Maintaining bone health in prostate cancer throughout the disease continuum.

Abstract:

:Prostate cancer (PC) is the most prevalent malignancy in men, with 604,506 new cases diagnosed yearly worldwide. Maintaining bone health is important during all stages of PC, including patients who experience bone loss from androgen-deprivation therapy and patients who develop bone metastases. Patients with bone metastases often experience severe bone pain and are at increased risk for potentially debilitating skeletal-related events. Bisphosphonates are a well-established treatment option for patients with bone metastases from solid tumors and bone lesions from multiple myeloma. Zoledronic acid (ZOL) is the only bisphosphonate (BP) that has been extensively studied in patients with castration-recurrent PC and is indicated for treating patients with bone metastases from PC in conjunction with standard antineoplastic therapy. This review will examine the breadth of evidence supporting a role for ZOL and emerging therapies in managing patients with PC throughout the disease continuum.

journal_name

Semin Oncol

journal_title

Seminars in oncology

authors

Saad F,Eastham J

doi

10.1053/j.seminoncol.2010.06.007

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

S30-7

eissn

0093-7754

issn

1532-8708

pii

S0093-7754(10)00086-2

journal_volume

37 Suppl 1

pub_type

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