Abstract:
:In the last few decades, the number of targeted chemotherapies approved for cancer treatment and undergoing clinical trials has risen. In comparison to conventional chemotherapy, targeted therapies (TTs) act on specific molecular targets involved in cancer development and progression, with reduced detrimental effects to normal tissues. TTs have now been recognised as key treatments in a number of common cancers, including solid tumours and haematological malignancies. The number of patients undergoing novel cancer treatment will continue to increase, and a significant population will likely present to the dental environment. This paper aims to provide an insight into TTs currently available, including monoclonal antibodies, fusion proteins, tyrosine kinase inhibitors, histone deacetylase inhibitors, mammalian target of rapamycin inhibitors, phosphoinositide 3-kinase inhibitors, proteasome inhibitors and hedgehog pathway inhibitors. The mechanisms of action, indications for use and how to identify the medications will be summarised. Dental implications of these novel therapies include medication-related osteonecrosis of the jaw, delayed healing, immunosuppression and thrombocytopenia. These will be discussed to ensure oral healthcare providers are aware of their impact in a dental setting.
journal_name
Br Dent Jjournal_title
British dental journalauthors
King R,Zebic L,Patel Vdoi
10.1038/s41415-020-1365-5subject
Has Abstractpub_date
2020-03-01 00:00:00pages
415-421issue
6eissn
0007-0610issn
1476-5373pii
10.1038/s41415-020-1365-5journal_volume
228pub_type
杂志文章abstract::The use of problem-based learning as part of a vocational training scheme for vocational dental practitioners is described and evaluated. Problem-based learning is currently viewed as an effective means of delivering medical education and has been adopted as a principal style of education by many undergraduate medical...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4800213
更新日期:1999-07-24 00:00:00
abstract:OBJECTIVES:To gather information on the types of panoramic x-ray equipment used in NHS dental practice and whether dentists satisfy the legal requirements for safety, to determine which practice personnel take panoramic radiographs and to assess the prevalence of the practice of 'routine' panoramic radiography among NH...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4800098
更新日期:1999-04-10 00:00:00
abstract:OBJECTIVE:To evaluate orthodontic practice websites for the reliability of information presented, accessibility, usability for patients and compliance to General Dental Council (GDC) regulations on ethical advertising. SETTING:World Wide Web. MATERIALS AND METHODS:The term 'orthodontic practice' was entered into thre...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2014.403
更新日期:2014-05-01 00:00:00
abstract:AIM:To compare the demographics (age, sex, ethnicity, social status, disability, country/region) and academic experience (school type) of accepted UK applicants to the five-year and four-year dental programmes in 2007 and 2008. METHODS:Retrospective descriptive analysis was carried out on the University and College Ad...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2013.107
更新日期:2013-02-01 00:00:00
abstract::Introduction Despite excellent reviews in the past several years, the use of antibiotics as prophylaxis for implant placement remains controversial.Aim To assess the literature on the efficacy of prophylactic antibiotics prescribed prior to and immediately following implant surgery (PIFS).Outcomes Whether administrati...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/s41415-020-1649-9
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of an orofacial trauma-based brief intervention, designed to raise adolescent males' awareness about the immediate dangers of binge drinking. DESIGN:Non-randomised controlled exploratory trial. SETTING:Secondary level schools. MATERIALS & METHODS:Pre, post and follow up valida...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4814204
更新日期:2006-11-11 00:00:00
abstract::Statement of the problem Digital workflows (CAD/CAM) have been introduced in dentistry during recent years. No published information exists on dentists' use and reporting of this technology.Purpose The purpose of this survey was to identify the infiltration of CAD/CAM technology in UK dental practices and to investiga...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2016.862
更新日期:2016-11-18 00:00:00
abstract:OBJECTIVES:To determine the methods currently being used to decontaminate photographic retractors in specialist orthodontic practice and to investigate the effectiveness of the cleaning methods. DESIGN:The study was carried out in two parts: I - a postal self-report questionnaire, and II - a cross-sectional clinical a...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2010.310
更新日期:2010-04-10 00:00:00
abstract::It is widely accepted that the practice support staff, and particularly the dental nurse, have a major role to play in ensuring patient satisfaction and reassurance. Despite this, findings from recent research by Maria Mindak show that dental nurses do not as a rule receive praise, encouragement or feedback from their...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4809036
更新日期:1996-04-06 00:00:00
abstract::There is evidence, although limited, for beneficial effects of bisphophonates (BPs) across multiple dental specialties. Within implant dentistry BP coatings have been shown to significantly increase pull out forces and bone density in animal models, and significantly increase implant stability whilst reducing marginal...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/sj.bdj.2017.412
更新日期:2017-05-12 00:00:00
abstract::The development of adhesive restorative materials has led to more conservative cavity design with greater reliance being placed upon the bond of a material with tooth tissue for retention of the restoration. Glass-ionomer cements may offer particular advantages but have yet to achieve the durability reported for amalg...
journal_title:British dental journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.bdj.4808867
更新日期:1995-09-09 00:00:00
abstract::There are certain advantages to restoring a complete arch simultaneously, however, attempting to do this requires that the dentist maintains control during all stages of treatment. Maintaining control alleviates the preassure of time, which in turn allows for precision to be obtained at all clinical and laboratory sta...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/bdj.2008.3
更新日期:2008-01-26 00:00:00
abstract::This review article presents an overview of craniofacial malformations and the role of the orthodontist in their management. The first part of this article focuses on cleft lip and palate, followed by more complex deformities including craniosynostosis and craniofacial microsomia. The main features of these anomalies ...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/sj.bdj.2015.48
更新日期:2015-02-16 00:00:00
abstract:AIM:To seek children's opinions about the acceptability of resin fissure sealant placement. STUDY DESIGN:Service evaluation using a child-centred questionnaire issued to a prospective sample of consecutive hospital patients.Method Questionnaires were issued to children, aged 3 to 16 years, immediately after resin fiss...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2014.553
更新日期:2014-07-11 00:00:00
abstract::The regulation of cell growth is fundamental to the maintenance of health: disturbed regulation can result in neoplasia. Genes in normal cells (protooncogenes) code for proteins involved in the regulation of cell growth and differentiation; abnormalities in these genes (oncogenes) or their expression are often involve...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/sj.bdj.4807936
更新日期:1992-07-25 00:00:00
abstract::Introduction People from vulnerable groups have higher levels of untreated dental disease compared to the general population, yet often experience barriers to accessing care. Difficulties accessing oral healthcare services have been suggested as one of the pathways that contribute to oral health inequalities.Aim To co...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/s41415-019-0529-7
更新日期:2019-07-01 00:00:00
abstract::Participation in sport carries an increased risk of sustaining dental trauma which can be reduced by the use of a mouthguard. Mouthguards work by dissipating the force of impact, thus reducing the force which is transferred to the dentition. There are different types of mouthguard available which vary in design, costs...
journal_title:British dental journal
pub_type: 杂志文章,评审
doi:10.1038/sj.bdj.2017.365
更新日期:2017-04-21 00:00:00
abstract::Since the outbreak of war in the former Yugoslavia, the British Government has accepted a number of people with special humanitarian needs from Bosnia. In October 1992, seven families, comprising of ten adults aged between 24 and 42 years old and 13 children aged between 18 months and 15 years old, arrived in Surrey h...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4808265
更新日期:1993-09-11 00:00:00
abstract:BACKGROUND:Contemporary evidence for the effectiveness of water fluoridation schemes in the U.K. is sparse. The utility of routinely collected data in providing evidence warrants further research. OBJECTIVES:To examine inpatient hospital episodes statistics for dental extractions as an alternative population marker fo...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2014.180
更新日期:2014-03-01 00:00:00
abstract::Treatment planning for compromised first permanent molars (FPM) can be difficult. In this paper, we present a clinical protocol to support decision-making. Interceptive loss of an FPM should be considered: where the restoration required to repair the compromised FPM is likely to be large; if the FPM is compromised bec...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/s41415-019-0561-7
更新日期:2019-08-01 00:00:00
abstract::As we debate shaping the future oral health workforce within the UK, to meet the needs of current and future populations, it is helpful to take an international perspective on this very important issue. Globally, there is a strong recognition that human resources for health (HRH) are fundamentally important to deliver...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2018.532
更新日期:2018-07-27 00:00:00
abstract:AIM:To examine the experience of being an outreach teacher of undergraduate restorative dentistry; to describe the desirable characteristics of such teachers; and to consider the management of outreach teaching. DESIGN:A three year pilot of an outreach course in fourth year restorative dentistry began in 2001. Student...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/bdj.2007.681
更新日期:2007-08-11 00:00:00
abstract:OBJECTIVE:To assess the long-term follow-up of patients successfully treated for disc displacement with anterior repositioning splint therapy and patients successfully treated for pain dysfunction syndrome with stabilisation therapy. DESIGN:Retrospective analysis. SETTING:Dental school clinic unit. METHODS:Maintenan...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4809495
更新日期:1997-10-25 00:00:00
abstract::Osteoradionecrosis (ORN) remains a difficult clinical problem. In large refractory cases surgery appears to be the only option but it does not guarantee a cure and is expensive. Cost analysis of 31 patients who had resection with or without reconstruction of their mandible was £892,357. The largest cost was in-patient...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2017.121
更新日期:2017-02-10 00:00:00
abstract::Dental standards play a vital and important role in society by contributing to the quality and safety levels of products used in dental treatments by dental professionals as well as the hygiene products used by the general public. Few members of the public or indeed many dentists fully appreciate the contribution made...
journal_title:British dental journal
pub_type: 历史文章,杂志文章
doi:10.1038/sj.bdj.2012.835
更新日期:2012-09-01 00:00:00
abstract::Angiotensin converting enzyme (ACE) inhibitors are a commonly prescribed, effective medication in the treatment of hypertension and heart failure. Several side-effects of dental relevance can occur including angioedema of the lips, mouth and throat. This adverse effect is well reported and can be fatal, but it is not ...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2008.982
更新日期:2008-11-22 00:00:00
abstract:UNLABELLED:There is significant evidence to support the regular review of patients with chronic periodontitis. There is, however, comparatively little evidence to demonstrate how often such reviews should take place. This paper looks at the periodontal healing period, the risks of periodontal progression and current th...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2011.868
更新日期:2011-10-21 00:00:00
abstract:INTRODUCTION:General referral letters to any hospital specialty are universally poor. These letters are the main source of information regarding the clinical problem and shortfalls can compromise the management of the patient. METHOD:One hundred retrospective randomly selected oral surgery referral letters in the form...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.2012.929
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To investigate the dental health of 12-year-old children and the effectiveness of dental services in 1997 and compare the results with studies carried out in 1960 and 1988. BASIC RESEARCH DESIGN:Analytical survey using a one in five random sample of children in all seven secondary schools in Salford UK. Stan...
journal_title:British dental journal
pub_type: 杂志文章
doi:10.1038/sj.bdj.4809642
更新日期:1998-04-25 00:00:00
abstract::Despite the extensive and regular use of dental elevators on a daily basis in both general dental and specialist oral and maxillofacial surgical practice, little is known about the history and origins of such instruments and this remains an intriguing question. This question has been the basis for the following articl...
journal_title:British dental journal
pub_type: 传,历史文章,杂志文章
doi:10.1038/sj.bdj.2008.933
更新日期:2008-11-08 00:00:00