Abstract:
:The pathogenesis of seborrhoeic dermatitis is controversial and remains unclear. Malassezia is considered to be a commensal fungi and is found not only in the stratum corneum but also in hair follicles. It is an important pathogenic factor in seborrhoeic dermatitis. The aim of this study was to clarify the pathogenesis of seborrhoeic dermatitis, morphologically, through comparison with psoriasis vulgaris. Fifteen cases of seborrhoeic dermatitis, 7 of psoriasis, and 6 of normal skin were examined using routine histopathology, immunohistochemistry, and electron microscopy. Macrophages were found to be diffusely distributed in the upper dermis of seborrhoeic dermatitis and psoriasis. In contrast, a significant increase in the number of dendritic cells in the follicular epithelium and dendritic cell clusters in the perifollicular dermis were found only in seborrhoeic dermatitis. Ultrastructural examination of the clusters demonstrated that dendritic cells interacted with lymphocytes, macrophages, and other dendritic cells. In conclusion, folliculotropic distribution of dendritic cells as well as dendritic cell-immune cell clusters play an important role in the pathogenesis of seborrhoeic dermatitis.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Ito A,Sugita K,Goto H,Yamamoto Odoi
10.2340/00015555-3519subject
Has Abstractpub_date
2020-06-15 00:00:00pages
adv00183issue
13eissn
0001-5555issn
1651-2057journal_volume
100pub_type
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journal_title:Acta dermato-venereologica
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journal_title:Acta dermato-venereologica
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journal_title:Acta dermato-venereologica
pub_type: 杂志文章
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journal_title:Acta dermato-venereologica
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journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章
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journal_title:Acta dermato-venereologica
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pub_type: 杂志文章
doi:
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