Abstract:
OBJECTIVE:The purpose of this study is to compare the thyroid hormone (TH) profile in male infertile subjects with normal and altered sperm parameters and assess its relationship with spermogram and reproductive hormones. DESIGN:This cross-sectional study was conducted in Karachi from August 2017 till September 2018 on 376 male subjects between 25 and 55 years of age. The reference values for the "Normal Sperm Parameters" group was; sperm count (TC) >39 million per ejaculate, total sperm motility (Progressive and Non-progressive) >40% and normal morphology of ≥4%. Male subjects, having any one of the sperm parameters below the reference values comprised the group of "Altered Sperm Parameters". The thyroid profile; Thyroxine (T4), triiodothyronine (T3), thyroid stimulating hormone, Thyroid Peroxidase antibodies (Anti-TPO) was estimated in addition to reproductive hormones Testosterone and Sex hormone binding globulin (SHBG). Independent sample T test and Analysis of Variance was applied for comparison of groups. Linear regression was performed and unadjusted and adjusted beta coefficient with 95% CI was reported. A P-value of <.05 was considered significant. RESULTS:Two hundred and sixteen subjects had normal, whereas 160 had "Abnormal Sperm Parameters." In "Normal Sperm Parameter" group; 206 (95.3%) were euthyroid while 10 (4.6%) were having subclinical hypothyroidism (SCH). Among the "Abnormal Sperm Parameters" group; eighty-seven (54%) subjects were euthyroid, sixty-two (38.75%) had SCH and eleven (6.8%) were having overt hypothyroidism. Testosterone and SHBG were significantly lower in "Altered Sperm Parameters" group as compared with "Normal Sperm Parameters" (P < .001 for both). CONCLUSION:A higher frequency of SCH, decreased levels of testosterone and SHBG was observed in the "Altered Sperm Parameters" group. The results establish relationship of disturbance in TH with alteration of sperm parameters and reproductive hormones thus contributing to male infertility.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Rehman R,Zafar A,Fatima SS,Mohib A,Sheikh Adoi
10.1111/ijcp.13555subject
Has Abstractpub_date
2020-09-01 00:00:00pages
e13555issue
9eissn
1368-5031issn
1742-1241journal_volume
74pub_type
杂志文章abstract::In 2006 Meiron Thomas, writing in the British Journal of Surgery, made the following statement about the value of sentinel lymph node biopsy (SLNB) as a staging procedure in cutaneous malignant melanoma (1): "Perhaps a more important concern for those hoping to gain reassurance from accurate nodal staging relates to p...
journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
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journal_title:International journal of clinical practice
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,meta分析,评审
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journal_title:International journal of clinical practice
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pub_type: 杂志文章,meta分析,评审
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journal_title:International journal of clinical practice
pub_type: 杂志文章,meta分析,评审
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journal_title:International journal of clinical practice
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