Crystal structure of a novel non-Pfam protein PF2046 solved using low resolution B-factor sharpening and multi-crystal averaging methods.

abstract：:Flea-borne transmission is a recent evolutionary adaptation that distinguishes the deadly Yersinia pestis from its progenitor Y. Pseudotuberculosis, a mild pathogen transmitted via the food-borne route. Y. Pestis synthesizes biofilms in the flea gut, which is important for fleaborne transmission. Yersinia biofilms are...

journal_title：Protein & cell

authors： Zhou D,Yang R

更新日期：2011-03-01 00:00:00

abstract：:MTUS1 (microtubule-associated tumor suppressor 1) has been identified that can function as a tumor suppressor gene in many malignant tumors. However, the function and mechanisms underlying the regulation of MTUS1 are unclear. In the present study, we reported that miR-19a and miR-19b (miR-19a/b) promote proliferation ...

journal_title：Protein & cell

authors： Gu Y,Liu S,Zhang X,Chen G,Liang H,Yu M,Liao Z,Zhou Y,Zhang CY,Wang T,Wang C,Zhang J,Chen X

更新日期：2017-06-01 00:00:00

abstract：:Dendritic cells (DCs) comprise two functionally distinct subsets: plasmacytoid DCs (pDCs) and myeloid DCs (mDCs). pDCs are specialized in rapid and massive secretion of type I interferon (IFN-I) in response to nucleic acids through Toll like receptor (TLR)-7 or TLR-9. In this report, we characterized a CD56(+) DC popu...

journal_title：Protein & cell

authors： Yu H,Zhang P,Yin X,Yin Z,Shi Q,Cui Y,Liu G,Wang S,Piccaluga PP,Jiang T,Zhang L

更新日期：2015-04-01 00:00:00

abstract：:In the original publication the author's name 'Dimitri Lavillete' is published incorrectly. The correct author name should be spelt as 'Dimitri Lavillette' is provided in this correction. ...

journal_title：Protein & cell

authors： Xiong R,Zhang L,Li S,Sun Y,Ding M,Wang Y,Zhao Y,Wu Y,Shang W,Jiang X,Shan J,Shen Z,Tong Y,Xu L,Chen Y,Liu Y,Zou G,Lavillette D,Zhao Z,Wang R,Zhu L,Xiao G,Lan K,Li H,Xu K

更新日期：2020-11-09 00:00:00

abstract：:FcγRIIB, the only inhibitory IgG Fc receptor, functions to suppress the hyper-activation of immune cells. Numerous studies have illustrated its inhibitory function through the ITIM motif in the cytoplasmic tail of FcγRIIB. However, later studies revealed that in addition to the ITIM, the transmembrane (TM) domain of F...

journal_title：Protein & cell

authors： Wang J,Li Z,Xu L,Yang H,Liu W

更新日期：2018-12-01 00:00:00

abstract：:The fruit fly, Drosophila melanogaster, is able to discriminate visual landmarks and form visual long-term memory in a flight simulator. Studies focused on the molecular mechanism of long-term memory have shown that memory formation requires mRNA transcription and protein synthesis. However, little is known about the ...

journal_title：Protein & cell

authors： Jiang H,Hou Q,Gong Z,Liu L

更新日期：2011-03-01 00:00:00

abstract：:Therapeutic monoclonal antibodies are among the most effective biotherapeutics to date. An important aspect of antibodies is their ability to bind antigen while at the same time recruit immune effector functions. The majority of approved recombinant monoclonal antibody therapies are of the human IgG1 subclass, which c...

journal_title：Protein & cell

authors： Wang X,Mathieu M,Brezski RJ

更新日期：2018-01-01 00:00:00

abstract：:Plexins and semaphorins are a large family of proteins that are involved in cell movement and response. The importance of plexins and semaphorins has been emphasized by their discovery in many organ systems including the nervous (Nkyimbeng-Takwi and Chapoval, 2011; McCormick and Leipzig, 2012; Yaron and Sprinzak, 2012...

journal_title：Protein & cell

authors： Roney K,Holl E,Ting J

更新日期：2013-01-01 00:00:00

abstract：:SARS coronavirus (SARS-CoV) develops an antagonistic mechanism by which to evade the antiviral activities of interferon (IFN). Previous studies suggested that SARS-CoV papain-like protease (PLpro) inhibits activation of the IRF3 pathway, which would normally elicit a robust IFN response, but the mechanism(s) used by S...

journal_title：Protein & cell

authors： Chen X,Yang X,Zheng Y,Yang Y,Xing Y,Chen Z

更新日期：2014-05-01 00:00:00

abstract：:Retinoic acid-inducible gene I (RIG-I) is an important pattern recognition receptor that detects viral RNA and triggers the production of type-I interferons through the downstream adaptor MAVS (also called IPS-1, CARDIF, or VISA). A series of structural studies have elaborated some of the mechanisms of dsRNA recogniti...

journal_title：Protein & cell

authors： Feng M,Ding Z,Xu L,Kong L,Wang W,Jiao S,Shi Z,Greene MI,Cong Y,Zhou Z

更新日期：2013-02-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a heterogeneous clonal disorder of myeloid precursors arrested in their maturation, creating a diverse disease entity with a wide range of responses to historically standard treatment approaches. While significant progress has been made in characterizing and individualizing the disease ...

journal_title：Protein & cell

authors： Peloquin GL,Chen YB,Fathi AT

更新日期：2013-10-01 00:00:00

abstract：:Treatment of latent tuberculosis infection remains an important goal of global TB eradication. To this end, targets that are essential for intracellular survival of Mycobacterium tuberculosis are particularly attractive. Arylamine N-acetyltransferase (NAT) represents such a target as it is, along with the enzymes enco...

journal_title：Protein & cell

authors： Abuhammad AM,Lowe ED,Fullam E,Noble M,Garman EF,Sim E

更新日期：2010-04-01 00:00:00

abstract：:Hearing impairment (HI) affects 1/1000 children and over 2% of the aged population. We have previously reported that mutations in the gene encoding gap junction protein connexin-31 (C×31) are associated with HI. The pathological mechanism of the disease mutations remains unknown. Here, we show that expression of C×31 ...

journal_title：Protein & cell

authors： Xia K,Ma H,Xiong H,Pan Q,Huang L,Wang D,Zhang Z

更新日期：2010-10-01 00:00:00

abstract：:While human induced pluripotent stem cells (hiPSCs) have promising applications in regenerative medicine, most of the hiPSC lines available today are not suitable for clinical applications due to contamination with nonhuman materials, such as sialic acid, and potential pathogens from animal-product-containing cell cul...

journal_title：Protein & cell

authors： Wang Q,Mou X,Cao H,Meng Q,Ma Y,Han P,Jiang J,Zhang H,Ma Y

更新日期：2012-01-01 00:00:00

abstract：:With the smooth move towards the coming expected clinical reports of anticancer pharmaceutical molecules targeting telomeres and telomerase, and also with the exciting success in the extension of lifespan by regulating telomerase activity without increased onset of oncogenesis in laboratory mouse models (Garcia-Cao et...

journal_title：Protein & cell

authors： Lu Y,Wei B,Zhang T,Chen Z,Ye J

更新日期：2013-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most frequent human malignancies worldwide with very poor prognosis. It is generally accepted that the progression of HCC is a long-term process with accumulation of multiple genetic and epigenetic alterations, which further lead to the activation of critical oncogenes or i...

journal_title：Protein & cell

authors： Liu M,Jiang L,Guan XY

更新日期：2014-09-01 00:00:00

abstract：:Alzheimer's disease (AD) pathogenesis is characterized by senile plaques in the brain and evidence of oxidative damage. Oxidative stress may precede plaque formation in AD; however, the link between oxidative damage and plaque formation remains unknown. Presenilins are transmembrane proteins in which mutations lead to...

journal_title：Protein & cell

authors： Wangler MF,Reiter LT,Zimm G,Trimble-Morgan J,Wu J,Bier E

更新日期：2011-07-01 00:00:00

abstract：:Dementia is a comprehensive category of brain diseases that is great enough to affect a person's daily functioning. The most common type of dementia is Alzheimer's disease, which makes most of cases. New researches indicate that gastrointestinal tract microbiota are directly linked to dementia pathogenesis through tri...

journal_title：Protein & cell

authors： Alkasir R,Li J,Li X,Jin M,Zhu B

更新日期：2017-02-01 00:00:00

abstract：:S-Nitros(yl)ation is a ubiquitous redox-based post-translational modification of protein cysteine thiols by nitric oxide or its derivatives, which transduces the bioactivity of nitric oxide (NO) by regulation of protein conformation, activity, stability, localization and protein-protein interactions. These years, more...

journal_title：Protein & cell

authors： Zhang X,Huang B,Zhang L,Zhang Y,Zhao Y,Guo X,Qiao X,Chen C

更新日期：2012-12-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) depend on glycolysis for energy and substrates for biosynthesis. To understand the mechanisms governing the metabolism of hESCs, we investigated the transcriptional regulation of glucose transporter 1 (GLUT1, SLC2A1), a key glycolytic gene to maintain pluripotency. By combining the g...

journal_title：Protein & cell

authors： Yu L,Ji KY,Zhang J,Xu Y,Ying Y,Mai T,Xu S,Zhang QB,Yao KT,Xu Y

更新日期：2019-09-01 00:00:00

abstract：:Histone deacetylase 6 (HDAC6), a predominantly cytoplasmic protein deacetylase, participates in a wide range of cellular processes through its deacetylase activity. However, the diverse functions of HDAC6 cannot be fully elucidated with its known substrates. In an attempt to explore the substrate diversity of HDAC6, w...

journal_title：Protein & cell

authors： Zhang L,Liu S,Liu N,Zhang Y,Liu M,Li D,Seto E,Yao TP,Shui W,Zhou J

更新日期：2015-01-01 00:00:00

abstract：:Osteosarcoma is the most common primary sarcoma of bone, and it is a leading cause of cancer death among adolescents and young adults. However, the molecular mechanism underlying osteosarcoma carcinogenesis remains poorly understood. Recently, cyclin-dependent kinase 6 (CDK6) was identified as an important oncogene. W...

journal_title：Protein & cell

authors： Zhu K,Liu L,Zhang J,Wang Y,Liang H,Fan G,Jiang Z,Zhang CY,Chen X,Zhou G

更新日期：2016-06-01 00:00:00

abstract：:Precision medicine emerges as a new approach that takes into account individual variability. Successful realization of precision medicine requires disease models that are able to incorporate personalized disease information and recapitulate disease development processes at the molecular, cellular and organ levels. Wit...

journal_title：Protein & cell

authors： Sun Y,Ding Q

更新日期：2017-05-01 00:00:00

abstract：:Thymic epithelial cells (TECs) are one of the most important components in thymic microenvironment supporting thymocyte development and maturation. TECs, composed of cortical and medullary TECs, are derived from a common bipotent progenitor, mediating thymocyte positive and negative selections. Multiple levels of sign...

journal_title：Protein & cell

authors： Sun L,Luo H,Li H,Zhao Y

更新日期：2013-05-01 00:00:00

abstract：:Dehydration is one of the key steps in the biosynthesis of mycolic acids and is vital to the growth of Mycobacterium tuberculosis (Mtb). Consequently, stalling dehydration cures tuberculosis (TB). Clinically used anti-TB drugs like thiacetazone (TAC) and isoxyl (ISO) as well as flavonoids inhibit the enzyme activity o...

journal_title：Protein & cell

authors： Dong Y,Qiu X,Shaw N,Xu Y,Sun Y,Li X,Li J,Rao Z

更新日期：2015-07-01 00:00:00

abstract：:Complement proteins in blood recognize charged particles. The anionic phospholipid (aPL) cardiolipin binds both complement proteins C1q and factor H. C1q is an activator of the complement classical pathway, while factor H is an inhibitor of the alternative pathway. To examine opposing effects of C1q and factor H on co...

journal_title：Protein & cell

authors： Tan LA,Yu B,Sim FC,Kishore U,Sim RB

更新日期：2010-11-01 00:00:00

abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary cerebrovascular disease caused by a NOTCH3 mutation. However, the underlying cellular and molecular mechanisms remain unidentified. Here, we generated non-integrative induced pluripotent stem cells...

journal_title：Protein & cell

authors： Ling C,Liu Z,Song M,Zhang W,Wang S,Liu X,Ma S,Sun S,Fu L,Chu Q,Belmonte JCI,Wang Z,Qu J,Yuan Y,Liu GH

更新日期：2019-04-01 00:00:00

abstract：:The self-renewal and multipotent potentials in neural stem cells (NSCs) maintain the normal physiological functions of central nervous system (CNS). The abnormal differentiation of NSCs would lead to CNS disorders. However, the mechanisms of how NSCs differentiate into astrocytes, oligodendrocytes (OLs) and neurons ar...

journal_title：Protein & cell

authors： Wang K,Wang H,Wang J,Xie Y,Chen J,Yan H,Liu Z,Wen T

更新日期：2012-03-01 00:00:00

abstract：:Coronaviruses are the causative agent of respiratory and enteric diseases in animals and humans. One example is SARS, which caused a worldwide health threat in 2003. In coronaviruses, the structural protein N (nucleocapsid protein) associates with the viral RNA to form the filamentous nucleocapsid and plays a crucial ...

journal_title：Protein & cell

authors： Ma Y,Tong X,Xu X,Li X,Lou Z,Rao Z

更新日期：2010-07-01 00:00:00

abstract：:Oral mucositis, a severe oral ulceration, is a common toxic effect of radio- or chemoradio-therapy and a limiting factor to using the maximum dose of radiation for effective cancer treatment. Among cancer patients, at least 40% and up to 70%, of individuals treated with standard chemotherapy regimens or upper-body rad...

journal_title：Protein & cell

authors： Bian L,Han G,Zhao CW,Garl PJ,Wang XJ

更新日期：2015-03-01 00:00:00