Abstract:
AIM:To establish the prevalence of dystonic pain in children and their response to deep brain stimulation (DBS). METHOD:Dystonic pain was assessed in a cohort of 140 children, 71 males and 69 females, median age 11 years 11 months (range 3y-19y 1mo), undergoing DBS in our centre over a period of 10 years. The cohort was divided into aetiological dystonia groups: 1a, inherited; 1b, heredodegenerative; 2, acquired; and 3, idiopathic. Motor responses were measured with the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS). RESULTS:Dystonic pain was identified in 63 (45%) patients, 38% of whom had a diagnosis of cerebral palsy (CP). Dystonic pain improved in 90% of children and in all aetiological subgroups 1 year after DBS, while the BFMDRS motor score improved in 70%. Statistically significant improvement (p<0.01) was noted for the whole cohort on the Numerical Pain Rating Scale (n=27), Paediatric Pain Profile (n=17), and Caregivers Priorities and Child Health Index of Life with Disabilities questionnaire (n=48). There was reduction of pain severity, frequency, and analgesia requirement. Findings were similar for the whole cohort and aetiological subgroups other than the inherited heredodegenerative group where the improvement did not reach statistical significance. INTERPRETATION:Dystonic pain is frequent in children with dystonia, including those with CP, who undergo DBS; this can be an important, realizable goal of surgery irrespective of aetiology. We encourage the use of multimodal approach in pain research to reduce the risk of bias.
journal_name
Dev Med Child Neuroljournal_title
Developmental medicine and child neurologyauthors
Perides S,Lin JP,Lee G,Gimeno H,Lumsden DE,Ashkan K,Selway R,Kaminska Mdoi
10.1111/dmcn.14555subject
Has Abstractpub_date
2020-08-01 00:00:00pages
917-925issue
8eissn
0012-1622issn
1469-8749journal_volume
62pub_type
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journal_title:Developmental medicine and child neurology
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journal_title:Developmental medicine and child neurology
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doi:10.1111/j.1469-8749.1975.tb03529.x
更新日期:1975-10-01 00:00:00
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journal_title:Developmental medicine and child neurology
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更新日期:1990-10-01 00:00:00
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journal_title:Developmental medicine and child neurology
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doi:10.1111/j.1469-8749.1980.tb04375.x
更新日期:1980-10-01 00:00:00
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journal_title:Developmental medicine and child neurology
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pub_type: 临床试验,杂志文章,随机对照试验
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doi:10.1111/j.1469-8749.1994.tb11879.x
更新日期:1994-06-01 00:00:00
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journal_title:Developmental medicine and child neurology
pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1469-8749.1986.tb03903.x
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abstract::The use of intramuscular alcohol in treating cerebral-palsied children has led to reduced spasticity for varying periods of time, although the periods diminish with each subsequent injection. During the period of reduced spasticity there is an opportunity for therapists and orthopaedic surgeons to determine whether co...
journal_title:Developmental medicine and child neurology
pub_type: 杂志文章
doi:10.1111/j.1469-8749.1980.tb04354.x
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更新日期:2011-10-01 00:00:00
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journal_title:Developmental medicine and child neurology
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更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1978-12-01 00:00:00
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更新日期:2006-06-01 00:00:00
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更新日期:1993-07-01 00:00:00
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更新日期:2011-05-01 00:00:00
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更新日期:2015-11-01 00:00:00