Abstract：
:Prostate cancer (PCa) is the fourth most common cancer in the world and treatment is currently based on surgical removal and/or radiotherapy and/or hormone therapy. In the last few years' immunotherapy has become an important cancer treatment option. While the principles of immunotherapy evolved, only sipuleucel-T was approved by the Food and Drug Administration (FDA) which lead to further studies with other agents, starting a new era in immuno-oncology. A number of vaccines are under clinical investigation as well as checkpoint inhibitors. Despite the current enthusiasm, it is unlikely that any of the approaches alone can dramatically change PCa outcomes, but strategies combination is more promising and provide a reason for optimism. The goal of immunotherapy in PCa does not have to be the complete eradication of advanced disease, but rather the return to an immunologic equilibrium with an indolent disease state. With such concerted efforts, the future of immunotherapy in PCa looks brighter than ever, with many clinical trial results being published soon.
journal_name
Actas Urol Espjournal_title
Actas urologicas espanolasauthors
Silva D,Abreu-Mendes P,Mourato C,Martins D,Cruz R,Mendes Fdoi
10.1016/j.acuro.2020.01.009subject
Has Abstractpub_date
2020-09-01 00:00:00pages
458-468issue
7eissn
0210-4806issn
1699-7980pii
S0210-4806(20)30054-1journal_volume
44pub_type
杂志文章,评审abstract：INTRODUCTION:Plaque and bovine pericardium graft surgery is a useful tool for treating Peyronie's disease. OBJECTIVE:To determine patient satisfaction following this operation. MATERIALS AND METHODS:This was a retrospective, observational and descriptive study. We collected data from the medical records of patients w...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2016.05.006
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:To communicate long-term results of the multicentre phase III trial post-prostatectomy urinary incontinence (PPI) treated with an adjustable male sling. PATIENTS AND METHODS:48 PPI patients were included in this trial from April 2003 to September 2004. 39 post radical prostatectomy and 9 post adenomectomy. 1...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,多中心研究
doi：10.1016/s0210-4806(09)74146-4
更新日期：2009-03-01 00:00:00
abstract：INTRODUCTION:With the routine use of prostate specific antigen, focal carcinomas and atypical small acini proliferation (ASAP) are currently detected more frequently. The number of sections per cylinder needed to detect most of them is still unknown. METHODS:We reviewed 250 sextant prostate biopsies in the 2008-2011 p...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2012.04.002
更新日期：2012-11-01 00:00:00
abstract：:Severe vesicouretheral reflux sometimes causes terminal renal failure which then requires renal transplantation. In these patients it may be necessary to perform bilateral nephrectomy when associated to serious hypertension or urinary infections with a significant clinical impact. This paper presents the clinical pict...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:Fournier's gangrene (FG) is a rare and potentially fatal infectious disease characterised by necrotic fasciitis of the perineum and abdominal wall in addition to the scrotum and penis in men and the vulva in women. Skin loss can be very damaging and difficult to repair. This condition must be treated aggressively. Sev...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(09)72884-0
更新日期：2009-09-01 00:00:00
abstract：:About 2% of adults have an urachal cyst. The diagnosis is usually made due to its clinical complications. We report an inusual case of acute urinary retention due to an urachal cyst, with hipogastric pain and anuria as initial syntoms. ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(05)73365-9
更新日期：2005-10-01 00:00:00
abstract：OBJECTIVE:To validate a simplified model of neural manipulation of the lower urinary tract of the rat, by means of alcoholic blockade of sacral roots. MATERIAL AND METHODS:Twenty Sprague-Dawle rats (aged 3 months) underwent alcohol sacral root blockade under total anesthesia with previous needle placement monitoring (...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(00)72497-1
更新日期：2000-07-01 00:00:00
abstract：:Report on the results of a survey conducted among Urology residents in the Valencian Community. Evaluation of the training level of the MIR system, both overall and by areas. Presentation of the views obtained with regard to possible modifications to raise their training level and improve their professional future. ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：INTRODUCTION:To know the incidence and clinical and pathologic characteristics of the paratesticular leiomyosarcoma (LMS) with the contribution of a case of long evolution, studying the histopathologic criteria that must be valued for this type of tumours. MATERIAL AND METHODS:A 73-year-old patient includes for study ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：10.1016/s0210-4806(08)73922-6
更新日期：2008-07-01 00:00:00
abstract：:Report of a case of vesical adenocarcinoma of the rarely occurring signet-ring cell type, characterized by an insidious development, predominance of urination disorders, submucosal growth, late diagnosis and very poor prognosis since it is not susceptible to radiotherapy or chemotherapy. ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：INTRODUCTION:Overactive bladder (OB) is one of the no-neurogenic voiding dysfunctions whose prevalence has been precisely defined among the general population but not so among the paediatric population. Its clinical manifestations are various, and its association with other pathologies like enuresis, vesico-ureteral re...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(04)73050-8
更新日期：2004-02-01 00:00:00
abstract：:Presentation of one case of hyporreflexic bladder like a first step of neurotoxicity due to Vinca alkaloids. These drugs produces peripheral neuropathies as usual, but in some rare occasions they may affect to the autonomic nervous system with its effects in the bladder producing hyporreflexic. This disease reverts sp...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(00)72447-8
更新日期：2000-03-01 00:00:00
abstract：:Endometriosis is a common gynecologic disease in which endometrial tissue is deposited outside the normal confines of the uterine cavity. Rarely endometriosis involves urinary tract. The bladder is the most frequent organ affected into this tract. A delay in detection can result in months or years of morbidity. ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(03)72943-x
更新日期：2003-05-01 00:00:00
abstract：:There is an increasement on the incidence of tumours within the population of renal transplanted, from three to five times over general population. Related to urological tumours, it emphasizes an increase in the incidence of the renal carcinoma, around 4,7% against 3% on general population. In this case, we present a ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(09)74007-0
更新日期：2009-01-01 00:00:00
abstract：:Presentation of one case of penis-located multiple skin metastasis from prostate adenocarcinoma after hormonal blockade for 11 years. Revision and update of the topic, corroborating the poor prognosis of these patients. ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1999-02-01 00:00:00
abstract：PURPOSE:To compare the efficacy of ureteroscopy and extracorporeal shock wave lithotripsy (ESWL) in treating distal ureteral calculi and evaluate the best treatment alternative for this disease. MATERIAL AND METHODS:A total of 104 patients with distal ureteral calculi requiring surgical intervention were enrolled and ...
journal_title：Actas urologicas espanolas
pub_type： 临床试验,杂志文章
doi：10.1016/s0210-4806(09)72874-8
更新日期：2009-09-01 00:00:00
abstract：INTRODUCTION:The short-term results of endoscopic treatment of vesicoureteral reflux (VUR) are excellent. Over time, however, a number of patients have been identified for whom VUR reappeared after being resolved with this technique. The aim of this study was to analyse the factors related to this event. MATERIAL AND ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2017.11.006
更新日期：2018-06-01 00:00:00
abstract：:Bladder hernia is a very uncommon but not exceptional condition. It tends to occur in adult patients over 50, and is favoured by a cervical-urethral obstruction. It is often diagnosed during inguinal hernia surgery, although in other cases pre-operative diagnosis can be achieved through radiological studies (filling c...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：
更新日期：1999-07-01 00:00:00
abstract：:There are several causes for orchitis and among them there are inflammatory process. We want to communicate the case of a young man with a clinical history and physical examination compatible with orchitis produced by the extension of a pancreatic pseudocyst that was not suspected in the beginning and discovered by im...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(08)73824-5
更新日期：2008-02-01 00:00:00
abstract：GOALS:To evaluate functional results and complications in a group of pediatric patients who received kidney transplants from donors aged 6 years or less. MATERIAL & METHODS:Thirty-four consecutive renal transplants were reviewed. Of 34 patients, 19 (55.8%) received kidneys from donors aged below 3 years (Group A) and ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(04)73034-x
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:We present our 20 years experience treating patients with vena cava extension in whom an extracorporeal circulation, hypothermia, cardio circulatory arrest (ECC-H-CCA) in order to perform, together with a tumoral resection, a thrombus resection. MATERIAL AND METHODS:From 1985 to 2005 a total of 28 retroperit...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.4321/s0210-48062008000400003
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:To analyze the expression of metalloprotein 11 (MMP11) in cultured fibroblasts obtained from human prostate tumors with different clinical and pathological characteristics. MATERIAL AND METHODS:For this study we analyzed samples of transrectal prostate biopsies from tumors with different characteristics, tre...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2016.12.001
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:For the treatment of the urinary stress incontinence, there are many techniques, and today the gold standard is that described by Burch. We compared the global and each technique results about rates of postoperative continence and complications seen in our experience. MATERIALS AND METHODS:We made a retro...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(07)73740-3
更新日期：2007-09-01 00:00:00
abstract：:Contribution of a new case of vesical haemangioma in a 65-year old male. This is a benign and very rare tumour with not even 90 cases described in the urology literature to date. Haematuria was reported in all cases. This paper presents a review of the literature and a discussion of clinical and pathological features ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：
更新日期：1997-05-01 00:00:00
abstract：:Lately, nuclear morphometry methods are being used to analyze the malignant potential of tumoral cells. This paper presents a retrospective study of a series of 163 patients with the three histological grades (WHO), of superficial papillary transitional cell carcinoma (pTa-pT1) of the bladder with a mean follow-up of ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1994-11-01 00:00:00
abstract：OBJECTIVE:Renal haematomas after extracorporeal shockwave lithotrity are an immediate and potentially serious complication. The incidence of post-ESWL renal haematoma with the new Siemens' Lithostar Multiline lithotripter is analyzed in an attempt to know its occurrence, predisposing factors and presentations signs and...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/s0210-4806(00)72399-0
更新日期：2000-01-01 00:00:00
abstract：:We report on a fibroepithelial polyp case with inflammatory characteristics located in the pelvian ureter, and related with an ureteral calculus, which was treated in a conservative way with ureteroscopic resection, after the pincer extraction of the stone. Our team found two fibroepithelial polyp cases in the bibliog...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,评审
doi：
更新日期：1994-07-01 00:00:00
abstract：:A case is presented of melanoma located at the distal urethra in a 74-year-old patient who underwent local surgery. At present the survival rate is 5 years and local relapse and metastases of one inguinal ganglion has been observed. The different clinical, diagnostic and therapeutic aspects of this neoplasia are discu...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：UNLABELLED:Overactive Bladder Syndrome (OAB) is defined by the ICS (International Continence Society) as urinary urgency, with or without urgency incontinence and frequently associated with increase of frequency and nocturia. PURPOSE:The aim of the study was to establish a correlation between OAB symptoms and Age in w...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章
doi：10.1016/j.acuro.2012.07.009
更新日期：2013-03-01 00:00:00
abstract：INTRODUCTION AND OBJECTIVES:The aim of this study was to analyse prognostic impact of tumour histological grade on survival differences between primary G2 and G3 WHO1973 stage T1 tumours which were graded as HG according to WHO2004 grading system. MATERIALS AND METHODS:Data from 481 patients with primary T1HG bladder ...
journal_title：Actas urologicas espanolas
pub_type： 杂志文章,多中心研究
doi：10.1016/j.acuro.2019.03.011
更新日期：2019-11-01 00:00:00
