Abstract:
OBJECTIVE:Sleep quality is diminished in patients with psoriatic arthritis (PsA) and close to 40% of PsA patients consider sleep difficulties a priority domain. This work analyzes determinants of impaired sleep in patients with PsA. METHODS:This was a cross-sectional analysis of an observational study (ReFlap, NCT NCT03119805), which included adult patients with definite PsA with≥2 years disease duration from 14 countries. Sleep was assessed using the patient self-reported evaluation of sleep on a 0-10 numerical scale, included in the Psoriatic Arthritis Impact of Disease questionnaire (PSAID-12). A score≥4 was considered as sleep impairment. Demographic and clinical variables associated to sleep impairment were assessed through univariate analysis and Poisson regression modeling leading to prevalence ratio (PR) [95% confidence interval]. RESULTS:A total of 396 patients were analyzed: mean age 51.9±12.6 years, 51% were females, 59.7% were receiving biologic therapy, 53.3% had 1-5% of body surface area affected by psoriasis; 23.7% were in remission and 36.9% in low disease activity according to the Disease Activity in Psoriatic Arthritis (DAPSA) score. Median (25th-75th) patient's self-evaluation of sleep difficulties was 2 (0-6), 157 (39.6%) had sleep impairment. In the Poisson regression model, self-reported levels of anxiety (PR: 1.05 [1.02-1.08], P=0.003) and pain (PR: 1.06 [1.04-1.09], P<0.001) were independently associated to sleep impairment. CONCLUSIONS:In this multicentric study, sleep impairment was present in 40% of PsA patients; pain and anxiety were associated to sleep impairment whereas inflammation was not. Impact on sleep appears multifactorial in PsA.
journal_name
Joint Bone Spinejournal_title
Joint bone spineauthors
Palominos PE,Coates L,Kohem CL,Orbai AM,Smolen J,de Wit M,Kiltz U,Leung YY,Cañete JD,Scrivo R,Balanescu A,Dernis E,Meisalu S,Soubrier M,Aydin SZ,Gaydukova I,Kalyoncu U,Gossec Ldoi
10.1016/j.jbspin.2020.03.014subject
Has Abstractpub_date
2020-10-01 00:00:00pages
449-454issue
5eissn
1297-319Xissn
1778-7254pii
S1297-319X(20)30061-0journal_volume
87pub_type
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