Abstract:
:Permafrost covers a quarter of the northern hemisphere land surface and contains twice the amount of carbon that is currently present in the atmosphere. Future climate change is expected to reduce its near-surface cover by over 90% by the end of the 21st century, leading to thermokarst lake formation. Thermokarst lakes are point sources of carbon dioxide and methane which release long-term carbon stocks into the atmosphere, thereby initiating a positive climate feedback potentially contributing up to a 0.39°C rise of surface air temperatures by 2300. This review describes the potential role of thermokarst lakes in a warming world and the microbial mechanisms that underlie their contributions to the global greenhouse gas budget.
journal_name
Trends Microbioljournal_title
Trends in microbiologyauthors
In 't Zandt MH,Liebner S,Welte CUdoi
10.1016/j.tim.2020.04.002subject
Has Abstractpub_date
2020-09-01 00:00:00pages
769-779issue
9eissn
0966-842Xissn
1878-4380pii
S0966-842X(20)30091-3journal_volume
28pub_type
杂志文章,评审abstract::The ability of bacterial cells to use small signalling molecules to monitor population growth may help them to react rapidly to environmental change. Regulatory systems made up of a small sensor molecule, an N-acyl homoserine lactone and a protein effector have been identified recently in a wide range of Gram-negative...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/0966-842x(94)90110-q
更新日期:1994-06-01 00:00:00
abstract::Bacterial motility relies chiefly on the rotation of a molecular propeller, the flagellar filament, which is constructed from the protein flagellin. Here, flagellin sequence conservation and diversity is examined in the light of the recently determined flagellar filament structure. As expected, the surface-exposed dom...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2006.02.008
更新日期:2006-04-01 00:00:00
abstract::The discovery of 'molecular syringes' in several important gastrointestinal pathogens including Escherichia coli, Salmonella, Shigella and Yersinia, together with a better understanding of M cells and the mucosal immune system, has advanced our appreciation of multistage microorganism-host cell interactions. Recent st...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(00)01828-x
更新日期:2000-10-01 00:00:00
abstract::A new genetic locus mediating avirulence in the potato late blight pathogen Phytophthora infestans has been discovered. The Avr3b-Avr10-Avr11 locus is recognized by three different potato resistance genes, and is different from other Avr loci that have been identified thus far. This locus encodes a large protein with ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2006.09.004
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.09.010
更新日期:2019-02-01 00:00:00
abstract::Badgers represent a wildlife reservoir for bovine tuberculosis in Britain, which persists in the south west despite almost 20 years of badger control. The influence of landscape structure on patterns of badger urinatory behaviour may be one reason for the localized persistence of the disease in cattle within the regio...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/0966-842x(94)90124-4
更新日期:1994-02-01 00:00:00
abstract::Subunit vaccines based on recombinant proteins can suffer from poor immunogenicity owing to incorrect folding of the target protein or poor presentation to the immune system. Virus-like particles (VLPs) represent a specific class of subunit vaccine that mimic the structure of authentic virus particles. They are recogn...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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更新日期:2003-09-01 00:00:00
abstract::The intestine harbors an ecosystem composed of the intestinal mucosa and the commensal microbiota. The microbiota fosters development, aids digestion and protects host cells from pathogens - a function referred to as colonization resistance. Little is known about the molecular basis of colonization resistance and how ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2007.12.008
更新日期:2008-03-01 00:00:00
abstract::The formation of biofilms is initiated by bacteria transitioning from the planktonic to the surface-associated mode of growth. Several regulatory systems have been described to govern the initiation and subsequent formation of biofilms. Recent evidence suggests that regulatory networks governing the decision of bacter...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2012.10.008
更新日期:2013-01-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2015.10.012
更新日期:2016-02-01 00:00:00
abstract::The term 'type III secretion' has seen widespread use. However, problems persist in nomenclature. We propose that the standard abbreviation for this kind of secretion should be 'T3S' and that 'type III secretion system' should be abbreviated to 'T3SS'. There is also a need for a new terminology to distinguish flagella...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2006.02.009
更新日期:2006-04-01 00:00:00
abstract::Insect endogenous retroviruses (IERVs) are present in the genome of several species. Previous studies have shown a relationship between the envelope glycoproteins (Envs) and fusion proteins (FPs) of several baculoviruses. We used this sequence similarity to predict fusion domains in the Envs of IERVs. We suggest that ...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/s0966-842x(03)00119-7
更新日期:2003-06-01 00:00:00
abstract::In nongrowing microbes, proteome turnover is reduced and identification of newly synthesized, low-abundance proteins is challenging. Babin and colleagues recently utilized bio-orthogonal noncanonical amino acid tagging (BONCAT) to identify actively synthesized proteins in nongrowing Pseudomonas aeruginosa, discovering...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2016.02.014
更新日期:2016-05-01 00:00:00
abstract::Many proteins are transported to the cell surface of Saccharomyces cerevisiae and Candida albicans to be either integrated into the cell-wall structure or exported to the external medium. Secretion of many of these proteins through the classical endoplasmic reticulum-Golgi pathway is driven by a canonical N-terminal s...
journal_title:Trends in microbiology
pub_type: 杂志文章
doi:10.1016/j.tim.2005.11.009
更新日期:2006-01-01 00:00:00
abstract::No curative drug against HIV has yet been found, despite enormous efforts aimed at reverse transcriptase and a variety of other targets. The long terminal repeat (LTR) of HIV-1 has recently become a promising site for antiviral action. This article briefly summarizes information on the nature of this target and potent...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/0966-842x(94)90666-1
更新日期:1994-05-01 00:00:00
abstract::Many reports have documented that Staphylococcus aureus can invade host cells and persist intracellularly for various periods of time in cell culture models. However, it is not clear whether intracellular persistence of S. aureus also occurs in the course of infections in whole organisms. This is a subject of intense ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2008.11.005
更新日期:2009-02-01 00:00:00
abstract::Over the past two decades infections due to antibiotic-resistant bacteria have escalated world-wide, affecting patient morbidity, mortality, and health care costs. Among these bacteria, Enterococcus faecium and Enterococcus faecalis represent opportunistic nosocomial pathogens that cause difficult-to-treat infections ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.01.004
更新日期:2017-06-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2016.06.010
更新日期:2016-11-01 00:00:00
abstract::The interferon-inducible, transmembrane protein BST-2 (CD317, tetherin) directly holds fully formed enveloped virus particles to the cells that produce them, inhibiting their spread. BST-2 inhibits members of the retrovirus, filovirus, arenavirus and herpesvirus families. These viruses encode a variety of proteins to ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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更新日期:2010-09-01 00:00:00
abstract::Antibiotic-associated diarrhoea (AAD) is a common and unintended consequence of antibiotic use. Clostridium difficile is the most common infectious aetiology of AAD; however, only approximately 25% of all AAD cases are associated with C. difficile infection, with the aetiology in the majority of cases remaining undete...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2016.02.001
更新日期:2016-06-01 00:00:00
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journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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journal_title:Trends in microbiology
pub_type: 评论,杂志文章
doi:10.1016/j.tim.2008.03.008
更新日期:2008-06-01 00:00:00
abstract::The lipid phosphatidylethanolamine (PE) is the first chemoattractant to be described for a surface-motile bacterium. In Myxococcus xanthus, the specific activity of PE is determined by its fatty acid components. Two active species have been identified: dilauroyl PE and dioleoyl PE. Excitation to dilauroyl PE requires ...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(01)01948-5
更新日期:2001-03-01 00:00:00
abstract::Microbial pathogens possess a diversity of weapons that disrupt host homeostasis and immune defenses, thus resulting in the establishment of infection. The best-characterized system mediating bacterial protein delivery into target eukaryotic cells is the type III secretion system (T3SS) expressed by Gram-negative bact...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2018.01.010
更新日期:2018-04-01 00:00:00
abstract::The dramatic clinical manifestations of toxigenic infections such as cholera and diphtheria occur without substantial bacterial invasion. Disease is mediated by the secretion of potent toxins that use ADP-ribosylation as the catalytic mechanism underlying their action. ADP-ribosylating toxins comprise a large family, ...
journal_title:Trends in microbiology
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更新日期:2001-01-01 00:00:00
abstract::Vaccines preventing seasonal influenza infections save many lives every year; however, due to rapid viral evolution, they have to be updated frequently to remain effective. To identify appropriate vaccine strains, the World Health Organization (WHO) operates a global program that continually generates and interprets s...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.tim.2017.09.001
更新日期:2018-02-01 00:00:00
abstract::The pleiotropic post-transcriptional regulator Hfq is an RNA chaperone that facilitates pairing interactions between small regulatory RNAs (sRNAs) and their mRNA targets in several bacteria. However, this classical pattern, derived from the Escherichia coli model, is not applicable to the whole bacterial kingdom. In t...
journal_title:Trends in microbiology
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doi:10.1016/j.tim.2009.06.003
更新日期:2009-09-01 00:00:00
abstract::Although APOBEC3 degradation is the canonical function of HIV-1 Vif, this viral protein also induces potent cell cycle arrest through a newly defined mechanism. Here, we review recent advances in this area and propose that the scope of this activity may go beyond subversion of the host cell cycle. ...
journal_title:Trends in microbiology
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doi:10.1016/j.tim.2021.01.001
更新日期:2021-01-19 00:00:00
abstract::Until recently, bacterial responses to changes in light environments were regarded as specialized adaptations in a small number of phototrophs. However, the genomes of many photosynthetic and chemotrophic bacteria not known to have photophysiological responses also encode photoreceptor proteins. What new trends in the...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
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更新日期:2011-09-01 00:00:00
abstract::In bacteria, Ca(2+) is implicated in a wide variety of cellular processes, including the cell cycle and cell division. Dedicated influx and efflux systems tightly control the low cytoplasmic Ca(2+) levels in prokaryotes. Additionally, the growing number of proteins containing various Ca(2+)-binding motifs supports the...
journal_title:Trends in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s0966-842x(01)02284-3
更新日期:2002-02-01 00:00:00