynamometry with and without fixation for measuring ankle plantarflexion strength in healthy adolescents and adults.

    abstract:INTRODUCTION:Hand-held dynamometry (HHD) is commonly used to measure ankle plantarflexion strength but has variable reliability measuring higher forces. Fixed HHD is suggested to improve reliability. We, therefore, compared the reliability, consistency, and accuracy of measuring plantarflexion strength. METHODS:Planta...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.25576

    authors: Davis PR,McKay MJ,Baldwin JN,Burns J,Pareyson D,Rose KJ

    更新日期:2017-11-01 00:00:00

  • Genetic variability and clinical spectrum of Chinese patients with limb-girdle muscular dystrophy type 2A.

    abstract:INTRODUCTION:Previous studies of limb-girdle muscular dystrophy type 2A (LGMD2A) patients in many countries have suggested a heterogeneous genetic and clinical spectrum, but the genotypes and phenotypes of Chinese LGMD2A patients remain unclear. METHODS:We directly screened calpain-3 (CAPN3) in 18 Chinese Han subjects...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.23381

    authors: Luo SS,Xi JY,Zhu WH,Zhao CB,Lu JH,Lin J,Wang Y,Lu J,Qiao K

    更新日期:2012-11-01 00:00:00

  • Comparison of neuromuscular blockade and recovery with botulinum toxins A and F.

    abstract::Intramuscular injection of botulinum toxin A is used to treat focal dystonias. Because immunoresistance has been documented in some patients, other molecular forms of the toxin have been evaluated clinically. The present investigation compared the time course and extent of neuromuscular blockade and recovery of botuli...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.10213

    authors: Billante CR,Zealear DL,Billante M,Reyes JH,Sant'Anna G,Rodriguez R,Stone RE Jr

    更新日期:2002-09-01 00:00:00

  • Vibration injury damages arterial endothelial cells.

    abstract::Prolonged exposure to hand-transmitted vibration can cause debilitating neural and vascular dysfunction in humans. It is unclear whether the pathophysiology involves simultaneous or sequential injury of arteries and nerves. The mechanism of vibration injury was investigated in a rat tail model, containing arteries and...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.10058

    authors: Curry BD,Bain JL,Yan JG,Zhang LL,Yamaguchi M,Matloub HS,Riley DA

    更新日期:2002-04-01 00:00:00

  • In vivo bioluminescent imaging of Schwann cells in a poly(DL-lactide-epsilon-caprolactone) nerve guide.

    abstract::Nerve guides seeded with Schwann cells (SCs) promote axonal regeneration in peripheral nerve lesions. We examined the applicability of bioluminescent imaging (BLI) for monitoring the fate of SCs in nerve guides after implantation. Rat SCs were transfected with the firefly luciferase (Fluc) gene and subsequently seeded...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.21372

    authors: Ma MS,Van Dam G,Meek M,Boddeke E,Copray S

    更新日期:2009-11-01 00:00:00

  • Burden of hereditary transthyretin amyloidosis on quality of life.

    abstract:INTRODUCTION:Hereditary transthyretin (hATTR) amyloidosis is a progressive, degenerative disease, with peripheral neuropathy, cardiomyopathy, and other clinical manifestations. In this study we examine the impact of hATTR amyloidosis on quality of life (QOL). METHODS:Neuropathy-specific QOL, measured with the Norfolk ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26515

    authors: Yarlas A,Gertz MA,Dasgupta NR,Obici L,Pollock M,Ackermann EJ,Lovley A,Kessler AS,Patel PA,White MK,Guthrie SD

    更新日期:2019-08-01 00:00:00

  • Interaction of monoclonal antibodies to Torpedo acetylcholine receptor with the receptor of skeletal muscle.

    abstract::Several monoclonal antibodies (mcAbs) elicited against the nicotinic acetylcholine receptor (AChR) from Torpedo react also with skeletal muscle AChR. Such mcAbs were used to define antigenic determinants on muscle AChR and to elucidate their effect on muscle AChR functions. Primary chick muscle cultures were used as a...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880060410

    authors: Souroujon MC,Mochly-Rosen D,Gordon AS,Fuchs S

    更新日期:1983-05-01 00:00:00

  • Molecular indicators of denervation in aging human skeletal muscle.

    abstract:INTRODUCTION:Muscle fiber denervation increases with age, yet studies at the tissue level are sparse due to the challenging nature of establishing the relative role of regeneration and denervation. METHODS:Muscle biopsies were obtained from the vastus lateralis of 70 healthy men (aged 72 ± 6 years; range, 65-94). Mess...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26638

    authors: Soendenbroe C,Heisterberg MF,Schjerling P,Karlsen A,Kjaer M,Andersen JL,Mackey AL

    更新日期:2019-10-01 00:00:00

  • Slow-type C-protein in dystrophic chicken fast pectoralis muscle.

    abstract::C-protein isoform expression in hereditary dystrophic chicken skeletal muscle was compared with that in normal chicken muscle during postnatal development by immunocytochemical and immunoblot methods. In the pectoralis muscle (PM) of both normal and dystrophic chicken, slow- and fast-type C-proteins were coexpressed i...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880100412

    authors: Obinata T,Shinbo K

    更新日期:1987-05-01 00:00:00

  • Molecular architecture of the neuromuscular junction.

    abstract::The neuromuscular junction (NMJ) is a complex structure that serves to efficiently communicate the electrical impulse from the motor neuron to the skeletal muscle to signal contraction. Over the last 200 years, technological advances in microscopy allowed visualization of the existence of a gap between the motor neuro...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/mus.20440

    authors: Hughes BW,Kusner LL,Kaminski HJ

    更新日期:2006-04-01 00:00:00

  • Assessment of upper and lower motor neurons in Kennedy's disease: implications for corticomotoneuronal PSTH studies.

    abstract::We used peristimulus time histograms (PSTHs) to estimate characteristics of the composite excitatory postsynaptic potentials (EPSPs) generated at the anterior horn cell by a descending cortical volley induced by subthreshold transcranial magnetic stimuli in 11 normal subjects, 9 patients with DNA-confirmed Kennedy's d...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-4598(199903)22:3<299::aid-mus2>

    authors: Weber M,Eisen A

    更新日期:1999-03-01 00:00:00

  • The tarsal tunnel syndrome.

    abstract::Tarsal tunnel syndrome is relatively rare and the diagnosis may be difficult even though the etiologies for the syndrome are multiple. The symptoms are often vague but are usually burning pain and paresthesias in the toes and soles of the feet with nocturnal exacerbations. The physical examination may elicit a sensory...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880060908

    authors: DeLisa JA,Saeed MA

    更新日期:1983-11-01 00:00:00

  • Prolonged erythropoietin treatment does not impact gene expression in human skeletal muscle.

    abstract:INTRODUCTION:We tested for the presence of erythropoietin receptor (Epo-R) in human skeletal muscle and alterations in gene expression after prolonged use of an erythropoiesis-stimulating agent (ESA). METHODS:Nine healthy men were treated with ESA for 10 weeks (darbepoietin alfa). Muscle biopsies were collected before...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24355

    authors: Christensen B,Nellemann B,Thorsen K,Nielsen MM,Pedersen SB,Ornstrup MJ,JØrgensen JO,Jessen N

    更新日期:2015-04-01 00:00:00

  • An 8-generation family with X-linked Charcot-Marie-Tooth: Confirmation Of the pathogenicity Of a 3' untranslated region mutation in GJB1 and its clinical features.

    abstract:INTRODUCTION:Mutations in gap junction protein beta 1 (GJB1) on the X chromosome represent one of the most common causes of hereditary neuropathy. We assessed manifestations associated with a rare 3' untranslated region mutation (UTR) of GJB1 in a large family with X-linked Charcot-Marie-Tooth disease (CMTX). METHODS:...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.26037

    authors: Chen DH,Ma M,Scavina M,Blue E,Wolff J,Karna P,Dorschner MO,Raskind WH,Bird TD

    更新日期:2018-05-01 00:00:00

  • Congenital cervical spinal atrophy.

    abstract::Three children presented at birth with axial hypotonia and symmetrical flaccid paresis limited to the upper extremities, and involving proximal and distal muscle groups. At birth, palmar flexion creases were poorly developed, and the hand muscles were atrophic. These clinical features, the muscle biopsy findings, and ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880040205

    authors: Darwish H,Sarnat H,Archer C,Brownell K,Kotagal S

    更新日期:1981-03-01 00:00:00

  • Polyradiculopathy in sarcoidosis.

    abstract::We present three new and 14 retrospective cases of polyradiculopathy in sarcoidosis. Of these, 71% had weakness and 59% areflexia of the lower extremities, and 35% had sphincter dysfunction. Cases often were associated with central nervous system sarcoidosis. All cases involved thoracolumbar or lumbosacral roots, exce...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-4598(199905)22:5<608::aid-mus9>

    authors: Koffman B,Junck L,Elias SB,Feit HW,Levine SR

    更新日期:1999-05-01 00:00:00

  • Function of thick and thin nerve fibers in carpal tunnel syndrome before and after surgical treatment.

    abstract::Present studies evaluated the functions of thick and thin nerve fibers in carpal tunnel syndrome (CTS) to determine whether data of thin nerve fibers can add further information to the diagnosis of CTS. Measurements were performed in 22 patients and 16 age-matched control subjects. Motor and sensory nerve conduction, ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880180210

    authors: Lang E,Spitzer A,Pfannmüller D,Claus D,Handwerker HO,Neundörfer B

    更新日期:1995-02-01 00:00:00

  • Distal excitability properties of median motor axons.

    abstract::Excitability properties were recorded from 14 volunteers following stimulation of the recurrent motor branch of the median nerve in the palm. Distal stimulation resulted in significantly lower strength-duration time constant and lower threshold during prolonged hyperpolarization than did wrist stimulation in the same ...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.1205

    authors: Walters RJ,Kiernan MC,Murray NM,Bostock H

    更新日期:2001-12-01 00:00:00

  • Accuracy of electromyography needle placement in cadavers: non-guided vs. ultrasound guided.

    abstract:INTRODUCTION:Accuracy of needle electromyography is typically ensured by use of anatomical landmarks and auditory feedback related to voluntary activation of the targeted muscle; however, in certain clinical situations, landmarks may not be palpable, auditory feedback may be limited or not present, and targeting a spec...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.22008

    authors: Boon AJ,Oney-Marlow TM,Murthy NS,Harper CM,McNamara TR,Smith J

    更新日期:2011-07-01 00:00:00

  • Pain location and intensity impacts function in persons with myotonic dystrophy type 1 and facioscapulohumeral dystrophy with chronic pain.

    abstract:INTRODUCTION:We examined the effects of pain site and intensity on function in patients with myotonic dystrophy type 1 (DM1) and facioscapulohumeral muscular dystrophy (FSHD) and chronic pain. METHODS:Questionnaires assessing pain sites, pain extent (number of sites), pain intensity, and pain interference were complet...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.24079

    authors: Miró J,Gertz KJ,Carter GT,Jensen MP

    更新日期:2014-06-01 00:00:00

  • The effects of chronic muscular activity on age-related changes in single fiber electromyography.

    abstract::Single fiber electromyography ( SFEMG ) of the extensor digitorum communis (EDC) muscle and nerve conduction studies were performed on healthy, active elderly men (66-77 years old) to assess age-related changes in neuromuscular physiology and the effect of long-term increased muscular activity on these changes. The fo...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.880070403

    authors: Shields RW Jr,Robbins N,Verrilli AA 3rd

    更新日期:1984-05-01 00:00:00

  • Myonuclear domains in muscle adaptation and disease.

    abstract::Adult skeletal muscle fibers are among the few cell types that are truly multinucleated. Recently, evidence has accumulated supporting a role for the modulation of myonuclear number during muscle remodeling in response to injury, adaptation, and disease. These studies have demonstrated that muscle hypertrophy is assoc...

    journal_title:Muscle & nerve

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-4598(199910)22:10<1350::aid-mus

    authors: Allen DL,Roy RR,Edgerton VR

    更新日期:1999-10-01 00:00:00

  • Chronic nerve compression alters Schwann cell myelin architecture in a murine model.

    abstract:INTRODUCTION:Myelinating Schwann cells compartmentalize their outermost layer to form actin-rich channels known as Cajal bands. Herein we investigate changes in Schwann cell architecture and cytoplasmic morphology in a novel mouse model of carpal tunnel syndrome. METHODS:Chronic nerve compression (CNC) injury was crea...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.22276

    authors: Gupta R,Nassiri N,Hazel A,Bathen M,Mozaffar T

    更新日期:2012-02-01 00:00:00

  • Systematic test of neurotoxin dose and volume on muscle function in a rat model.

    abstract:INTRODUCTION:Onabotulinum toxin serotype A (BT-A) is used for a variety of motor and sensory disorders related to abnormal muscle activity. METHODS:We developed a high-resolution rodent model to allow precise determination of the effect of BT-A dose (measured in units) and injectate volume (measured in μl) on the effi...

    journal_title:Muscle & nerve

    pub_type: 杂志文章

    doi:10.1002/mus.23983

    authors: Hulst JB,Minamoto VB,Lim MB,Bremner SN,Ward SR,Lieber RL

    更新日期:2014-05-01 00:00:00