Long-term outcome after resection of brainstem hemangioblastomas in von Hippel-Lindau disease.

Abstract:

OBJECT:Brainstem hemangioblastomas are frequently encountered in patients with von Hippel-Lindau (VHL) disease. These tumors can cause significant morbidity, and their optimal management has not been defined. To better define the outcome and management of these tumors, the authors analyzed the long-term results in patients who underwent resection of brainstem hemangioblastomas. METHODS:Consecutive patients with VHL disease who underwent resection of brainstem hemangioblastomas with a follow-up of 12 months or more were included in this study. Serial functional assessments, radiographic examinations, and operative records were analyzed. RESULTS:Forty-four patients (17 male and 27 female) underwent 51 operations for resection of 71 brainstem hemangioblastomas. The most common presenting symptoms were headache, swallowing difficulties, singultus, gait difficulties, and sensory abnormalities. The mean follow-up was 5.9 ± 5.0 years (range 1.0-20.8 years). Immediately after 34 operations (66.7%), the patients remained at their preoperative functional status; they improved after 8 operations (15.7%) and worsened after 9 operations (17.6%) as measured by the McCormick scale. Eight (88.9%) of the 9 patients who were worse immediately after resection returned to their preoperative status within 6 months. Two patients experienced functional decline during long-term follow-up (beginning at 2.5 and 5 years postoperatively) caused by extensive VHL disease-associated CNS disease. CONCLUSIONS:Generally, resection of symptomatic brainstem hemangioblastomas is a safe and effective management strategy in patients with VHL disease. Most patients maintain their preoperative functional status, although long-term decline in functional status may occur due to VHL disease-associated progression.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Wind JJ,Bakhtian KD,Sweet JA,Mehta GU,Thawani JP,Asthagiri AR,Oldfield EH,Lonser RR

doi

10.3171/2010.9.JNS10839

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

1312-8

issue

5

eissn

0022-3085

issn

1933-0693

journal_volume

114

pub_type

杂志文章
  • Effects of tacrolimus on hemispheric water content and cerebrospinal fluid levels of glutamate, hypoxanthine, interleukin-6, and tumor necrosis factor-alpha following controlled cortical impact injury in rats.

    abstract:OBJECT:Disturbance of calcium homeostasis contributes to evolving tissue damage and energetic impairment following traumatic brain injury (TBI). Calcium-mediated activation of calcineurin results in production of tissue-damaging nitric oxide and free oxygen radicals. Inhibition of calcineurin induced by the immunosuppr...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2001.94.5.0782

    authors: Stover JF,Schöning B,Sakowitz OW,Woiciechowsky C,Unterberg AW

    更新日期:2001-05-01 00:00:00

  • Venous sinus stenting for reduction of intracranial pressure in IIH: a prospective pilot study.

    abstract::OBJECTIVE Idiopathic intracranial hypertension (IIH) may cause blindness due to elevated intracranial pressure (ICP). Venous sinus stenosis has been identified in select patients, leading to stenting as a potential treatment, but its effects on global ICP have not been completely defined. The purpose of this pilot stu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2016.8.JNS16879

    authors: Liu KC,Starke RM,Durst CR,Wang TR,Ding D,Crowley RW,Newman SA

    更新日期:2017-11-01 00:00:00

  • Effects of cerebral magnetic resonance imaging in outpatients on observed incidence of intracranial tumors and patient survival: a national observational study.

    abstract:OBJECT:It is assumed that the observed increase in brain tumor incidence may at least partially be explained by increased use of MRI. However, to date no direct estimate of this effect is available. The authors undertook this registry-based study to examine whether regional frequencies of cerebral MRI use correlate to ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2013.12.JNS131312

    authors: Solheim O,Torsteinsen M,Johannesen TB,Jakola AS

    更新日期:2014-04-01 00:00:00

  • Early reversal of acidosis and metabolic recovery following ischemia.

    abstract::Tissue acidosis is believed to be a key element in ischemic injury of neural tissue. The goal of this study was to determine whether persisting postischemic acidosis or the extent of acidosis would affect metabolic recovery following an ischemic event. Intracellular pH (pHi), adenosine triphosphate, phosphocreatine, a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.81.4.0567

    authors: Hoffman TL,LaManna JC,Pundik S,Selman WR,Whittingham TS,Ratcheson RA,Lust WD

    更新日期:1994-10-01 00:00:00

  • Gamma knife surgery for choroidal neovascularization in age-related macular degeneration. Technical note.

    abstract::The authors conducted a study to determine a way of overcoming the poor-quality demonstration of choroidal neovascularization (CNV) associated with age-related macular degeneration (AMD) on conventional magnetic resonance (MR) imaging studies. The poor MR imaging demonstration of CNV in patients with AMD makes the use...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.102.s_supplement.0200

    authors: Hayashi M,Chernov M,Usukura M,Abe K,Ono Y,Izawa M,Hori S,Hori T,Takakura K

    更新日期:2005-01-01 00:00:00

  • Definition of cellular immune responses to brain antigens in human head trauma.

    abstract::Cellular immune responses to brain antigens in patients with head injury were studied by applying the leukocyte adherence inhibition (LAI) assay. The investigation was conducted in three phases. 1) In the initial phase, evaluation of a series of 22 test and 25 control cases obtained at random during a 2- to 6-week tim...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1979.51.3.0317

    authors: Apuzzo ML,Sheikh KM,Heiden JS,Weiss MH,Kurze T

    更新日期:1979-09-01 00:00:00

  • Radiosurgery for benign tumors of the spine using the Synergy S with cone-beam computed tomography image guidance.

    abstract:OBJECT:There is a growing body of evidence to support the safe and effective use of spine radiosurgery. However, there is much less experience regarding the use of radiosurgery for the treatment of benign as opposed to malignant spine tumors. This study represents an evaluation of, and reporting on, the technical aspec...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2012.8.GKS12981

    authors: Gerszten PC,Chen S,Quader M,Xu Y,Novotny J Jr,Flickinger JC

    更新日期:2012-12-01 00:00:00

  • Spontaneous development of a de novo suprasellar arachnoid cyst. Case report.

    abstract::Arachnoid cysts are commonly thought to arise from either congenital defects or trauma. In this article the authors report the spontaneous development of a suprasellar third ventricular arachnoid cyst whose origin was not clearly congenital or traumatic. At the age of 4 months, the patient presented with hypertonia, a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2006.104.6.426

    authors: Struck AF,Murphy MJ,Iskandar BJ

    更新日期:2006-06-01 00:00:00

  • Neurocutaneous melanosis with extensive intracerebral and spinal cord involvement. Report of two cases.

    abstract::Two unusual cases of neurocutaneous melanosis are presented. Both patients had congenital giant hairy nevi and both developed hydrocephalus, seizures, and myelopathy. The first patient displayed multicentric cerebral and spinal cord melanosis, as opposed to the more commonly described basilar leptomeningeal involvemen...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.61.4.0782

    authors: Faillace WJ,Okawara SH,McDonald JV

    更新日期:1984-10-01 00:00:00

  • Proximal occlusion of the anterior cerebral artery for anterior communicating aneurysm.

    abstract::Results of proximal anterior cerebral artery occlusion are described in 68 patients with anterior communicating artery aneurysms. The procedure is found useful in the treatment of these aneurysms because of its technical simplicity and the low rates of mortality and morbidity achieved. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1975.43.4.0426

    authors: Hockley AD

    更新日期:1975-10-01 00:00:00

  • Deep brain stimulation in movement disorders: stereotactic coregistration of two-dimensional electrical field modeling and magnetic resonance imaging.

    abstract:OBJECT:Adjusting electrical parameters used in deep brain stimulation (DBS) for dystonia remains time consuming and is currently based on clinical observation alone. The goal of this study was to visualize electrical parameters around the electrode, to correlate these parameters with the anatomy of the globus pallidus ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.103.6.0949

    authors: Hemm S,Mennessier G,Vayssiere N,Cif L,El Fertit H,Coubes P

    更新日期:2005-12-01 00:00:00

  • Release of endothelium-derived relaxing factor after subarachnoid hemorrhage.

    abstract::The purpose of this study was to determine the cause of the loss of endothelium-dependent relaxation observed in chronic cerebral vasospasm. A bioassay system was developed to measure the release of endothelium-derived relaxing factor (EDRF) from canine basilar arteries. Subarachnoid hemorrhage (SAH) was induced in do...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1989.70.1.0108

    authors: Kim P,Lorenz RR,Sundt TM Jr,Vanhoutte PM

    更新日期:1989-01-01 00:00:00

  • Intraoperative nerve action and compound motor action potential recordings in patients with obstetric brachial plexus lesions.

    abstract:OBJECT:A typical finding in supraclavicular exploration of infants with severe obstetric brachial plexus lesions (OBPLs) is a neuroma-in-continuity with the superior trunk and/or a root avulsion at C-5, C-6, or C-7. The operative strategy in these cases is determined by the intraoperative assessment of the severity of ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS/2008/109/11/0946

    authors: Pondaag W,van der Veken LP,van Someren PJ,van Dijk JG,Malessy MJ

    更新日期:2008-11-01 00:00:00

  • Split facial nerve course in vestibular schwannomas.

    abstract:OBJECT:The facial nerve in vestibular schwannomas (VSs) is located on the ventral tumor surface in more than 90% of cases; other courses are rare. A split facial nerve course with two distinct bundles has thus far been described exclusively for medial extrameatal tumors. METHODS:Between 1996 and 2005, 16 consecutive c...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2006.105.5.698

    authors: Strauss C,Prell J,Rampp S,Romstöck J

    更新日期:2006-11-01 00:00:00

  • Long-term follow-up studies of Gamma Knife surgery with a low margin dose for vestibular schwannoma.

    abstract:OBJECT:The aim of this study was to assess long-term clinical outcomes in patients who underwent Gamma Knife surgery (GKS) with a low margin dose-14 Gy or less-to treat vestibular schwannoma (VS) unrelated to neurofibromatosis Type II. METHODS:Between December 1994 and December 2001, 200 patients with VSs underwent GK...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2012.7.GKS12783

    authors: Sun S,Liu A

    更新日期:2012-12-01 00:00:00

  • Clinical evaluation of intravenous nitroglycerin for neurosurgery.

    abstract::Moment-to-moment control of blood pressure is important in the management of the neurosurgical patient. The ideal agent to control blood pressure or induce hypotension should be non-toxic, maintain cerebrovascular autoregulation, and not alter cardiac output or change intracranial pressure. Intravenous nitroglycerin h...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1978.48.5.0704

    authors: Chestnut JS,Albin MS,Gonzalez-Abola E,Newfield P,Maroon JC

    更新日期:1978-05-01 00:00:00

  • Interstitial radiosurgery of low-grade gliomas.

    abstract::The treatment of patients with low-grade gliomas remains a subject of controversy, especially with respect to new treatment modalities such as interstitial radiosurgery (brachytherapy), radiosurgery, and stereotactic radiotherapy. In a retrospective analysis conducted between 1979 and 1991, the authors studied the res...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1995.82.3.0418

    authors: Kreth FW,Faist M,Warnke PC,Rossner R,Volk B,Ostertag CB

    更新日期:1995-03-01 00:00:00

  • Phase II study of ifosfamide, carboplatin, and etoposide in patients with a first recurrence of glioblastoma multiforme.

    abstract:OBJECT:The prognosis of recurrent glioblastoma multiforme (GBM) remains unsatisfactory. The authors conducted a Phase II study of ifosfamide, carboplatin, and etoposide (ICE) for a first recurrence of GBM to determine whether it prolonged a patient's good-quality life. METHODS:This trial was an open-label, single-cent...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2009.5.JNS081738

    authors: Aoki T,Mizutani T,Nojima K,Takagi T,Okumura R,Yuba Y,Ueba T,Takahashi JA,Miyatake S,Nozaki K,Taki W,Matsutani M

    更新日期:2010-01-01 00:00:00

  • Prenatal assignation of lesion levels in neural tube defects by using ultrasonography. Case report and review of the literature.

    abstract::Myelomeningoceles are routinely diagnosed prenatally by using ultrasonography. Because the level of the neural defect has been shown to correlate with functional and cognitive outcome in infants with myelomeningocele, it is of prognostic importance to identify the level prenatally. The authors report on a case in whic...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.2005.102.2.0248

    authors: McEwing RL,Pretorius DH,James HE,Daneshmand S

    更新日期:2005-03-01 00:00:00

  • Awake surgery for WHO Grade II gliomas within "noneloquent" areas in the left dominant hemisphere: toward a "supratotal" resection. Clinical article.

    abstract:OBJECT:It has been demonstrated that an extensive resection (total or subtotal) may significantly increase the overall survival in patients with WHO Grade II gliomas (low-grade gliomas [LGGs]). Yet, recent data have shown that conventional MR imaging underestimates the spatial extent of LGG, since tumor cells were foun...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2011.3.JNS101333

    authors: Yordanova YN,Moritz-Gasser S,Duffau H

    更新日期:2011-08-01 00:00:00

  • Value of gas myelography in early management of acute cervical spinal cord injuries.

    abstract::Gas myelography was carried out in 22 patients with acute cervical spinal cord injuries in whom oily contrast media seemed contraindicated. The authors believe this technique makes a valuable contribution to the basic decision regarding the surgical versus medical treatment of a specific patient with a cervical cord i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1975.42.3.0330

    authors: Rossier AB,Berney J,Rosenbaum AE,Hachen J

    更新日期:1975-03-01 00:00:00

  • Experience with a shunt system using the third ventricle. Technical note.

    abstract::The authors present a technique involving placement of a catheter in the third ventricle in shunt systems for hydrocephalus, in order to avoid obstruction of the proximal catheter by particles of chorioid plexus. They emphasize the simplicity of the technique, lack of morbidity, and the good results they have obtained...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1975.42.1.0104

    authors: Gutierrez-Lara F,Hakim S

    更新日期:1975-01-01 00:00:00

  • Failure of surgical decompression for a presumed case of piriformis syndrome. Case report.

    abstract::Diagnosis of piriformis syndrome is difficult and its precise definition is highly controversial. In this article, the authors present the case of a patient who had clinical features suggestive of piriformis syndrome. During surgery the patient was found to have a rare variation in anatomical structures, in which the ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2001.94.4.0652

    authors: Spinner RJ,Thomas NM,Kline DG

    更新日期:2001-04-01 00:00:00

  • Thoracic spinal stenosis: experience with seven cases.

    abstract::The authors report seven cases of thoracic spinal stenosis caused by thickening of the laminar arch and facet joints. Claudication was a prominent clinical feature of this disorder. Motor and sensory abnormalities were found in all cases with either segmental or peripheral distribution. Diagnosis was best made from th...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1988.68.1.0037

    authors: Yamamoto I,Matsumae M,Ikeda A,Shibuya N,Sato O,Nakamura K

    更新日期:1988-01-01 00:00:00

  • Clinical and electrophysiological expression of deafferentation pain alleviated by dorsal root entry zone lesions in rats.

    abstract:OBJECT:The aims of this study were to construct an animal model of deafferentation of the spinal cord by brachial plexus avulsion and to analyze the effects of subsequent dorsal root entry zone (DREZ) lesions in this model. To this end, the authors measured the clinical and electrophysiological effects of total deaffer...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2002.97.6.1402

    authors: Guenot M,Bullier J,Sindou M

    更新日期:2002-12-01 00:00:00

  • Megadose corticosteroid therapy following experimental traumatic spinal injury.

    abstract::Corticosteroids are frequently used in the treatment of spinal trauma, although neither experimental nor clinical evidence to support their use is persuasive. Recently there have been claims that extremely high doses ("megadoses") of corticosteroids (equivalent to 15 to 30 mg/kg of methylprednisolone) improve neurolog...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.4.0712

    authors: Faden AI,Jacobs TP,Patrick DH,Smith MT

    更新日期:1984-04-01 00:00:00

  • Unilateral septal technique for transsphenoidal microsurgical approach to the sella turcica. Technical note.

    abstract::A modification of the transseptal, transsphenoidal appraoch to the sella turcica is described; it consists of a unilateral separation of the nasal mucosa from the nasal septum. Experience with the technique in 215 cases has indicated that it is a useful, practical appraoch. The advantages are that the septum is spared...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1978.49.1.0138

    authors: Tindall GT,Collins WF Jr,Kirchner JA

    更新日期:1978-07-01 00:00:00

  • Surgically reversible hypothalamic hypopituitarism due to aqueductal stenosis. Case report.

    abstract::A 13-year-old girl was referred for evaluation of the deceleration in her rate of linear growth, an arrest in the progression of her pubertal maturation, and bifrontal headaches. Detailed endocrinological and radiological studies revealed the following abnormalities: partial growth hormone deficiency, prepubertal lute...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1983.58.6.0932

    authors: Dempsey RJ,Chandler WF,Sauder SE

    更新日期:1983-06-01 00:00:00

  • Effect of perioperative aspirin use on hemorrhagic complications in elective craniotomy for brain tumors: results of a single-center, retrospective cohort study.

    abstract:OBJECTIVE:In daily practice, neurosurgeons face increasing numbers of patients using aspirin (acetylsalicylic acid, ASA). While many of these patients discontinue ASA 7-10 days prior to elective intracranial surgery, there are limited data to support whether or not perioperative ASA use heightens the risk of hemorrhagi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.12.JNS182483

    authors: Hanalioglu S,Sahin B,Sahin OS,Kozan A,Ucer M,Cikla U,Goodman SL,Baskaya MK

    更新日期:2019-04-05 00:00:00

  • Cerebrovascular effects of hypocapnia during adenosine-induced arterial hypotension.

    abstract::Profound arterial hypotension is a commonly used adjunct in surgery for aneurysms and arteriovenous malformations. Hyperventilation with hypocapnia is also used in these patients to increase brain slackness. Both measures reduce cerebral blood flow (CBF). Of concern is whether CBF is reduced below ischemic thresholds ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.63.6.0937

    authors: Boarini DJ,Kassell NF,Sprowell JA,Olin JJ,Coester HC

    更新日期:1985-12-01 00:00:00