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Recent advances in DNA gyrase-targeted antimicrobial agents.

Abstract：

:Antimicrobial resistance is one of the greatest challenges facing the world today. In the United States alone, it is responsible for the death of more than 20,000 people each year. DNA gyrase, a well-validated drug target, is involved in bacterial DNA replication, repair and decatenation. Currently, the fluoroquinolone class of antibacterials act via inhibition of the DNA gyrase enzyme. However, their efficacy is hindered by the increasing incidence of antimicrobial resistance. Therefore, in this review, we provide an account regarding the structure of DNA gyrase and quinoline and non-quinolone inhibitors published within the last five years (2015-2019). Further, we also discuss molecular interactions and structure-activity relationship studies of the published inhibitors.

journal_name

Eur J Med Chem

journal_title

European journal of medicinal chemistry

authors

Dighe SN,Collet TA

doi

10.1016/j.ejmech.2020.112326

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

112326

eissn

0223-5234

issn

1768-3254

pii

S0223-5234(20)30295-6

journal_volume

199

pub_type

杂志文章,评审

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