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An amphotericin B-based drug for treating experimental Leishmania major infection.

Abstract：

:There is an urgent need for a non-toxic and low-cost treatment for cutaneous leishmaniasis. We synthesised and tested in vivo an amphotericin B-poly(methacrylic acid) drug (AmB-PMA) that had previously shown in-vitro activity against Leishmania major and L. donovani parasites. Efficacy was determined using L. major footpad infection in 30 non-healing BALB/c mice. Three subcutaneous injections of AmB-PMA at days 7, 14 and 21 post-infection resulted in a reduction of ∼80% in lesion size by day 35 post-infection in 18 treated mice compared with six untreated controls, and complete healing of lesions by day 50 with no lesion relapse seen at day 80 post-infection in six treated mice. Healing was associated with decreased IL-10 (P=0.002) and increased IFN-γ (P=0.005) in the footpad.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Corware KD,Rogers M,Teo I,Müller I,Shaunak S

doi

10.1016/j.trstmh.2010.08.010

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

749-50

issue

11

eissn

0035-9203

issn

1878-3503

pii

S0035-9203(10)00184-7

journal_volume

104

pub_type

杂志文章

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