Cryptococcus gattii: in vitro susceptibility to photodynamic inactivation.

Abstract:

:Cryptococus gattii is an emergent primary human pathogen that causes meningismus, papilledema, high intracranial pressure and focal involvement of the central nervous system in immunocompetent hosts. Prolonged antifungal therapy is the conventional treatment, but it is highly toxic, selects for resistant strains, contributes to therapy failure and has a poor prognosis. Photodynamic inactivation (PDI) offers a promising possibility for the alternative treatment of cryptococcosis. The aim of this study was to test the effectiveness of toluidine blue O (TBO) and light-emitting diode (LED) against C. gattii strains with distinct susceptibility profile to antifungal drugs (amphotericin B: 0.015-1.0 μg mL(-1); itraconazole: 0.015-2 μg mL(-1); fluconazole: 4-64 μg mL(-1)). Using 25 μM (6.76 μg mL(-1)) TBO and LED energy density of 54 J cm(-2) these fungal isolates presented variable susceptibility to PDI. The production of reactive oxygen species (ROS)/peroxynitrite was determined, and the catalase and peroxidase activities were measured. After PDI, high amounts of ROS/peroxynitrite are produced and higher catalase and peroxidase activities could be correlated with a lower susceptibility of C. gattii isolates to PDI. These results indicate that PDI could be an alternative to C. gattii growth inhibition, even of isolates less susceptible to classical antifungal drugs, also pointing to mechanisms related to their variable susceptibility behavior.

journal_name

Photochem Photobiol

authors

Soares BM,Alves OA,Ferreira MV,Amorim JC,Sousa GR,Silveira Lde B,Prates RA,Avila TV,Baltazar Lde M,de Souza Dda G,Santos DA,Modolo LV,Cisalpino PS,Pinotti M

doi

10.1111/j.1751-1097.2010.00868.x

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

357-64

issue

2

eissn

0031-8655

issn

1751-1097

journal_volume

87

pub_type

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