Abstract:
PURPOSE:The primary feasibility steps of demonstrating the ability of microwave-induced thermoacoustic (TA) in phantoms have been previously reported. However, none were shown to target a diseased site in living subjects in thermoacoustic tomography (TAT) field so far. To determine the expressions of oncogenic surface molecules, it is quite necessary to image tumor lesions and acquire pathogenic status on them via TAT. METHODS:Compared to biological tissues, iron oxide nanoparticles have a much higher microwave absorbance. Fe3O4/polyaniline (PANI) nanoparticles were prepared via polymerization of aniline in the Fe304 superparamagnetic fluids. Then Fe3O4/PANI was conjugated to folic acid (FA), which can bind specifically to the surface of the folate receptor used as a tumor marker. FA-Fe3O4/PANI targeted tumor was irradiated by pulsed microwave at 6 GHz for thermoacoustic detection and imaging. RESULTS:The effect of the Fe3O4/PANI superparamagnetic nanoparticles for enhancing TAT images was successfully investigated in ex vivo human blood and in vivo mouse tail. Intravenous administration of the targeted nanoparticles to mice bearing tumors showed fivefold greater thermoacoustic signal and much longer elimination time than that of mice injected with nontargeted nanoparticles in the tumor. The specific targeting ability of FA-Fe3O4/PANI to tumor was also verified on fluorescence microscopy. CONCLUSIONS:Fabricated iron oxide nanoparticles conjugated with tumor ligands for targeted TAT tumor detection at the molecular level was reported for the first time. The results indicate that thermoacoustic molecular imaging with functionalized iron oxide nanoparticles may contribute to targeted and functional early cancer imaging. Also, the modified iron oxide nanoparticles combined with suitable tumor markers may also be used as novel nanomaterials for targeted and guided cancer thermal therapy.
journal_name
Med Physjournal_title
Medical physicsauthors
Nie L,Ou Z,Yang S,Xing Ddoi
10.1118/1.3466696subject
Has Abstractpub_date
2010-08-01 00:00:00pages
4193-200issue
8eissn
0094-2405issn
2473-4209journal_volume
37pub_type
杂志文章相关文献
MEDICAL PHYSICS文献大全abstract:PURPOSE:The main objective of this work was to design a comprehensive dosimetry package that would keep all aspects of internal dose calculation within the framework of a single software environment and that would be applicable for a variety of dose calculation approaches. METHODS:Our MATLAB-based graphical user inter...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4810963
更新日期:2013-07-01 00:00:00
abstract:PURPOSE:The research is to develop a novel CNN-based adversarial deep learning method to improve and expedite the multi-organ semantic segmentation of CT images and to generate accurate contours on pelvic CT images. METHODS:Planning CT and structure datasets for 120 patients with intact prostate cancer were retrospect...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.14580
更新日期:2020-11-05 00:00:00
abstract::Preclinical experiments are carried out with approximately 20-30 microm wide, approximately 10 mm high parallel microbeams of hard, broad-"white"-spectrum x rays (approximately 50-600 keV) to investigate microbeam radiation therapy (MRT) of brain tumors in infants for whom other kinds of radiotherapy are inadequate an...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.1562169
更新日期:2003-04-01 00:00:00
abstract:PURPOSE:To perform a comprehensive and systematic comparison of fixed-beam IMRT and volumetric modulated arc therapy (VMAT) patient-specific QA measurements for a common set of geometries using typical measurement methods. METHODS:Fixed-beam IMRT and VMAT plans were constructed for structure set geometries provided by...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4729738
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:To eliminate or reduce the error to Pareto optimality that arises in Pareto surface navigation when the Pareto surface is approximated by a small number of plans. METHODS:The authors propose to project the navigated plan onto the Pareto surface as a postprocessing step to the navigation. The projection attempt...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4930252
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:To study if malfunction of a receiver can be detected robustly using the simple ACR SNR measurement approach on a 32-channel head coil. METHODS:Standard ACR T1W images (11slice) were acquired with a commercial 32 channel head coil on a 3T Philips Achieva MR scanner following the ACR recommended setup. Raw data...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4736227
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:Fluence field modulated computed tomography (FFMCT) presents a novel approach for acquiring CT images, whereby a patient model guides dynamically changing fluence patterns in an attempt to achieve task-based, user-prescribed, regional variations in image quality, while also controlling dose to the patient. This...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4829513
更新日期:2013-12-01 00:00:00
abstract::A beam intensity monitor was tested in a 230-MeV proton beam at the Loma Linda Proton Therapy Accelerator during its commissioning at Fermi National Accelerator Laboratory. The intensity monitor was designed to regulate the beam intensity extracted from the proton synchrotron. The proton beam is tunable between 70 and...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.596636
更新日期:1991-07-01 00:00:00
abstract::This paper investigates the effect of the waterproofing sleeve on the calibration of kilovoltage photon beams (50-300 kV). The sleeve effect correction factor, ps has been calculated using the Monte Carlo method as the ratios of the air kerma in an air cavity of a cylindrical chamber without the waterproofing sleeve t...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.598039
更新日期:1997-09-01 00:00:00
abstract::Noise, partial volume (PV) effect, and image-intensity inhomogeneity render a challenging task for segmentation of brain magnetic resonance (MR) images. Most of the current MR image segmentation methods focus on only one or two of the above-mentioned effects. The objective of this paper is to propose a unified framewo...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.1944912
更新日期:2005-07-01 00:00:00
abstract:PURPOSE:Brachytherapy with 106 Ru/106 Rh plaques offers good outcomes for small-to-medium choroidal melanomas and retinoblastomas. The dose measurement of the plaques is challenging, due to the small range of the emitted beta particles and steep dose gradients involved. The scarce publications on film dosimetry of 106 ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.12777
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:Both spatial and biological information are necessary in order to perform true optimization of a treatment plan and for predicting clinical outcome. The goal of this work is to develop an enhanced treatment plan evaluation tool which incorporates biological parameters and retains spatial dose information. METH...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3497152
更新日期:2010-11-01 00:00:00
abstract:PURPOSE:To characterize the modulation transfer function (MTF) of proton/carbon radiography using Monte Carlo simulations. To assess the spatial resolution of proton/carbon radiographic imaging. METHODS:A phantom was specifically modeled with inserts composed of two materials with three different densities of bone and...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4819816
更新日期:2013-09-01 00:00:00
abstract::Radiation therapy treatment modalities continue to develop and have become increasingly complex. With this, dose verification and quality assurance (QA) is of great importance to ensure that a prescribed dose is accurately and precisely delivered to a patient. Radiochromic film dosimetry has been adopted as a convenie...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4740126
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:The GammaPod is a novel dedicated prone breast stereotactic radiosurgery (SRS) device recently developed at the University of Maryland Medical Center. This device utilizes multiple rotating Co-60 sources to create highly conformal dose distributions for breast treatments, including boosts, partial breast irradi...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.14197
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:The spatial resolution of iterative reconstruction (IR) in computed tomography (CT) is contrast- and noise-dependent because of the nonlinear regularization. Due to the severe noise contamination, it is challenging to perform precise spatial-resolution measurements at very low-contrast levels. The purpose of th...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4916802
更新日期:2015-05-01 00:00:00
abstract::Transmission data for 4-MV bremsstrahlung beams have been measured with a combination of lead and aluminum attenuators. From these data, the original energy spectra have been reconstructed using an iterative least-squares technique, previously evaluated by simulation studies. The spectra on the central axis for three ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.595356
更新日期:1983-11-01 00:00:00
abstract::In this x-ray/MR hybrid system an x-ray flat panel detector is placed under the patient cradle, close to the MR volume of interest (VOI), where the magnetic field strength is approximately 0.5 T. Immersed in this strong field, several electronic components inside the detector become magnetized and create an additional...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2963994
更新日期:2008-09-01 00:00:00
abstract::Based on direction from AAM Board of Directors, JMPLSC has redefined its scope and name. On November 4, 2011 the subcommittee renamed itself the Medical Physics Licensure and Regulatory Recognition Subcommittee. Its newly defined charge is to promote the protection of the public through the recognition of the professi...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4735947
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:To report on significant dose enhancement effects caused by magnetic fields aligned parallel to 6 MV photon beam radiotherapy of small lung tumors. Findings are applicable to future inline MRI-guided radiotherapy systems. METHODS:A total of eight clinical lung tumor cases were recalculated using Monte Carlo me...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4938580
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Deep learning methods for radiomics/computer-aided diagnosis (CADx) are often prohibited by small datasets, long computation time, and the need for extensive image preprocessing. AIMS:We aim to develop a breast CADx methodology that addresses the aforementioned issues by exploiting the efficiency of pre-tra...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.12453
更新日期:2017-10-01 00:00:00
abstract::Bioluminescent imaging (BLI) of luciferase-expressing cells in live small animals is a powerful technique for investigating tumor growth, metastasis, and specific biological molecular events. Three-dimensional imaging would greatly enhance applications in biomedicine since light emitting cell populations could be unam...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2138007
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:Photon counting arrays (PCAs), capable of measuring the spectral information of individual x-ray photons and recording that information digitally, provide a number of advantages compared to conventional, energy-integrating active matrix flat-panel imagers - such as reducing the undesirable effects of electronic...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.13128
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:To demonstrate the ultra-high resolution capability of a small field-of-view (FOV) solid state x-ray imaging detector based on an EMCCD sensor. METHODS:A micro-solid state x-ray image intensifier (micro-SSXII) was developed to serve as an ultra-high resolution region-of-interest (ROI) imaging detector. It is b...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4734816
更新日期:2012-06-01 00:00:00
abstract::The purpose of this paper is to determine the correlation between dose-volume histogram (DVH) and dose wall-histogram (DWH) in the evaluation of rectal complications for prostate cancer patients treated with three-dimensional conformal radiotherapy (3D-CRT). A retrospective analysis of DVHs and DWHs of a subset of 25 ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.1951427
更新日期:2005-08-01 00:00:00
abstract:PURPOSE:Radiation scattered from the breast in digital breast tomosynthesis (DBT) causes image degradation, including loss of contrast between cancerous and background tissue. Unlike in 2-dimensional (2D) mammography, an antiscatter grid cannot readily be used in DBT because changing alignment between the tube and dete...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4943632
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:In intensity-modulated proton therapy (IMPT), protons are used to deliver highly conformal dose distributions, targeting tumors, and sparing organs-at-risk. However, due to uncertainties in both patient setup and relative stopping power (RSP) calculation, margins are added to the treatment volume during treatme...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.14347
更新日期:2020-09-01 00:00:00
abstract::A new beam line for radiotherapy and radiosurgery with accelerated helium-ion beams has been set up at the Bevalac. The new treatment room has been equipped with a very precise patient positioner in order to utilize the superior dose localization properties of light-ion beams. The beam spreading and shaping system is ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.596696
更新日期:1991-01-01 00:00:00
abstract::Pixel size is of great interest in the flat-panel detector design because of its potential impact on image quality. In the particular case of angiographic x-ray fluoroscopy, small pixels are required in order to adequately visualize interventional devices such as guidewires and stents which have wire diameters as smal...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2169907
更新日期:2006-03-01 00:00:00
abstract:PURPOSE:To measure patient-specific maximum skin dose (MSD) associated with CT fluoroscopy (CTF) lung biopsies and to compare measured MSD with the MSD estimated from phantom measurements, as well as with the CTDIvol of patient examinations. METHODS:Data from 50 patients with lung lesions who underwent a CT fluoroscop...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4884231
更新日期:2014-07-01 00:00:00