Abstract:
INTRODUCTION:Osteoarthritis (OA) is characterised by synovial joint pain, functional disability and affects ∼13 % of people worldwide, of which ∼16-27 % report Knee-OA (KOA). Glucosamine (Glu) is the most widely used nutraceutical treatment for OA despite a lack of scientific consensus, therefore alternative nutraceutical treatments are required. The aim of this study was to investigate the effect of Lithothamnion species, seawater-derived magnesium and pine bark (Aq+) on pain, symptoms and improve physical function in symptomatic (sKOA), compared to Glu. METHODS:358 participants were screened. In a double-blinded crossover pilot-trial, sKOA participant (n = 30) were randomly assigned to either the Glu group (2000 mg day-1) or Aq+ (3056 mg day-1) for 12 weeks (clinicaltrials.gov:NCT03106584). The Knee Injury and Osteoarthritis Outcome Score was used to assess subjective pain and symptoms. Timed-up-and-Go (TuG) and Six minute walking distance were used to assess functional change and analgesic use was recorded. RESULTS:Aq+ improved pain, with a large effect (P < 0.01, d' = 0.73, 95 %CI 0.201-1.265) and no change for Glu (d' = 0.38, P = 0.06). Only Aq+ improved pain (P < 0.05) for males (d' = 0.91, 95 %CI 0.162-1.667) and females (d' = 0.55, 95 %CI 0.210-1.299). In females, Aq+ improved TuG by -7.02 % (d' = 0.92, 95 %CI 1.699-0.141) while Glu worsened performance by 4.18 % (P = 0.04). Aq+ reduced analgesia by 71.6 %, compared to Glu (P = 0.02; d' = 0.82, 95 %CI 1.524-0.123). Aq+ was superior to Glu at improving pain, KOOS subscales, physical function and analgesia use in mild-sKOA. Given these data, Aq+ should be considered as a supplementary treatment for early-stage-KOA and may have the potential to reduce use of pain medication, although larger replication studies are required.
journal_name
Complement Ther Medjournal_title
Complementary therapies in medicineauthors
Heffernan SM,McCarthy C,Eustace S,FitzPatrick RE,Delahunt E,De Vito Gdoi
10.1016/j.ctim.2020.102349subject
Has Abstractpub_date
2020-05-01 00:00:00pages
102349eissn
0965-2299issn
1873-6963pii
S0965-2299(19)31831-Xjournal_volume
50pub_type
杂志文章,随机对照试验abstract:BACKGROUND:The aim of this study was to evaluate the clinical efficacy of using western anti-tinnitus therapy with or without Chai-Hu-Jia-Long-Gu-Mu-Li-Tang (CHJLGMLT) to treat patients with chronic tinnitus. METHODS:A descriptive case series with chart review was established to compare patients with chronic tinnitus ...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
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abstract::The description of individual cases is probably the most important didactic tool for teaching in medicine, especially in complementary and alternative medicine (CAM). However, only very rarely is the information provided in traditional single case reports sufficient to answer scientific questions. These reports typica...
journal_title:Complementary therapies in medicine
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abstract::Established in 2004, the Pediatric Complementary and Alternative Medicine Research & Education (PedCAM) Network (www.pedcam.ca) is a multidisciplinary national and international network focused on pediatric research and education with the vision of safe and effective use of complementary and alternative medicine (CAM)...
journal_title:Complementary therapies in medicine
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doi:10.1016/j.ctim.2011.03.002
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abstract::Amidst the substantial change currently gripping primary health care are two developments central to contemporary debate regarding the very nature, territory and identity of general practice - the integration of complementary and alternative medicine (CAM) and the rise of evidence-based medicine (EBM). This paper repo...
journal_title:Complementary therapies in medicine
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doi:10.1054/ctim.2000.0396
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abstract::Traditional Chinese medicine (TCM) has long justified its practice on empirical phenomenology. Questions remain, however, as to the legitimacy of this approach and its relevance to TCM practice and educational developments in the 21st century. General medical practice (GMP) has used practice-based data collected over ...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,评审
doi:10.1016/j.ctim.2006.06.006
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abstract::Despite the recognition for rising consumption rate of traditional medicine (TRM) in health and spatio-medical literature in the global scale, the impact of location in traditional therapy use has been explored least in Ghana. This paper analysed the role of spatial variation in TRM use in Kumasi Metropolis and Sekyer...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2015.04.007
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abstract:OBJECTIVES:To evaluate utility of biofeedback assisted diaphragmatic breathing and systematic relaxation in migraine and to compare their efficacy with propranolol in long term prophylaxis of migraine. METHODS:192 migraine patients were randomly distributed into two groups. Propranolol group received propranolol 80 mg...
journal_title:Complementary therapies in medicine
pub_type: 临床试验,杂志文章,随机对照试验
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abstract:OBJECTIVES:The aim of this preliminary clinical study was to assess if the daily intake of Agaricus blazei Murill (ABM) granulated powder (SSI Co., Ltd., Tokyo, Japan) for 6 months improved the quality of life (QOL) in cancer patients in remission. DESIGN:Open study. SETTING:Subjects diurnally took 1 (1.8 g; N=23), 2...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2013.07.001
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journal_title:Complementary therapies in medicine
pub_type: 杂志文章,评审
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更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:To investigate whether a footbath inhibits spasticity in the hemiplegic lower limbs of post-stroke patients. DESIGN:Randomized, controlled study. SETTING:Rehabilitation education and research hospital. INTERVENTIONS:Twenty-two post-stroke patients were randomly allocated to control or experimental groups....
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2014.09.006
更新日期:2014-12-01 00:00:00
abstract::In this paper I critically address what is becoming the wholesale adoption of the concept of complementary medicine in researchers' analyses of lay participation in alternative therapies. This paper emerged out of a qualitative study of 21 Canadians who use and/or practice alternative therapies. I found that only seve...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1054/ctim.2000.0423
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:To examine the factors correlating with repetitive use of complementary and alternative medicine (CAM). RESEARCH DESIGN:In 2006, a community-based epidemiological survey was conducted in Taiwan. A total of 2457 participants (1237 men and 1220 women) aged 18 and over participated in the study. RESULTS:From t...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2012.01.003
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:Cupping worldwide has been part of traditional medicine systems and is in the western world used as CAM therapy mainly for treating pain syndromes. The mode of action is up to now unclear. In order to investigate its mechanism we measured in parallel metabolic changes in the tissue under the cupping glass an...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2013.12.013
更新日期:2014-02-01 00:00:00
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journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2019.102215
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:School children undergo stress, which could impact their psychological functions and cognitive abilities. Yoga practices have been found useful in enhancing psychological functions and performance. The current study was planned to evaluate a yoga-based relaxation technique's efficacy as an extracurricular act...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2020.102606
更新日期:2020-11-13 00:00:00
abstract::Traditional Chinese medicine (TCM), the ancient medicine popular in China and surrounding areas, has been recognized as a typical representative of complementary and alternative medicine. Over long period in clinical practice, especially the progress in basic research, data on the effectiveness and beneficial contribu...
journal_title:Complementary therapies in medicine
pub_type: 信件
doi:10.1016/j.ctim.2013.01.001
更新日期:2013-06-01 00:00:00
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journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2007.01.004
更新日期:2007-09-01 00:00:00
abstract::This study aimed to evaluate questionnaire development to measure the knowledge of Complementary-Alternative Medicine (CAM), attitudes towards CAM, CAM experiences, and CAM educational needs of clinical psychologists in Indonesia. A 26-item questionnaire was developed through an extensive literature search. Data was o...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2017.05.003
更新日期:2017-08-01 00:00:00
abstract::Danggui Buxue Tang has been used for menopausal women in China for more than 800 years. However, the potential effective ingredients and pathways require further investigation. The main objective of this work was to explore the potential effective ingredients and pathways. The optimal administration time was optimized...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2019.102247
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abstract::This brief lifestyle intervention, including a vegan diet rich in fresh fruits and vegetables, whole grains and various legumes, nuts and seeds, significantly improved health risk factors and reduced systemic inflammation as measured by circulating CRP. The degree of improvement was associated with baseline CRP such t...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2014.11.001
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journal_title:Complementary therapies in medicine
pub_type: 杂志文章,meta分析
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journal_title:Complementary therapies in medicine
pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
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更新日期:2017-06-01 00:00:00
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journal_title:Complementary therapies in medicine
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2014.01.006
更新日期:2014-04-01 00:00:00
abstract:INTRODUCTION:Herbs have been reported to be effective in reducing lymphedema burden. This paper aimed to review literature reporting on herbs for lymphedema treatment. METHODS:A systematic review was performed using the PRISMA guideline. Clinical studies on herbal intervention and lymphedema were included. Evidence on...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,评审
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更新日期:2020-12-01 00:00:00
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journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
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更新日期:2016-04-01 00:00:00
abstract::Chondroitin sulphate (CS) is widely consumed orally by humans, and non-humans as it is believed to be beneficial for those with joint-related pathologies. Data concerning the functions of chondroitin sulphate in this, and other, biological systems are being actively extended. However, it is important to appreciate tha...
journal_title:Complementary therapies in medicine
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abstract:OBJECTIVES:This study was designed to determine the effects of fenugreek seed (FS) on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus (T2DM). METHODS:In an 8-week randomized controlled clinical trial, T2DM patients (n = 50) were assigned to the intervention ...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ctim.2020.102315
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:Idiopathic Environmental Intolerance (IEI) is an acquired disorder with multiple recurrent symptoms, which is associated with diverse environmental factors that are tolerated by the majority of people. IEI is an illness of uncertain aetiology, making it difficult to treat using conventional medicine. Therefo...
journal_title:Complementary therapies in medicine
pub_type: 杂志文章
doi:10.1016/j.ctim.2012.07.005
更新日期:2012-12-01 00:00:00