Abstract：
:The past decade has witnessed a paradigm shift in cancer therapy owing to the introduction of immune checkpoint inhibitors (ICIs) and it is now commonplace for radiologists to image patients on therapy with these agents. The purpose of this review is to detail the mechanism, radiological manifestations and clinical significance of ICI related toxicities, according to the organ system involved. ICI related toxicities that have known imaging manifestations include colitis, enterocolitis, pancreatitis, hepatitis, endocrine toxicities, pneumonitis, cardiovascular toxicity and musculoskeletal toxicity. These toxicities may be acute, recurrent or chronic in nature. Radiologists must be aware of the imaging features and clinical significance of these toxicities in order to effectively participate in personalized cancer therapy.
journal_name
Clin Imagingjournal_title
Clinical imagingauthors
Thomas R,Sebastian B,George T,Majeed NF,Akinola T,Laferriere SL,Braschi-Amirfarzan Mdoi
10.1016/j.clinimag.2020.04.007subject
Has Abstractpub_date
2020-08-01 00:00:00pages
70-79eissn
0899-7071issn
1873-4499pii
S0899-7071(20)30107-8journal_volume
64pub_type
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