The role of biofilms: are we hitting the right target?

Abstract:

BACKGROUND:Chronic infections affect 17 million people yearly, and approximately 550,000 people die each year from, or with, their chronic infections. Acute and chornic infection differences are well known to clinicians, but the role of bacteria in producing these clinical differences remains poorly understood. METHODS:This review relies on basic science, clinical studies, and a general review of the medical biofilm literature. The basic science studies are level A and B quality of evidence. The clinical studies are mainly retrospective cohort (level B) and case studies (level C). The biofilm literature includes reviews with varying levels of evidence. All articles have been peer reviewed and meet the standard of evidence-based medicine. RESULTS:Acute infections are associated with planktonic bacteria and must be diagnosed rapidly and accurately to prevent tissue damage and/or death. In contrast, biofilm behavior pursues a more parasitic course by producing sustained host hyperinflammation, with the biofilm feeding on plasma exudate. Chronic infections vacillate over long periods of time, responding only partially to antibiotics and reemerging once the antibiotics are withdrawn. Chronic wounds exhibit similar clinical behavior seen in other chronic infections and are associated with biofilm phenotype bacteria on their surface. Biofilm infections, such as chronic wounds, cannot be adequately diagnosed with current clinical cultures; therefore, molecular methods are necessary. CONCLUSIONS:Biofilm phenotype bacteria require multiple concurrent strategies, including débridement and targeted antibiofilm agents. Biofilm phenotype bacteria predominate on the surface of wounds, and biofilm-based management improves wound healing outcomes, indicating that biofilm is the right target for managing the bioburden barrier of chronic wounds.

journal_name

Plast Reconstr Surg

authors

Wolcott R,Dowd S

doi

10.1097/PRS.0b013e3181fca244

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

28S-35S

eissn

0032-1052

issn

1529-4242

pii

00006534-201101001-00007

journal_volume

127 Suppl 1

pub_type

杂志文章,评审
  • Airway hazards associated with pharyngeal flaps in patients who have the Pierre Robin syndrome.

    abstract::We describe 3 patients with the Pierre Robin Syndrome who developed severe problems of airway obstruction after having the cleft palate closed and a pharyngeal flap done simultaneously. We now believe that, even at a later age, pharyngeal flaps should be done in these patients only after a most careful assessment of t...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197608000-00007

    authors: Jackson P,Whitaker LA,Randall P

    更新日期:1976-08-01 00:00:00

  • Newer Understanding of Specific Anatomic Targets in the Aging Face as Applied to Injectables: Aging Changes in the Craniofacial Skeleton and Facial Ligaments.

    abstract::Logical correction of aging contour changes of the face is based on understanding its structure and the processes involved in the aging appearance. Aging changes are seen at all tissue levels between the skin and bone although the relative contribution of each component to the overall change of facial appearance has y...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0000000000001752

    authors: Wong CH,Mendelson B

    更新日期:2015-11-01 00:00:00

  • A reinvestigation of murine cranial suture biology: microcomputed tomography versus histologic technique.

    abstract:BACKGROUND:Histology remains the standard form to analyze cranial suture in murine models, but this technique provides only limited "snapshots" of the entire suture and requires animal euthanasia with tissue destruction. Because of the bone complex microarchitecture, better methods are required to study the behavior of...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000232979.78132.b2

    authors: Stadler JA 3rd,Cortes W,Zhang LL,Hanger CC,Gosain AK

    更新日期:2006-09-01 00:00:00

  • Myxoma of the maxilla: surgical treatment of an unusual case in a child.

    abstract::A case of unusual myxoma in a 2-year-old child is reported with its surgical treatment and postoperative outcome. Differential diagnosis with other pathologies such as mucocele and sarcoma is discussed. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Caleffi E,Toschi S,Bocchi A

    更新日期:1994-05-01 00:00:00

  • Experimental and clinical study on the vitality of orthotopic cartilage transplants.

    abstract::Orthotopic cartilage transplants are performed in the course of numerous rhinosurgical operations. Precondition of a permanent success of the operation is preservation of vitality of the transplanted cartilage. Although numerous study results of heterotopic cartilage transplants exist, corresponding examinations in or...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199504000-00007

    authors: Gubisch W,Greulich M,Donath K

    更新日期:1995-04-01 00:00:00

  • External distraction osteogenesis in the pediatric mandible.

    abstract:SUMMARY:Mandibular distraction osteogenesis is an effective tool with which to correct facial asymmetry, restore proper occlusion and, more importantly, create an appropriate airway in the micrognathic infant. As a component of many syndromes, micrognathia can impair feeding and speech development and can obstruct the ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e318193485e

    authors: Kaufman Y,Cole PD,McKnight A,Hatef DA,Hollier LH

    更新日期:2009-01-01 00:00:00

  • Rat ear reattachment as an animal model.

    abstract::The external ear of the rat is an excellent model for practicing microsurgical dissection and for the refinement of microvascular anastomoses, techniques that are crucial for microvascular en bloc tissue transfer and replantation. Preparation of the rat ear for replantation requires familiarity with the vascular anato...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199005000-00020

    authors: Chiu DT,Chen L,Chen ZW

    更新日期:1990-05-01 00:00:00

  • Subcutaneous mastectomy in small, large, or ptotic breasts with immediate submuscular placement of implants.

    abstract::We present a series of 70 patients who have had bilateral subcutaneous mastectomies with immediate placement of implants under the intact pectoralis major and upper part of the serratus anterior. Twenty-two of these patients have had a simultaneous mastopexy, with a free nipple graft. All 70 patients have both of thei...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197811000-00006

    authors: Jarrett JR,Cutler RG,Teal DF

    更新日期:1978-11-01 00:00:00

  • Radial forearm free flap: hybrid version.

    abstract::The hybrid version of the radial forearm free flap provides an alternative method for reconstruction in the head and neck. It is versatile and has certain theoretical and practical advantages, including high-flow venous drainage, long venous pedicle, lymphatic drainage, and the avoidance of venous anastomosis or venou...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199909040-00026

    authors: To EW,Wang JC

    更新日期:1999-09-01 00:00:00

  • Bioactive sutures.

    abstract::With the first wave of bioactive sutures already in the marketplace, research is ongoing in the development of future products. Such sutures could potentially have not only antimicrobial activity but also anesthetic and antineoplastic functions. Some clinical trials have already been completed in Russia. This technolo...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/01.prs.0000248418.23513.1f

    authors: Neligan PC,Plastic Surgery Educational Foundation Technology Assessment Committee.

    更新日期:2006-12-01 00:00:00

  • Diagnosis and treatment of diabetic foot infections.

    abstract::EXECUTIVE SUMMARY: 1. Foot infections in patients with diabetes cause substantial morbidity and frequent visits to health care professionals and may lead to amputation of a lower extremity. 2. Diabetic foot infections require attention to local (foot) and systemic (metabolic) issues and coordinated management, prefera...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000222737.09322.77

    authors: Lipsky BA,Berendt AR,Deery HG,Embil JM,Joseph WS,Karchmer AW,LeFrock JL,Lew DP,Mader JT,Norden C,Tan JS,Infectious Diseases Society of America.

    更新日期:2006-06-01 00:00:00

  • Quality of life long-term after body contouring surgery following bariatric surgery: sustained improvement after 7 years.

    abstract:BACKGROUND:Bariatric surgery for morbid obesity results in massive weight loss and improvement of health and quality of life. A downside of the major weight loss is the excess of overstretched skin, which may influence the patient's quality of life by causing functional and aesthetic problems. The purpose of the curren...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e318267d51d

    authors: van der Beek ESJ,Geenen R,de Heer FAG,van der Molen ABM,van Ramshorst B

    更新日期:2012-11-01 00:00:00

  • Reverse dorsal digital island flap.

    abstract::The anatomic and clinical bases for a reliable and versatile homodigital flap for covering difficult distal dorsal and dorsolateral wounds of the long fingers are presented. This one-step procedure, which uses the dorsal skin of the first or second phalanx transposed as a reverse island flap, preserving the collateral...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Bene MD,Petrolati M,Raimondi P,Tremolada C,Muset A

    更新日期:1994-03-01 00:00:00

  • Cross-linking in biomaterials: a primer for clinicians.

    abstract::The purpose of this primer is to provide the clinical surgeon with a survey overview of the basic biochemistry of collagen and the methods and rationale of collagen cross-linking in the processing and preparation of bioprosthetics for surgical implantation. The author highlights the critical biologic factors, such as ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0b013e31825efea6

    authors: Dunn RM

    更新日期:2012-11-01 00:00:00

  • Health-related quality-of-life assessment and surgical outcomes for auricular reconstruction using autologous costal cartilage.

    abstract:BACKGROUND:This study aims to assess the health-related quality-of-life benefit following auricular reconstruction using autologous costal cartilage in children. In addition, key aspects of the surgical reconstruction are assessed. METHODS:After auricular reconstruction, patients completed two questionnaires. The firs...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3182402ca7

    authors: Soukup B,Mashhadi SA,Bulstrode NW

    更新日期:2012-03-01 00:00:00

  • Sensate thoracodorsal artery perforator flap: a focus on its preoperative design and harvesting technique.

    abstract:BACKGROUND:Free sensate thoracodorsal artery perforator flaps that include the posterior divisions of the lateral cutaneous branches of the intercostal nerves have been described. The authors used preoperative color Doppler sonography to identify the nerves and demonstrate its clinical value. METHODS:Fourteen free sen...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181909c34

    authors: Lin CT,Yang KC,Hsu KC,Liu WC,Chen JS,Chen LW

    更新日期:2009-01-01 00:00:00

  • National plastic surgery survey: face lift techniques and complications.

    abstract::The purpose of this study was to assess trends in technique and philosophy of face lifting, associated procedures, and the incidence and management of complications. Surveys were sent to 3800 members of the American Society of Plastic and Reconstructive Surgeons (ASPRS); 570 surveys (15 percent) were returned. Numerou...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200010000-00033

    authors: Matarasso A,Elkwood A,Rankin M,Elkowitz M

    更新日期:2000-10-01 00:00:00

  • Important Developments in Burn Care.

    abstract:LEARNING OBJECTIVES:After studying this article, the participant should be able to: 1. Explain the epidemiology of severe burn injury in the context of socioeconomic status, gender, age, and burn cause. 2. Describe challenges with burn depth evaluation and novel methods of adjunctive assessment. 3. Summarize the surviv...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0000000000002908

    authors: Zuo KJ,Medina A,Tredget EE

    更新日期:2017-01-01 00:00:00

  • The role of primary bone grafting in complex craniomaxillofacial trauma.

    abstract::The role of craniofacial surgical techniques and immediate bone grafting in the management of complex craniofacial trauma has been reviewed. Four hundred and one patients with complex facial injuries have been treated. Two hundred and forty-one primary bone and cartilage grafts have been performed in 66 patients. Comp...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198501000-00005

    authors: Gruss JS,Mackinnon SE,Kassel EE,Cooper PW

    更新日期:1985-01-01 00:00:00

  • Salvage of seeing eyes after avulsion of upper and lower lids.

    abstract::It is often stated that any injury severe enough to avulse both lids will inevitably destroy the globe. Two cases are presented in which the globe was uninjured but exposed, requiring immediate coverage. Local skin flaps placed over mobilized conjunctiva were used for emergency cover. One was eventually made into func...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198501000-00003

    authors: Achauer BM,Menick FJ

    更新日期:1985-01-01 00:00:00

  • Management of wrist injuries.

    abstract:LEARNING OBJECTIVES:After studying this article, the participant should be able to: 1. Understand the anatomy and the biomechanical properties of the wrist. 2. Understand the standard examination process for wrist injuries. 3. Accurately diagnose common wrist conditions. 4. Establish a management plan for wrist problem...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/01.prs.0000279385.39997.34

    authors: Kawamura K,Chung KC

    更新日期:2007-10-01 00:00:00

  • Growth Hormone Therapy Accelerates Axonal Regeneration, Promotes Motor Reinnervation, and Reduces Muscle Atrophy following Peripheral Nerve Injury.

    abstract:BACKGROUND:Therapies to improve outcomes following peripheral nerve injury are lacking. Prolonged denervation of muscle and Schwann cells contributes to poor outcomes. In this study, the authors assess the effects of growth hormone therapy on axonal regeneration, Schwann cell and muscle maintenance, and end-organ reinn...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000002188

    authors: Tuffaha SH,Budihardjo JD,Sarhane KA,Khusheim M,Song D,Broyles JM,Salvatori R,Means KR Jr,Higgins JP,Shores JT,Cooney DS,Hoke A,Lee WPA,Brandacher G

    更新日期:2016-06-01 00:00:00

  • Benchmarking outcomes in plastic surgery: national complication rates for abdominoplasty and breast augmentation.

    abstract:BACKGROUND:The authors evaluated the use of national databases to track surgical complications among abdominoplasty and breast augmentation patients. METHODS:Their study population included all patients with abdominoplasty or breast augmentation in the Tracking Operations and Outcomes for Plastic Surgeons (TOPS) and C...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181bf8378

    authors: Alderman AK,Collins ED,Streu R,Grotting JC,Sulkin AL,Neligan P,Haeck PC,Gutowski KA

    更新日期:2009-12-01 00:00:00

  • The "knot twist": a new method of securing wire loops--an assessment of mechanical properties.

    abstract::A model simulating intraosseous wire fixation was used to assess different methods of securing wire loops. Square knotting, twisting, and a new method, the "knot twist," were assessed. The importance of anchoring the butt ends of twisted wire is emphasized. A new, convenient technique of wire fixation is described. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Green RA,Zins JE

    更新日期:1988-06-01 00:00:00

  • Craniectomy gap patency and neosuture formation following endoscopic suturectomy for unilateral coronal craniosynostosis.

    abstract:BACKGROUND:The combination of endoscope-assisted suturectomy and postoperative helmet therapy has been advocated to treat unilateral coronal synostosis. However, surgical outcomes can vary. One possible explanation for this inconsistency is early closure of the craniectomy gap. The authors examined short-term postopera...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000000285

    authors: Sauerhammer TM,Seruya M,Ropper AE,Oh AK,Proctor MR,Rogers GF

    更新日期:2014-07-01 00:00:00

  • Experimental study and clinical use of the fasciosteal flap.

    abstract::Thirty-seven domestic rabbits, 4 dogs, and 2 freshly amputated human limbs were divided into three groups as three different models of fasciosteal flaps that were taken from the distal radii or the tibiae. Through the methods of histology, fluorochrome bone labeling, and perfusing stain, it was confirmed that viabilit...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Shi ZM,Xu ZG

    更新日期:1986-08-01 00:00:00

  • Clinical applications of the posterior rectus sheath-peritoneal free flap.

    abstract::Soft-tissue injuries involving the dorsum of the hand and foot continue to pose complex reconstructive challenges in terms of function and contour. Requirements for coverage include thin, vascularized tissue that supports skin grafts and at the same time provides a gliding surface for tendon excursion. This article re...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200008000-00013

    authors: Salgado CJ,Orlando GS,Serletti JM

    更新日期:2000-08-01 00:00:00

  • From birth to maturity: a group of patients who have completed their protocol management. Part I. Unilateral cleft lip and palate.

    abstract::The optimal management of the cleft lip and palate patient from birth to completion of treatment presents a formidable challenge to the plastic surgeon and the associated health care system. The multidisciplinary team approach for the management of these patients is widely accepted. However, a paucity of literature ex...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000105332.57124.89

    authors: Schnitt DE,Agir H,David DJ

    更新日期:2004-03-01 00:00:00

  • Noninvasive Ultrasound of the Tibial Muscle for Longitudinal Analysis of Nerve Regeneration in Rats.

    abstract:BACKGROUND:Today's criterion standards for measuring functional recovery after nerve trauma in experimental studies are the muscle mass ratio and the isometric tetanic force; both tests are invasive and require a sacrificial procedure. The authors propose ultrasound as a noninvasive method to determine muscle atrophy, ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000001681

    authors: Hundepool CA,Nijhuis THJ,Rbia N,Bulstra LF,Selles RW,Hovius SER

    更新日期:2015-11-01 00:00:00

  • Cutaneous ciliated cyst: case report and literature review.

    abstract::An 18-year-old girl had a cyst excised from the left buttock in 1988. The cyst was diagnosed to be a cutaneous ciliated cyst, since histologic examination using special stains demonstrated its lining to be similar to fallopian tube epithelium. Only 20 such cases have been published to date, and this report is probably...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:

    authors: Varma SK,Rayner SS,Brown LJ

    更新日期:1990-08-01 00:00:00