Abstract:
UNLABELLED:The study was aimed at detecting the expression of a newly found oncogene, astrocyte elevated gene-1 (AEG-1), in renal cell carcinoma (RCC) and its correlation with histopathologic features and the survival of patients. Real-time reverse transcription-PCR and Western blot showed markedly higher expression of AEG-1 in 8 cases of RCC tissue compared with the paired normal tissue from the same patient. The expression level of AEG-1 was also increased in four RCC cell lines in contrast with normal tubular epithelial human kidney cells 2 (HK-2) at both mRNA and protein levels. Furthermore, immunohistochemistry analysis showed highly expressed AEG-1 in 96 of 102 (94.1%) cases of paraffin-embedded archival RCC tissue. Statistical analysis showed a significant correlation of AEG-1 expression with tumor grade (P <0.001), clinical staging (P = 0.003), T classification (P = 0.003) as well as metastasis classification (P=0.032). The means for survival time of low AEG-1 expression group was 76.98m
while high AEG-1expression group was 60.94m. Our results suggest that AEG-1 protein is overexpressed in RCC and plays an important role in tumor differentiation and progression.
High AEG-1 expression is closely associated with poor prognosis.
KEYWORDS:Astrocyte elevated gene-1, AEG-1, renal cell carcinoma, prognosis.
journal_name
Neoplasmajournal_title
Neoplasmaauthors
Chen W,Ke Z,Shi H,Yang S,Wang Ldoi
10.4149/neo_2010_06_522subject
Has Abstractpub_date
2010-01-01 00:00:00pages
522-9issue
6eissn
0028-2685issn
1338-4317journal_volume
57pub_type
杂志文章相关文献
NEOPLASMA文献大全abstract::In the blood of 39 women with endometrial carcinoma the FSH, LH, estrone, androstendion, estradiol and dehydroepiandrosterone were determined by the RIA method. Compared to the control group the estrone (303.3 +/- 44.3 pmol/l), estradiol (165.2 +/- 29.4 pmol/l) and the androstendion (5.24 +/- 0.44 nmol/l) were signifi...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::The development of distant metastases is the final stage in the progression of solid cancer and is responsible for the majority of cancer-related deaths. Epithelial-mesenchymal transition (EMT) is involved in cancer progression and metastasis. In the present study we used different types of intracellular bacteria isol...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_181120N874
更新日期:2019-02-06 00:00:00
abstract::Currently, mechanisms leading to both apoptosis induction and the development of hormone-independence of prostate carcinoma cells are intensively studied. Attention is also given to the possibility of restoring cell sensitivity to hormone-antagonists. The present study focuses on the effect of the combined synthetic c...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::Sera from 51 melanoma patients and from 55 healthy donors were examined for the presence of immune complexes (ICs) by the EA-rosette forming cell inhibition assay. Using a cut-off point of 5% rosette inhibition, ICs were found in 144 out of 213 sera from patients with melanoma (67.6%) and in 11 out of 55 control subje...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::The effect of oxoplatinum on blastic transformation of human peripheral blood mononuclear cells (PBMC) was monitored following phytohemagglutinin (PHA) stimulation. The results were compared with those published in part III of the present work as well as with the effect of cisplatinum and carboplatinum on the blastic ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Although Flotillin 1 (FLOT1) is highly expressed in various human cancers, its relationship with ovarian cancer (OC) remains unknown. This study determines FLOT1 expression in human ovarian tumors and examines its effect on OC cell proliferation. FLOT1 protein expression was assessed in a tissue microarray by immuno...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_170714N483
更新日期:2018-01-01 00:00:00
abstract::The inhibition of incorporation of 3H-thymidine and the changes of the rate of nascent DNA chain elongation were investigated in CHO Chinese hamster cells treated with (S)-(3-hydroxy-2-phosphonomethoxypropyl) (HPMP) and N-(2-phosphonomethoxyethyl) (PME) derivatives of adenine (A), guanine (G) and 2,6-diaminopurine (DA...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::The mannose 6-phosphate/insulin-like growth factor 2 receptor (CD222, M6P/IGF2R) is a multifunctional transmembrane type I receptor, mostly localized intracellularly, less on the surface of all types of mammalian cells. It is known both to transport lysosomal enzymes through their mannose 6-phosphate moieties and to i...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_171203N792
更新日期:2018-09-19 00:00:00
abstract::Eighty-four biopsies derived from cervical tissues were analyzed for the presence of human papillomavirus (HPV) DNA types 6, 16 and 18 using Southern blot hybridization. HPV 6 was found in none of the cervical biopsies, and HPV types 16 and 18 were found in 44% of them. The rate of HPV 16/18 positive samples increased...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The present study was undertaken to provide complementary information on heterochromatin condensation in central and peripheral nuclear regions during maturation of human leukemic lymphocytes using simple image processing and DNA image densitometry at the single cell level. Such approach indicated that the heterochrom...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2011_06_476
更新日期:2011-01-01 00:00:00
abstract::Expression of microRNA-129-5p (miR-129-5p) has been reported to decrease in gastric cancer (GC). However, little information is available about how miR-129-5p affects cell migration and invasion of GC. Cancer samples and matched non-tumor adjacent tissues were obtained from patients with GC. Besides, peripheral blood ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2016_503
更新日期:2016-01-01 00:00:00
abstract::Heat Shock proteins 70 (Hsp70) is a family of highly conserved molecules that maintain the function of crucial cellular pathways during stress. Hsp70 derived from tumor cells is bound with tumor antigenic peptides from the diverse antigen cytosolic pool. Tumor-derived Hsp70 preparations after ex vivo administration pe...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2009_03_259
更新日期:2009-01-01 00:00:00
abstract::Mode of releasing of associated 4S RNA species was studied during a controlled transition of aggregate structure of high-molecular-weight AMV-RNA. It has been found that associated 4S RNA constitutes 2.5% of 60S AMV-RNA complex. Approximately 60% of associated 4S RNA is successively released during treatment of viral ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::The significance of CEA, AFP, HCG and SP1 determinations in 85 patients with ovarian cancer were analyzed from the point of view of evaluation of the clinical status of the patients. On the basis of the trials it was stated that a satisfactory correlation between the extension of the tumor and the serum CEA level was ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Polymorphisms in tobacco carcinogen metabolizing enzymes may generate interindividual variations towards the risk of developing prostate cancer. One of these enzymes is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found in cigarette smoke. The activity of...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2012_010
更新日期:2012-01-01 00:00:00
abstract::We report on 12 patients who fulfilled the FAB diagnosis criteria of chronic myelomonocytic leukemia (CMML). Some clinical findings (splenomegaly) as well as biological parameters (WBC count, cellularity of bone marrow sections, presence of dyserythropoiesis in bone marrow smears) were subjected to particular analysis...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::The effect of dibutyryl cyclic nucleotides, dbcAMP and dbcGMP, on the growth of BSC-1 cells has been studied in the presence and absence of kidney epithelial cell growth inhibitor. The growth response of the cells was dependent on concentrations of the dibutyryl cyclic nucleotides and on the presence or absence of ser...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Olfactomedin 4 (OLFM4) is a member of olfactomedin domain-containing protein family. Human OLFM4 is preferentially expressed in the gastrointestinal tract (stomach, small intestine and colon), prostate, and bone marrow. Recent studies demonstrate that OLFM4 is involved in the establishment and/or development of some t...
journal_title:Neoplasma
pub_type: 杂志文章,评审
doi:10.4149/neo_2011_01_9
更新日期:2011-01-01 00:00:00
abstract::The macrocyclic Cu(II)-tetraanhydroaminobenzaldehyde complex Cu(TAAB)C12 induces various cytotoxic effects in the dependence on a cell line, concentration and time of exposition. The highest complex concentration of 914 nmol/l induces degeneration of certain part of the HeLa cells population after 24 hours of cultivat...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Bladder cancer (BCa) is a common carcinoma of the urinary tract which occurs in the bladder mucosa. In recent years, people have recognized that epigenetic changes such as DNA methylation play important roles in the development of BCa, but the specific mechanism is unclear. In this study we detected the methylation ra...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_200928N1035
更新日期:2021-01-14 00:00:00
abstract::A 65-kDa tumor-associated protein (P65) is a potential non- specific tumor marker expressed by many types of tumor cells. Our recent studies indicate that P65 gene expression is connected with poor prognosis for the patients with colorectal cancer. In the present study P65 gene expression was determined by means of RT...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::The flavonol aglycone isorhamnetin shows anti-proliferative activity in a variety of cancer cells. Previous work, from our laboratory showed that isorhamnetin inhibits the proliferation of human esophageal squamous carcinoma Eca-109 cells in vitro, but only after 72 h of exposure. This led us to propose that isorhamne...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2012_047
更新日期:2012-01-01 00:00:00
abstract::Relation between the electronic structure of aromatic compounds and their carcinogenic activity has been correlated. Hypotheses of K, L regions have been employed. Possibilities of better theoretical description of carcinogenic activity have been examined by including the effect of medium and by using a more exact qua...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::Results obtained in 50 children with abdominal non-Hodgkin's lymphoma after a treatment program that comprised entire abdominal irradiation and chemotherapy are presented. Actuarial survival of the series at 3, 5 and 10 years is 65.8%, with 75.2% for patients in Stage II and 58.6% in Stage III. Patients in 5-9-year ag...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::Glioma is among the most fatal brain tumors characterized by a highly malignancy and rapid progression and early metastasis. Dysregulation of long non-coding RNA differentiation antagonizing non-protein coding RNA (LncRNA DANCR) is associated with the development, progression and metastasis of various cancers. In the ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2018_170724N498
更新日期:2018-09-19 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and it carries a poor prognosis. Clarifying the pathologic mechanisms of this disease will be beneficial for the diagnosis and treatment of HCC. LncRNA MEG8 is involved in several tumors but its role in HCC progression remains unknown. This st...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_200730N785
更新日期:2020-11-05 00:00:00
abstract::Apurinic/apyrimidinic endonuclease1 (APE1), which has the dual functions of DNA repair and redox regulation, is considered to be a promising potential target in cancer treatment. Microarray and qRT-PCR were used to confirm the change of miRNA followed by analysis with comprehensive bioinformatics-based analysis. Both ...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2013_050
更新日期:2013-01-01 00:00:00
abstract::The therapeutic potential of cisplatin in ovarian cancer treatment is restricted by the occurrence of cellular resistance. We aimed to explore the role of SRPK1 in cisplatin resistance related to the long non-coding RNA UCA1 in ovarian cancer cell.Totally, 24 ovarian cancer tissues and 16 normal tissues were used to a...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
abstract::Puerarin has recently been demonstrated to play anti-cancer roles in a series of human cancers, including non-small cell lung cancer (NSCLC), possibly through regulation of cancer-related microRNAs (miRNAs). The purpose of the present study was to further investigate the detailed role and underlying mechanism of puera...
journal_title:Neoplasma
pub_type: 杂志文章
doi:10.4149/neo_2020_191107N1145
更新日期:2020-11-01 00:00:00
abstract::The influence of hypothyroidism on AFB1 carcinogenesis in inbred Wistar rats was studied. The primary AFB1 hepatocarcinogenesis was significantly delayed and reduced. The transplantable hepatomas showed prolonged latency periods in rats of both sexes, and in males decreased tumor weights and a lower number of lung met...
journal_title:Neoplasma
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00