Use of statins in patients with chronic hepatitis C.

Abstract:

:Hepatitis C is a leading cause of liver failure and transplantation in the United States and a major public health issue. Studies have shown that patients with hepatitis C are at an increased risk of cardiovascular disease, which make statins of particular benefit in this patient population. However, the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) lists active or chronic liver disease as an absolute contraindication to statin therapy. The available literature regarding the safety of statins in this patient population is limited, but has not shown clinically significant differences in aminotransferase elevations or evidence of hepatotoxicity in patients with hepatitis C who have received statins versus those who have not. Statins should continue to be avoided in advanced end-stage liver disease, as there is a lack of safety data in these patients and drug metabolism would be severely compromised. Treatment with statins can be used in those with chronic, stable hepatitis C with elevated cardiac risk or a previous cardiac event.

journal_name

South Med J

journal_title

Southern medical journal

authors

Andrus MR,East J

doi

10.1097/SMJ.0b013e3181f0c6b4

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

1018-22; quiz 1023

issue

10

eissn

0038-4348

issn

1541-8243

journal_volume

103

pub_type

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